General Information of the Cell Line
Cell Line ID
CL000099
Cell Line Name
SaOS-2
Synonyms
SAOS-2
Saos-2
SAOS 2
Saos 2
Saos2
SaOs2
SAOS2
Sarcoma OSteogenic-2
SaOS
SAOS
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0548
Tissue Information
Bone
Disease
Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT00894, Androgen receptor
 Protein Info 
Compound ID Compound Name Compound Formula
CP0044960
 Compound Info 
(1S,2S,7S,10R,11S,14S,15S)-14-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-5-one
   Show/Hide
C19H30O2
  1
1
IC50 = 0.05 nM
 Bioactivity Info 
   TI
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CP0394285
 Compound Info 
trifluoromethyl 10-methoxy-4-methyl-2,5-dioxo-1H-chromeno[3,4-f]quinoline-9-carboxylate
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C20H12F3NO6
  1
1
IC50 = 0.2 nM
 Bioactivity Info 
   TI
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CP0399724
 Compound Info 
9-hydroxy-10-methoxy-4-methyl-1H-chromeno[3,4-f]quinoline-2,5-dione
   Show/Hide
C18H13NO5
  1
1
IC50 = 0.2 nM
 Bioactivity Info 
   TI
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CP0373226
 Compound Info 
10-(hydroxymethyl)-4-methyl-1,5-dihydrochromeno[3,4-f]quinolin-2-one
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C18H15NO3
  1
1
IC50 = 0.3 nM
 Bioactivity Info 
   TI
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CP0432041
 Compound Info 
9-methoxy-4-methyl-1H-chromeno[3,4-f]quinoline-2,5-dione
   Show/Hide
C18H13NO4
  1
1
IC50 = 0.8 nM
 Bioactivity Info 
   TI
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CP0373230
 Compound Info 
10-hydroxy-4-(trifluoromethyl)-1,5-dihydrochromeno[3,4-f]quinolin-2-one
   Show/Hide
C17H10F3NO3
  1
1
IC50 = 1.1 nM
 Bioactivity Info 
   TI
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CP0373223
 Compound Info 
9-hydroxy-10-methoxy-4-methyl-1,5-dihydrochromeno[3,4-f]quinolin-2-one
   Show/Hide
C18H15NO4
  1
1
IC50 = 1.2 nM
 Bioactivity Info 
   TI
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CP0373227
 Compound Info 
tert-butyl 4-methyl-2,5-dioxo-1H-chromeno[3,4-f]quinoline-10-carboxylate
   Show/Hide
C22H19NO5
  1
1
IC50 = 1.9 nM
 Bioactivity Info 
   TI
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CP0373217
 Compound Info 
10-methoxy-4-methyl-9-propan-2-yloxy-1H-chromeno[3,4-f]quinoline-2,5-dione
   Show/Hide
C21H19NO5
  1
1
IC50 = 2.8 nM
 Bioactivity Info 
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CP0433628
 Compound Info 
9-ethoxy-10-methoxy-4-methyl-1H-chromeno[3,4-f]quinoline-2,5-dione
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C20H17NO5
  1
1
IC50 = 10 nM
 Bioactivity Info 
   TI
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CP0373229
 Compound Info 
10-methoxy-4-methyl-1,5-dihydrochromeno[3,4-f]quinolin-2-one
   Show/Hide
C18H15NO3
  1
1
IC50 = 12 nM
 Bioactivity Info 
   TI
   LI
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CP0373224
 Compound Info 
10-methoxy-4-(trifluoromethyl)-1,5-dihydrochromeno[3,4-f]quinolin-2-one
   Show/Hide
C18H12F3NO3
  1
1
IC50 = 14 nM
 Bioactivity Info 
   TI
   LI
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   TS
CP0373218
 Compound Info 
10-methoxy-4-methyl-1H-chromeno[3,4-f]quinoline-2,5-dione
   Show/Hide
C18H13NO4
  1
1
IC50 = 21 nM
 Bioactivity Info 
   TI
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CP0373219
 Compound Info 
10-hydroxy-4-(trifluoromethyl)-1H-isochromeno[3,4-f]quinoline-2,6-dione
   Show/Hide
C17H8F3NO4
  1
1
IC50 = 22 nM
 Bioactivity Info 
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CP0432040
 Compound Info 
4-(trifluoromethyl)-1,6-dihydroisochromeno[3,4-f]quinolin-2-one
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C17H10F3NO2
  1
1
IC50 = 40 nM
 Bioactivity Info 
   TI
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CP0373228
 Compound Info 
5-hydroxy-10-methoxy-4-methyl-1,5-dihydrochromeno[3,4-f]quinolin-2-one
   Show/Hide
C18H15NO4
  1
1
IC50 = 50 nM
 Bioactivity Info 
   TI
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CP0394282
 Compound Info 
10-methoxy-4-(trifluoromethyl)-1H-isochromeno[3,4-f]quinoline-2,6-dione
   Show/Hide
C18H10F3NO4
  1
1
IC50 = 89 nM
 Bioactivity Info 
   TI
