Protein Information

General Information of the Protein

Protein ID	PT02997
Protein Name	Isocitrate dehydrogenase [NADP] cytoplasmic
Secondarily Protein Name	Cytosolic NADP-isocitrate dehydrogenase IDPc NADP(+)-specific ICDH Oxalosuccinate decarboxylase
Gene Name	IDH1
Secondarily Gene Name	PICD
Sequence	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Enzyme > Oxidoreductase
Function	Catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate (D-threo-isocitrate) to 2-ketoglutarate (2-oxoglutarate), which is required by other enzymes such as the phytanoyl-CoA dioxygenase (PubMed:10521434, PubMed:19935646). Plays a critical role in the generation of NADPH, an important cofactor in many biosynthesis pathways (PubMed:10521434). May act as a corneal epithelial crystallin and may be involved in maintaining corneal epithelial transparency (By similarity). Show/Hide
Uniprot ID	Primary ID: O75874 Secondarily ID: Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8 Show/Hide
Ensembl ID	ENSG00000138413
HGNC ID	HGNC:5382
Subcellular Location	Cytoplasm Cytosol Peroxisome

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000539 , COR-L105

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0096015 Compound Info	(2S)-2-(2-chlorophenyl)-2-[[2-[(2S)-1-(4-cyanopyridin-2-yl)-5-oxopyrrolidin-2-yl]acetyl]-(5-fluoropyridin-3-yl)amino]-N-(3,3-difluorocyclobutyl)acetamide Show/Hide	C29H24ClF3N6O3	1
1	IC50 = 15 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000968 , HCCC-9810

