Brief Information of the Compound and Protein
Compound Name
N-[2,4-difluoro-3-[[3-(7H-purin-6-yl)pyridin-2-yl]amino]phenyl]pyridine-2-sulfonamide
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PubChem ID
CID: 127045991
Canonical SMILES
Fc1ccc(NS(=O)(=O)c2ccccn2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12
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Compound Formula C21H14F2N8O2S
Compound Structure
Protein Name
Serine/threonine-protein kinase B-raf
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase RAF family
Uniprot ID
P15056
Gene Name
BRAF
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000045 A-375 Homo sapiens (Human)  1
1
IC50 = 177 nM
   TI
   LI
   LO
   TS
CL000207 MIA PaCa-2 Homo sapiens (Human)  1
1
EC50 = 7940 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 21 nM
2 IC50 = 41 nM