Brief Information of the Compound and Protein
Compound Name
 Compound Info 
CEP-32496
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 PubChem ID
CID: 56846693
Canonical SMILES
COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C(F)(F)F)c3)c2cc1OC
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Compound Formula C24H22F3N5O5
Compound Structure
Protein Name
 Protein Info 
Serine/threonine-protein kinase B-raf
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase RAF family
Uniprot ID
P15056
Gene Name
BRAF
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000045 A-375
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 82 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  2
1
Kd = 14 nM
   TI
   LI
   LO
   TS
2
Kd = 36 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Kd = 14 nM
2 Kd = 36 nM