Brief Information of the Compound and Protein
Compound Name
 Compound Info 
PLX-4032
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 PubChem ID
CID: 42611257
SID: 123055406
Canonical SMILES
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F
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Compound Formula C23H18ClF2N3O3S
Compound Structure
Protein Name
 Protein Info 
Serine/threonine-protein kinase B-raf
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase RAF family
Uniprot ID
P15056
Gene Name
BRAF
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000045 A-375
 Cell Line Info 
Homo sapiens (Human)  6
1
IC50 = 17 nM
   TI
   LI
   LO
   TS
2
IC50 = 33.1 nM
   TI
   LI
   LO
   TS
3
IC50 = 127 nM
   TI
   LI
   LO
   TS
4
IC50 = 150 nM
   TI
   LI
   LO
   TS
5
IC50 = 190 nM
   TI
   LI
   LO
   TS
6
IC50 = 260 nM
   TI
   LI
   LO
   TS
CL000212 Malme-3M
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 61 nM
   TI
   LI
   LO
   TS
CL000207 MIA PaCa-2
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 2290 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 4 nM
2 IC50 = 6.1 nM
3 IC50 = 6.9 nM
4 IC50 = 9.6 nM
5 IC50 = 20 nM
6 IC50 = 21 nM
7 IC50 = 23 nM
8 IC50 = 31 nM
9 IC50 = 31.6 nM
10 IC50 = 33 nM
11 IC50 = 34 nM
12 IC50 = 100 nM
13 IC50 = 280 nM
14 IC50 = 1140 nM
15 Kd = 50.7 nM
16 Kd = 58.2 nM