Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(2S)-2-(2-chlorophenyl)-2-[[2-[(2S)-1-(4-cyanopyridin-2-yl)-5-oxopyrrolidin-2-yl]acetyl]-(5-fluoropyridin-3-yl)amino]-N-(3,3-difluorocyclobutyl)acetamide
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 PubChem ID
CID: 145982246
Canonical SMILES
Fc1cncc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)C[C@@H]1CCC(=O)N1c1cc(ccn1)C#N
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Compound Formula C29H24ClF3N6O3
Compound Structure
Protein Name
 Protein Info 
Isocitrate dehydrogenase [NADP] cytoplasmic
Protein Classification
Enzyme
>
Oxidoreductase
Uniprot ID
O75874
Gene Name
IDH1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000539 COR-L105
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 15 nM
   TI
   LI
   LO
   TS
CL000968 HCCC-9810
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 12 nM
   TI
   LI
   LO
   TS
CL000156 HT-1080
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 8 nM
   TI
   LI
   LO
   TS
CL000102 U-87MG ATCC
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 19 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 3 nM
2 IC50 = 5 nM
3 IC50 = 8 nM
4 IC50 = 12 nM
5 IC50 = 13 nM
6 IC50 = 24 nM
7 IC50 = 71 nM