2-(4-methylpiperazin-1-yl)-N-[4-methyl-5-[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]-1,3-thiazol-2-yl]acetamide

N-{4-Methyl-5-[3-((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-yl]-thiazol-2-yl}-2-(3-trifluoromethyl-phenyl)-acetamide

2-(3-Chloro-phenyl)-N-{4-methyl-5-[3-((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-yl]-thiazol-2-yl}-acetamide

1-{4-Methyl-5-[3-((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-yl]-thiazol-2-yl}-3-(3-trifluoromethyl-phenyl)-urea

N-{4-Methyl-5-[3-((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-yl]-thiazol-2-yl}-3-trifluoromethyl-benzamide

Selitrectinib

4-(4-Methyl-piperazin-1-ylmethyl)-N-{4-methyl-5-[3-((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-yl]-thiazol-2-yl}-benzamide

2-Amino-N-{4-methyl-5-[3-((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-yl]-thiazol-2-yl}-4-methylsulfanyl-butyramide

(E)-N-(4((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-4-yl)vinyl)-1H-indazol-6-yl)thio)propanamide

2-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-N-{4-methyl-5-[3-((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-yl]-thiazol-2-yl}-acetamide

US10005783, 14

2-(1-Methyl-piperidin-4-yl)-N-{4-methyl-5-[3-((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-yl]-thiazol-2-yl}-acetamide

N-{4-Methyl-5-[3-((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-yl]-thiazol-2-yl}-2-naphthalen-1-yl-acetamide

2-(2-Methoxy-ethoxy)-N-{4-methyl-5-[3-((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-yl]-thiazol-2-yl}-acetamide

2-(3,4-Dimethoxy-phenyl)-N-{4-methyl-5-[3-((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-yl]-thiazol-2-yl}-acetamide

4-(4-Methyl-piperazin-1-ylmethyl)-N-{4-methyl-5-[3-((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-ylsulfanyl]-thiazol-2-yl}-3-trifluoromethyl-benzamide

N-{5-[3-(5-Fluoro-pyridin-3-yl)-1H-indazol-6-yl]-4-methyl-thiazol-2-yl}-2-(4-methyl-piperazin-1-yl)-acetamide

1-[4-(4-Methyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]-3-{3-[3-((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-ylsulfanyl]-phenyl}-urea

N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]propanamide

2-Amino-N-{4-methyl-5-[3-((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-yl]-thiazol-2-yl}-3-phenyl-propionamide

N-{4-Methyl-5-[3-(1-methyl-1H-pyrazol-3-yl)-1H-indazol-6-yl]-thiazol-2-yl}-2-(4-methyl-piperazin-1-yl)-acetamide

N-[4-(4-Methyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]-3-[3-((E)-2-pyrazin-2-yl-vinyl)-1H-indazol-6-ylsulfanyl]-propionamide

1-Methyl-piperidine-4-carboxylic acid {4-methyl-5-[3-((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-yl]-thiazol-2-yl}-amide

N-{4-Methyl-5-[3-((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-yl]-thiazol-2-yl}-2-piperidin-4-yl-acetamide

Piperidine-4-carboxylic acid {4-methyl-5-[3-((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-yl]-thiazol-2-yl}-amide

N-[4-(4-Methyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]-N'-[3-((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-yl]-malonamide

N-(4-methyl-5-(3-(pyridin-3-yl)-1H-indazol-6-yl)thiazol-2-yl)-2-(4-methylpiperazin-1-yl)acetamide

N-{4-Methyl-5-[3-((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-yl]-thiazol-2-yl}-isobutyramide

N-{4-Methyl-5-[3-((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-yl]-thiazol-2-yl}-2-piperidin-3-yl-acetamide

(E)-4-((4-Methylpiperazin-1-yl)methyl)-N-(2-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)ethyl)-3-(trifluoromethyl)benzamide

(E)-4-((4-Methylpiperazin-1-yl)methyl)-N-(3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propyl)-3-(trifluoromethyl)benzamide

