General Information of the Protein
Protein ID
PT01303
Protein Name
Endothelial lipase
Secondarily
Protein Name
Endothelial cell-derived lipase
Phospholipase A1
Gene Name
LIPG
Secondarily
Gene Name
UNQ387/PRO719
Sequence
MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPEHEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVVVDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGNFVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHIDIYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDSNRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKNMGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGASQSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWFRKCRDGWRMKNETSPTVELP
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Hydrolase
Function
Exerts both phospholipase and triglyceride lipase activities (PubMed:12032167, PubMed:10318835, PubMed:10192396). More active as a phospholipase than a triglyceride lipase (PubMed:12032167). Hydrolyzes triglycerides, both with short-chain fatty acyl groups (tributyrin) and long-chain fatty acyl groups (triolein) with similar levels of activity toward both types of substrates (PubMed:12032167). Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins (PubMed:12032167, PubMed:10192396).
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Uniprot ID
Primary ID:
Q9Y5X9

Secondarily ID:
B0LPG6
Q6P9C8
Q6UW82
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Ensembl ID
ENSG00000101670
HGNC ID
HGNC:6623
Subcellular Location
Secreted
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000053 , COS-7
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0230197
 Compound Info 
5-amino-2,4-dioxo-N-[(1R)-5-phenylmethoxy-2,3-dihydro-1H-inden-1-yl]-1H-pyrimidine-6-carboxamide
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C21H20N4O4
  1
1
IC50 = 17 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0164059
 Compound Info 
5-amino-2,4-dioxo-N-[4-(4-phenylmethoxyphenyl)cyclohexyl]-1H-pyrimidine-6-carboxamide
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C24H26N4O4
  1
1
IC50 = 21 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0210858
 Compound Info 
5-hydroxy-2,4-dioxo-N-(4-phenylcyclohexyl)-1H-pyrimidine-6-carboxamide
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C17H19N3O4
  1
1
IC50 = 26 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0140160
 Compound Info 
5-amino-2,4-dioxo-N-[(1R)-5-phenylmethoxy-1,2,3,4-tetrahydronaphthalen-1-yl]-1H-pyrimidine-6-carboxamide
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C22H22N4O4
  1
1
IC50 = 49 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0143507
 Compound Info 
5-amino-2,4-dioxo-N-[(1R,4R)-4-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl]-1H-pyrimidine-6-carboxamide
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C21H20N4O3
  1
1
IC50 = 50 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0140179
 Compound Info 
5-hydroxy-3-(2-methylpropyl)-2,4-dioxo-N-(4-phenylcyclohexyl)-1H-pyrimidine-6-carboxamide
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C21H27N3O4
  1
1
IC50 = 59 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0230198
 Compound Info 
5-hydroxy-3-(2-hydroxyethyl)-2,4-dioxo-N-(4-phenylcyclohexyl)-1H-pyrimidine-6-carboxamide
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C19H23N3O5
  1
1
IC50 = 80 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0565190
 Compound Info 
1-ethyl-4-hydroxy-5-oxo-N-(4-phenylcyclohexyl)-2H-pyrrole-3-carboxamide
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C19H24N2O3
  1
1
IC50 = 82 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0439917
 Compound Info 
5-amino-2,4-dioxo-N-(4-phenylcyclohexyl)-1H-pyrimidine-6-carboxamide
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C17H20N4O3
  1
1
IC50 = 91 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0426419
 Compound Info 
3-benzyl-5-hydroxy-2,4-dioxo-N-(4-phenylcyclohexyl)-1H-pyrimidine-6-carboxamide
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C24H25N3O4
  1
1
IC50 = 117 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0565169
 Compound Info 
CHEMBL4440524
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C22H28N4O3
  1
1
IC50 = 156 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0326153
 Compound Info 
5-amino-2,4-dioxo-N-[(1R,3S)-3-phenylcyclopentyl]-1H-pyrimidine-6-carboxamide
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C16H18N4O3
  1
1
IC50 = 175 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0210857
 Compound Info 
5-amino-2,4-dioxo-N-[(1S,3R)-3-phenylcyclopentyl]-1H-pyrimidine-6-carboxamide
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C16H18N4O3
  1
1
IC50 = 218 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0405325
 Compound Info 
N-[4-(3,4-dichlorophenyl)butan-2-yl]-1-ethyl-4-hydroxy-5-oxo-2H-pyrrole-3-carboxamide
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C17H20Cl2N2O3
  1
1
IC50 = 218 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0355382
 Compound Info 
5-amino-N-[4-(4-fluorophenyl)-4-methoxycyclohexyl]-2,4-dioxo-1H-pyrimidine-6-carboxamide
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C18H21FN4O4
  1
1
IC50 = 1010 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0471737
 Compound Info 
5-amino-2,6-dioxo-3-phenyl-N-(4-phenylcyclohexyl)pyrimidine-4-carboxamide
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C23H24N4O3
  1
1
IC50 = 2350 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000156 , HT-1080
 Cell Line Info 
Cell Line ID: CL000749 , HUVEC-C
