| Compound ID |
Compound Name |
Compound Formula |
|
CP0525130
|
2-[5-(4-amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydroindol-1-yl]-1-[3-fluoro-5-(trifluoromethyl)phenyl]ethanone
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|
C24H19F4N5O
|
3
|
| 1 |
IC50 = 6 nM
|
|
|
| 2 |
IC50 = 20 nM
|
|
|
| 3 |
IC50 > 50000 nM
|
|
|
|
CP0116137
|
4-[2-amino-4-methyl-3-[2-(methylamino)quinazolin-7-yl]oxybenzoyl]-1-methyl-2,5-diphenylpyrazol-3-one
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|
C33H28N6O3
|
3
|
| 1 |
IC50 = 12 nM
|
|
|
| 2 |
IC50 = 480 nM
|
|
|
| 3 |
IC50 = 550 nM
|
|
|
|
CP0411443
|
2-[5-(4-amino-2,7-dimethylpyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydroindol-1-yl]-1-[3-fluoro-5-(trifluoromethyl)phenyl]ethanone
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|
C25H21F4N5O
|
3
|
| 1 |
IC50 = 12 nM
|
|
|
| 2 |
IC50 = 89 nM
|
|
|
| 3 |
IC50 > 50000 nM
|
|
|
|
CP0283781
|
4-[2-amino-4-methyl-3-(2-methyl-1,3-benzothiazol-6-yl)benzoyl]-1-methyl-2,5-diphenylpyrazol-3-one
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|
C32H26N4O2S
|
3
|
| 1 |
IC50 = 20 nM
|
|
|
| 2 |
IC50 = 320 nM
|
|
|
| 3 |
IC50 > 50000 nM
|
|
|
|
CP0116138
|
4-[2-amino-3-[5-fluoro-2-(methylamino)quinazolin-7-yl]oxy-4-methylbenzoyl]-1-methyl-2,5-diphenylpyrazol-3-one
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|
C33H27FN6O3
|
3
|
| 1 |
IC50 = 30 nM
|
|
|
| 2 |
IC50 = 400 nM
|
|
|
| 3 |
IC50 = 520 nM
|
|
|
|
CP0141514
|
4-[2-amino-4-methyl-3-(2-methylquinazolin-7-yl)oxybenzoyl]-1-methyl-2,5-diphenylpyrazol-3-one
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|
C33H27N5O3
|
3
|
| 1 |
IC50 = 35 nM
|
|
|
| 2 |
IC50 = 2300 nM
|
|
|
| 3 |
IC50 = 6000 nM
|
|
|
|
CP0116139
|
4-[2-amino-3-(2-amino-1,3-benzothiazol-6-yl)-4-methylbenzoyl]-1-methyl-2,5-diphenylpyrazol-3-one
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|
C31H25N5O2S
|
3
|
| 1 |
IC50 = 41 nM
|
|
|
| 2 |
IC50 = 1100 nM
|
|
|
| 3 |
IC50 = 1200 nM
|
|
|
|
CP0398457
|
4-[4-amino-3-[2-(methylamino)quinazolin-7-yl]oxybenzoyl]-1-methyl-2,5-diphenylpyrazol-3-one
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|
C32H26N6O3
|
3
|
| 1 |
IC50 = 45 nM
|
|
|
| 2 |
IC50 = 240 nM
|
|
|
| 3 |
IC50 = 320 nM
|
|
|
|
CP0398458
|
4-[2-amino-3-[5-chloro-2-(methylamino)quinazolin-7-yl]oxy-4-methylbenzoyl]-1-methyl-2,5-diphenylpyrazol-3-one
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|
C33H27ClN6O3
|
3
|
| 1 |
IC50 = 59 nM
|
|
|
| 2 |
IC50 = 650 nM
|
|
|
| 3 |
IC50 = 1100 nM
|
|
|
|
CP0089446
|
2-amino-N-[4-methoxy-3-(trifluoromethyl)phenyl]-4-methyl-3-[2-(methylamino)quinazolin-6-yl]benzamide
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|
C25H22F3N5O2
|
3
|
| 1 |
IC50 = 65 nM
|
|
|
| 2 |
IC50 = 640 nM
|
|
|
| 3 |
IC50 = 1200 nM
|
|
|
|
CP0116140
|
4-[2-amino-3-[2-(fluoromethyl)-1,3-benzothiazol-6-yl]-4-methylbenzoyl]-1-methyl-2,5-diphenylpyrazol-3-one
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|
C32H25FN4O2S
|
3
|
| 1 |
IC50 = 65 nM
|
|
|
| 2 |
IC50 = 2100 nM
|
|
|
| 3 |
IC50 = 3700 nM
|
|
|
|
CP0281682
|
4-[2-amino-4-methyl-3-[2-(methylamino)-1,3-benzothiazol-6-yl]benzoyl]-1-methyl-2,5-diphenylpyrazol-3-one
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|
C32H27N5O2S
|
3
|
| 1 |
IC50 = 82 nM
|
|
|
| 2 |
IC50 = 760 nM
|
|
|
| 3 |
IC50 = 1300 nM
|
|
|
|
CP0206867
|
4-[2-amino-4-methyl-3-(2-methylquinolin-6-yl)benzoyl]-1-methyl-2,5-diphenylpyrazol-3-one
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|
C34H28N4O2
|
3
|
| 1 |
IC50 = 84 nM
|
|
|
| 2 |
IC50 = 770 nM
|
|
|
| 3 |
IC50 > 50000 nM
|
|
|
|
CP0089447
|
4-[2-amino-3-[2-(difluoromethyl)-1,3-benzothiazol-6-yl]-4-methylbenzoyl]-1-methyl-2,5-diphenylpyrazol-3-one
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|
C32H24F2N4O2S
|
3
|
| 1 |
IC50 = 86 nM
|
|
|
| 2 |
IC50 = 1900 nM
|
|
|
| 3 |
IC50 = 4800 nM
|
|
|
|
CP0327329
|
4-[2-amino-4-methyl-3-[2-(trifluoromethyl)-1,3-benzothiazol-6-yl]benzoyl]-1-methyl-2,5-diphenylpyrazol-3-one
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|
C32H23F3N4O2S
|
3
|
| 1 |
IC50 = 88 nM
|
|
|
| 2 |
IC50 = 3000 nM
|
|
|
| 3 |
IC50 > 50000 nM
|
|
|
|
CP0089461
|
1-methyl-4-[4-methyl-3-[2-(methylamino)quinazolin-7-yl]oxybenzoyl]-2,5-diphenylpyrazol-3-one
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|
C33H27N5O3
|
3
|
| 1 |
IC50 = 110 nM
|
|
|
| 2 |
IC50 = 140 nM
|
|
|
| 3 |
IC50 = 480 nM
|
|
|
|
CP0283779
|
4-[4-chloro-3-[2-(methylamino)quinazolin-7-yl]oxybenzoyl]-1-methyl-2,5-diphenylpyrazol-3-one
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|
C32H24ClN5O3
|
3
|
| 1 |
IC50 = 120 nM
|
|
|
| 2 |
IC50 = 140 nM
|
|
|
| 3 |
IC50 = 1000 nM
|
|
|
|
CP0206866
|
4-[2-amino-4-methyl-3-(2-methyl-1,3-benzothiazol-5-yl)benzoyl]-1-methyl-2,5-diphenylpyrazol-3-one
Show/Hide
|
C32H26N4O2S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
