General Information of the Cell Line
Cell Line ID
CL000481
Cell Line Name
HCC1954
Synonyms
HCC-1954
Hamon Cancer Center 1954
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_1259
Tissue Information
Breast
Disease
Breast ductal carcinoma (NCIt: C4017)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT01045, Phosphoinositide 3-kinase alpha
 Protein Info 
Compound ID Compound Name Compound Formula
CP0543864
 Compound Info 
(S)-2-((2-((S)-4-(difluoromethyl)- 2-oxooxazolidin-3-yl)-5,6- dihydrobenzo[f]imidazo[1,2- d][1,4]oxazepin-9- yl)amino)propanamide
   Show/Hide
C18H19F2N5O4
  1
1
EC50 = 19 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0101176
 Compound Info 
2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide
   Show/Hide
C24H28N8O2
  1
1
EC50 = 24 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0579285
 Compound Info 
(S)-2-cyclopropyl-2-((2-((S)-4- (fluoromethyl)-2-oxooxazolidin-3- yl)-5,6- dihydrobenzo[f]imidazo[1,2- d][1,4]oxazepin-9- yl)amino)acetamide
   Show/Hide
C20H22FN5O4
  1
1
EC50 = 27 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0567669
 Compound Info 
(S)-2-cyclopropyl-2-((2-((S)-4- (difluoromethyl)-2-oxooxazolidin- 3-yl)-5,6- dihydrobenzo[f]imidazo[1,2- d][1,4]oxazepin-9- yl)amino)acetamide
   Show/Hide
C20H21F2N5O4
  1
1
EC50 = 28 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0576041
 Compound Info 
(2S)-2-[[2-[5-(hydroxymethyl)-2-(2,2,2-trifluoroethyl)-1,2,4-triazol-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]oxy]propanamide
   Show/Hide
C19H19F3N6O4
  1
1
EC50 = 39 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0550609
 Compound Info 
(2S)-1-[2-[(4S)-2-oxo-4-(trifluoromethyl)-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]pyrrolidine-2-carboxamide
   Show/Hide
C20H20F3N5O4
  1
1
EC50 = 40 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0579284
 Compound Info 
(2S)-2-[[2-[(4S)-2-oxo-4-(trifluoromethyl)-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]propanamide
   Show/Hide
C18H18F3N5O4
  1
1
EC50 = 49 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0569719
 Compound Info 
(2S)-2-cyclopropyl-2-[[2-[(4S)-2-oxo-4-(trifluoromethyl)-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]acetamide
   Show/Hide
C20H20F3N5O4
  1
1
EC50 = 52 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0580037
 Compound Info 
(2S)-2-[[2-[(4S)-2-oxo-4-(trifluoromethyl)-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]butanamide
   Show/Hide
C19H20F3N5O4
  1
1
EC50 = 56 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0576522
 Compound Info 
(2S)-1-[2-[(3S)-3-hydroxy-2-oxopyrrolidin-1-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]pyrrolidine-2-carboxamide
   Show/Hide
C20H23N5O4
  1
1
EC50 = 63 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0579283
 Compound Info 
(2S)-2-[[2-(5-amino-2-propan-2-yl-1,2,4-triazol-3-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]oxy]propanamide
   Show/Hide
C19H23N7O3
  1
1
EC50 = 65 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0212773
 Compound Info 
(2S)-2-[[2-(2-propan-2-yl-1,2,4-triazol-3-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]oxy]propanamide
   Show/Hide
C19H22N6O3
  1
1
EC50 = 89 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0578777
 Compound Info 
(2S)-3-methyl-2-[[2-[(4S)-2-oxo-4-(trifluoromethyl)-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]butanamide
   Show/Hide
C20H22F3N5O4
  1
1
EC50 = 157 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein ID: PT01033, Serine/threonine protein kinase PIK3CB
 Protein Info 
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0093020
 Compound Info 
2-methyl-5-(2-methylmorpholin-4-yl)-3-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-one
   Show/Hide
 C20H22F3N5O2  1
1
EC50 = 2200 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Breast)
Cell Line Name Organism Disease
MX-1
 Cell Line Info 
Homo sapiens (Human) Breast carcinoma
HDQ-P1
 Cell Line Info 
Homo sapiens (Human) Breast ductal carcinoma
SUM159PT
 Cell Line Info 
Homo sapiens (Human) Breast pleomorphic carcinoma
HCC1806
 Cell Line Info 
Homo sapiens (Human) Breast squamous cell carcinoma, acantholytic variant
BT-474
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
Hs 578T
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
BT-20
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
BT-549
 Cell Line Info 
Homo sapiens (Human) Invasive breast carcinoma of no special type
MCF-10A
 Cell Line Info 
Homo sapiens (Human) -
184B5
 Cell Line Info 
Homo sapiens (Human) -
UFH-001
 Cell Line Info 
Homo sapiens (Human) -
184A1N4
 Cell Line Info 
Homo sapiens (Human) -