General Information of the Cell Line
Cell Line ID
CL000410
Cell Line Name
SJSA-1
Synonyms
SJSA1
SJSA
OsA-CL
OSA-CL
OsACL
OSACL
Os-A
OSA
OsA
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_1697
Tissue Information
Bone
Disease
Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT03225, Cellular tumor antigen p53
 Protein Info 
Compound ID Compound Name Compound Formula
CP0073355
 Compound Info 
2-[(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-[(2S,3S)-2-hydroxypentan-3-yl]-3-methyl-2-oxopiperidin-3-yl]acetic acid
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C25H29Cl2NO4
  1
1
IC50 = 760 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0543287
 Compound Info 
2-[(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-[(2S)-1-hydroxybutan-2-yl]-3-methyl-2-oxopiperidin-3-yl]acetic acid
   Show/Hide
C24H27Cl2NO4
  1
1
IC50 = 1500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0076255
 Compound Info 
tert-butyl (2S)-2-[(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-3-(2H-tetrazol-5-ylmethyl)piperidin-1-yl]butanoate
   Show/Hide
C28H33Cl2N5O3
  1
1
IC50 = 1600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0246368
 Compound Info 
2-[(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-[(2S)-1-[(2-methylpropan-2-yl)oxy]-1-oxobutan-2-yl]-2-oxopiperidin-3-yl]acetic acid
   Show/Hide
C28H33Cl2NO5
  1
1
IC50 = 1900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0480920
 Compound Info 
tert-butyl (2S)-2-[(2S,3R,5R)-3-(3-chlorophenyl)-2-(4-chlorophenyl)-6-oxo-5-(2H-tetrazol-5-ylmethyl)piperidin-1-yl]butanoate
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C27H31Cl2N5O3
  1
1
IC50 = 3100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0543288
 Compound Info 
2-[(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-[(2S)-1-[(2-methylpropan-2-yl)oxy]-1-oxobutan-2-yl]-2-oxopiperidin-3-yl]acetic acid
   Show/Hide
C27H31Cl2NO5
  1
1
IC50 = 4300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0507199
 Compound Info 
2-[(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-pentan-3-ylpiperidin-3-yl]acetic acid
   Show/Hide
C25H29Cl2NO3
  1
1
IC50 = 5500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0041876
 Compound Info 
(4S,5R)-Nutlin-3
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C30H30Cl2N4O4
  1
1
IC50 = 7100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0491289
 Compound Info 
2-[(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-[(2S)-1-ethoxy-1-oxobutan-2-yl]-2-oxopiperidin-3-yl]acetic acid
   Show/Hide
C25H27Cl2NO5
  1
1
IC50 = 10700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0141684
 Compound Info 
2-[(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl]acetic acid
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C23H23Cl2NO3
  1
1
IC50 = 34400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein ID: PT01771, E3 ubiquitin-protein ligase Mdm2
 Protein Info 
Protein ID: PT02499, Ubiquitin carboxyl-terminal hydrolase 7
 Protein Info 
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0005066
 Compound Info 
NR9
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 C18H13N3OS2  1
1
IC50 = 4550 nM
   TI
   LI
   LO
   TS
CP0041876
 Compound Info 
(4S,5R)-Nutlin-3
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 C30H30Cl2N4O4  1
1
IC50 = 700 nM
   TI
   LI
   LO
   TS
CP0141684
 Compound Info 
2-[(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl]acetic acid
