Protein Information

General Information of the Protein

Protein ID	PT01045
Protein Name	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Secondarily Protein Name	Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha Phosphoinositide 3-kinase alpha Phosphoinositide-3-kinase catalytic alpha polypeptide Serine/threonine protein kinase PIK3CA
Gene Name	PIK3CA
Sequence	MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQLLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFAIGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKHIYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMDCFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGIYHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHCPLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWFSSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPLSEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILKQEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Enzyme > Transferase
Function	Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides (PubMed:15135396, PubMed:23936502, PubMed:28676499). Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (PubMed:15135396, PubMed:28676499). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. In addition to its lipid kinase activity, it displays a serine-protein kinase activity that results in the autophosphorylation of the p85alpha regulatory subunit as well as phosphorylation of other proteins such as 4EBP1, H-Ras, the IL-3 beta c receptor and possibly others (PubMed:23936502, PubMed:28676499). Plays a role in the positive regulation of phagocytosis and pinocytosis (By similarity). Show/Hide
Uniprot ID	Primary ID: P42336 Secondarily ID: Q14CW1 Q99762 Show/Hide
Ensembl ID	ENSG00000121879
HGNC ID	HGNC:8975

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000072 , A2780

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0355792 Compound Info	6-(2-aminopyrimidin-5-yl)-N-[6-(1-methylpiperidin-4-yl)oxypyridin-3-yl]-2-morpholin-4-ylpyrimidin-4-amine Show/Hide	C23H29N9O2	1
1	EC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0067162 Compound Info	2-morpholino-N6-(quinolin-3-yl)-4,5'-bipyrimidine-2',6-diamine Show/Hide	C21H20N8O	1
1	EC50 = 40 nM Bioactivity Info	TI LI LO TS
CP0066324 Compound Info	N-[6-[6-amino-5-(trifluoromethyl)pyridin-3-yl]imidazo[1,2-b]pyridazin-2-yl]acetamide Show/Hide	C14H11F3N6O	1
1	EC50 < 40 nM Bioactivity Info	TI LI LO TS
CP0074362 Compound Info	N-[6-(5-amino-6-ethoxypyrazin-2-yl)imidazo[1,2-a]pyridin-2-yl]acetamide Show/Hide	C15H16N6O2	1
1	EC50 < 40 nM Bioactivity Info	TI LI LO TS
CP0074363 Compound Info	N-[6-(6-amino-5-ethoxypyridin-3-yl)imidazo[1,2-b]pyridazin-2-yl]acetamide Show/Hide	C15H16N6O2	1
1	EC50 < 40 nM Bioactivity Info	TI LI LO TS
CP0099482 Compound Info	N-[6-[5-amino-6-(1,1,1-trifluoropropan-2-yloxy)pyrazin-2-yl]imidazo[1,2-a]pyridin-2-yl]acetamide Show/Hide	C16H15F3N6O2	1
1	EC50 < 40 nM Bioactivity Info	TI LI LO TS
CP0133918 Compound Info	N-[6-[5-amino-6-(2,2,2-trifluoroethoxy)pyrazin-2-yl]imidazo[1,2-a]pyridin-2-yl]acetamide Show/Hide	C15H13F3N6O2	1
1	EC50 < 40 nM Bioactivity Info	TI LI LO TS
CP0403436 Compound Info	N-[6-(5-amino-6-propan-2-yloxypyrazin-2-yl)imidazo[1,2-a]pyridin-2-yl]acetamide Show/Hide	C16H18N6O2	1
1	EC50 < 40 nM Bioactivity Info	TI LI LO TS
CP0067896 Compound Info	N-[6-(5-amino-6-methoxypyrazin-2-yl)imidazo[1,2-a]pyridin-2-yl]acetamide Show/Hide	C14H14N6O2	1
1	EC50 = 60 nM Bioactivity Info	TI LI LO TS
CP0044152 Compound Info	N-[6-[6-amino-5-(trifluoromethyl)pyridin-3-yl]imidazo[1,2-a]pyridin-2-yl]acetamide Show/Hide	C15H12F3N5O	1
1	EC50 = 80 nM Bioactivity Info	TI LI LO TS
CP0057731 Compound Info	6-(2-aminopyrimidin-5-yl)-N-(6-methoxypyridin-3-yl)-2-morpholin-4-ylpyrimidin-4-amine Show/Hide	C18H20N8O2	1
1	EC50 = 90 nM Bioactivity Info	TI LI LO TS
CP0455105 Compound Info	N-[6-(6-amino-5-methoxypyridin-3-yl)imidazo[1,2-a]pyridin-2-yl]acetamide Show/Hide	C15H15N5O2	1
1	EC50 = 90 nM Bioactivity Info	TI LI LO TS
CP0067148 Compound Info	2-morpholino-N6-(6-phenoxypyridin-3-yl)-4,5'-bipyrimidine-2',6-diamine Show/Hide	C23H22N8O2	1
1	EC50 = 110 nM Bioactivity Info	TI LI LO TS
CP0267762 Compound Info	N-[6-[2-(methylamino)pyrimidin-5-yl]-2-morpholin-4-ylpyrimidin-4-yl]quinolin-3-amine Show/Hide	C22H22N8O	1
1	EC50 = 110 nM Bioactivity Info	TI LI LO TS
CP0350954 Compound Info	N-[6-(6-amino-5-methoxypyridin-3-yl)imidazo[1,2-b]pyridazin-2-yl]acetamide Show/Hide	C14H14N6O2	1
1	EC50 = 110 nM Bioactivity Info	TI LI LO TS
CP0014549 Compound Info	2-morpholino-4,5'-bipyrimidin-2'-amine Show/Hide	C12H14N6O	1
1	EC50 = 130 nM Bioactivity Info	TI LI LO TS
CP0350953 Compound Info	N-[6-[6-amino-5-(2-methoxyethoxy)pyridin-3-yl]imidazo[1,2-b]pyridazin-2-yl]acetamide Show/Hide	C16H18N6O3	1
1	EC50 = 150 nM Bioactivity Info	TI LI LO TS
CP0429707 Compound Info	N-[6-[5-amino-6-(2-methoxyethoxy)pyrazin-2-yl]imidazo[1,2-a]pyridin-2-yl]acetamide Show/Hide	C16H18N6O3	1
1	EC50 = 170 nM Bioactivity Info	TI LI LO TS
CP0353573 Compound Info	2-morpholino-N6-(tetrahydro-2H-pyran-4-yl)-4,5'-bipyrimidine-2',6-diamine Show/Hide	C17H23N7O2	1
1	EC50 = 220 nM Bioactivity Info	TI LI LO TS
CP0447635 Compound Info	N-[6-(6-amino-5-ethoxypyridin-3-yl)imidazo[1,2-a]pyridin-2-yl]acetamide Show/Hide	C16H17N5O2	1
1	EC50 = 270 nM Bioactivity Info	TI LI LO TS
CP0355469 Compound Info	N-[6-(6-aminopyridin-3-yl)-2-morpholin-4-ylpyrimidin-4-yl]quinolin-3-amine Show/Hide	C22H21N7O	1
1	EC50 = 310 nM Bioactivity Info	TI LI LO TS
CP0264752 Compound Info	3-(2-morpholino-6-(quinolin-3-ylamino)pyrimidin-4-yl)phenol Show/Hide	C23H21N5O2	1
1	EC50 = 370 nM Bioactivity Info	TI LI LO TS
CP0287208 Compound Info	N-(2-morpholin-4-yl-6-pyrazin-2-ylpyrimidin-4-yl)quinolin-3-amine Show/Hide	C21H19N7O	1
1	EC50 = 390 nM Bioactivity Info	TI LI LO TS
CP0492328 Compound Info	N-(2-morpholin-4-yl-6-pyrimidin-5-ylpyrimidin-4-yl)quinolin-3-amine Show/Hide	C21H19N7O	1
1	EC50 = 450 nM Bioactivity Info	TI LI LO TS
CP0492327 Compound Info	N-(2-morpholin-4-yl-6-pyridin-3-ylpyrimidin-4-yl)quinolin-3-amine Show/Hide	C22H20N6O	1
1	EC50 = 650 nM Bioactivity Info	TI LI LO TS
CP0322007 Compound Info	N-[6-(5-aminopyrazin-2-yl)-2-morpholin-4-ylpyrimidin-4-yl]quinolin-3-amine Show/Hide	C21H20N8O	1
1	EC50 = 3300 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000457 , BT-20

