Brief Information of the Cell Line and Protein
Cell Line ID: CL000542 , Malme-3
Synonyms
MALME-3
Category Finite cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_1437
Protein ID: PT01381 , Serine/threonine-protein kinase B-raf
Gene Name BRAF
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID P15056
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000542  Protein ID: PT01381
 
Compound ID Compound Name Compound Formula
CP0114052
2,6-difluoro-N-(2-phenylpyrazolo[1,5-a]pyrimidin-6-yl)-3-(propylsulfonylamino)benzamide
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C22H19F2N5O3S
 1
1
IC50 = 17 nM
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CP0104718
2,6-difluoro-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-3-(propylsulfonylamino)benzamide
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C17H17F2N5O4S
 1
1
IC50 = 19 nM
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CP0416095
2,6-difluoro-3-(propylsulfonylamino)-N-(2-pyridin-3-ylpyrazolo[1,5-a]pyrimidin-6-yl)benzamide
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C21H18F2N6O3S
 1
1
IC50 = 27 nM
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CP0420829
2,6-difluoro-N-[2-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-6-yl]-3-(propylsulfonylamino)benzamide
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C20H19F2N7O3S
 1
1
IC50 = 48 nM
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CP0385592
2,6-difluoro-N-[2-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-6-yl]-3-(propylsulfonylamino)benzamide
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C22H18F3N5O3S
 1
1
IC50 = 54 nM
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CP0423927
2,6-difluoro-N-[2-(3-fluorophenyl)pyrazolo[1,5-a]pyrimidin-6-yl]-3-(propylsulfonylamino)benzamide
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C22H18F3N5O3S
 1
1
IC50 = 60 nM
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CP0134382
2,6-difluoro-N-(2-methoxypyrazolo[1,5-a]pyrimidin-6-yl)-3-(propylsulfonylamino)benzamide
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C17H17F2N5O4S
 1
1
IC50 = 68 nM
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CP0432348
2,6-difluoro-N-[2-(2-methoxyethoxy)pyrazolo[1,5-a]pyrimidin-6-yl]-3-(propylsulfonylamino)benzamide
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C19H21F2N5O5S
 1
1
IC50 = 110 nM
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CP0410192
N-(2-ethoxypyrazolo[1,5-a]pyrimidin-6-yl)-2,6-difluoro-3-(propylsulfonylamino)benzamide
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C18H19F2N5O4S
 1
1
IC50 = 205 nM
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CP0420824
N-(2-ethylpyrazolo[1,5-a]pyrimidin-6-yl)-2,6-difluoro-3-(propylsulfonylamino)benzamide
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C18H19F2N5O3S
 1
1
IC50 = 228 nM
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CP0524800
2,6-difluoro-N-(2-methylpyrazolo[1,5-a]pyrimidin-6-yl)-3-(propylsulfonylamino)benzamide
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C17H17F2N5O3S
 1
1
IC50 = 248 nM
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CP0420825
N-(2-cyclopropylpyrazolo[1,5-a]pyrimidin-6-yl)-2,6-difluoro-3-(propylsulfonylamino)benzamide
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C19H19F2N5O3S
 1
1
IC50 = 299 nM
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CP0420828
2,6-difluoro-N-(2-morpholin-4-ylpyrazolo[1,5-a]pyrimidin-6-yl)-3-(propylsulfonylamino)benzamide
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C20H22F2N6O4S
 1
1
IC50 = 315 nM
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CP0410276
2,6-difluoro-3-(propylsulfonylamino)-N-[2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]benzamide
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C17H14F5N5O3S
 1
1
IC50 = 374 nM
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CP0524806
2,6-difluoro-N-[2-(methylamino)pyrazolo[1,5-a]pyrimidin-6-yl]-3-(propylsulfonylamino)benzamide
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C17H18F2N6O3S
 1
1
IC50 = 382 nM
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CP0420827
2,6-difluoro-N-[2-(propan-2-ylamino)pyrazolo[1,5-a]pyrimidin-6-yl]-3-(propylsulfonylamino)benzamide
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C19H22F2N6O3S
 1
1
IC50 = 395 nM
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CP0470544
N-(2-cyclopentylpyrazolo[1,5-a]pyrimidin-6-yl)-2,6-difluoro-3-(propylsulfonylamino)benzamide
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C21H23F2N5O3S
 1
1
IC50 = 448 nM
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CP0435994
2,6-difluoro-N-(2-propan-2-yloxypyrazolo[1,5-a]pyrimidin-6-yl)-3-(propylsulfonylamino)benzamide
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C19H21F2N5O4S
 1
1
IC50 = 449 nM
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CP0392016
2,6-difluoro-3-(propylsulfonylamino)-N-pyrazolo[1,5-a]pyrimidin-6-ylbenzamide
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C16H15F2N5O3S
 1
1
IC50 = 488 nM
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CP0517475
2,6-difluoro-3-(propylsulfonylamino)-N-(2-pyrrolidin-1-ylpyrazolo[1,5-a]pyrimidin-6-yl)benzamide
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C20H22F2N6O3S
 1
1
IC50 = 664 nM
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CP0213065
2,6-difluoro-3-(propylsulfonylamino)-N-quinolin-3-ylbenzamide
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C19H17F2N3O3S
 1
1
IC50 = 1381 nM
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CP0450680
2,6-difluoro-3-(propylsulfonylamino)-N-(1H-pyrrolo[3,2-b]pyridin-6-yl)benzamide
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C17H16F2N4O3S
 1
1
IC50 = 1513 nM
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CP0438366
2,6-difluoro-3-(propylsulfonylamino)-N-pyridin-3-ylbenzamide
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C15H15F2N3O3S
 1
1
IC50 = 6730 nM
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