| Compound ID |
Compound Name |
Compound Formula |
|
CP0039817
|
(R)-N-(4-(3,4-dimethoxyphenyl)-4-(4-(4-ethylpiperazin-1-yl)-1-oxoisoindolin-2-yl)butyl)thiophene-2-sulfonamide
Show/Hide
|
C30H38N4O5S2
|
2
|
| 1 |
IC50 = 8 nM
|
|
|
| 2 |
Ki = 4 nM
|
|
|
|
CP0272883
|
(R)-2-bromo-4,5-dimethoxy-N-(3-(1-methylpyrrolidin-3-yloxy)-4-(trifluoromethyl)phenyl)benzenesulfonamide
Show/Hide
|
C20H22BrF3N2O5S
|
2
|
| 1 |
IC50 = 8 nM
|
|
|
| 2 |
Ki = 8 nM
|
|
|
|
CP0405446
|
N-[(4R)-4-(3,4-dimethoxyphenyl)-4-[1,3-dioxo-4-[4-[(1R)-1-phenylethyl]piperazin-1-yl]isoindol-2-yl]butyl]-3,5-dimethyl-1H-pyrazole-4-carboxamide
Show/Hide
|
C38H44N6O5
|
2
|
| 1 |
IC50 = 37 nM
|
|
|
| 2 |
Ki = 87 nM
|
|
|
|
CP0398531
|
N-[(4R)-4-(3,4-dimethoxyphenyl)-4-[1,3-dioxo-4-[4-[(1R)-1-phenylethyl]piperazin-1-yl]isoindol-2-yl]butyl]-3,5-dimethyl-1H-pyrazole-4-sulfonamide
Show/Hide
|
C37H44N6O6S
|
2
|
| 1 |
IC50 = 47 nM
|
|
|
| 2 |
Ki = 13 nM
|
|
|
|
CP0374116
|
(R)-N-(4-(3,4-dimethoxyphenyl)-4-(4-(4-ethylpiperazin-1-yl)-1-oxoisoindolin-2-yl)butyl)-1H-imidazole-4-sulfonamide
Show/Hide
|
C29H38N6O5S
|
2
|
| 1 |
IC50 = 51 nM
|
|
|
| 2 |
Ki = 25 nM
|
|
|
|
CP0373777
|
(R)-N-(4-(3,4-dimethoxyphenyl)-4-(4-(4-isopropylpiperazin-1-yl)-1-oxoisoindolin-2-yl)butyl)thiophene-2-sulfonamide
Show/Hide
|
C31H40N4O5S2
|
2
|
| 1 |
IC50 = 53 nM
|
|
|
| 2 |
Ki = 4 nM
|
|
|
|
CP0447573
|
(R)-2-(1-(3,4-dimethoxyphenyl)-4-(thiophen-2-ylmethylamino)butyl)-4-(4-ethylpiperazin-1-yl)isoindolin-1-one
Show/Hide
|
C31H40N4O3S
|
2
|
| 1 |
IC50 = 59 nM
|
|
|
| 2 |
Ki = 18 nM
|
|
|
|
CP0373774
|
(R)-2-(1-(3,4-dimethoxyphenyl)-4-(6-methoxypyrazin-2-ylamino)butyl)-4-(4-ethylpiperazin-1-yl)isoindolin-1-one
Show/Hide
|
C31H40N6O4
|
2
|
| 1 |
IC50 = 62 nM
|
|
|
| 2 |
Ki = 8 nM
|
|
|
|
CP0415735
|
(R)-N-(4-(3,4-dimethoxyphenyl)-4-(4-(4-ethylpiperazin-1-yl)-1-oxoisoindolin-2-yl)butyl)-N-methylthiophene-2-sulfonamide
Show/Hide
|
C31H40N4O5S2
|
2
|
| 1 |
IC50 = 88 nM
|
|
|
| 2 |
Ki < 5 nM
|
|
|
|
CP0397180
|
(R)-N-(4-(3,4-dimethoxyphenyl)-4-(4-(4-ethylpiperazin-1-yl)-1-oxoisoindolin-2-yl)butyl)-3,5-dimethyl-1H-pyrazole-4-carboxamide
Show/Hide
|
C32H42N6O4
|
2
|
| 1 |
IC50 = 130 nM
|
|
|
| 2 |
Ki = 11 nM
|
|
|
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CP0447570
|
N-[(4R)-4-(3,4-dimethoxyphenyl)-4-[1,3-dioxo-4-[4-[(1R)-1-phenylethyl]piperazin-1-yl]isoindol-2-yl]butyl]-5-methyl-1,2-oxazole-4-sulfonamide
Show/Hide
|
C36H41N5O7S