Cell Line Info

Cell Line ID: CL000067 , HCT 116

Cell Line Info

Cell Line ID: CL000156 , HT-1080

Cell Line Info

Cell Line ID: CL000243 , MCF-10A

Cell Line Info

Cell Line ID: CL000013 , Sf9

Cell Line Info

Cell Line ID: CL000855 , TS603

Cell Line Info

Cell Line ID: CL000102 , U-87MG ATCC

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0076794 Compound Info	US10028961, Compound 101 Show/Hide	C14H13ClF6N6	1
1	IC50 = 0.04 nM
CP0096015 Compound Info	(2S)-2-(2-chlorophenyl)-2-[[2-[(2S)-1-(4-cyanopyridin-2-yl)-5-oxopyrrolidin-2-yl]acetyl]-(5-fluoropyridin-3-yl)amino]-N-(3,3-difluorocyclobutyl)acetamide Show/Hide	C29H24ClF3N6O3	7
1	IC50 = 3 nM
2	IC50 = 5 nM
3	IC50 = 8 nM
4	IC50 = 12 nM
5	IC50 = 13 nM
6	IC50 = 24 nM
7	IC50 = 71 nM
CP0720560 Compound Info	(R)-1-(4-fluorobenzyl)-N-(3-((S)-1-hydroxyethyl)phenyl)-7-methyl-5-(1H-pyrrole-2-carbonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-3-carboxamide Show/Hide	C28H28FN5O3	4
1	IC50 = 3.8 nM
2	IC50 = 4.6 nM
3	IC50 = 15 nM
4	IC50 = 17 nM
CP0465228 Compound Info	(4S)-3-[2-[[(1S)-1-[5-(2-tert-butylpyridin-4-yl)pyridin-2-yl]ethyl]amino]pyrimidin-4-yl]-4-propan-2-yl-1,3-oxazolidin-2-one Show/Hide	C26H32N6O2	1
1	IC50 = 4 nM
CP0076796 Compound Info	5-[[(1S)-1-[6-chloro-2-oxo-7-[(1R)-1-pyridin-2-ylethoxy]-1H-quinolin-3-yl]ethyl]amino]-1-methyl-6-oxopyridine-2-carbonitrile Show/Hide	C25H22ClN5O3	3
1	IC50 = 4 nM
2	IC50 = 8 nM
3	IC50 < 10 nM
CP0762758 Compound Info	(S)-2-(1-(6-chloro-7-isopropoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethylamino)-4-methoxypyrimidine-5-carbonitrile Show/Hide	C20H20ClN5O3	2
1	IC50 = 4 nM
2	IC50 = 26 nM
CP0355999 Compound Info	(4S)-N-[(1S)-7-chloro-1-[(3,3-difluorocyclobutyl)carbamoyl]-2,3-dihydroinden-1-yl]-3-(4-cyanopyrimidin-2-yl)-N-(3-fluorophenyl)-2-oxo-1,3-oxazolidine-4-carboxamide Show/Hide	C29H22ClF3N6O4	1
1	IC50 = 5.6 nM
CP0196436 Compound Info	US10112931, Example 388 Show/Hide	C20H20ClFN6O2	1
1	IC50 = 6 nM
CP0368867 Compound Info	(2S)-2-(2-chlorophenyl)-2-(N-[2-[(2S)-1-(4-cyanopyridin-2-yl)-5-oxopyrrolidin-2-yl]acetyl]-3,5-difluoroanilino)-N-(3,3-difluorocyclobutyl)acetamide Show/Hide	C30H24ClF4N5O3	1
1	IC50 = 6 nM
CP0179106 Compound Info	(2S)-2-(2-chlorophenyl)-2-(N-[2-[(2S,4S)-1-(4-cyanopyrimidin-2-yl)-4-hydroxy-5-oxopyrrolidin-2-yl]acetyl]-3,5-difluoroanilino)-N-(3,3-difluorocyclobutyl)acetamide Show/Hide	C29H23ClF4N6O4	1
1	IC50 = 7 nM
CP0188595 Compound Info	5-[[(1S)-1-[6-chloro-7-(cyclopropylmethoxy)-2-oxo-1H-quinolin-3-yl]ethyl]amino]-1-methyl-6-oxopyridine-2-carbonitrile Show/Hide	C22H21ClN4O3	3
1	IC50 = 8 nM
2	IC50 < 10 nM
3	IC50 = 24 nM
CP0315105 Compound Info	(2S)-2-(2-chlorophenyl)-2-(N-[2-[(2S)-1-(4-cyanopyridin-2-yl)-5-oxopyrrolidin-2-yl]acetyl]-3-fluoroanilino)-N-(3,3-difluorocyclobutyl)acetamide Show/Hide	C30H25ClF3N5O3	1
1	IC50 = 9 nM
