Compound Information

General Information of the Compound

Compound ID

CP0002778

Compound Name

4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide

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Synonyms

112GI019

152459-95-5

BKJ8M8G5HI

CCRIS 9076

CGP-57148

CHEMBL941

Cgp 57148

Glamox

Glamox (TN)

Gleevec (TN)

Glivec (TN)

Imatinib

Imatinib (INN)

Imatinib (STI571)

Imatinib Methansulfonate

Imatinib [INN:BAN]

Imatinib free base

STI

UNII-BKJ8M8G5HI

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Structure

Formula

C29H31N7O

Molecular Weight

493.615

Canonical SMILES

CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1

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InChI

InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)

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InChIKey

KTUFNOKKBVMGRW-UHFFFAOYSA-N

CAS

152459-95-5

Physicochemical Property

logP	4.59032
Rotatable Bonds	7
Heavy Atom Count	37
Polar Areas	86.28
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Complexity	37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID

CID: 5291

SID: 14859628

ChEMBL ID

CHEMBL941

DrugBank ID

DB00619

Map of Molecular Bioactivity Related to the Compound

Map of Molecular Bioactivity Related to the Compound Compound Cell Line Protein Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Compound

Protein ID: PT01546, ATP-dependent translocase ABCB1

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000137	K562/A02 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 580 nM Bioactivity Info	TI LI LO TS
CL000135	A2780ADR Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 7244.36 nM Bioactivity Info	TI LI LO TS
CL000072	A2780 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 7244.36 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	IC50 = 12589.25 nM

Protein ID: PT00649, BCR/ABL p210 fusion protein

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000077	Ba/F3 Cell Line Info	Mus musculus (Mouse)	1
1	GI50 = 270 nM Bioactivity Info	TI LI LO TS

Protein ID: PT04542, Bile salt export pump

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000013	Sf9 Cell Line Info	Spodoptera frugiperda (Fall armyworm)	1
1	IC50 = 25100 nM Bioactivity Info	TI LI LO TS

Protein ID: PT02718, Broad substrate specificity ATP-binding cassette transporter ABCG2

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000013	Sf9 Cell Line Info	Spodoptera frugiperda (Fall armyworm)	1
1	IC50 = 900 nM Bioactivity Info	TI LI LO TS
CL000031	MDCK Cell Line Info	Canis lupus familiaris (Dog)	1
1	IC50 = 3380 nM Bioactivity Info	TI LI LO TS
CL000756	MCF/MX Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 4070 nM Bioactivity Info	TI LI LO TS
CL000083	MCF-7 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 4897.79 nM Bioactivity Info	TI LI LO TS

Protein ID: PT01678, Discoidin domain-containing receptor 2

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000077	Ba/F3 Cell Line Info	Mus musculus (Mouse)	1
1	GI50 > 10000 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	IC50 = 675 nM
2	Kd = 15 nM

Protein ID: PT02113, Epithelial discoidin domain-containing receptor 1

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000077	Ba/F3 Cell Line Info	Mus musculus (Mouse)	1
1	GI50 > 10000 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	IC50 = 337 nM
2	IC50 = 31000 nM
3	Kd = 0.7 nM
4	Kd = 0.7943 nM

Protein ID: PT06109, Geminin

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000015	SW480 Cell Line Info	Homo sapiens (Human)	1
1	Potency ~ 33498.3 nM Bioactivity Info	TI LI LO TS

Protein ID: PT00991, Histone deacetylase 1

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS

Protein ID: PT01213, Histone deacetylase 6

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS

Protein ID: PT01008, Macrophage colony-stimulating factor 1 receptor

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000077	Ba/F3 Cell Line Info	Mus musculus (Mouse)	1
1	GI50 = 110 nM Bioactivity Info	TI LI LO TS
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	1
1	IC50 = 960 nM Bioactivity Info	TI LI LO TS
CL000121	FDC-P1 Cell Line Info	Mus musculus (Mouse)	1
1	IC50 = 1274 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	Kd = 10 nM
2	Kd = 11 nM
3	Kd = 19 nM

