Brief Information of the Compound and Protein
Compound Name
 Compound Info 
3-(2-cyanopropan-2-yl)-N-[4-methyl-3-[(3-methyl-4-oxoquinazolin-6-yl)amino]phenyl]benzamide
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 PubChem ID
CID: 11676786
SID: 16780810
Canonical SMILES
Cc1ccc(NC(=O)c2cccc(c2)C(C)(C)C#N)cc1Nc1ccc2ncn(C)c(=O)c2c1
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Compound Formula C27H25N5O2
Compound Structure
Protein Name
 Protein Info 
Serine/threonine-protein kinase B-raf
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase RAF family
Uniprot ID
P15056
Gene Name
BRAF
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000045 A-375
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 15 nM
   TI
   LI
   LO
   TS
CL000212 Malme-3M
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 27 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  3
1
IC50 = 34 nM
   TI
   LI
   LO
   TS
2
IC50 = 270 nM
   TI
   LI
   LO
   TS
3
IC50 = 2640 nM
   TI
   LI
   LO
   TS