General Information of the Cell Line
Cell Line ID
CL000156
Cell Line Name
HT-1080
Synonyms
Ht-1080
HT 1080
HT1080
HT 1080.T
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0317
Tissue Information
Bone
Disease
Fibrosarcoma (NCIt: C3043)
Fibrosarcoma (ORDO: Orphanet_2030)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT01896, Bone morphogenetic protein 1
 Protein Info 
Compound ID Compound Name Compound Formula
CP0449647
 Compound Info 
methyl 4-[[(2R)-2-[1,3-benzodioxol-5-ylmethyl-(4-methoxyphenyl)sulfonylamino]-3-(hydroxyamino)-3-oxopropyl]carbamoyl]benzoate
   Show/Hide
C27H27N3O10S
  1
1
Ki = 7 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0506165
 Compound Info 
N-[(2R)-2-[1,3-benzodioxol-5-ylmethyl-(4-methoxyphenyl)sulfonylamino]-3-(hydroxyamino)-3-oxopropyl]-2-pyrrol-1-ylbenzamide
   Show/Hide
C29H28N4O8S
  1
1
Ki = 8 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0401244
 Compound Info 
N-[(2R)-2-[1,3-benzodioxol-5-ylmethyl-(4-methoxyphenyl)sulfonylamino]-3-(hydroxyamino)-3-oxopropyl]benzamide
   Show/Hide
C25H25N3O8S
  1
1
Ki = 14 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0524561
 Compound Info 
2-[Benzo[1,3]dioxol-5-ylmethyl-((R)-4-methoxy-benzenesulfonyl)-amino]-N-hydroxy-3-[3-{4-chloro-phenyl-sulfonyl}-urea-1-yl]-propionamide
   Show/Hide
C25H25ClN4O10S2
  1
1
Ki = 18 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0502242
 Compound Info 
2-[Benzo[1,3]dioxol-5-ylmethyl-((R)-4-methoxy-benzenesulfonyl)-amino]-3-[3-(4-ethoxy-phenyl)-ureido]-N-hydroxy-propionamide
   Show/Hide
C27H30N4O9S
  1
1
Ki = 22 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0451334
 Compound Info 
2-[Benzo[1,3]dioxol-5-ylmethyl-((R)-4-methoxy-benzenesulfonyl)-amino]-N-hydroxy-3-(3-nitro-phenylmethanesulfonylamino)-propionamide
   Show/Hide
C25H26N4O11S2
  1
1
Ki = 28 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0451385
 Compound Info 
5-Methyl-isoxazole-4-carboxylic acid {3-[benzo[1,3]dioxol-5-ylmethyl-((R)-4-methoxy-benzenesulfonyl)-amino]-3-hydroxycarbamoyl-propyl}-amide
   Show/Hide
C24H26N4O9S
  1
1
Ki = 86 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0164742
 Compound Info 
N-[(4R)-4-[1,3-benzodioxol-5-ylmethyl-(4-methoxyphenyl)sulfonylamino]-5-(hydroxyamino)-5-oxopentyl]benzamide
   Show/Hide
C27H29N3O8S
  1
1
Ki = 100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0449520
 Compound Info 
2-[Benzo[1,3]dioxol-5-ylmethyl-((R)-4-methoxy-benzenesulfonyl)-amino]-N-hydroxy-3-[2-(pyrazin-2-ylamino)-acetylamino]-propionamide
   Show/Hide
C24H26N6O8S
  1
1
Ki = 250 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0406671
 Compound Info 
N-[(5R)-5-[1,3-benzodioxol-5-ylmethyl-(4-methoxyphenyl)sulfonylamino]-6-(hydroxyamino)-6-oxohexyl]benzamide
   Show/Hide
C28H31N3O8S
  1
1
Ki = 350 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0502195
 Compound Info 
2-[Benzo[1,3]dioxol-5-ylmethyl-((R)-4-methoxy-benzenesulfonyl)-amino]-4-(3-1H-benzoimidazol-2-yl-propionylamino)-N-hydroxy-butyramide