CP0669565 Compound Info	(S)-2-(1-(6-chloro-7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethylamino)-4-methoxypyrimidine-5-carbonitrile Show/Hide	C18H16ClN5O3	3
1	IC50 = 9 nM
2	IC50 < 10 nM
3	IC50 = 36 nM
CP0714072 Compound Info	(S)-2-(1-(6-chloro-7-cyclopropyl-2-oxo-1,2-dihydroquinolin-3-yl)ethylamino)-4-methoxypyrimidine-5-carbonitrile Show/Hide	C20H18ClN5O2	2
1	IC50 = 9 nM
2	IC50 = 305 nM
CP0096013 Compound Info	(2S)-2-(2-chlorophenyl)-2-(N-[2-[(2S,4S)-1-(4-cyanopyridin-2-yl)-4-hydroxy-5-oxopyrrolidin-2-yl]acetyl]-3,5-difluoroanilino)-N-(3,3-difluorocyclobutyl)acetamide Show/Hide	C30H24ClF4N5O4	1
1	IC50 = 10 nM
CP0179575 Compound Info	5-[[(1S)-1-[6-chloro-2-oxo-7-(pyridin-2-ylmethoxy)-1H-quinolin-3-yl]ethyl]amino]-1-methyl-6-oxopyridine-2-carbonitrile Show/Hide	C24H20ClN5O3	2
1	IC50 < 10 nM
2	IC50 = 11 nM
CP0660547 Compound Info	(S)-4-(1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethylamino)-2-methoxybenzonitrile Show/Hide	C19H16ClN3O2	3
1	IC50 < 10 nM
2	IC50 = 14 nM
3	IC50 = 111 nM
CP0107120 Compound Info	US10112931, Example 466 Show/Hide	C23H22F4N6O2	5
1	IC50 = 11 nM
2	IC50 = 18 nM
3	IC50 = 27 nM
4	IC50 = 28 nM
5	IC50 = 6140 nM
CP0202839 Compound Info	(2S)-2-(2-chlorophenyl)-2-(N-[2-[(2S)-1-(4-cyanopyridin-2-yl)-5-oxopyrrolidin-2-yl]acetyl]-3-fluoro-5-sulfamoylanilino)-N-(3,3-difluorocyclobutyl)acetamide Show/Hide	C30H26ClF3N6O5S	1
1	IC50 = 11 nM
CP0326564 Compound Info	5-[[(1S)-1-(6-chloro-7-methoxy-2-oxo-1H-quinolin-3-yl)ethyl]amino]-1-methyl-6-oxopyridine-2-carbonitrile Show/Hide	C19H17ClN4O3	2
1	IC50 = 11 nM
2	IC50 = 40 nM
CP0745638 Compound Info	(S)-2-(1-(6-chloro-7-(cyclopropylmethoxy)-2-oxo-1,2-dihydroquinolin-3-yl)ethylamino)-4-methoxypyrimidine-5-carbonitrile Show/Hide	C21H20ClN5O3	2
1	IC50 = 11 nM
2	IC50 = 53 nM
CP0217390 Compound Info	(4S)-3-[2-[[(1S)-1-[4-methyl-5-[2-(trifluoromethyl)pyridin-4-yl]pyridin-2-yl]ethyl]amino]pyrimidin-4-yl]-4-propan-2-yl-1,3-oxazolidin-2-one Show/Hide	C24H25F3N6O2	1
1	IC50 = 13 nM
CP0465227 Compound Info	(4S)-3-[2-[[(1S)-1-[6-methyl-5-[2-(trifluoromethyl)pyridin-4-yl]pyridin-2-yl]ethyl]amino]pyrimidin-4-yl]-4-propan-2-yl-1,3-oxazolidin-2-one Show/Hide	C24H25F3N6O2	1
1	IC50 = 15 nM
CP0660534 Compound Info	(S)-6-((1-(6-Chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-4-methoxynicotinonitrile Show/Hide	C18H15ClN4O2	2
1	IC50 = 17 nM
2	IC50 = 178 nM
CP0839866 Compound Info	(S)-2-(1-(6-chloro-2-oxo-7-(pyridin-2-ylmethoxy)-1,2-dihydroquinolin-3-yl)ethylamino)-4-methoxypyrimidine-5-carbonitrile Show/Hide	C23H19ClN6O3	2
1	IC50 = 17 nM
2	IC50 = 43 nM
CP0714073 Compound Info	(S)-2-((1-(6-Chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-4-methoxypyrimidine-5-carbonitrile Show/Hide	C17H14ClN5O2	4
1	IC50 = 18 nM
2	IC50 = 81.4 nM
3	IC50 = 130 nM
4	IC50 = 35000 nM
CP0267135 Compound Info	US10640534, Compound 176 Show/Hide	C28H22ClF3N6O3	3
1	IC50 = 19 nM
2	IC50 = 63 nM
3	IC50 = 65 nM
