General Information of the Cell Line
Cell Line ID
CL000243
Cell Line Name
MCF-10A
Synonyms
MCF 10A
MCF.10A
MCF10A
MCF10-A
MCF10a
MCF-10 Attached
Michigan Cancer Foundation-10A
Category
Spontaneously immortalized cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0598
Tissue Information
Breast
Disease None
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT01014, Cysteine protease CPP32
 Protein Info 
Compound ID Compound Name Compound Formula
CP0210512
 Compound Info 
CID6851947
   Show/Hide
C23H28N4O2
  1
1
IC50 = 3200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein ID: PT00922, Epidermal growth factor receptor
 Protein Info 
Protein ID: PT00934, High affinity nerve growth factor receptor
 Protein Info 
Protein ID: PT02997, Isocitrate dehydrogenase [NADP] cytoplasmic
 Protein Info 
Protein ID: PT03005, Serine protease hepsin
 Protein Info 
Protein ID: PT01042, Serine/threonine-protein kinase PAK 1
 Protein Info 
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0003832
 Compound Info 
N'-hydroxy-N-phenyloctanediamide
   Show/Hide
 C14H20N2O3  2
1
IC50 = 420 nM
   TI
   LI
   LO
   TS
2
IC50 = 1100 nM
   TI
   LI
   LO
   TS
CP0120515
 Compound Info 
4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbonyl]-4-fluorophenyl}methyl)-1,2-dihydrophthalazin-1-one
   Show/Hide
 C24H23FN4O3  1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0174641
 Compound Info 
1-methyl-4-[[4-[4-[(4-methyl-1,4-diazepan-1-yl)methyl]phenyl]phenyl]methyl]-1,4-diazepane
   Show/Hide
 C26H38N4  1
1
GI50 = 27000 nM
   TI
   LI
   LO
   TS
CP0228522
 Compound Info 
4-[[4-[2-fluoro-5-[(4-oxo-3H-phthalazin-1-yl)methyl]benzoyl]piperazin-1-yl]methyl]-N-hydroxybenzamide
   Show/Hide
 C28H26FN5O4  1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0229896
 Compound Info 
(E)-3-[4-[[4-[2-fluoro-5-[(4-oxo-3H-phthalazin-1-yl)methyl]benzoyl]piperazin-1-yl]methyl]phenyl]-N-hydroxyprop-2-enamide
   Show/Hide
 C30H28FN5O4  1
1
IC50 = 17350 nM
   TI
   LI
   LO
   TS
CP0356249
 Compound Info 
2-[2-fluoro-4-[(4-methyl-1,4-diazepan-1-yl)methyl]phenyl]-5-[(4-methyl-1,4-diazepan-1-yl)methyl]benzonitrile
   Show/Hide
 C27H36FN5  1
1
GI50 = 18000 nM
   TI
   LI
   LO
   TS
CP0360699
 Compound Info 
2-[4-[[4-[2-fluoro-5-[(4-oxo-3H-phthalazin-1-yl)methyl]benzoyl]piperazin-1-yl]methyl]phenyl]-N-hydroxyacetamide
   Show/Hide
 C29H28FN5O4  1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0373044
 Compound Info 
methyl (2S)-2-[[8-(hydroxyamino)-8-oxooctanoyl]amino]-3-(4-thiophen-2-ylphenyl)propanoate
   Show/Hide
 C22H28N2O5S  1
1
IC50 = 8000 nM
   TI
   LI
   LO
   TS
CP0386673
 Compound Info 
5-[4-[(Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-1-(4-hydroxyphenyl)but-1-en-2-yl]phenyl]-N-hydroxypentanamide
   Show/Hide
 C31H38N2O4  1
1
IC50 = 1830 nM
   TI
   LI
   LO
   TS
CP0513642
 Compound Info 
methyl (2S)-2-[[9-(hydroxyamino)-9-oxononanoyl]amino]-3-(4-phenylphenyl)propanoate
   Show/Hide
 C25H32N2O5  1
1
IC50 = 42000 nM
   TI
   LI
   LO
   TS
CP0526505
 Compound Info 
methyl (2S)-3-[4-(furan-3-yl)phenyl]-2-[[9-(hydroxyamino)-9-oxononanoyl]amino]propanoate
   Show/Hide
 C23H30N2O6  1
1
IC50 = 44000 nM
   TI
   LI
   LO
   TS
CP0528463
 Compound Info 
methyl (2S)-3-(4-bromophenyl)-2-[[8-(hydroxyamino)-8-oxooctanoyl]amino]propanoate
   Show/Hide
 C18H25BrN2O5  1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0551675
 Compound Info 
2-(dimethylamino)ethyl 4-[4-[[5-chloro-4-[2-(methylcarbamoyl)anilino]pyrimidin-2-yl]amino]benzoyl]piperazine-1-carbodithioate
   Show/Hide
 C28H33ClN8O2S2  1
1
IC50 = 720 nM
   TI
   LI
   LO
   TS
CP0555017
 Compound Info 
2-(dimethylamino)ethyl 4-[4-[[4-[2-(methylcarbamoyl)anilino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzoyl]piperazine-1-carbodithioate
   Show/Hide
 C29H33F3N8O2S2  1
1
IC50 = 280 nM
   TI
   LI
   LO
   TS
CP0573445
 Compound Info 
6-chloro-7-methyl-3-[1-(4-nitrophenyl)-4,5-diphenylimidazol-2-yl]chromen-4-one
   Show/Hide
 C31H20ClN3O4  1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0576207
 Compound Info 
2-(dimethylamino)ethyl 4-[4-[[5-methyl-4-[2-(methylcarbamoyl)anilino]pyrimidin-2-yl]amino]benzoyl]piperazine-1-carbodithioate
   Show/Hide
 C29H36N8O2S2  1
1
IC50 = 1080 nM
   TI
   LI
   LO
   TS
CP0577056
 Compound Info 
2-(dimethylamino)ethyl 4-[4-[[5-fluoro-4-[2-(methylcarbamoyl)anilino]pyrimidin-2-yl]amino]benzoyl]piperazine-1-carbodithioate
   Show/Hide
 C28H33FN8O2S2  1
1
IC50 = 1750 nM
   TI
   LI
   LO
   TS
CP0648741
 Compound Info 
4-Hydroxytamoxifen
   Show/Hide
 C26H29NO2  1
1
IC50 = 4000 nM
   TI
   LI
   LO
   TS
CP0689377
 Compound Info 
SPEBRUTINIB
   Show/Hide
 C22H22FN5O3  1
1
IC50 = 4360 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Breast)
Cell Line Name Organism Disease
MX-1
 Cell Line Info 
Homo sapiens (Human) Breast carcinoma
HCC1954
 Cell Line Info 
Homo sapiens (Human) Breast ductal carcinoma
HDQ-P1
 Cell Line Info 
Homo sapiens (Human) Breast ductal carcinoma
SUM159PT
 Cell Line Info 
Homo sapiens (Human) Breast pleomorphic carcinoma
HCC1806
 Cell Line Info 
Homo sapiens (Human) Breast squamous cell carcinoma, acantholytic variant
BT-474
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
Hs 578T
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
BT-20
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
BT-549
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
184B5
 Cell Line Info 
Homo sapiens (Human) -
UFH-001
 Cell Line Info 
Homo sapiens (Human) -
184A1N4
 Cell Line Info 
Homo sapiens (Human) -