Brief Information of the Compound and Protein
Compound Name
 Compound Info 
4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
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 PubChem ID
CID: 5291
SID: 14859628
Canonical SMILES
CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1
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Compound Formula C29H31N7O
Compound Structure
Protein Name
 Protein Info 
Platelet-derived growth factor receptor alpha
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase PDGFR family
Uniprot ID
P16234
Gene Name
PDGFRA
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3
 Cell Line Info 
Mus musculus (Mouse)  5
1
GI50 = 10.7 nM
   TI
   LI
   LO
   TS
2
GI50 = 34 nM
   TI
   LI
   LO
   TS
3
GI50 = 46 nM
   TI
   LI
   LO
   TS
4
GI50 = 567 nM
   TI
   LI
   LO
   TS
5
GI50 > 10000 nM
   TI
   LI
   LO
   TS
CL000136 G-292 clone A141B1
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 96 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 90 nM
2 IC50 = 1.995 nM
3 IC50 = 4.6 nM
4 IC50 = 18 nM
5 IC50 = 71 nM
6 IC50 = 160 nM
7 Kd = 31 nM