Brief Information of the Compound and Protein
Compound Name
1-[2-chloro-6-(2,2-difluoroethoxy)pyridin-4-yl]-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea
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PubChem ID
CID: 141537981
Canonical SMILES
Cc1cc(CNC(=O)Nc2cc(Cl)nc(OCC(F)F)c2)nnc1-c1cn(C)nc1C(F)(F)F
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Compound Formula C19H17ClF5N7O2
Compound Structure
Protein Name
Sphingosine 1-phosphate receptor 2
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
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Small molecule receptor (family A GPCR)
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Lipid-like ligand receptor (family A GPCR)
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EDG receptor
Uniprot ID
O95136
Gene Name
S1PR2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  3
1
IC50 = 36 nM
   TI
   LI
   LO
   TS
2
IC50 = 5100 nM
   TI
   LI
   LO
   TS
3
IC50 = 7200 nM
   TI
   LI
   LO
   TS
CL000673 HFL1 Homo sapiens (Human)  2
1
IC50 = 36 nM
   TI
   LI
   LO
   TS
2
IC50 = 71000 nM
   TI
   LI
   LO
   TS