Brief Information of the Compound and Protein
Compound Name
N-(4-chloro-3-methylphenyl)-4-methyl-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]benzamide
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PubChem ID
CID: 73331039
Canonical SMILES
Cc1cc(NC(=O)c2ccc(C)c(Nc3ncccc3-c3ncnc4[nH]cnc34)c2)ccc1Cl
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Compound Formula C25H20ClN7O
Compound Structure
Protein Name
Serine/threonine-protein kinase B-raf
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase RAF family
Uniprot ID
P15056
Gene Name
BRAF
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000045 A-375 Homo sapiens (Human)  1
1
IC50 = 7.13 nM
   TI
   LI
   LO
   TS
CL000619 SK-MEL-2 Homo sapiens (Human)  1
1
IC50 = 15.9 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 1.43 nM