General Information of the Compound
Compound ID
CP0366771
Compound Name
(4S)-3-(4-cyanopyrimidin-2-yl)-N-[(1S)-1-[(3,3-difluorocyclobutyl)carbamoyl]-2,3-dihydroinden-1-yl]-N-(3,5-difluorophenyl)-2-oxo-1,3-oxazolidine-4-carboxamide
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Structure
Formula
C29H22F4N6O4
Molecular Weight
594.525
Canonical SMILES
Fc1cc(F)cc(c1)N(C(=O)[C@@H]1COC(=O)N1c1nccc(n1)C#N)[C@]1(CCc2ccccc12)C(=O)NC1CC(F)(F)C1
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InChI
InChI=1S/C29H22F4N6O4/c30-17-9-18(31)11-21(10-17)39(24(40)23-15-43-27(42)38(23)26-35-8-6-19(14-34)37-26)29(7-5-16-3-1-2-4-22(16)29)25(41)36-20-12-28(32,33)13-20/h1-4,6,8-11,20,23H,5,7,12-13,15H2,(H,36,41)/t23-,29-/m0/s1
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InChIKey
XGPNCPKVIDLLOB-IADCTJSHSA-N
Physicochemical Property
logP
3.74048
Rotatable Bonds
6
Heavy Atom Count
43
Polar Areas
128.52
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
43

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 145975511
ChEMBL ID
CHEMBL4202711
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02997, Isocitrate dehydrogenase [NADP] cytoplasmic
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000156 HT-1080 Homo sapiens (Human)  1
1
IC50 = 308 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 40 nM