   Show/Hide
C29H31N5O8S
  1
1
Ki = 410 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0377221
 Compound Info 
4-[({3-[Benzo[1,3]dioxol-5-ylmethyl-((R)-4-methoxy-benzenesulfonyl)-amino]-3-hydroxycarbamoyl-propylcarbamoyl}-methyl)-amino]-cyclohexanecarboxylic acid ethyl ester
   Show/Hide
C30H40N4O10S
  1
1
Ki = 470 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0531864
 Compound Info 
N-[(3R)-3-[1,3-benzodioxol-5-ylmethyl-(4-methoxyphenyl)sulfonylamino]-4-(hydroxyamino)-4-oxobutyl]benzamide
   Show/Hide
C26H27N3O8S
  1
1
Ki = 470 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0511684
 Compound Info 
N-[(3R)-3-[1,3-benzodioxol-5-ylmethyl-(4-methoxyphenyl)sulfonylamino]-4-(hydroxyamino)-4-oxobutyl]-2-pyrrol-1-ylbenzamide
   Show/Hide
C30H30N4O8S
  1
1
Ki = 530 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0497000
 Compound Info 
methyl 4-[[(3R)-3-[1,3-benzodioxol-5-ylmethyl-(4-methoxyphenyl)sulfonylamino]-4-(hydroxyamino)-4-oxobutyl]carbamoyl]benzoate
   Show/Hide
C28H29N3O10S
  1
1
Ki = 840 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0496560
 Compound Info 
5-Methyl-3-phenyl-isoxazole-4-carboxylic acid {3-[benzo[1,3]dioxol-5-ylmethyl-((R)-4-methoxy-benzenesulfonyl)-amino]-3-hydroxycarbamoyl-propyl}-amide
   Show/Hide
C30H30N4O9S
  1
1
Ki = 960 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0375914
 Compound Info 
3-(4-Acetylamino-benzylamino)-2-[benzo[1,3]dioxol-5-ylmethyl-((R)-4-methoxy-benzenesulfonyl)-amino]-N-hydroxy-propionamide
   Show/Hide
C27H30N4O8S
  1
1
Ki = 1010 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0534119
 Compound Info 
5-Methyl-isoxazole-4-carboxylic acid {2-[benzo[1,3]dioxol-5-ylmethyl-((R)-4-methoxy-benzenesulfonyl)-amino]-2-hydroxycarbamoyl-ethyl}-amide
   Show/Hide
C23H24N4O9S
  1
1
Ki = 1960 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0406635
 Compound Info 
2-[Benzo[1,3]dioxol-5-ylmethyl-((R)-4-methoxy-benzenesulfonyl)-amino]-N-hydroxy-4-[2-(pyrazin-2-ylamino)-acetylamino]-butyramide
   Show/Hide
C25H28N6O8S
  1
1
Ki = 2500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein ID: PT01191, Baculoviral IAP repeat-containing protein 2
 Protein Info 
Protein ID: PT00903, C-C chemokine receptor type 5
 Protein Info 
Protein ID: PT00926, Cyclin-dependent kinase 1
 Protein Info 
Protein ID: PT01303, Endothelial lipase
 Protein Info 
Protein ID: PT01194, Histamine H3 receptor
 Protein Info 
Protein ID: PT03665, Histamine H3 receptor
 Protein Info 
Protein ID: PT00848, Interstitial collagenase
 Protein Info 
Protein ID: PT02997, Isocitrate dehydrogenase [NADP] cytoplasmic
 Protein Info 
Protein ID: PT00973, Methionine aminopeptidase 2
 Protein Info 
Protein ID: PT01903, Nicotinamide phosphoribosyltransferase
 Protein Info 
Protein ID: PT02815, PRKR-like endoplasmic reticulum kinase
 Protein Info 
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0033135