Protein ID: PT00888, Mast/stem cell growth factor receptor Kit

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000077	Ba/F3 Cell Line Info	Mus musculus (Mouse)	47
1	GI50 = 1 nM Bioactivity Info	TI LI LO TS
2	GI50 = 5 nM Bioactivity Info	TI LI LO TS
3	GI50 = 17 nM Bioactivity Info	TI LI LO TS
4	GI50 = 24.9 nM Bioactivity Info	TI LI LO TS
5	GI50 = 36 nM Bioactivity Info	TI LI LO TS
6	GI50 = 39 nM Bioactivity Info	TI LI LO TS
7	GI50 = 45.1 nM Bioactivity Info	TI LI LO TS
8	GI50 = 70 nM Bioactivity Info	TI LI LO TS
9	GI50 = 100 nM Bioactivity Info	TI LI LO TS
10	GI50 = 102 nM Bioactivity Info	TI LI LO TS
11	GI50 = 115 nM Bioactivity Info	TI LI LO TS
12	GI50 = 148.2 nM Bioactivity Info	TI LI LO TS
13	GI50 = 192 nM Bioactivity Info	TI LI LO TS
14	GI50 = 216 nM Bioactivity Info	TI LI LO TS
15	GI50 = 223 nM Bioactivity Info	TI LI LO TS
16	GI50 = 267 nM Bioactivity Info	TI LI LO TS
17	GI50 = 312 nM Bioactivity Info	TI LI LO TS
18	GI50 = 360 nM Bioactivity Info	TI LI LO TS
19	GI50 = 364 nM Bioactivity Info	TI LI LO TS
20	GI50 = 370 nM Bioactivity Info	TI LI LO TS
21	GI50 = 381.9 nM Bioactivity Info	TI LI LO TS
22	GI50 = 392 nM Bioactivity Info	TI LI LO TS
23	GI50 = 400 nM Bioactivity Info	TI LI LO TS
24	GI50 = 406 nM Bioactivity Info	TI LI LO TS
25	GI50 = 535 nM Bioactivity Info	TI LI LO TS
26	GI50 = 590 nM Bioactivity Info	TI LI LO TS
27	GI50 = 669 nM Bioactivity Info	TI LI LO TS
28	GI50 = 700 nM Bioactivity Info	TI LI LO TS
29	GI50 = 701 nM Bioactivity Info	TI LI LO TS
30	GI50 = 803 nM Bioactivity Info	TI LI LO TS
31	GI50 = 803.1 nM Bioactivity Info	TI LI LO TS
32	GI50 = 823 nM Bioactivity Info	TI LI LO TS
33	GI50 = 1191 nM Bioactivity Info	TI LI LO TS
34	GI50 = 1245 nM Bioactivity Info	TI LI LO TS
35	GI50 = 1290 nM Bioactivity Info	TI LI LO TS
36	GI50 = 1466 nM Bioactivity Info	TI LI LO TS
37	GI50 = 1523 nM Bioactivity Info	TI LI LO TS
38	GI50 = 1570 nM Bioactivity Info	TI LI LO TS
39	GI50 = 2300 nM Bioactivity Info	TI LI LO TS
40	GI50 = 2490 nM Bioactivity Info	TI LI LO TS
41	GI50 = 2749 nM Bioactivity Info	TI LI LO TS
42	GI50 = 3947 nM Bioactivity Info	TI LI LO TS
43	GI50 = 5200 nM Bioactivity Info	TI LI LO TS
44	GI50 = 6670 nM Bioactivity Info	TI LI LO TS
45	GI50 = 9600 nM Bioactivity Info	TI LI LO TS
46	GI50 = 9930 nM Bioactivity Info	TI LI LO TS
47	GI50 > 10000 nM Bioactivity Info	TI LI LO TS
CL000122	GIST-T1 Cell Line Info	Homo sapiens (Human)	3
1	GI50 = 10 nM Bioactivity Info	TI LI LO TS
2	GI50 = 27 nM Bioactivity Info	TI LI LO TS
3	GI50 >= 30000 nM Bioactivity Info	TI LI LO TS
CL000123	GIST430 Cell Line Info	Homo sapiens (Human)	1
1	GI50 = 1100 nM Bioactivity Info	TI LI LO TS
CL000854	GIST-5R Cell Line Info	Homo sapiens (Human)	1
1	GI50 = 8300 nM Bioactivity Info	TI LI LO TS
CL000138	M-07e Cell Line Info	Homo sapiens (Human)	2
1	IC50 = 46 nM Bioactivity Info	TI LI LO TS
2	IC50 = 219 nM Bioactivity Info	TI LI LO TS
CL000013	Sf9 Cell Line Info	Spodoptera frugiperda (Fall armyworm)	5
1	IC50 = 53 nM Bioactivity Info	TI LI LO TS
2	IC50 = 319 nM Bioactivity Info	TI LI LO TS
3	IC50 = 769 nM Bioactivity Info	TI LI LO TS
4	IC50 = 5210 nM Bioactivity Info	TI LI LO TS
5	IC50 = 9818 nM Bioactivity Info	TI LI LO TS
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	1
1	IC50 = 260 nM Bioactivity Info	TI LI LO TS
CL000755	Ba/F3 c-Kit D816V Cell Line Info	Mus musculus (Mouse)	1
1	IC50 = 5000 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	EC50 = 100 nM
2	IC50 = 16.4 nM
3	IC50 = 21.6 nM
4	IC50 = 41 nM
5	IC50 = 52 nM
6	IC50 = 58 nM
7	IC50 = 100 nM
8	IC50 = 370 nM
9	IC50 = 400 nM
10	IC50 = 413 nM
11	IC50 >= 100000 nM
12	Kd = 12.59 nM
13	Kd = 13 nM
14	Kd = 14 nM
15	Kd = 15 nM
16	Kd = 71 nM
17	Kd = 91 nM
18	Kd = 560 nM
19	Kd = 820 nM
20	Kd = 830 nM
21	Kd = 980 nM
22	Kd = 2500 nM
23	Kd = 2900 nM

