Brief Information of the Compound and Protein
Compound Name
 Compound Info 
2-(4-methylpiperazin-1-yl)-N-[4-methyl-5-[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]-1,3-thiazol-2-yl]acetamide
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Canonical SMILES
CN1CCN(CC(=O)Nc2nc(C)c(s2)-c2ccc3c(\C=C\c4ccccn4)n[nH]c3c2)CC1
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Compound Formula C25H27N7OS
Compound Structure
Protein Name
 Protein Info 
High affinity nerve growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase Trk family
Uniprot ID
P04629
Gene Name
NTRK1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3
 Cell Line Info 
Mus musculus (Mouse)  7
1
EC50 = 26 nM
   TI
   LI
   LO
   TS
2
EC50 = 67 nM
   TI
   LI
   LO
   TS
3
EC50 = 120 nM
   TI
   LI
   LO
   TS
4
GI50 = 7 nM
   TI
   LI
   LO
   TS
5
GI50 = 8.5 nM
   TI
   LI
   LO
   TS
6
GI50 = 34 nM
   TI
   LI
   LO
   TS
7
GI50 = 194 nM
   TI
   LI
   LO
   TS
CL000567 KM12-Luc
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 < 30 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 10.5 nM