|
2
|
| 1 |
IC50 = 130 nM
|
|
|
| 2 |
Ki = 32 nM
|
|
|
|
CP0415734
|
(R)-N-(4-(3,4-dimethoxyphenyl)-4-(4-(4-ethylpiperazin-1-yl)-1-oxoisoindolin-2-yl)butyl)thiophene-2-carboxamide
Show/Hide
|
C31H38N4O4S
|
2
|
| 1 |
IC50 = 140 nM
|
|
|
| 2 |
Ki = 18 nM
|
|
|
|
CP0447568
|
(R)-N-(4-(3,4-dimethoxyphenyl)-4-(4-(4-ethylpiperazin-1-yl)-1,3-dioxoisoindolin-2-yl)butyl)thiophene-2-sulfonamide
Show/Hide
|
C30H36N4O6S2
|
2
|
| 1 |
IC50 = 150 nM
|
|
|
| 2 |
Ki = 35 nM
|
|
|
|
CP0497024
|
(R)-N-(4-(3,4-dimethoxyphenyl)-4-(4-(4-isopropylpiperazin-1-yl)-1,3-dioxoisoindolin-2-yl)butyl)thiophene-2-sulfonamide
Show/Hide
|
C31H38N4O6S2
|
2
|
| 1 |
IC50 = 150 nM
|
|
|
| 2 |
Ki = 45 nM
|
|
|
|
CP0405440
|
N-[(4R)-4-(3,4-dimethoxyphenyl)-4-[1,3-dioxo-4-[4-[(1R)-1-phenylethyl]piperazin-1-yl]isoindol-2-yl]butyl]-1,2-dimethylimidazole-4-sulfonamide
Show/Hide
|
C37H44N6O6S
|
2
|
| 1 |
IC50 = 220 nM
|
|
|
| 2 |
Ki = 16 nM
|
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|
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CP0415733
|
(R)-N-(4-(3,4-dimethoxyphenyl)-4-(4-(4-methylpiperazin-1-yl)-1,3-dioxoisoindolin-2-yl)butyl)thiophene-2-sulfonamide
Show/Hide
|
C29H34N4O6S2
|
2
|
| 1 |
IC50 = 220 nM
|
|
|
| 2 |
Ki = 59 nM
|
|
|
|
CP0405442
|
N-[(4R)-4-(3,4-dimethoxyphenyl)-4-[1,3-dioxo-4-[4-[(1R)-1-phenylethyl]piperazin-1-yl]isoindol-2-yl]butyl]thiophene-2-sulfonamide
Show/Hide
|
C36H40N4O6S2
|
2
|
| 1 |
IC50 = 240 nM
|
|
|
| 2 |
Ki = 49 nM
|
|
|
|
CP0375545
|
N-[4-(3,4-dimethoxyphenyl)-4-[1,3-dioxo-4-[4-[(1R)-1-phenylethyl]piperazin-1-yl]isoindol-2-yl]butyl]thiophene-2-sulfonamide
Show/Hide
|
C36H40N4O6S2
|
2
|
| 1 |
IC50 = 250 nM
|
|
|
| 2 |
Ki = 76 nM
|
|
|
|
CP0415728
|
N-[(4S)-4-(3,4-dimethoxyphenyl)-4-[1,3-dioxo-4-[4-[(1R)-1-phenylethyl]piperazin-1-yl]isoindol-2-yl]butyl]thiophene-2-sulfonamide
Show/Hide
|
C36H40N4O6S2
|
2
|
| 1 |
IC50 = 260 nM
|
|
|
| 2 |
Ki = 120 nM
|
|
|
|
CP0272891
|
1-(2-(4-benzyl-4-hydroxypiperidin-1-yl)ethyl)-3-(2-methylquinolin-4-yl)urea
Show/Hide
|
C25H30N4O2
|
2
|
| 1 |
IC50 = 320 nM
|
|
|
| 2 |
Ki = 41 nM
|
|
|
|
CP0415736
|
N-[(4R)-4-(3,4-dimethoxyphenyl)-4-[3-oxo-7-[4-[(1R)-1-phenylethyl]piperazin-1-yl]-1H-isoindol-2-yl]butyl]-5-methyl-1,2-oxazole-4-carboxamide
Show/Hide
|
C37H43N5O5
|
2
|
| 1 |
IC50 = 320 nM
|
|
|
| 2 |
Ki = 15 nM
|
|
|
|
CP0381116
|
(R)-N-(4-(3,4-dimethoxyphenyl)-4-(4-(4-methylpiperazin-1-yl)-1-oxoisoindolin-2-yl)butyl)-N-methylthiophene-2-sulfonamide