 Compound Info 
N-[2-[2-[4-(4-acetylpiperazin-1-yl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]-1,3-dihydroisoindol-4-yl]-N-methylmethanesulfonamide
   Show/Hide
 C27H30F3N7O3S  1
1
GI50 = 1800 nM
   TI
   LI
   LO
   TS
CP0036761
 Compound Info 
2-[(2-{[(1-methylpiperidin-4-yl)methyl]amino}benzene)sulfonamido]-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid
   Show/Hide
 C24H31N3O4S  1
1
EC50 = 130 nM
   TI
   LI
   LO
   TS
CP0045276
 Compound Info 
2-{[2-({2-[bis(propan-2-yl)amino]ethyl}amino)benzene]sulfonamido}-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid
   Show/Hide
 C25H35N3O4S  2
1
EC50 = 640 nM
   TI
   LI
   LO
   TS
2
EC50 = 1800 nM
   TI
   LI
   LO
   TS
CP0057375
 Compound Info 
N-cyclohexyl-2-(3-fluoro-N-[2-(2-methylimidazol-1-yl)acetyl]anilino)-2-(2-methylphenyl)acetamide
   Show/Hide
 C27H31FN4O2  1
1
GI50 > 20000 nM
   TI
   LI
   LO
   TS
CP0075373
 Compound Info 
2-{[2-({[1-(propan-2-yl)piperidin-4-yl]methyl}amino)benzene]sulfonamido}-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid
   Show/Hide
 C26H35N3O4S  1
1
EC50 = 950 nM
   TI
   LI
   LO
   TS
CP0075383
 Compound Info 
2-({2-[(piperidin-3-ylmethyl)amino]benzene}sulfonamido)-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid
   Show/Hide
 C23H29N3O4S  1
1
EC50 = 290 nM
   TI
   LI
   LO
   TS
CP0096344
 Compound Info 
2-[(2-{[2-(diethylamino)ethyl]amino}benzene)sulfonamido]-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid
   Show/Hide
 C23H31N3O4S  2
1
EC50 = 540 nM
   TI
   LI
   LO
   TS
2
EC50 = 3400 nM
   TI
   LI
   LO
   TS
CP0108229
 Compound Info 
2-[(2-{[3-(diethylamino)propyl]amino}benzene)sulfonamido]-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid
   Show/Hide
 C24H33N3O4S  2
1
EC50 = 140 nM
   TI
   LI
   LO
   TS
2
EC50 = 1700 nM
   TI
   LI
   LO
   TS
CP0109097
 Compound Info 
1-[(6-aminopyridin-3-yl)methyl]-3-[4-(benzenesulfonyl)phenyl]urea
   Show/Hide
 C19H18N4O3S  1
1
IC50 = 104 nM
   TI
   LI
   LO
   TS
CP0145542
 Compound Info 
2-({2-[(pyrrolidin-3-ylmethyl)amino]benzene}sulfonamido)-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid
   Show/Hide
 C22H27N3O4S  1
1
EC50 = 380 nM
   TI
   LI
   LO
   TS
CP0145817
 Compound Info 
2-[(2-{[2-(pyrrolidin-2-yl)ethyl]amino}benzene)sulfonamido]-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid
   Show/Hide
 C23H29N3O4S  1
1
EC50 = 140 nM
   TI
   LI
   LO
   TS
CP0160675
 Compound Info 
2-[(2-{[2-(diethylamino)ethyl]carbamoyl}benzene)sulfonamido]-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid
   Show/Hide
 C24H31N3O5S  2
1
EC50 = 520 nM
   TI
   LI
   LO
   TS
2
EC50 = 1200 nM
   TI
   LI
   LO
   TS
CP0186448
 Compound Info 
2-[(2-{[3-(4-methylpiperazin-1-yl)propyl]amino}benzene)sulfonamido]-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid
   Show/Hide
 C25H34N4O4S  1
1
EC50 = 410 nM
   TI
   LI
   LO
   TS
CP0192620