N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(pyridin-4-yl)-1H-indazol-6-yl)thio)propanamide

N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(6-methylpyridin-3-yl)-1H-indazol-6-yl)thio)propanamide

(E)-1-(4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(2-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)ethyl)urea

3-((3-Methyl-1H-indazol-6-yl)thio)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)propanamide

N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(pyridin-3-yl)-1H-indazol-6-yl)thio)propanamide

N-{5-[3-(2-Amino-pyrimidin-5-yl)-1H-indazol-6-yl]-4-methyl-thiazol-2-yl}-2-(4-methyl-piperazin-1-yl)-acetamide

4-(4-Methyl-piperazin-1-ylmethyl)-N-{3-[3-((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-ylsulfanyl]-phenyl}-3-trifluoromethyl-benzamide

N-{5-[3-(3-Fluoro-phenyl)-1H-indazol-6-yl]-4-methyl-thiazol-2-yl}-2-(4-methyl-piperazin-1-yl)-acetamide

(E)-N-(4-methyl-5-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thiazol-2-yl)acetamide

2-[4-[4-[6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]piperazin-1-yl]acetic acid

6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]-3-pyridin-2-ylimidazo[1,2-b]pyridazine

1-[4-[6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]piperidin-4-ol

5,18-dimethyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-14-oxo-9-oxa-15,18,23,25,26-pentazatetracyclo[17.5.2.14,8.022,25]heptacosa-1(24),4,6,8(27),19(26),20,22-heptaen-2-yne-6-carboxamide

1-[6-[6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]piperidin-4-ol

N-[3-(6-{[(3-Fluorophenyl)methyl]amino}imidazo[1,2-b]pyridazin-3-yl)phenyl]oxane-4-carboxamide

4-[6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]benzonitrile

4-[6-[(3-fluorophenyl)methylamino]imidazo[1,2-b]pyridazin-3-yl]benzenesulfonamide

4-[6-[(3-fluorophenyl)methylamino]imidazo[1,2-b]pyridazin-3-yl]benzonitrile

4-[6-[2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]benzonitrile

4-[6-[3-(3-fluorophenyl)morpholin-4-yl]imidazo[1,2-b]pyridazin-3-yl]benzonitrile

[4-[6-[(3-fluorophenyl)methylamino]imidazo[1,2-b]pyridazin-3-yl]phenyl]methanol

4-[6-[2-(3-fluorophenyl)piperidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]benzonitrile

4-(6-{[(2-Methoxyphenyl)methyl]amino}imidazo[1,2-b]pyridazin-3-yl)benzonitrile

4-[6-[benzyl(methyl)amino]imidazo[1,2-b]pyridazin-3-yl]benzonitrile

3-[6-(Benzylamino)imidazo[1,2-b]pyridazin-3-yl]benzonitrile

4-[6-(benzylamino)imidazo[1,2-b]pyridazin-3-yl]benzonitrile

3-(4-Amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-phenol

3-[4-amino-7-[3-(hydroxymethyl)cyclobutyl]pyrrolo[2,3-d]pyrimidin-5-yl]phenol

methyl N-[4-[7-amino-3-(3,4-dimethoxyphenyl)-5-(1-methylpiperidin-4-yl)oxypyrazolo[1,5-a]pyrimidin-6-yl]phenyl]carbamate

4-[6-[(2S)-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]benzonitrile

1-[4-[3-[4-amino-5-(2-fluoro-5-hydroxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl]piperazin-1-yl]ethanone

3-(3,4-dimethoxyphenyl)-5-(1-methylpiperidin-4-yl)oxy-6-(1,3-thiazol-2-yl)pyrazolo[1,5-a]pyrimidin-7-amine

3-(3,4-dimethoxyphenyl)-5-(1-methylpiperidin-4-yl)oxy-6-phenylpyrazolo[1,5-a]pyrimidin-7-amine