Show/Hide
|
C30H38N4O5S2
|
2
|
| 1 |
IC50 = 340 nM
|
|
|
| 2 |
Ki < 6 nM
|
|
|
|
CP0485420
|
(R)-N-(4-(3,4-dimethoxyphenyl)-4-(1-oxo-4-(piperazin-1-yl)isoindolin-2-yl)butyl)-N-methylthiophene-2-sulfonamide
Show/Hide
|
C29H36N4O5S2
|
2
|
| 1 |
IC50 = 410 nM
|
|
|
| 2 |
Ki = 49 nM
|
|
|
|
CP0388410
|
(R)-N-(4-(3,4-dimethoxyphenyl)-4-(1,3-dioxo-4-(piperazin-1-yl)isoindolin-2-yl)butyl)thiophene-2-sulfonamide
Show/Hide
|
C28H32N4O6S2
|
2
|
| 1 |
IC50 = 500 nM
|
|
|
| 2 |
Ki = 150 nM
|
|
|
|
CP0405443
|
(R)-N-(4-(3,4-dimethoxyphenyl)-4-(4-(4-isopropylpiperazin-1-yl)-1-oxoisoindolin-2-yl)butyl)-N-methylthiophene-2-sulfonamide
Show/Hide
|
C32H42N4O5S2
|
2
|
| 1 |
IC50 = 500 nM
|
|
|
| 2 |
Ki = 11 nM
|
|
|
|
CP0405445
|
(R)-2-(4-(6-chloropyrazin-2-ylamino)-1-(3,4-dimethoxyphenyl)butyl)-4-(4-ethylpiperazin-1-yl)isoindolin-1-one
Show/Hide
|
C30H37ClN6O3
|
2
|
| 1 |
IC50 = 500 nM
|
|
|
| 2 |
Ki = 62 nM
|
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|
|
CP0373771
|
(R)-N-(4-(4-(4-cyclobutylpiperazin-1-yl)-1-oxoisoindolin-2-yl)-4-(3,4-dimethoxyphenyl)butyl)-N-methylthiophene-2-sulfonamide
Show/Hide
|
C33H42N4O5S2
|
2
|
| 1 |
IC50 = 510 nM
|
|
|
| 2 |
Ki = 44 nM
|
|
|
|
CP0374115
|
N-[(4R)-4-(3,4-dimethoxyphenyl)-4-[1,3-dioxo-4-[4-[(1R)-1-phenylethyl]piperazin-1-yl]isoindol-2-yl]butyl]-5-methyl-1,2-oxazole-4-carboxamide
Show/Hide
|
C37H41N5O6
|
2
|
| 1 |
IC50 = 760 nM
|
|
|
| 2 |
Ki = 130 nM
|
|
|
|
CP0488898
|
(R)-N-(4-(3,4-dimethoxyphenyl)-4-(4-(4-ethylpiperazin-1-yl)-1,3-dioxoisoindolin-2-yl)butyl)-1,2-dimethyl-1H-imidazole-4-sulfonamide
Show/Hide
|
C31H40N6O6S
|
2
|
| 1 |
IC50 = 810 nM
|
|
|
| 2 |
Ki = 97 nM
|
|
|
|
CP0447574
|
(R)-N-(4-(4-(4-cyclopropylpiperazin-1-yl)-1-oxoisoindolin-2-yl)-4-(3,4-dimethoxyphenyl)butyl)-N-methylthiophene-2-sulfonamide
Show/Hide
|
C32H40N4O5S2
|
2
|
| 1 |
IC50 = 1200 nM
|
|
|
| 2 |
Ki = 59 nM
|
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|
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CP0374113
|
(R)-2-(3,4-dimethoxybenzyl)-4-(4-(1-phenylethyl)piperazin-1-yl)isoindoline-1,3-dione
Show/Hide
|
C29H31N3O4
|
2
|
| 1 |
IC50 = 1900 nM
|
|
|
| 2 |
Ki = 570 nM
|
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CP0463956
|
5-chloro-N-((1-(3,3-dimethylbutanoyl)piperidin-4-yl)methyl)-2-(1-(2-(3-oxo-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)ethyl)piperidin-4-yl)benzamide
Show/Hide
|