 Compound Info 
2-[(2-{[3-(piperidin-1-yl)propyl]amino}benzene)sulfonamido]-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid
   Show/Hide
 C25H33N3O4S  1
1
EC50 = 3900 nM
   TI
   LI
   LO
   TS
CP0199496
 Compound Info 
2-{[2-({2-[(dimethylamino)methyl]-2-methylpropyl}amino)benzene]sulfonamido}-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid
   Show/Hide
 C24H33N3O4S  1
1
EC50 = 2000 nM
   TI
   LI
   LO
   TS
CP0199544
 Compound Info 
2-[(2-{[3-(dimethylamino)propyl]amino}benzene)sulfonamido]-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid
   Show/Hide
 C22H29N3O4S  2
1
EC50 = 190 nM
   TI
   LI
   LO
   TS
2
EC50 = 1700 nM
   TI
   LI
   LO
   TS
CP0215395
 Compound Info 
2-({2-[(1E)-4-(diethylamino)but-1-en-1-yl]benzene}sulfonamido)-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid
   Show/Hide
 C25H32N2O4S  2
1
EC50 = 170 nM
   TI
   LI
   LO
   TS
2
EC50 = 2000 nM
   TI
   LI
   LO
   TS
CP0215409
 Compound Info 
2-[(2-{[2-(diethylamino)ethane]sulfinyl}-4-fluorobenzene)sulfonamido]-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid
   Show/Hide
 C23H29FN2O5S2  2
1
EC50 = 110 nM
   TI
   LI
   LO
   TS
2
EC50 = 600 nM
   TI
   LI
   LO
   TS
CP0215410
 Compound Info 
2-[(2-{[2-(diethylamino)ethane]sulfinyl}benzene)sulfonamido]-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid
   Show/Hide
 C23H30N2O5S2  1
1
EC50 = 270 nM
   TI
   LI
   LO
   TS
CP0215439
 Compound Info 
2-({2-[4-(piperidin-1-yl)butanamido]benzene}sulfonamido)-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid
   Show/Hide
 C26H33N3O5S  1
1
EC50 = 480 nM
   TI
   LI
   LO
   TS
CP0215440
 Compound Info 
2-({2-[4-(pyrrolidin-1-yl)butanamido]benzene}sulfonamido)-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid
   Show/Hide
 C25H31N3O5S  2
1
EC50 = 430 nM
   TI
   LI
   LO
   TS
2
EC50 = 2800 nM
   TI
   LI
   LO
   TS
CP0254865
 Compound Info 
2-[(2-{[2-(pyrrolidin-1-yl)ethyl]amino}benzene)sulfonamido]-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid
   Show/Hide
 C23H29N3O4S  1
1
EC50 = 7800 nM
   TI
   LI
   LO
   TS
CP0277100
 Compound Info 
2-({2-[(1Z)-5-(diethylamino)pent-1-en-1-yl]benzene}sulfonamido)-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid
   Show/Hide
 C26H34N2O4S  2
1
EC50 = 33 nM
   TI
   LI
   LO
   TS
2
EC50 = 630 nM
   TI
   LI
   LO
   TS
CP0277819
 Compound Info 
2-[(2-{[3-(pyrrolidin-1-yl)propyl]amino}benzene)sulfonamido]-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid
   Show/Hide
 C24H31N3O4S  1
1
EC50 = 85 nM
   TI
   LI
   LO
   TS
CP0286441
 Compound Info 
2-[(2-{[2-(1-methylpyrrolidin-2-yl)ethyl]amino}benzene)sulfonamido]-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid
   Show/Hide
 C24H31N3O4S  2
1
EC50 = 96 nM
   TI
   LI
   LO
   TS
2
EC50 = 1200 nM
   TI
   LI
   LO
   TS
CP0286878
 Compound Info 
N-cyclohexyl-2-(3-fluoro-N-(2-pyridin-4-ylacetyl)anilino)-2-(2-methylphenyl)acetamide
   Show/Hide
