General Information of the Compound
Compound ID
CP0373776
Compound Name
tert-butyl N-[(5R)-5-(3,4-dimethoxyphenyl)-5-[1,3-dioxo-4-[4-[(1R)-1-phenylethyl]piperazin-1-yl]isoindol-2-yl]pentyl]carbamate
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Structure
Formula
C38H48N4O6
Molecular Weight
656.824
Canonical SMILES
COc1ccc(cc1OC)[C@@H](CCCCNC(=O)OC(C)(C)C)N1C(=O)c2cccc(N3CCN(CC3)[C@H](C)c3ccccc3)c2C1=O
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InChI
InChI=1S/C38H48N4O6/c1-26(27-13-8-7-9-14-27)40-21-23-41(24-22-40)31-17-12-15-29-34(31)36(44)42(35(29)43)30(28-18-19-32(46-5)33(25-28)47-6)16-10-11-20-39-37(45)48-38(2,3)4/h7-9,12-15,17-19,25-26,30H,10-11,16,20-24H2,1-6H3,(H,39,45)/t26-,30-/m1/s1
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InChIKey
KOLWWPAODLKMSJ-PDDLMNHVSA-N
Physicochemical Property
logP
6.6193
Rotatable Bonds
12
Heavy Atom Count
48
Polar Areas
100.65
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
8
Complexity
48

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 45486916
ChEMBL ID
CHEMBL568358
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03174, Urotensin-2 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
IC50 = 65000 nM
   TI
   LI
   LO
   TS
Protein ID: PT02463, Urotensin-2 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000397 RMS13 Mus musculus (Mouse)  1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS