| Compound ID |
Compound Name |
Compound Formula |
|
CP0015544
|
3-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-yl)benzamide
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|
C18H13F3N4O2
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0272876
|
N-(2-hydroxyethyl)-3-[6-[4-(trifluoromethoxy)anilino]pyrimidin-4-yl]benzamide
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|
C20H17F3N4O3
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0388540
|
4-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-yl)benzenesulfonamide
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|
C17H13F3N4O3S
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0388541
|
N-[4-[6-[4-(trifluoromethoxy)anilino]pyrimidin-4-yl]phenyl]methanesulfonamide
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|
C18H15F3N4O3S
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0388542
|
(4-methylpiperazin-1-yl)(4-(4-(trifluoromethoxy)phenylamino)thieno[2,3-d]pyrimidin-6-yl)methanone
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|
C19H18F3N5O2S
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0388544
|
6-(1H-pyrazol-4-yl)-N-(4-(trifluoromethoxy)phenyl)pyrimidin-4-amine
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|
C14H10F3N5O
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0388545
|
1-tert-butyl-N-(4-(trifluoromethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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|
C16H16F3N5O
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0477483
|
7-(2-morpholinoethyl)-N-(4-(trifluoromethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
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|
C19H20F3N5O2
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0510287
|
2-(4-(4-(Trifluoromethoxy)phenylamino)-1H-pyrazolo-[3,4-d]pyrimidin-1-yl)ethanol
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|
C14H12F3N5O2
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0002778
|
4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
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|
C29H31N7O
|
2
|
| 1 |
IC50 = 730 nM
|
|
|
| 2 |
IC50 = 20030 nM
|
|
|
|
CP0408606
|
N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-2-hydroxyacetamide
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|
C24H27ClN6O4
|
2
|
| 1 |
IC50 = 1120 nM
|
|
|
| 2 |
IC50 = 1480 nM
|
|
|
|
CP0478346
|
4-(2-azidophenoxy)-5-chloro-N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine
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|
C22H23ClN8O2
|
2
|
| 1 |
IC50 = 1330 nM
|
|
|
| 2 |
IC50 = 1450 nM
|
|
|
|
CP0905680
|
N-(2-(5-Chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)-2-benzyloxyacetamide
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|
C31H33ClN6O4
|
2
|
| 1 |
IC50 = 1370 nM
|
|
|
| 2 |
IC50 = 3500 nM
|
|
|
|
CP0472904
|
N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-3-hydroxypropanamide
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|
C25H29ClN6O4
|
2
|
| 1 |
IC50 = 1390 nM
|
|
|
| 2 |
IC50 = 2070 nM
|
|
|
|
CP0429397
|
N-[4-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-3-phenylmethoxypropanamide
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|
C32H35ClN6O4
|
2
|
| 1 |
IC50 = 1430 nM
|
|
|
| 2 |
IC50 = 1500 nM
|
|
|
|
CP0518127
|
4-(3-aminophenoxy)-5-chloro-N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine
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|
C22H25ClN6O2
|
2
|
| 1 |
IC50 = 1900 nM
|
|
|
| 2 |
IC50 = 1960 nM
|
|
|
|
CP0408607
|
N-[2-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-2-hydroxyacetamide
Show/Hide
|
C24H27ClN6O4
|
2
|
| 1 |
IC50 = 2070 nM
|
|
|
| 2 |
IC50 = 4180 nM
|
|
|
|
CP0534556
|
N-[4-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]acetamide
Show/Hide
|
C24H27ClN6O3
|
2
|
| 1 |
IC50 = 2080 nM
|
|
|
| 2 |
IC50 = 2890 nM
|
|
|
|
CP0408613
|
N-[4-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-2-phenylmethoxyacetamide
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|
C31H33ClN6O4
|
2
|
| 1 |
IC50 = 2110 nM
|
|
|
| 2 |
IC50 = 3620 nM
|
|
|
|
CP0408596
|
N-[2-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-3-hydroxypropanamide
Show/Hide
|
C25H29ClN6O4
|
2
|
| 1 |
IC50 = 2120 nM
|
|
|
| 2 |
IC50 = 3860 nM
|
|
|
|