 C28H30FN3O2  1
1
GI50 > 20000 nM
   TI
   LI
   LO
   TS
CP0290647
 Compound Info 
2-[(2-{[2-(dimethylamino)ethyl]amino}benzene)sulfonamido]-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid
   Show/Hide
 C21H27N3O4S  2
1
EC50 = 1300 nM
   TI
   LI
   LO
   TS
2
EC50 = 15000 nM
   TI
   LI
   LO
   TS
CP0296999
 Compound Info 
2-[(2-{[5-(diethylamino)pentan-2-yl]carbamoyl}benzene)sulfonamido]-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid
   Show/Hide
 C27H37N3O5S  1
1
EC50 = 2600 nM
   TI
   LI
   LO
   TS
CP0319796
 Compound Info 
2-({2-[(1-benzylpiperidin-4-yl)amino]benzene}sulfonamido)-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid
   Show/Hide
 C29H33N3O4S  1
1
EC50 = 86000 nM
   TI
   LI
   LO
   TS
CP0320158
 Compound Info 
2-{[2-({[2-(diethylamino)ethoxy]carbonyl}amino)benzene]sulfonamido}-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid
   Show/Hide
 C24H31N3O6S  1
1
EC50 = 830 nM
   TI
   LI
   LO
   TS
CP0700243
 Compound Info 
2-[({2-[(1Z)-3-(diethylamino)-1-propenyl]-4-fluorophenyl}-sulfonyl)amino]-5,6,7,8-tetrahydro-1-naphthalenecarboxylic acid
   Show/Hide
 C24H29FN2O4S  1
1
EC50 = 56 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Bone)
Cell Line Name Organism Disease
Raji
 Cell Line Info 
Homo sapiens (Human) EBV-related Burkitt lymphoma
Cheptage
 Cell Line Info 
Homo sapiens (Human) EBV-related Burkitt lymphoma
2fTGH-U3A
 Cell Line Info 
Homo sapiens (Human) Fibrosarcoma
HT1080-luc2
 Cell Line Info 
Homo sapiens (Human) Fibrosarcoma
U2OS
 Cell Line Info 
Homo sapiens (Human) Osteosarcoma
SaOS-2
 Cell Line Info 
Homo sapiens (Human) Osteosarcoma
G-292 clone A141B1
 Cell Line Info 
Homo sapiens (Human) Osteosarcoma
HOS
 Cell Line Info 
Homo sapiens (Human) Osteosarcoma
MG-63
 Cell Line Info 
Homo sapiens (Human) Osteosarcoma
SJSA-1
 Cell Line Info 
Homo sapiens (Human) Osteosarcoma
GHOST(3).CXCR4
 Cell Line Info 
Homo sapiens (Human) Osteosarcoma
GHOST(3).CCR5
 Cell Line Info 
Homo sapiens (Human) Osteosarcoma
143.98.2
 Cell Line Info 
Homo sapiens (Human) Osteosarcoma
GHOST(3).X4/R5
 Cell Line Info 
Homo sapiens (Human) Osteosarcoma
PathHunter U2OS DRD3 beta-arrestin
 Cell Line Info 
Homo sapiens (Human) Osteosarcoma
SW1353
 Cell Line Info 
Homo sapiens (Human) Primary central chondrosarcoma
PC-3
 Cell Line Info 
Homo sapiens (Human) Prostate carcinoma
PC-3M
 Cell Line Info 
Homo sapiens (Human) Prostate carcinoma
PC-3-AR
 Cell Line Info 
Homo sapiens (Human) Prostate carcinoma
PPC-1
 Cell Line Info 
Homo sapiens (Human) Prostate carcinoma
VCaP
 Cell Line Info 
Homo sapiens (Human) Prostate carcinoma
MDA-PCa-2b
 Cell Line Info 
Homo sapiens (Human) Prostate carcinoma
RMS13
 Cell Line Info 
Mus musculus (Mouse) Mouse rhabdomyosarcoma
UMR-106
 Cell Line Info 
Rattus norvegicus (Rat) Rat osteosarcoma
ROS 17/2.8
 Cell Line Info 
Rattus norvegicus (Rat) Rat osteosarcoma
MC3T3-E1
 Cell Line Info 
Mus musculus (Mouse) -