General Information of the Compound
Compound ID
CP0076680
Compound Name
1,1-DIMETHYLBIGUANIDE HYDROCHLORIDE
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Synonyms
1,1-Dimethyl
1,1-Dimethyl biguanide
1,1-Dimethylbiguanide
3-(diaminomethylidene)-1,1-dimethylguanidine
657-24-9
DMGG
Diabetosan
Diabex
Diabex (TN)
Diaformin (TN)
Dianben (TN)
Dimethylbiguanide
Dimethylbiguanidine
Dimethyldiguanide
Dimethylguanylguanidine
Fluamine
Flumamine
Fortamet
Fortamet (TN)
Gen-Metformin
Glifage
Gliguanid
Glucophage
Glucophage (TN)
Glumetza
Glumetza (TN)
Glycon
Haurymelin
Imidodicarbonimidic diamide, N,N-dimethyl-
Islotin
LA-6023
Melbin
Metformin
Metformin (USAN/INN)
Metformin [USAN:INN:BAN]
Metformina
Metformina [DCIT]
Metformina [Spanish]
Metformine
Metformine [INN-French]
Metforminum
Metforminum [INN-Latin]
Metiguanide
N,N-Dimethylbiguanide
N,N-Dimethyldiguanide
N,N-dimethylimidodicarbonimidic diamide
N1,N1-Dimethylbiguanide
NNDG
Nu-Metformin
Obimet (TN)
Riomet (TN)
Siofor
[14C]metformin
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Structure
Formula
C4H11N5
Molecular Weight
129.167
Canonical SMILES
CN(C)C(N)=NC(N)=N
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InChI
InChI=1S/C4H11N5/c1-9(2)4(7)8-3(5)6/h1-2H3,(H5,5,6,7,8)
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InChIKey
XZWYZXLIPXDOLR-UHFFFAOYSA-N
CAS
657-24-9
Physicochemical Property
logP
-1.24383
Rotatable Bonds
0
Heavy Atom Count
9
Polar Areas
91.49
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
1
Complexity
9

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 4091
SID: 15297229
ChEMBL ID
CHEMBL1431
DrugBank ID
DB00331
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT06109, Geminin
 Protein Info 
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000015 SW480
 Cell Line Info 
Homo sapiens (Human)  1
1
Potency ~ 5080.7 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( Metformin )
Drug Name Metformin
Company Bristol-Myers Squibb
Indication
Type-2 diabetes
Phase 2
Target(s)
Solute carrier family 47 member 1 (SLC47A1)
 Target Info 
Modulator
Acetyl-CoA carboxylase 2 (ACACB)
 Target Info 
Activator
Drug 2 ( Metformin )
Drug Name Metformin
Indication
Type-2 diabetes
Approved
Coronavirus Disease 2019 (COVID-19)
Investigative
Target(s)
HUMAN mannose receptor (MRC1)
 Target Info 
Inhibitor