Brief Information of the Compound and Protein
Compound Name
 Compound Info 
1-(2-chloro-6-ethoxypyridin-4-yl)-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea
    Show/Hide
 PubChem ID
CID: 137377865
Canonical SMILES
CCOc1cc(NC(=O)NCc2cc(C)c(nn2)-c2cn(C)nc2C(F)(F)F)cc(Cl)n1
    Show/Hide
Compound Formula C19H19ClF3N7O2
Compound Structure
Protein Name
 Protein Info 
Sphingosine 1-phosphate receptor 2
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Lipid-like ligand receptor (family A GPCR)
>
EDG receptor
Uniprot ID
O95136
Gene Name
S1PR2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  3
1
IC50 = 20 nM
   TI
   LI
   LO
   TS
2
IC50 = 5000 nM
   TI
   LI
   LO
   TS
3
IC50 = 7700 nM
   TI
   LI
   LO
   TS
CL000673 HFL1
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 20 nM
   TI
   LI
   LO
   TS
2
IC50 = 45000 nM
   TI
   LI
   LO
   TS