Brief Information of the Compound and Protein
Compound Name
2-amino-N-[4-methoxy-3-(trifluoromethyl)phenyl]-4-methyl-3-[2-(methylamino)quinazolin-6-yl]benzamide
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PubChem ID
CID: 86583042
Canonical SMILES
CNc1ncc2cc(ccc2n1)-c1c(C)ccc(C(=O)Nc2ccc(OC)c(c2)C(F)(F)F)c1N
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Compound Formula C25H22F3N5O2
Compound Structure
Protein Name
Eukaryotic translation initiation factor 2-alpha kinase 3
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
Other protein kinase group
>
Other protein kinase PEK family
>
Other protein kinase PEK subfamily
Uniprot ID
Q9NZJ5
Gene Name
EIF2AK3
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000156 HT-1080 Homo sapiens (Human)  3
1
IC50 = 65 nM
   TI
   LI
   LO
   TS
2
IC50 = 640 nM
   TI
   LI
   LO
   TS
3
IC50 = 1200 nM
   TI
   LI
   LO
   TS
CL000043 U2OS Homo sapiens (Human)  1
1
EC50 = 310 nM
   TI
   LI
   LO
   TS