General Information of the Protein
Protein ID
PT05367
Protein Name
Multidrug and toxin extrusion protein 1
Secondarily
Protein Name
Solute carrier family 47 member 1
Gene Name
SLC47A1
Secondarily
Gene Name
MATE1
Sequence
MEAPEEPAPVRGGPEATLEVRGSRCLRLSAFREELRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTGVSVGFGLSSACDTLISQTYGSQNLKHVGVILQRSALVLLLCCFPCWALFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVAANLVNALANYLFLHQLHLGVIGSALANLISQYTLALLLFLYILGKKLHQATWGGWSLECLQDWASFLRLAIPSMLMLCMEWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVGLPIGIALMFATTLGVMGLWSGIIICTVFQAVCFLGFIIQLNWKKACQQAQVHANLKVNNVPRSGNSALPQDPLHPGCPENLEGILTNDVGKTGEPQSDQQMRQEEPLPEHPQDGAKLSRKQLVLRRGLLLLGVFLILLVGILVRFYVRIQ
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Organism
Homo sapiens, Human
Protein Classification
Transporter
>
Electrochemical transporter
>
SLC superfamily of solute carriers
>
SLC47 family of multidrug and toxin extrusion transporters
Function
Multidrug efflux pump that functions as a H(+)/organic cation antiporter (PubMed:16330770, PubMed:17509534). Plays a physiological role in the excretion of cationic compounds including endogenous metabolites, drugs, toxins through the kidney and liver, into urine and bile respectively (PubMed:16330770, PubMed:17495125, PubMed:17509534, PubMed:17582384, PubMed:18305230, PubMed:19158817, PubMed:21128598, PubMed:24961373). Mediates the efflux of endogenous compounds such as creatinine, vitamin B1/thiamine, agmatine and estrone-3-sulfate (PubMed:16330770, PubMed:17495125, PubMed:17509534, PubMed:17582384, PubMed:18305230, PubMed:19158817, PubMed:21128598, PubMed:24961373). May also contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (Probable).
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Uniprot ID
Primary ID:
Q96FL8

Secondarily ID:
Q53HF5
Q6PD77
Q86VL4
Q9NVA3
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Ensembl ID
ENSG00000142494
HGNC ID
HGNC:25588
Subcellular Location
Cell membrane
Apical cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000088 , Flp-In-293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0000082
 Compound Info 
CAS_68647
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C18H19N3O
  1
1
IC50 = 150 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0001598
 Compound Info 
1,2,3,4-tetrahydro-9-acridinamine
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C13H14N2
  1
1
IC50 = 1100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0035927
 Compound Info 
(Cimetidine) N-Methyl-N''''-[2-(5-methyl-1H-imidazol-4-ylmethylsulfanyl)-ethyl]-guanidine,cyanide
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C10H16N6S
  1
1
IC50 = 5700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0036757
 Compound Info 
3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine
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C19H24N2
  1
1
IC50 = 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0069487
 Compound Info 
2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin-1-yl)pyrimido[5,4-d][1,3]diazin-2-yl}(2-hydroxyethyl)amino)ethan-1-ol
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C24H40N8O4
  1
1
IC50 = 26000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0066121
 Compound Info 
N,N-dimethyl-2-[(2-methylphenyl)-phenylmethoxy]ethanamine
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C18H23NO
  1
1
IC50 = 65000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0049757
 Compound Info 
4-(diisopropylamino)-2-phenyl-2-pyridin-2-ylbutanamide
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C21H29N3O
  1
1
IC50 = 66000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Cell Line ID: CL000036 , MDCK-II
 Cell Line Info 
Clinical Information about the Protein
Target 1 ( Solute carrier family 47 member 1 (SLC47A1) )
Target Type Successful Target
Disease 1 Target-related Disease  1
1 Type-2 diabetes [ICD-11: 5A11]
Approved Drug(s) 1 Approved Drug  1
1 Metformin
 Drug Info 
Approved
Type-2 diabetes