CP0408595
|
N-[2-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide
Show/Hide
|
C25H27ClN6O3
|
2
|
| 1 |
IC50 = 2370 nM
|
|
|
| 2 |
IC50 = 2920 nM
|
|
|
|
CP0408609
|
N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-2-phenylmethoxyacetamide
Show/Hide
|
C31H33ClN6O4
|
2
|
| 1 |
IC50 = 2440 nM
|
|
|
| 2 |
IC50 = 2870 nM
|
|
|
|
CP0472903
|
N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-3-phenylmethoxypropanamide
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|
C32H35ClN6O4
|
2
|
| 1 |
IC50 = 2470 nM
|
|
|
| 2 |
IC50 = 2490 nM
|
|
|
|
CP0471792
|
N-[4-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-2-hydroxyacetamide
Show/Hide
|
C24H27ClN6O4
|
2
|
| 1 |
IC50 = 2740 nM
|
|
|
| 2 |
IC50 = 6680 nM
|
|
|
|
CP0482008
|
4-(4-aminophenoxy)-5-chloro-N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine
Show/Hide
|
C22H25ClN6O2
|
2
|
| 1 |
IC50 = 2810 nM
|
|
|
| 2 |
IC50 = 5470 nM
|
|
|
|
CP0408612
|
N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]acetamide
Show/Hide
|
C24H27ClN6O3
|
2
|
| 1 |
IC50 = 2910 nM
|
|
|
| 2 |
IC50 = 5560 nM
|
|
|
|
CP0905681
|
N-(2-(5-Chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)-3-benzyloxypropanamide
Show/Hide
|
C32H35ClN6O4
|
2
|
| 1 |
IC50 = 3060 nM
|
|
|
| 2 |
IC50 = 3120 nM
|
|
|
|
CP0408610
|
N-[4-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-3-hydroxypropanamide
Show/Hide
|
C25H29ClN6O4
|
2
|
| 1 |
IC50 = 3250 nM
|
|
|
| 2 |
IC50 = 3350 nM
|
|
|
|
CP0472905
|
(E)-N-[4-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-4-(dimethylamino)but-2-enamide
Show/Hide
|
C28H34ClN7O3
|
2
|
| 1 |
IC50 = 3410 nM
|
|
|
| 2 |
IC50 = 4720 nM
|
|
|
|
CP0432757
|
5-chloro-N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]-4-(4-nitrophenoxy)pyrimidin-2-amine
Show/Hide
|
C22H23ClN6O4
|
2
|
| 1 |
IC50 = 3480 nM
|
|
|
| 2 |
IC50 = 6890 nM
|
|
|
|
CP0408652
|
4-(3-azidophenoxy)-5-chloro-N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine
Show/Hide
|
C22H23ClN8O2
|
2
|
| 1 |
IC50 = 3870 nM
|
|
|
| 2 |
IC50 = 4670 nM
|
|
|
|
CP0408611
|
N-[2-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]acetamide
Show/Hide
|
C24H27ClN6O3
|
2
|
| 1 |
IC50 = 4730 nM
|
|
|
| 2 |
IC50 = 8490 nM
|
|
|
|
CP0408650
|
5-chloro-4-(3-isothiocyanatophenoxy)-N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine
Show/Hide
|
C23H23ClN6O2S
|
2
|
| 1 |
IC50 = 4990 nM
|
|
|
| 2 |
IC50 = 8410 nM
|
|
|
|
CP0482004
|
5-chloro-4-(2-isothiocyanatophenoxy)-N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine
Show/Hide
|
C23H23ClN6O2S
|
2
|
| 1 |
IC50 = 5560 nM
|
|
|
| 2 |
IC50 = 8990 nM
|
|
|
|
CP0429398
|
4-(2-aminophenoxy)-5-chloro-N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine
Show/Hide
|
C22H25ClN6O2
|
2
|
| 1 |
IC50 = 5740 nM
|
|
|
| 2 |
IC50 = 6730 nM
|
|
|
|
CP0511869
|
(E)-N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-4-(dimethylamino)but-2-enamide
Show/Hide
|
C28H34ClN7O3
|
2
|
| 1 |
IC50 = 6020 nM
|
|
|
| 2 |
IC50 = 7020 nM
|
|
|
|
CP0482007
|
N-[4-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide
Show/Hide
|
C25H27ClN6O3
|
2
|
| 1 |
IC50 = 6390 nM
|
|
|
| 2 |
IC50 = 7700 nM
|
|
|
|
CP0432729
|
5-chloro-N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]-4-(3-nitrophenoxy)pyrimidin-2-amine
Show/Hide
|
C22H23ClN6O4
|
2
|
| 1 |
IC50 = 6800 nM
|
|
|
| 2 |
IC50 = 9150 nM
|
|
|
|
CP0478344
|
5-chloro-N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]-4-(2-nitrophenoxy)pyrimidin-2-amine
Show/Hide
|
C22H23ClN6O4
|
2
|
| 1 |
IC50 = 6810 nM
|
|
|
| 2 |
IC50 = 11570 nM
|
|
|
|
CP0494495
|
5-chloro-4-(4-isothiocyanatophenoxy)-N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine
Show/Hide
|
C23H23ClN6O2S
|
2
|
| 1 |
IC50 = 7500 nM
|
|
|
| 2 |
IC50 = 9530 nM
|
|
|
|
CP0432728
|
(E)-N-[2-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-4-(dimethylamino)but-2-enamide
Show/Hide
|
C28H34ClN7O3
|
2
|
| 1 |
IC50 = 8120 nM
|
|
|
| 2 |
IC50 = 9100 nM
|
|
|
|
CP0059062
|
N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide
Show/Hide
|
C25H27ClN6O3
|
2
|
| 1 |
IC50 = 9690 nM
|
|
|
| 2 |
IC50 = 16280 nM
|
|
|
|
CP0482006
|
4-(4-azidophenoxy)-5-chloro-N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine
Show/Hide
|
C22H23ClN8O2
|
2
|
| 1 |
IC50 = 13060 nM
|
|
|
| 2 |
IC50 = 15130 nM
|
|
|