CP0240938 Compound Info	(4S)-3-[2-[[(1S)-1-[5-(4-fluoro-3-methylphenyl)pyrimidin-2-yl]ethyl]amino]pyrimidin-4-yl]-4-propan-2-yl-1,3-oxazolidin-2-one Show/Hide	C23H25FN6O2	1
1	IC50 = 20 nM
CP0750884 Compound Info	(S)-6-(1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethylamino)-2-methylnicotinonitrile Show/Hide	C18H15ClN4O	2
1	IC50 = 20 nM
2	IC50 = 183 nM
CP0315190 Compound Info	(4R)-4-(fluoromethyl)-3-[2-[[(1S)-1-[1-[4-(trifluoromethyl)phenyl]imidazol-4-yl]ethyl]amino]pyrimidin-4-yl]-1,3-oxazolidin-2-one Show/Hide	C20H18F4N6O2	3
1	IC50 = 21 nM
2	IC50 = 45 nM
3	IC50 = 2520 nM
CP0117201 Compound Info	Ft-2102 Show/Hide	C18H15ClN4O2	3
1	IC50 = 21.2 nM
2	IC50 = 114 nM
3	IC50 = 22400 nM
CP0233817 Compound Info	(2S)-N-[(1S)-7-chloro-1-[(3,3-difluorocyclobutyl)carbamoyl]-2,3-dihydroinden-1-yl]-1-(4-cyanopyrimidin-2-yl)-N-(3-fluorophenyl)-5-oxopyrrolidine-2-carboxamide Show/Hide	C30H24ClF3N6O3	1
1	IC50 = 22 nM
CP0239174 Compound Info	(2S)-1-(4-cyanopyrimidin-2-yl)-N-[(1S)-1-[(3,3-difluorocyclobutyl)carbamoyl]-2,3-dihydroinden-1-yl]-N-(3,5-difluorophenyl)-5-oxopyrrolidine-2-carboxamide Show/Hide	C30H24F4N6O3	1
1	IC50 = 22 nM
CP0762754 Compound Info	(S)-6-((1-(6-Chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-2-methoxynicotinonitrile Show/Hide	C18H15ClN4O2	2
1	IC50 = 24 nM
2	IC50 = 190 nM
CP0147089 Compound Info	5-[[(1S)-1-(6-chloro-7-fluoro-2-oxo-1H-quinolin-3-yl)ethyl]amino]-1-methyl-6-oxopyridine-2-carbonitrile Show/Hide	C18H14ClFN4O2	2
1	IC50 = 25 nM
2	IC50 = 159 nM
CP0306593 Compound Info	(4R)-3-[2-[[1-[1-(3-chloro-4-fluorophenyl)imidazol-4-yl]cyclopropyl]amino]pyrimidin-4-yl]-4-[(1S)-1-fluoroethyl]-1,3-oxazolidin-2-one Show/Hide	C21H19ClF2N6O2	1
1	IC50 = 25 nM
CP0220583 Compound Info	(4R)-3-[2-[[1-[1-(3-chloro-5-fluorophenyl)imidazol-4-yl]cyclopropyl]amino]pyrimidin-4-yl]-4-[(1S)-1-fluoroethyl]-1,3-oxazolidin-2-one Show/Hide	C21H19ClF2N6O2	1
1	IC50 = 27 nM
CP0393056 Compound Info	(4R)-4-(fluoromethyl)-3-[2-[[(1S)-1-[4-methyl-5-[2-(trifluoromethyl)pyridin-4-yl]pyridin-2-yl]ethyl]amino]pyrimidin-4-yl]-1,3-oxazolidin-2-one Show/Hide	C22H20F4N6O2	1
1	IC50 = 28 nM
CP0164416 Compound Info	(4R)-3-[6-chloro-2-[[1-[1-(3-chloro-4-fluorophenyl)imidazol-4-yl]cyclopropyl]amino]pyrimidin-4-yl]-4-[(1S)-1-fluoroethyl]-1,3-oxazolidin-2-one Show/Hide	C21H18Cl2F2N6O2	1
1	IC50 = 32 nM
CP0509652 Compound Info	(4R)-4-[(1S)-1-fluoroethyl]-3-[2-[[1-[1-[3-(trifluoromethyl)phenyl]imidazol-4-yl]cyclopropyl]amino]pyrimidin-4-yl]-1,3-oxazolidin-2-one Show/Hide	C22H20F4N6O2	1
1	IC50 = 32 nM
CP0412482 Compound Info	US10112931, Example 59 Show/Hide	C23H23F3N6O3	1
1	IC50 = 33 nM
CP0239715 Compound Info	(2S)-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-2-(3-fluoro-N-[2-[(2S)-1-pyrimidin-2-ylpyrrolidin-2-yl]acetyl]anilino)acetamide Show/Hide	C28H27ClF3N5O2	1
1	IC50 = 34 nM