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 C23H23Cl2NO3  1
1
IC50 = 3350 nM
   TI
   LI
   LO
   TS
CP0159201
 Compound Info 
6-[[(3R,5R,6S)-1-[(1S)-2-tert-butylsulfonyl-1-cyclopropylethyl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]methyl]pyridine-3-carboxylic acid
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 C34H38Cl2N2O5S  1
1
IC50 = 5 nM
   TI
   LI
   LO
   TS
CP0177375
 Compound Info 
ROCHE screening, 70
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 C22H17N3OS  1
1
IC50 = 1850 nM
   TI
   LI
   LO
   TS
CP0246368
 Compound Info 
2-[(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-[(2S)-1-[(2-methylpropan-2-yl)oxy]-1-oxobutan-2-yl]-2-oxopiperidin-3-yl]acetic acid
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 C28H33Cl2NO5  1
1
IC50 = 190 nM
   TI
   LI
   LO
   TS
CP0474716
 Compound Info 
2-[(2R,5R,6R)-4-[(1S)-2-tert-butylsulfonyl-1-cyclopropylethyl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acid
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 C27H31Cl2NO6S  1
1
IC50 = 25 nM
   TI
   LI
   LO
   TS
CP0507199
 Compound Info 
2-[(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-pentan-3-ylpiperidin-3-yl]acetic acid
   Show/Hide
 C25H29Cl2NO3  1
1
IC50 = 540 nM
   TI
   LI
   LO
   TS
CP0543287
 Compound Info 
2-[(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-[(2S)-1-hydroxybutan-2-yl]-3-methyl-2-oxopiperidin-3-yl]acetic acid
   Show/Hide
 C24H27Cl2NO4  1
1
IC50 = 210 nM
   TI
   LI
   LO
   TS
CP0702723
 Compound Info 
(Z)-2-amino-5-(quinolin-6-ylmethylene)thiazol-4(5H)-one
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 C13H9N3OS  1
1
IC50 = 2840 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Bone)
Cell Line Name Organism Disease
Raji
 Cell Line Info 
Homo sapiens (Human) EBV-related Burkitt lymphoma
Cheptage
 Cell Line Info 
Homo sapiens (Human) EBV-related Burkitt lymphoma
HT-1080
 Cell Line Info 
Homo sapiens (Human) Fibrosarcoma
2fTGH-U3A
 Cell Line Info 
Homo sapiens (Human) Fibrosarcoma
HT1080-luc2
 Cell Line Info 
Homo sapiens (Human) Fibrosarcoma
U2OS
 Cell Line Info 
Homo sapiens (Human) Osteosarcoma
SaOS-2
 Cell Line Info 
Homo sapiens (Human) Osteosarcoma
G-292 clone A141B1
 Cell Line Info 
Homo sapiens (Human) Osteosarcoma
HOS
 Cell Line Info 
Homo sapiens (Human) Osteosarcoma
MG-63
 Cell Line Info 
Homo sapiens (Human) Osteosarcoma
GHOST(3).CXCR4
 Cell Line Info 
Homo sapiens (Human) Osteosarcoma
GHOST(3).CCR5
 Cell Line Info 
Homo sapiens (Human) Osteosarcoma
143.98.2
 Cell Line Info 
Homo sapiens (Human) Osteosarcoma
GHOST(3).X4/R5
 Cell Line Info 
Homo sapiens (Human) Osteosarcoma
PathHunter U2OS DRD3 beta-arrestin
 Cell Line Info 
Homo sapiens (Human) Osteosarcoma
SW1353
 Cell Line Info 
Homo sapiens (Human) Primary central chondrosarcoma
PC-3
 Cell Line Info 
Homo sapiens (Human) Prostate carcinoma
PC-3M
 Cell Line Info 
Homo sapiens (Human) Prostate carcinoma
PC-3-AR
 Cell Line Info 
Homo sapiens (Human) Prostate carcinoma
PPC-1
 Cell Line Info 
Homo sapiens (Human) Prostate carcinoma
VCaP
 Cell Line Info 
Homo sapiens (Human) Prostate carcinoma
MDA-PCa-2b
 Cell Line Info 
Homo sapiens (Human) Prostate carcinoma
RMS13
 Cell Line Info 
Mus musculus (Mouse) Mouse rhabdomyosarcoma
UMR-106
 Cell Line Info 
Rattus norvegicus (Rat) Rat osteosarcoma
ROS 17/2.8
 Cell Line Info 
Rattus norvegicus (Rat) Rat osteosarcoma
MC3T3-E1
 Cell Line Info 
Mus musculus (Mouse) -