Protein ID: PT05367, Multidrug and toxin extrusion protein 1

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000036	MDCK-II Cell Line Info	Canis lupus familiaris (Dog)	1
1	IC50 = 40 nM Bioactivity Info	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	2
1	IC50 = 50 nM Bioactivity Info	TI LI LO TS
2	IC50 = 350 nM Bioactivity Info	TI LI LO TS

Protein ID: PT05330, Multidrug and toxin extrusion protein 2

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	2
1	IC50 = 350 nM Bioactivity Info	TI LI LO TS
2	IC50 = 2900 nM Bioactivity Info	TI LI LO TS

Protein ID: PT01092, Platelet-derived growth factor receptor alpha

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000077	Ba/F3 Cell Line Info	Mus musculus (Mouse)	5
1	GI50 = 10.7 nM Bioactivity Info	TI LI LO TS
2	GI50 = 34 nM Bioactivity Info	TI LI LO TS
3	GI50 = 46 nM Bioactivity Info	TI LI LO TS
4	GI50 = 567 nM Bioactivity Info	TI LI LO TS
5	GI50 > 10000 nM Bioactivity Info	TI LI LO TS
CL000136	G-292 clone A141B1 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 96 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	EC50 = 90 nM
2	IC50 = 1.995 nM
3	IC50 = 4.6 nM
4	IC50 = 18 nM
5	IC50 = 71 nM
6	IC50 = 160 nM
7	Kd = 31 nM

Protein ID: PT00844, Platelet-derived growth factor receptor beta

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000077	Ba/F3 Cell Line Info	Mus musculus (Mouse)	2
1	GI50 = 19 nM Bioactivity Info	TI LI LO TS
2	GI50 = 102 nM Bioactivity Info	TI LI LO TS
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	1
1	IC50 = 240 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	IC50 = 240 nM
2	IC50 = 386 nM
3	IC50 = 607 nM
4	Kd = 14 nM
5	Kd = 28 nM

Protein ID: PT05989, Platelet-derived growth factor receptor beta

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000139	A-10 Cell Line Info	Rattus norvegicus (Rat)	1
1	IC50 = 162 nM Bioactivity Info	TI LI LO TS