CP0080002 Compound Info	(4S)-4-ethyl-3-[2-[[(1S)-1-[4-methyl-5-[2-(trifluoromethyl)pyridin-4-yl]pyridin-2-yl]ethyl]amino]pyrimidin-4-yl]-1,3-oxazolidin-2-one Show/Hide	C23H23F3N6O2	1
1	IC50 = 35 nM
CP0237916 Compound Info	(4R)-3-[2-[[1-[1-(3-chloro-4-fluorophenyl)imidazol-4-yl]cyclopropyl]amino]-5-fluoropyrimidin-4-yl]-4-[(1S)-1-fluoroethyl]-1,3-oxazolidin-2-one Show/Hide	C21H18ClF3N6O2	1
1	IC50 = 35 nM
CP0440444 Compound Info	(4R)-3-[2-[[1-[1-(3,5-dichlorophenyl)imidazol-4-yl]cyclopropyl]amino]pyrimidin-4-yl]-4-[(1S)-1-fluoroethyl]-1,3-oxazolidin-2-one Show/Hide	C21H19Cl2FN6O2	1
1	IC50 = 36 nM
CP0762757 Compound Info	(S)-2-(1-(6-chloro-7-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)ethylamino)-4-methoxypyrimidine-5-carbonitrile Show/Hide	C17H13ClFN5O2	2
1	IC50 = 36.5 nM
2	IC50 = 184 nM
CP0248665 Compound Info	(2S)-1-(4-cyanopyridin-2-yl)-N-[(1S)-1-(cyclohexylcarbamoyl)-2,3-dihydroinden-1-yl]-N-(3-fluorophenyl)-5-oxopyrrolidine-2-carboxamide Show/Hide	C33H32FN5O3	1
1	IC50 = 37 nM
CP0366771 Compound Info	(4S)-3-(4-cyanopyrimidin-2-yl)-N-[(1S)-1-[(3,3-difluorocyclobutyl)carbamoyl]-2,3-dihydroinden-1-yl]-N-(3,5-difluorophenyl)-2-oxo-1,3-oxazolidine-4-carboxamide Show/Hide	C29H22F4N6O4	1
1	IC50 = 40 nM
CP0315104 Compound Info	(2S)-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-2-(3-fluoro-N-[2-[(2S)-1-(4-fluoropyridin-2-yl)-5-oxopyrrolidin-2-yl]acetyl]anilino)acetamide Show/Hide	C29H25ClF4N4O3	1
1	IC50 = 40 nM
CP0243212 Compound Info	(4R)-3-[2-[[1-[1-(3-chloro-4-fluorophenyl)imidazol-4-yl]cyclobutyl]amino]pyrimidin-4-yl]-4-[(1S)-1-fluoroethyl]-1,3-oxazolidin-2-one Show/Hide	C22H21ClF2N6O2	1
1	IC50 = 40 nM
CP0714071 Compound Info	(S)-2-((1-(6-Chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-4-methylpyrimidine-5-carbonitrile Show/Hide	C17H14ClN5O	2
1	IC50 = 40 nM
2	IC50 = 443 nM
CP0168841 Compound Info	(4R)-3-[2-[[1-[5-chloro-1-[3-(trifluoromethyl)phenyl]imidazol-4-yl]cyclopropyl]amino]pyrimidin-4-yl]-4-[(1S)-1-fluoroethyl]-1,3-oxazolidin-2-one Show/Hide	C22H19ClF4N6O2	1
1	IC50 = 41 nM
CP0230166 Compound Info	(4S)-N-[(1S)-7-chloro-1-[(3,3-difluorocyclobutyl)carbamoyl]-2,3-dihydroinden-1-yl]-3-(4-cyanopyridin-2-yl)-N-(3-fluorophenyl)-2-oxo-1,3-oxazolidine-4-carboxamide Show/Hide	C30H23ClF3N5O4	1
1	IC50 = 42 nM
CP0144333 Compound Info	(4R)-3-[2-[[1-[1-(3-chlorophenyl)imidazol-4-yl]cyclopropyl]amino]pyrimidin-4-yl]-4-[(1S)-1-fluoroethyl]-1,3-oxazolidin-2-one Show/Hide	C21H20ClFN6O2	1
1	IC50 = 42 nM
CP0179104 Compound Info	methyl (2S)-2-[2-(N-[(1S)-1-(2-chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl]-3-fluoroanilino)-2-oxoethyl]pyrrolidine-1-carboxylate Show/Hide	C26H27ClF3N3O4	1
1	IC50 = 44 nM
CP0660539 Compound Info	(S)-5-((1-(6-Chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-6-methoxypicolinonitrile Show/Hide	C18H15ClN4O2	2
1	IC50 = 44 nM
2	IC50 = 1015 nM
