Brief Information of the Compound and Protein
Compound Name
1-[[5-[(1,3-dimethylpyrazol-4-yl)amino]-4-methylpyridin-2-yl]methyl]-3-[2-ethoxy-6-(trifluoromethyl)pyridin-4-yl]urea
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Canonical SMILES
CCOc1cc(NC(=O)NCc2cc(C)c(Nc3cn(C)nc3C)cn2)cc(n1)C(F)(F)F
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Compound Formula C21H24F3N7O2
Compound Structure
Protein Name
Sphingosine 1-phosphate receptor 2
Protein Classification
Membrane receptor
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Family A G protein-coupled receptor
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Small molecule receptor (family A GPCR)
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Lipid-like ligand receptor (family A GPCR)
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EDG receptor
Uniprot ID
O95136
Gene Name
S1PR2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  3
1
IC50 = 55 nM
   TI
   LI
   LO
   TS
2
IC50 = 4800 nM
   TI
   LI
   LO
   TS
3
IC50 = 12000 nM
   TI
   LI
   LO
   TS
CL000673 HFL1 Homo sapiens (Human)  1
1
IC50 = 55 nM
   TI
   LI
   LO
   TS