US10633379, Compound X

8-(2,4-difluorophenyl)-15-methyl-4-(methylsulfonylmethyl)-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-14-one

US9296741, 328

15-methyl-4-(methylsulfonylmethyl)-8-pyridin-2-yl-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-14-one

N-[4-(2,4-difluorophenoxy)-3-(1-methyl-7-oxo-6H-pyrrolo[2,3-c]pyridin-3-yl)phenyl]methanesulfonamide

3-methyl-1-(2-phenoxyphenyl)-2,5,6,7-tetrahydro-4H-isoindol-4-one

N-[4-(2,4-difluorophenoxy)-3-(7-methyl-1-oxo-2,6-dihydropyrrolo[3,4-d]pyridazin-5-yl)phenyl]methanesulfonamide

N-[3-(3-methyl-4-oxo-4,5,6,7-tetrahydro-2H-isoindol-1-yl)-4-phenoxyphenyl]methanesulfonamide

US9296741, 21

8-(cyclopropylmethyl)-15-methyl-4-methylsulfonyl-8,12,15-triazatetracyclo[8.6.1.02,7.014,17]heptadeca-1(16),2(7),3,5,10,14(17)-hexaen-13-one

8-(cyclopropylmethyl)-15-methyl-8,12,15-triazatetracyclo[8.6.1.02,7.014,17]heptadeca-1(16),2,4,6,10,14(17)-hexaen-13-one

US9296741, 29

1-methyl-5-(2-phenoxyphenyl)pyridin-2-one

US9296741, 27

12-methyl-4-(methylsulfonylmethyl)-8-pyridin-2-yl-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-14-one

US9296741, 329

3-[2-(2,4-difluorophenoxy)-5-methylsulfonylphenyl]-1-methyl-6H-pyrrolo[2,3-c]pyridin-7-one

N-[4-[4-(dimethylamino)cyclohexyl]oxy-3-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl]ethanesulfonamide

US9296741, 19

3-methyl-1-(2-phenoxyphenyl)-2,5-dihydropyrrolo[3,4-c]pyridin-4-one

15-methyl-4-(methylsulfonylmethyl)-8-propanoyl-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-14-one

US9296741, 5

N-[4-(2,4-difluorophenoxy)-3-(1-methyl-7-oxo-6H-pyrrolo[2,3-c]pyridin-3-yl)phenyl]ethanesulfonamide

N-[3-(7-methyl-1-oxo-2,6-dihydropyrrolo[3,4-d]pyridazin-5-yl)-4-phenoxyphenyl]methanesulfonamide

5-[2-(2,4-difluorophenoxy)-5-methylsulfonylphenyl]-2-methyl-1H-pyrrole-3-carboxamide

8-(cyclopropylmethyl)-15-methyl-4-(methylsulfonylmethyl)-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-14-one

N-[4-(4-chlorophenoxy)-3-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl]ethanesulfonamide

N-[4-(2,4-difluorophenoxy)-3-(4-methoxy-1-methyl-6-oxopyridin-3-yl)phenyl]ethanesulfonamide

N-[3-(4-ethoxy-1-methyl-6-oxopyridin-3-yl)-4-pyridin-3-yloxyphenyl]ethanesulfonamide

N-[4-(4,4-difluorocyclohexyl)oxy-3-(4-ethoxy-1-methyl-6-oxopyridin-3-yl)phenyl]ethanesulfonamide

N-[4-(2,4-difluorophenoxy)-3-(3-methyl-4-oxo-2,5,6,7-tetrahydropyrrolo[3,4-c]pyridin-1-yl)phenyl]methanesulfonamide

N-[3-(4-ethoxy-1-methyl-6-oxopyridin-3-yl)-4-phenoxyphenyl]ethanesulfonamide

N-[4-(4-chlorophenoxy)-3-(4-ethoxy-1-methyl-6-oxopyridin-3-yl)phenyl]ethanesulfonamide