CP0210764 Compound Info	(2S)-1-(4-cyanopyridin-2-yl)-N-[(1S)-1-[(3,3-difluorocyclobutyl)carbamoyl]-2,3-dihydroinden-1-yl]-N-(3,5-difluorophenyl)-5-oxopyrrolidine-2-carboxamide Show/Hide	C31H25F4N5O3	2
1	IC50 = 45 nM
2	IC50 = 3560 nM
CP0179105 Compound Info	(2S)-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-2-(3-fluoro-N-[2-[(2S)-5-oxo-1-pyrimidin-2-ylpyrrolidin-2-yl]acetyl]anilino)acetamide Show/Hide	C28H25ClF3N5O3	1
1	IC50 = 45 nM
CP0368868 Compound Info	methyl N-[2-(N-[(1S)-2-(cyclohexylamino)-1-(2-methylphenyl)-2-oxoethyl]-3-fluoroanilino)-2-oxoethyl]carbamate Show/Hide	C25H30FN3O4	1
1	IC50 = 46 nM
CP0101469 Compound Info	(2S)-N-[(1S)-5-chloro-1-[(3,3-difluorocyclobutyl)carbamoyl]-2,3-dihydroinden-1-yl]-1-(4-cyanopyridin-2-yl)-N-(3-fluorophenyl)-5-oxopyrrolidine-2-carboxamide Show/Hide	C31H25ClF3N5O3	2
1	IC50 = 49 nM
2	IC50 = 1780 nM
CP0069129 Compound Info	US10028961, Compound 121 Show/Hide	C17H22F3N7	1
1	IC50 < 50 nM
CP0179549 Compound Info	US10028961, Compound 128 Show/Hide	C15H13F7N6S	1
1	IC50 < 50 nM
CP0179571 Compound Info	US10028961, Compound 105 Show/Hide	C20H22F6N6	1
1	IC50 < 50 nM
CP0233887 Compound Info	US10028961, Compound 160 Show/Hide	C20H22F7N7	1
1	IC50 < 50 nM
CP0366769 Compound Info	(2S)-1-(4-cyanopyridin-2-yl)-N-[(1S)-1-[(3,3-difluorocyclobutyl)carbamoyl]-7-fluoro-2,3-dihydroinden-1-yl]-N-(3-fluorophenyl)-5-oxopyrrolidine-2-carboxamide Show/Hide	C31H25F4N5O3	1
1	IC50 = 51 nM
CP0541324 Compound Info	(2S)-N-[(1S)-4-chloro-1-[(3,3-difluorocyclobutyl)carbamoyl]-2,3-dihydroinden-1-yl]-1-(4-cyanopyridin-2-yl)-N-(3,5-difluorophenyl)-5-oxopyrrolidine-2-carboxamide Show/Hide	C31H24ClF4N5O3	1
1	IC50 = 53 nM
CP0311207 Compound Info	(4S)-3-(4-cyanopyridin-2-yl)-N-[(1S)-1-[(3,3-difluorocyclobutyl)carbamoyl]-2,3-dihydroinden-1-yl]-N-(3,5-difluorophenyl)-2-oxo-1,3-oxazolidine-4-carboxamide Show/Hide	C30H23F4N5O4	1
1	IC50 = 54 nM
CP0563808 Compound Info	(4R)-3-[2-[[1-[1-(4-chlorophenyl)imidazol-4-yl]cyclopropyl]amino]pyrimidin-4-yl]-4-[(1S)-1-fluoroethyl]-1,3-oxazolidin-2-one Show/Hide	C21H20ClFN6O2	1
1	IC50 = 54 nM
CP0164420 Compound Info	(4R)-4-[(1S)-1-fluoroethyl]-3-[2-[[1-[5-methyl-1-[3-(trifluoromethyl)phenyl]imidazol-4-yl]cyclopropyl]amino]pyrimidin-4-yl]-1,3-oxazolidin-2-one Show/Hide	C23H22F4N6O2	1
1	IC50 = 56 nM
CP0311204 Compound Info	(4S)-3-(4-cyanopyridin-2-yl)-N-[(1S)-1-[(3,3-difluorocyclobutyl)carbamoyl]-2,3-dihydroinden-1-yl]-N-(3-fluorophenyl)-2-oxo-1,3-oxazolidine-4-carboxamide Show/Hide	C30H24F3N5O4	1
1	IC50 = 58 nM
CP0517962 Compound Info	(4S)-3-[2-[[(1S)-1-[5-(4-fluoro-3-methylphenyl)pyrazin-2-yl]ethyl]amino]pyrimidin-4-yl]-4-propan-2-yl-1,3-oxazolidin-2-one Show/Hide	C23H25FN6O2	1
1	IC50 = 62 nM
CP0164418 Compound Info	(4R)-4-[(1S)-1-fluoroethyl]-3-[2-[[1-[1-[4-(trifluoromethyl)phenyl]imidazol-4-yl]cyclopropyl]amino]pyrimidin-4-yl]-1,3-oxazolidin-2-one Show/Hide	C22H20F4N6O2	1
1	IC50 = 65 nM