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0197531
 Compound Info 
US8754113, I-1-85
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C17H15N5O3S2
  2
1 IC50 = 5 nM
2 IC50 = 6 nM
CP0265840
 Compound Info 
2-[(3S)-3-(pyridin-2-ylmethoxy)pyrrolidin-1-yl]-5-(trifluoromethyl)benzoic acid
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C18H17F3N2O3
  2
1 IC50 = 110 nM
2 IC50 = 237 nM
CP0126566
 Compound Info 
(4-nonylphenyl)boranediol
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C15H25BO2
  1
1 IC50 = 1000 nM
CP0275757
 Compound Info 
(4-pentylphenyl)boronic acid
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C11H17BO2
  1
1 IC50 = 1000 nM
CP0275760
 Compound Info 
4,4,5,5-tetramethyl-2-(4-phenylphenyl)-1,3,2-dioxaborolane
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C18H21BO2
  1
1 IC50 = 1000 nM
CP0291699
 Compound Info 
4,4,5,5-tetramethyl-2-(4-thiophen-3-ylphenyl)-1,3,2-dioxaborolane
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C16H19BO2S
  1
1 IC50 = 1300 nM
CP0293797
 Compound Info 
2-[4-(4-fluorophenyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
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C18H20BFO2
  1
1 IC50 = 1600 nM
CP0275758
 Compound Info 
(4-heptylphenyl)boronic acid
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C13H21BO2
  1
1 IC50 = 1700 nM
CP0069649
 Compound Info 
4,4,5,5-tetramethyl-2-(4-thiophen-2-ylphenyl)-1,3,2-dioxaborolane
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C16H19BO2S
  1
1 IC50 = 1900 nM
CP0128905
 Compound Info 
2-[4-(furan-2-yl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
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C16H19BO3
  1
1 IC50 = 1900 nM
CP0128880
 Compound Info 
(4-undecylphenyl)boronic acid
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C17H29BO2
  1
1 IC50 = 2000 nM
CP0235662
 Compound Info 
4,4,5,5-tetramethyl-2-(4-naphthalen-2-ylphenyl)-1,3,2-dioxaborolane
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C22H23BO2
  1
1 IC50 = 2000 nM
CP0275756
 Compound Info 
(4-propylphenyl)boronic acid
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C9H13BO2
  1
1 IC50 = 2000 nM
CP0235765
 Compound Info 
4,4,5,5-tetramethyl-2-(4-nonylphenyl)-1,3,2-dioxaborolane
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C21H35BO2
  1
1 IC50 = 2500 nM
CP0298058
 Compound Info 
4,4,5,5-tetramethyl-2-(4-pentylphenyl)-1,3,2-dioxaborolane
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C17H27BO2
  1
1 IC50 = 2600 nM
CP0126567
 Compound Info 
(3-nonylphenyl)boronic acid
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C15H25BO2
  1
1 IC50 = 2800 nM
CP0282933
 Compound Info 
2-[4-(furan-3-yl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
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C16H19BO3
  1
1 IC50 = 2800 nM
CP0126569
 Compound Info 
2-(4-heptylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
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C19H31BO2
  1
1 IC50 = 3500 nM
CP0275755
 Compound Info 
4,4,5,5-tetramethyl-2-(3-pentylphenyl)-1,3,2-dioxaborolane
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C17H27BO2
  1
1 IC50 = 4200 nM
CP0275759
 Compound Info 
4,4,5,5-tetramethyl-2-(4-undecylphenyl)-1,3,2-dioxaborolane
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C23H39BO2
  1
1 IC50 = 4500 nM
CP0291700
 Compound Info 
4,4,5,5-tetramethyl-2-(4-propylphenyl)-1,3,2-dioxaborolane
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C15H23BO2
  1
1 IC50 = 5000 nM
CP0076293
 Compound Info 
(4-ethylphenyl)boronic acid
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C8H11BO2
  1
1 IC50 = 11000 nM
CP0275754
 Compound Info 
(3-pentylphenyl)boronic acid
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C11H17BO2
  1
1 IC50 = 12800 nM
CP0076286
 Compound Info 
(4-methylphenyl)boronic acid
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C7H9BO2
  1
1 IC50 = 17000 nM
CP0210858
 Compound Info 
CHEMBL4439500
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C17H19N3O4
  1
1 IC50 = 25000 nM
CP0426419
 Compound Info 
CHEMBL4448686
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C24H25N3O4
  1
1 IC50 = 32000 nM
CP0164059
 Compound Info 
CHEMBL4558644
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C24H26N4O4
  1
1 IC50 = 35000 nM
CP0140179
 Compound Info 
CHEMBL4555254
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C21H27N3O4
  1
1 IC50 = 48000 nM
CP0126568
 Compound Info 
(2-nonylphenyl)boronic acid
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C15H25BO2
  1
1 IC50 = 50000 nM
CP0143507
 Compound Info 
5-amino-2,4-dioxo-N-[(1R,4R)-4-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl]-1H-pyrimidine-6-carboxamide
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C21H20N4O3
  1
1 IC50 = 76000 nM
CP0230197
 Compound Info 
5-amino-2,4-dioxo-N-[(1R)-5-phenylmethoxy-2,3-dihydro-1H-inden-1-yl]-1H-pyrimidine-6-carboxamide
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C21H20N4O4
  1
1 IC50 = 80000 nM
CP0140160
 Compound Info 
5-amino-2,4-dioxo-N-[(1R)-5-phenylmethoxy-1,2,3,4-tetrahydronaphthalen-1-yl]-1H-pyrimidine-6-carboxamide
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C22H22N4O4
  1
1 IC50 = 81000 nM
Clinical Information about the Protein
Target 1 ( Endothelial lipase (LIPG) )
Target Type Clinical trial Target
Disease 1 Target-related Disease  1
1 Coagulation defect [ICD-11: 3B10.0]
Clinical Trial Drug(s) 1 Clinical Trial Drug  1
1 GSK-264220A
 Drug Info 
Clinical trial
Coagulation defect