General Information of the Compound
Compound ID
CP0426419
Compound Name
CHEMBL4448686
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Formula
C24H25N3O4
Molecular Weight
419.481
Canonical SMILES
Oc1c([nH]c(=O)n(Cc2ccccc2)c1=O)C(=O)N[C@H]1CC[C@H](CC1)c1ccccc1
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InChI
InChI=1S/C24H25N3O4/c28-21-20(26-24(31)27(23(21)30)15-16-7-3-1-4-8-16)22(29)25-19-13-11-18(12-14-19)17-9-5-2-6-10-17/h1-10,18-19,28H,11-15H2,(H,25,29)(H,26,31)/t18-,19+
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InChIKey
VKIYRHLWKIQIFA-KDURUIRLSA-N
Physicochemical Property
logP
2.7467
Rotatable Bonds
5
Heavy Atom Count
31
Polar Areas
104.19
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
5
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4448686
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01303, Endothelial lipase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000053 COS-7 Chlorocebus aethiops (Green monkey)  1
1
IC50 = 117 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 32000 nM