CP0541323 Compound Info	(2S)-N-[(1S)-4-chloro-1-[(3,3-difluorocyclobutyl)carbamoyl]-2,3-dihydroinden-1-yl]-1-(4-cyanopyridin-2-yl)-N-(3-fluorophenyl)-5-oxopyrrolidine-2-carboxamide Show/Hide	C31H25ClF3N5O3	1
1	IC50 = 67 nM
CP0239176 Compound Info	(2S)-1-(4-cyanopyridin-2-yl)-N-[(1S)-1-[(3,3-difluorocyclobutyl)carbamoyl]-4-fluoro-2,3-dihydroinden-1-yl]-N-(3-fluorophenyl)-5-oxopyrrolidine-2-carboxamide Show/Hide	C31H25F4N5O3	1
1	IC50 = 68 nM
CP0057375 Compound Info	N-cyclohexyl-2-(3-fluoro-N-[2-(2-methylimidazol-1-yl)acetyl]anilino)-2-(2-methylphenyl)acetamide Show/Hide	C27H31FN4O2	7
1	IC50 = 70 nM
2	IC50 = 160 nM
3	IC50 = 170 nM
4	IC50 = 200 nM
5	IC50 = 390 nM
6	IC50 > 20000 nM
7	IC50 > 100000 nM
CP0096016 Compound Info	(2S)-N-cyclohexyl-2-(3-fluoro-N-[2-(2-methylimidazol-1-yl)acetyl]anilino)-2-(2-methylphenyl)acetamide Show/Hide	C27H31FN4O2	1
1	IC50 = 70 nM
CP0165474 Compound Info	6-{[(6-chloro-2-oxo-1,2- Show/Hide	C17H13ClN4O	3
1	IC50 = 72 nM
2	IC50 = 820 nM
3	IC50 = 75000 nM
CP0465226 Compound Info	(4R)-4-[(1R)-1-fluoroethyl]-3-[2-[[(1S)-1-[4-methyl-5-[2-(trifluoromethyl)pyridin-4-yl]pyridin-2-yl]ethyl]amino]pyrimidin-4-yl]-1,3-oxazolidin-2-one Show/Hide	C23H22F4N6O2	1
1	IC50 = 73 nM
CP0482623 Compound Info	(4S)-4-propan-2-yl-3-[2-[[(1S)-1-[5-[2-(trifluoromethyl)pyridin-4-yl]pyridin-2-yl]ethyl]amino]pyrimidin-4-yl]-1,3-oxazolidin-2-one Show/Hide	C23H23F3N6O2	1
1	IC50 = 77 nM
CP0349878 Compound Info	(2S)-1-(4-cyanopyridin-2-yl)-N-[(1S)-1-[(4,4-difluorocyclohexyl)methylcarbamoyl]-2,3-dihydroinden-1-yl]-N-(3-fluorophenyl)-5-oxopyrrolidine-2-carboxamide Show/Hide	C34H32F3N5O3	1
1	IC50 = 80 nM
CP0269572 Compound Info	(4S)-3-[2-[[(1S)-1-[3-methyl-5-[2-(trifluoromethyl)pyridin-4-yl]pyridin-2-yl]ethyl]amino]pyrimidin-4-yl]-4-propan-2-yl-1,3-oxazolidin-2-one Show/Hide	C24H25F3N6O2	1
1	IC50 = 84 nM
CP0346830 Compound Info	(2S)-1-(4-cyanopyridin-2-yl)-N-[(1S)-1-[(3,3-difluorocyclobutyl)carbamoyl]-2,3-dihydroinden-1-yl]-N-(3-fluorophenyl)-5-oxopyrrolidine-2-carboxamide Show/Hide	C31H26F3N5O3	1
1	IC50 = 85 nM
CP0394027 Compound Info	5-[1-[[4-[(4R)-4-[(1S)-1-fluoroethyl]-2-oxo-1,3-oxazolidin-3-yl]pyrimidin-2-yl]amino]cyclopropyl]-3-[3-(trifluoromethyl)phenyl]imidazole-4-carbonitrile Show/Hide	C23H19F4N7O2	1
1	IC50 = 85 nM
CP0101474 Compound Info	(2S)-1-(4-cyanopyridin-2-yl)-N-[(1S)-1-[(3,3-difluorocyclobutyl)carbamoyl]-2,3-dihydroinden-1-yl]-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide Show/Hide	C30H25F3N6O3	1
1	IC50 = 94 nM
CP0179496 Compound Info	rac-ML309 Show/Hide	C29H29FN4O2	1
1	IC50 < 100 nM
CP0764924 Compound Info	(5S)-4,4-dideuterio-5-isopropyl-1-[2-[[(1S)-1-[1-[4-(trifluoromethyl)phenyl]imidazol-4-yl]ethyl]amino]pyrimidin-4-yl]imidazolidin-2-one Show/Hide	C22H24F3N7O	1
1	IC50 < 100 nM
CP0412483 Compound Info	(4S)-4-methyl-3-[2-[[(1S)-1-[4-methyl-5-[2-(trifluoromethyl)pyridin-4-yl]pyridin-2-yl]ethyl]amino]pyrimidin-4-yl]-1,3-oxazolidin-2-one Show/Hide	C22H21F3N6O2	1
1	IC50 = 116 nM