1-ethyl-3-[3-(4-methoxy-1-methyl-6-oxopyridazin-3-yl)-4-phenoxyphenyl]urea

N-(12-chloro-23-methyl-22-oxo-8,19-dioxa-23-azatetracyclo[18.4.0.02,7.09,14]tetracosa-1(24),2(7),3,5,9(14),10,12,20-octaen-4-yl)ethanesulfonamide

6-(5-amino-2-phenoxyphenyl)-5-methoxy-2-methylpyridazin-3-one

N-[4-(2,4-difluorophenoxy)-3-[1-methyl-4-(oxetan-3-yloxy)-6-oxopyridin-3-yl]phenyl]ethanesulfonamide

4-methoxy-1-methyl-5-(2-phenoxyphenyl)pyridin-2-one

N-[4-(2,4-difluorophenoxy)-3-[4-(2-hydroxy-2-methylpropoxy)-1-methyl-6-oxopyridin-3-yl]phenyl]ethanesulfonamide

12-chloro-23-methyl-4-(methylsulfonylmethyl)-8,19-dioxa-6,23-diazatetracyclo[18.4.0.02,7.09,14]tetracosa-1(24),2(7),3,5,9(14),10,12,20-octaen-22-one

3-[2-(cyclopropylmethylamino)-5-methylsulfonylphenyl]-1-methyl-6H-pyrrolo[2,3-c]pyridin-7-one

8-(cyclopropylmethyl)-15-methyl-4-(methylsulfonylmethyl)-8,12,15-triazatetracyclo[8.6.1.02,7.014,17]heptadeca-1(16),2(7),3,5,10,14(17)-hexaen-13-one

5-(2-amino-6-phenoxyphenyl)-2-methyl-1H-pyrrole-3-carboxamide

N-ethyl-3-(3-methyl-4-oxo-4,5,6,7-tetrahydro-2H-isoindol-1-yl)-4-phenoxybenzamide

ethyl N-[3-(4-methoxy-1-methyl-6-oxopyridazin-3-yl)-4-phenoxyphenyl]carbamate

N-(10,12-difluoro-23-methyl-22-oxo-8,19-dioxa-6,23-diazatetracyclo[18.4.0.02,7.09,14]tetracosa-1(24),2(7),3,5,9(14),10,12,20-octaen-4-yl)ethanesulfonamide

N-[4-(4-cyanophenoxy)-3-(4-ethoxy-1-methyl-6-oxopyridin-3-yl)phenyl]ethanesulfonamide

N-[8-(4-fluorophenyl)-12-methyl-14-oxo-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-4-yl]ethanesulfonamide

8-(4,4-difluorocyclohexyl)-15-methyl-4-(methylsulfonylmethyl)-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-14-one

N-[3-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-4-(1-methylpiperidin-4-yl)oxyphenyl]ethanesulfonamide

N-[3-(4-methoxy-1-methyl-6-oxopyridazin-3-yl)-4-phenoxyphenyl]methanesulfonamide

5-[2-(4-chlorophenoxy)phenyl]-2-methyl-1H-pyrrole-3-carboxamide

N-[3-(4-methoxy-1-methyl-6-oxopyridin-3-yl)-4-phenoxyphenyl]ethanesulfonamide

N-[3-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-4-[2-(trifluoromethyl)phenoxy]phenyl]methanesulfonamide

1-[2-(2,4-difluorophenoxy)-5-methylsulfonylphenyl]-3-methyl-2,5,6,7-tetrahydroisoindol-4-one

N-[3-(4-methoxy-1-methyl-6-oxopyridin-3-yl)-4-phenoxyphenyl]methanesulfonamide

4-ethylsulfonyl-23-methyl-8,19-dioxa-23-azatetracyclo[18.4.0.02,7.09,14]tetracosa-1(24),2(7),3,5,9,11,13,20-octaen-22-one

N-[3-(4-ethoxy-1-methyl-6-oxopyridin-3-yl)-4-(4-fluorophenoxy)phenyl]ethanesulfonamide

N-[3-(5-methyl-4-oxo-3,6-dihydropyrrolo[3,4-d]pyrimidin-7-yl)-4-phenoxyphenyl]methanesulfonamide