C34H45ClN4O4
|
1
|
| 1 |
Ki = 27 nM
|
|
|
|
CP0467763
|
N-benzyl-4-[[[5-chloro-2-[1-[2-(3-oxo-1,4-benzoxazin-4-yl)ethyl]piperidin-4-yl]benzoyl]amino]methyl]piperidine-1-carboxamide
Show/Hide
|
C36H42ClN5O4
|
1
|
| 1 |
Ki = 30 nM
|
|
|
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CP0477896
|
N-[(1-benzylsulfonylpiperidin-4-yl)methyl]-5-chloro-2-[1-[2-(3-oxo-1,4-benzoxazin-4-yl)ethyl]piperidin-4-yl]benzamide
Show/Hide
|
C35H41ClN4O5S
|
1
|
| 1 |
Ki = 30 nM
|
|
|
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CP0474426
|
benzyl 4-[[[5-chloro-2-[1-[2-(3-oxo-1,4-benzoxazin-4-yl)ethyl]piperidin-4-yl]benzoyl]amino]methyl]piperidine-1-carboxylate
Show/Hide
|
C36H41ClN4O5
|
1
|
| 1 |
Ki = 54 nM
|
|
|
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CP0105495
|
(4R,10bR)-4-(3,4-dimethoxyphenyl)-10-(4-ethylpiperazin-1-yl)-1,2,3,4-tetrahydropyrido[2,1-a]isoindol-6(10bH)-one
Show/Hide
|
C26H33N3O3
|
1
|
| 1 |
Ki = 64 nM
|
|
|
|
CP0477895
|
tert-butyl 4-[2-[[5-chloro-2-[1-[2-(3-oxo-1,4-benzoxazin-4-yl)ethyl]piperidin-4-yl]benzoyl]amino]ethyl]piperazine-1-carboxylate
Show/Hide
|
C33H44ClN5O5
|
1
|
| 1 |
Ki = 65 nM
|
|
|
|
CP0449740
|
tert-butyl 4-[2-[[5-chloro-2-[1-[2-(3-oxo-1,4-benzoxazin-4-yl)ethyl]piperidin-4-yl]benzoyl]amino]ethyl]piperidine-1-carboxylate
Show/Hide
|
C34H45ClN4O5
|
1
|
| 1 |
Ki = 77 nM
|
|
|
|
CP0477897
|
tert-butyl 4-[[[5-chloro-2-[1-[2-(3-oxo-1,4-benzoxazin-4-yl)ethyl]piperidin-4-yl]benzoyl]amino]methyl]piperidine-1-carboxylate
Show/Hide
|
C33H43ClN4O5
|
1
|
| 1 |
Ki = 140 nM
|
|
|
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CP0459831
|
N-[(1-benzoylpiperidin-4-yl)methyl]-5-chloro-2-[1-[2-(3-oxo-1,4-benzoxazin-4-yl)ethyl]piperidin-4-yl]benzamide
Show/Hide
|
C35H39ClN4O4
|
1
|
| 1 |
Ki = 160 nM
|
|
|
|
CP0374114
|
2-((S)-1-(3,4-dimethoxyphenyl)ethyl)-4-(4-((R)-1-phenylethyl)piperazin-1-yl)isoindoline-1,3-dione
Show/Hide
|
C30H33N3O4
|
1
|
| 1 |
Ki = 160 nM
|
|
|
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CP0405441
|
4-(4-benzylpiperazin-1-yl)-2-(3,4-dimethoxybenzyl)isoindoline-1,3-dione
Show/Hide
|
C28H29N3O4
|
1
|
| 1 |
Ki = 160 nM
|
|
|
|
CP0497022
|
tert-butyl N-[4-(3,4-dimethoxyphenyl)-4-[1,3-dioxo-4-[4-[(1R)-1-phenylethyl]piperazin-1-yl]isoindol-2-yl]butyl]carbamate
Show/Hide
|
C37H46N4O6
|
1
|
| 1 |
Ki = 200 nM
|
|
|
|
CP0480007
|
2-((R)-1-(3,4-dimethoxyphenyl)ethyl)-4-(4-((R)-1-phenylethyl)piperazin-1-yl)isoindoline-1,3-dione