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CP0394256
 Compound Info 
9-fluoro-4-methyl-1H-chromeno[3,4-f]quinoline-2,5-dione
   Show/Hide
C17H10FNO3
  1
1
IC50 = 101 nM
 Bioactivity Info 
   TI
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CP0373222
 Compound Info 
5,10-dimethoxy-4-methyl-1,5-dihydrochromeno[3,4-f]quinolin-2-one
   Show/Hide
C19H17NO4
  1
1
IC50 = 112 nM
 Bioactivity Info 
   TI
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CP0146696
 Compound Info 
Bicalutamide
   Show/Hide
C18H14F4N2O4S
  1
1
IC50 = 232 nM
 Bioactivity Info 
   TI
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CP0432039
 Compound Info 
10-methoxy-4-(trifluoromethyl)-1,6-dihydroisochromeno[3,4-f]quinolin-2-one
   Show/Hide
C18H12F3NO3
  1
1
IC50 = 477 nM
 Bioactivity Info 
   TI
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Protein ID: PT00914, Melanocortin receptor 4
 Protein Info 
Protein ID: PT00911, Melanocyte-stimulating hormone receptor
 Protein Info 
Protein ID: PT02986, PTH/PTHrP type I receptor
 Protein Info 
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0002778
 Compound Info 
4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
   Show/Hide
 C29H31N7O  2
1
IC50 = 25118.86 nM
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2
IC50 = 26000 nM
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CP0003832
 Compound Info 
N'-hydroxy-N-phenyloctanediamide
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 C14H20N2O3  1
1
IC50 = 2300 nM
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CP0069210
 Compound Info 
US8569511, 1
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 C22H20F2N6O2  1
1
IC50 = 948 nM
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CP0151685
 Compound Info 
N-(2-aminophenyl)-4-[[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]anilino]methyl]benzamide
   Show/Hide
 C30H27N7O  1
1
IC50 = 6309.57 nM
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CP0173297
 Compound Info 
3-[3-(benzofuran-2-carbonyl)phenyl]-N-hydroxyacrylamide
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 C18H13NO4  1
1
IC50 = 920 nM
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CP0204863
 Compound Info 
(E)-N-hydroxy-3-(4-((4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenylamino)methyl)phenyl)acrylamide
   Show/Hide
 C26H24N6O2  2
1
IC50 = 3160 nM
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2
IC50 = 3162.28 nM
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Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Bone)
Cell Line Name Organism Disease
Raji
 Cell Line Info 
Homo sapiens (Human) EBV-related Burkitt lymphoma
Cheptage
 Cell Line Info 
Homo sapiens (Human) EBV-related Burkitt lymphoma
HT-1080
 Cell Line Info 
Homo sapiens (Human) Fibrosarcoma
2fTGH-U3A
 Cell Line Info 
Homo sapiens (Human) Fibrosarcoma
HT1080-luc2
 Cell Line Info 
Homo sapiens (Human) Fibrosarcoma
U2OS
 Cell Line Info 
Homo sapiens (Human) Osteosarcoma
G-292 clone A141B1
 Cell Line Info 
Homo sapiens (Human) Osteosarcoma
HOS
 Cell Line Info 
Homo sapiens (Human) Osteosarcoma
MG-63
 Cell Line Info 
Homo sapiens (Human) Osteosarcoma
SJSA-1
 Cell Line Info 
Homo sapiens (Human) Osteosarcoma
GHOST(3).CXCR4
 Cell Line Info 
Homo sapiens (Human) Osteosarcoma
GHOST(3).CCR5
 Cell Line Info 
Homo sapiens (Human) Osteosarcoma
143.98.2
 Cell Line Info 
Homo sapiens (Human) Osteosarcoma
GHOST(3).X4/R5
 Cell Line Info 
Homo sapiens (Human) Osteosarcoma
PathHunter U2OS DRD3 beta-arrestin
 Cell Line Info 
Homo sapiens (Human) Osteosarcoma
SW1353
 Cell Line Info 
Homo sapiens (Human) Primary central chondrosarcoma
PC-3
 Cell Line Info 
Homo sapiens (Human) Prostate carcinoma
PC-3M
 Cell Line Info 
Homo sapiens (Human) Prostate carcinoma
PC-3-AR
 Cell Line Info 
Homo sapiens (Human) Prostate carcinoma
PPC-1
 Cell Line Info 
Homo sapiens (Human) Prostate carcinoma
VCaP
 Cell Line Info 
Homo sapiens (Human) Prostate carcinoma
MDA-PCa-2b
 Cell Line Info 
Homo sapiens (Human) Prostate carcinoma
RMS13
 Cell Line Info 
Mus musculus (Mouse) Mouse rhabdomyosarcoma
UMR-106
 Cell Line Info 
Rattus norvegicus (Rat) Rat osteosarcoma
ROS 17/2.8
 Cell Line Info 
Rattus norvegicus (Rat) Rat osteosarcoma
MC3T3-E1
 Cell Line Info 
Mus musculus (Mouse) -