Brief Information of the Compound and Protein
Compound Name
 Compound Info 
1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine
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 PubChem ID
CID: 11656518
SID: 16760016
Canonical SMILES
Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12
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Compound Formula C24H16F6N6O
Compound Structure
Protein Name
 Protein Info 
Serine/threonine-protein kinase B-raf
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase RAF family
Uniprot ID
P15056
Gene Name
BRAF
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000045 A-375
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 40 nM
   TI
   LI
   LO
   TS
CL000212 Malme-3M
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 40 nM
   TI
   LI
   LO
   TS
CL000313 SK-MEL-28
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 140 nM
   TI
   LI
   LO
   TS
CL000339 WM1799
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 40 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.5 nM
2 IC50 = 70 nM
3 Kd = 330 nM
4 Kd = 1200 nM