Show/Hide
|
C30H33N3O4
|
1
|
| 1 |
Ki = 230 nM
|
|
|
|
CP0405439
|
N-[3-(3,4-dimethoxyphenyl)-3-[1,3-dioxo-4-[4-[(1R)-1-phenylethyl]piperazin-1-yl]isoindol-2-yl]propyl]thiophene-2-sulfonamide
Show/Hide
|
C35H38N4O6S2
|
1
|
| 1 |
Ki = 270 nM
|
|
|
|
CP0388404
|
N-[2-(3,4-dimethoxyphenyl)-2-[1,3-dioxo-4-[4-[(1S)-1-phenylethyl]piperazin-1-yl]isoindol-2-yl]ethyl]thiophene-2-sulfonamide
Show/Hide
|
C34H36N4O6S2
|
1
|
| 1 |
Ki = 290 nM
|
|
|
|
CP0373775
|
2-(1-(3,4-dimethoxyphenyl)ethyl)-4-(4-((R)-1-phenylethyl)piperazin-1-yl)isoindoline-1,3-dione
Show/Hide
|
C30H33N3O4
|
1
|
| 1 |
Ki = 310 nM
|
|
|
|
CP0415738
|
4-(4-(2,6-difluorobenzyl)piperazin-1-yl)-2-(3,4-dimethoxybenzyl)isoindoline-1,3-dione
Show/Hide
|
C28H27F2N3O4
|
1
|
| 1 |
Ki = 310 nM
|
|
|
|
CP0485419
|
2-(1-(3,4-dimethoxyphenyl)propyl)-4-(4-((R)-1-phenylethyl)piperazin-1-yl)isoindoline-1,3-dione
Show/Hide
|
C31H35N3O4
|
1
|
| 1 |
Ki = 310 nM
|
|
|
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CP0372368
|
tert-butyl 4-[[[2-[1-[2-(3-oxo-1,4-benzoxazin-4-yl)ethyl]piperidin-4-yl]benzoyl]amino]methyl]piperidine-1-carboxylate
Show/Hide
|
C33H44N4O5
|
1
|
| 1 |
Ki = 430 nM
|
|
|
|
CP0405438
|
tert-butyl N-[2-(3,4-dimethoxyphenyl)-2-[1,3-dioxo-4-[4-[(1S)-1-phenylethyl]piperazin-1-yl]isoindol-2-yl]ethyl]carbamate
Show/Hide
|
C35H42N4O6
|
1
|
| 1 |
Ki = 430 nM
|
|
|
|
CP0473930
|
tert-butyl N-[3-(3,4-dimethoxyphenyl)-3-[1,3-dioxo-4-[4-[(1S)-1-phenylethyl]piperazin-1-yl]isoindol-2-yl]propyl]carbamate
Show/Hide
|
C36H44N4O6
|
1
|
| 1 |
Ki = 540 nM
|
|
|
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CP0447566
|
2-(2-amino-1-(3,4-dimethoxyphenyl)ethyl)-4-(4-((S)-1-phenylethyl)piperazin-1-yl)isoindoline-1,3-dione
Show/Hide
|
C30H34N4O4
|
1
|
| 1 |
Ki = 700 nM
|
|
|
|
CP0415726
|
N-[(4R)-4-(3,4-dimethoxyphenyl)-4-[1,3-dioxo-4-[4-[(1R)-1-phenylethyl]piperazin-1-yl]isoindol-2-yl]butyl]methanesulfonamide
Show/Hide
|
C33H40N4O6S
|
1
|
| 1 |
Ki = 1400 nM
|
|
|
|
CP0447567
|
2-(4-amino-1-(3,4-dimethoxyphenyl)butyl)-4-(4-((R)-1-phenylethyl)piperazin-1-yl)isoindoline-1,3-dione
Show/Hide
|
C32H38N4O4
|
1
|
| 1 |
Ki = 3200 nM
|
|
|
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CP0373776
|
tert-butyl N-[(5R)-5-(3,4-dimethoxyphenyl)-5-[1,3-dioxo-4-[4-[(1R)-1-phenylethyl]piperazin-1-yl]isoindol-2-yl]pentyl]carbamate
Show/Hide
|
C38H48N4O6
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