Protein ID: PT01204, Receptor-type tyrosine-protein kinase FLT3

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000013	Sf9 Cell Line Info	Spodoptera frugiperda (Fall armyworm)	1
1	IC50 = 131 nM Bioactivity Info	TI LI LO TS
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	Kd = 6300 nM
2	Kd > 10000 nM

Protein ID: PT04591, Solute carrier family 22 member 2

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 4200 nM Bioactivity Info	TI LI LO TS

Protein ID: PT06607, Solute carrier family 22 member 3

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 25500 nM Bioactivity Info	TI LI LO TS

Protein ID: PT01071, Tyrosine-protein kinase ABL1

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000077	Ba/F3 Cell Line Info	Mus musculus (Mouse)	2
1	GI50 = 260 nM Bioactivity Info	TI LI LO TS
2	GI50 > 10000 nM Bioactivity Info	TI LI LO TS
CL000013	Sf9 Cell Line Info	Spodoptera frugiperda (Fall armyworm)	6
1	IC50 = 43 nM Bioactivity Info	TI LI LO TS
2	IC50 = 223 nM Bioactivity Info	TI LI LO TS
3	IC50 = 300 nM Bioactivity Info	TI LI LO TS
4	IC50 = 470 nM Bioactivity Info	TI LI LO TS
5	IC50 = 1500 nM Bioactivity Info	TI LI LO TS
6	IC50 > 10000 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	IC50 = 25 nM
2	IC50 = 38 nM
3	IC50 = 40 nM
4	IC50 = 98 nM
5	IC50 = 110 nM
6	IC50 = 170 nM
7	IC50 = 188 nM
8	IC50 = 190 nM
9	IC50 = 200 nM
10	IC50 = 220 nM
11	IC50 = 234 nM
12	IC50 = 250 nM
13	IC50 = 300 nM
14	IC50 = 319 nM
15	IC50 = 658 nM
16	IC50 = 1000 nM
17	IC50 = 1100 nM
18	IC50 = 2700 nM
19	IC50 = 74000 nM
20	IC50 > 1000 nM
21	IC50 > 10000 nM
22	Kd = 1 nM
23	Kd = 1.1 nM
24	Kd = 1.8 nM
25	Kd = 2.2 nM
26	Kd = 2.5 nM
27	Kd = 5.9 nM
28	Kd = 8.3 nM
29	Kd = 8.5 nM
30	Kd = 12 nM
31	Kd = 14 nM
32	Kd = 21 nM
33	Kd = 24 nM
34	Kd = 35 nM
35	Kd = 44 nM
36	Kd = 62 nM
37	Kd = 65 nM
38	Kd = 77 nM
39	Kd = 92 nM
40	Kd = 110 nM
41	Kd = 130 nM
42	Kd = 170 nM
43	Kd = 580 nM
44	Kd = 6200 nM
45	Kd > 10000 nM
46	Ki = 13 nM
47	Ki = 37 nM
48	Ki = 7000 nM

Protein ID: PT03338, Tyrosine-protein kinase ABL1

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000077	Ba/F3 Cell Line Info	Mus musculus (Mouse)	2
1	IC50 = 730 nM Bioactivity Info	TI LI LO TS
2	IC50 = 20030 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	IC50 = 10.8 nM

Protein ID: PT01654, Tyrosine-protein kinase Blk

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000077	Ba/F3 Cell Line Info	Mus musculus (Mouse)	1
1	GI50 > 10000 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	Kd = 520 nM

Protein ID: PT00876, Tyrosine-protein kinase Lck

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000077	Ba/F3 Cell Line Info	Mus musculus (Mouse)	1
1	GI50 > 10000 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	IC50 = 160 nM
2	IC50 = 320 nM
3	Kd = 39.81 nM
4	Kd = 40 nM
5	Kd = 62 nM

Protein ID: PT00875, Tyrosine-protein kinase Lyn

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000013	Sf9 Cell Line Info	Spodoptera frugiperda (Fall armyworm)	1
1	IC50 = 220 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	Kd = 890 nM
2	Kd > 10000 nM

