General Information of the Compound
Compound ID
CP0533835
Compound Name
1-[2-chloro-6-(2-methoxyethoxy)pyridin-4-yl]-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea
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Structure
Formula
C20H21ClF3N7O3
Molecular Weight
499.881
Canonical SMILES
COCCOc1cc(NC(=O)NCc2cc(C)c(nn2)-c2cn(C)nc2C(F)(F)F)cc(Cl)n1
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InChI
InChI=1S/C20H21ClF3N7O3/c1-11-6-13(28-29-17(11)14-10-31(2)30-18(14)20(22,23)24)9-25-19(32)26-12-7-15(21)27-16(8-12)34-5-4-33-3/h6-8,10H,4-5,9H2,1-3H3,(H2,25,26,27,32)
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InChIKey
LIRIXOFWLZNCEA-UHFFFAOYSA-N
Physicochemical Property
logP
3.59962
Rotatable Bonds
8
Heavy Atom Count
34
Polar Areas
116.08
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
8
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 137377912
ChEMBL ID
CHEMBL4859853
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01837, Sphingosine 1-phosphate receptor 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
IC50 = 640 nM
   TI
   LI
   LO
   TS
2
IC50 = 3500 nM
   TI
   LI
   LO
   TS
CL000673 HFL1 Homo sapiens (Human)  1
1
IC50 = 640 nM
   TI
   LI
   LO
   TS