CP0225556 Compound Info	4-{[(6-chloro-2-oxo-1,2- Show/Hide	C18H14ClN3O2	3
1	IC50 = 127 nM
2	IC50 = 2250 nM
3	IC50 = 100000 nM
CP0239179 Compound Info	methyl N-[2-(N-[(1S)-1-(2-chlorophenyl)-2-(cyclohexylamino)-2-oxoethyl]-3-fluoroanilino)-2-oxoethyl]carbamate Show/Hide	C24H27ClFN3O4	1
1	IC50 = 230 nM
CP0224971 Compound Info	CHEMBL4798388 Show/Hide	C27H37N3O5	3
1	IC50 = 270 nM
2	IC50 = 470 nM
3	IC50 > 50000 nM
CP0117942 Compound Info	(4S)-3-[2-[[(1S)-1-[5-(2-methylpyridin-4-yl)pyridin-2-yl]ethyl]amino]pyrimidin-4-yl]-4-propan-2-yl-1,3-oxazolidin-2-one Show/Hide	C23H26N6O2	1
1	IC50 = 339 nM
CP0564946 Compound Info	2-[(3S)-1-[5-[(5-hydroxy-2-adamantyl)carbamoyl]-6-(3-methylbutoxy)pyridin-2-yl]piperidin-3-yl]acetic acid Show/Hide	C28H41N3O5	1
1	IC50 = 1300 nM
CP0070790 Compound Info	N-cyclohexyl-2-(3-fluoro-N-(2-thiophen-2-ylacetyl)anilino)-2-(2-methylphenyl)acetamide Show/Hide	C27H29FN2O2S	1
1	IC50 = 2900 nM
CP0224960 Compound Info	2-[(3S)-1-[5-(cyclohexylcarbamoyl)-6-[(2-fluorophenyl)methoxy]pyridin-2-yl]piperidin-3-yl]acetic acid Show/Hide	C26H32FN3O4	1
1	IC50 = 5600 nM
CP0070645 Compound Info	N-cyclohexyl-2-(3-fluoro-N-[2-(1H-indol-3-yl)acetyl]anilino)-2-(2-methylphenyl)acetamide Show/Hide	C31H32FN3O2	1
1	IC50 = 6300 nM
CP0070647 Compound Info	N-cyclopentyl-2-(3-fluoro-N-(2-thiophen-2-ylacetyl)anilino)-2-(2-methylphenyl)acetamide Show/Hide	C26H27FN2O2S	1
1	IC50 = 7700 nM
CP0286878 Compound Info	N-cyclohexyl-2-(3-fluoro-N-(2-pyridin-4-ylacetyl)anilino)-2-(2-methylphenyl)acetamide Show/Hide	C28H30FN3O2	1
1	IC50 = 19300 nM
CP0283017 Compound Info	N-cyclohexyl-2-(3-fluoro-N-[2-(1,3-thiazol-4-yl)acetyl]anilino)-2-(2-methylphenyl)acetamide Show/Hide	C26H28FN3O2S	1
1	IC50 = 19700 nM
CP0575184 Compound Info	2-[(3S)-1-[5-(cyclohexylcarbamoyl)-6-methoxypyridin-2-yl]piperidin-3-yl]acetic acid Show/Hide	C20H29N3O4	1
1	IC50 > 50000 nM
CP0057374 Compound Info	N-cyclohexyl-2-(3-fluoro-N-[2-(2-methylbenzimidazol-1-yl)acetyl]anilino)-2-(2-methylphenyl)acetamide Show/Hide	C31H33FN4O2	1
1	IC50 > 100000 nM
CP0176272 Compound Info	N-cyclohexyl-2-(3-fluoro-N-(2-indol-1-ylacetyl)anilino)-2-(2-methylphenyl)acetamide Show/Hide	C31H32FN3O2	1
1	IC50 > 100000 nM
CP0423040 Compound Info	6-benzyl-1-hydroxy-4-methylpyridin-2-one Show/Hide	C13H13NO2	1
1	Ki = 120 nM

Clinical Information about the Protein

Target 1 ( Oxalosuccinate decarboxylase (IDH1) )

Target Type	Successful Target
Disease	3 Target-related Diseases				3
1	Advanced malignancy [ICD-11: 2A00-2F9Z]
2	Cholangiocarcinoma [ICD-11: 2C12.10]
3	Acute myeloid leukaemia [ICD-11: 2A60]
Approved Drug(s)	2 Approved Drugs				2
1	Ivosidenib	Drug Info	Approved	Cholangiocarcinoma
2	Olutasidenib	Drug Info	Approved	Acute myeloid leukaemia
Clinical Trial Drug(s)	1 Clinical Trial Drug				1
1	IDH305	Drug Info	Phase 1	Advanced malignancy

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han