Protein ID: PT00864, Vascular endothelial growth factor receptor 2

Protein Info

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000077	Ba/F3 Cell Line Info	Mus musculus (Mouse)	1
1	GI50 > 10000 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

1	IC50 = 25800 nM
2	IC50 = 27186 nM
3	IC50 > 25000 nM
4	Kd > 10000 nM

Cell Viability or Cytotoxicity Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000002	K-562 Cell Line Info	Homo sapiens (Human)	4
1	GI50 = 147 nM	TI LI LO TS
2	GI50 = 250 nM	TI LI LO TS
3	IC50 = 100 nM	TI LI LO TS
4	IC50 = 13000 nM	TI LI LO TS
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	1
1	GI50 > 10000 nM	TI LI LO TS
CL000048	PC-3 Cell Line Info	Homo sapiens (Human)	2
1	IC50 = 24000 nM	TI LI LO TS
2	IC50 = 25118.86 nM	TI LI LO TS
CL000067	HCT 116 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 10000 nM	TI LI LO TS
CL000072	A2780 Cell Line Info	Homo sapiens (Human)	2
1	IC50 = 48000 nM	TI LI LO TS
2	IC50 = 50118.72 nM	TI LI LO TS
CL000075	EoL-1 Cell Line Info	Homo sapiens (Human)	2
1	GI50 < 1 nM	TI LI LO TS
2	IC50 = 0.1995 nM	TI LI LO TS
CL000077	Ba/F3 Cell Line Info	Mus musculus (Mouse)	1
1	GI50 = 6700 nM	TI LI LO TS
CL000082	HEL Cell Line Info	Homo sapiens (Human)	1
1	GI50 = 5300 nM	TI LI LO TS
CL000083	MCF-7 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 31622.78 nM	TI LI LO TS
CL000099	SaOS-2 Cell Line Info	Homo sapiens (Human)	2
1	IC50 = 25118.86 nM	TI LI LO TS
2	IC50 = 26000 nM	TI LI LO TS
CL000108	CCRF-CEM Cell Line Info	Homo sapiens (Human)	2
1	IC50 = 36000 nM	TI LI LO TS
2	IC50 = 45000 nM	TI LI LO TS
CL000111	MDA-MB-231 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 39810.72 nM	TI LI LO TS
CL000122	GIST-T1 Cell Line Info	Homo sapiens (Human)	1
1	GI50 = 40 nM	TI LI LO TS
CL000196	MDA-MB-468 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 17000 nM	TI LI LO TS
CL000217	CAL-27 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 19952.62 nM	TI LI LO TS
CL000248	OCI-AML-2 Cell Line Info	Homo sapiens (Human)	1
1	GI50 > 10000 nM	TI LI LO TS
CL000253	CCRF/VCR1000 Cell Line Info	Homo sapiens (Human)	2
1	IC50 = 37000 nM	TI LI LO TS
2	IC50 = 39810.72 nM	TI LI LO TS
CL000261	SK-BR-3 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 39810.72 nM	TI LI LO TS
CL000358	NCI-H69 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 31622.78 nM	TI LI LO TS
CL000960	NCI-H1703 Cell Line Info	Homo sapiens (Human)	2
1	GI50 = 230 nM	TI LI LO TS
2	GI50 = 2100 nM	TI LI LO TS

Clinical Information about the Compound

Drug 1 ( Imatinib )

Drug Name	Imatinib
Company	Novartis AG
Indication	Chronic myelogenous leukaemia Approved Acute lymphoblastic leukaemia Approved Intestinal cancer Phase 3 Lung cancer Phase 2 Systemic mastocytosis Investigative
Target(s)	Tyrosine-protein kinase Kit (KIT) Target Info Inhibitor Mcl-1 messenger RNA (MCL-1 mRNA) Target Info -

Drug 2 ( Imatinib )

Drug Name	Imatinib
Company	Novartis AG
Indication	Chronic myeloid leukaemia Approved Coronavirus Disease 2019 (COVID-19) Phase 3 Severe acute respiratory syndrome (SARS) Investigative Middle East Respiratory Syndrome (MERS) Investigative

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han