Brief Information of the Compound and Protein
Compound Name
1-(3-(6,7- dimethoxy- quinazolin- 4- yloxy)phenyl)- 3-(5- (1- methoxy-2- methylpropan-2- yl)isoxazol-3-yl) urea
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PubChem ID
CID: 56953873
SID: 135666074
Canonical SMILES
COCC(C)(C)c1cc(NC(=O)Nc2cccc(Oc3ncnc4cc(OC)c(OC)cc34)c2)no1
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Compound Formula C25H27N5O6
Compound Structure
Protein Name
Serine/threonine-protein kinase B-raf
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase RAF family
Uniprot ID
P15056
Gene Name
BRAF
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000045 A-375 Homo sapiens (Human)  1
1
IC50 = 324 nM
   TI
   LI
   LO
   TS
CL000006 HEK293 Homo sapiens (Human)  1
1
Kd = 151 nM
   TI
   LI
   LO
   TS