Cell Line Info

Cell Line ID: CL000218 , BT-474

Cell Line Info

Cell Line ID: CL000023 , BTI-Tn-5B1-4

Cell Line Info

Cell Line ID: CL000481 , HCC1954

Cell Line Info

Cell Line ID: CL000067 , HCT 116

Cell Line Info

Cell Line ID: CL000722 , HDQ-P1

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000017 , HeLa

Cell Line Info

Cell Line ID: CL000083 , MCF-7

Cell Line Info

Cell Line ID: CL000918 , MCF7-neo/Her2

Cell Line Info

Cell Line ID: CL000284 , MDA-MB-453

Cell Line Info

Cell Line ID: CL000145 , NCI-H460

Cell Line Info

Cell Line ID: CL000048 , PC-3

Cell Line Info

Cell Line ID: CL000019 , Rat1

Cell Line Info

Cell Line ID: CL000012 , Sf21

Cell Line Info

Cell Line ID: CL000013 , Sf9

Cell Line Info

Cell Line ID: CL000084 , SK-OV-3

Cell Line Info

Cell Line ID: CL000102 , U-87MG ATCC

Cell Line Info

Cell Line ID: CL000043 , U2OS

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0007933 Compound Info	2-(difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-1H-benzimidazole Show/Hide	C19H21F2N7O2	8
1	EC50 = 50 nM
2	IC50 = 5 nM
3	IC50 = 6 nM
4	IC50 = 8.9 nM
5	IC50 = 12 nM
6	IC50 = 16 nM
7	IC50 = 25 nM
8	IC50 = 26 nM
CP0017744 Compound Info	GSK2126458 Show/Hide	C25H17F2N5O3S	9
1	IC50 = 0.04 nM
2	IC50 = 0.3 nM
3	IC50 = 0.34 nM
4	IC50 = 0.41 nM
5	IC50 = 0.55 nM
6	IC50 = 0.63 nM
7	IC50 = 1.02 nM
8	IC50 = 1.1 nM
9	Ki = 0.019 nM
CP0007893 Compound Info	4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpiperazin-1-yl)methyl]thieno[3,2-d]pyrimidin-4-yl]morpholine Show/Hide	C23H27N7O3S2	18
1	IC50 = 0.1 nM
2	IC50 = 3 nM
3	IC50 = 4.7 nM
4	IC50 = 6.5 nM
5	IC50 = 7 nM
6	IC50 = 33 nM
7	IC50 = 50.12 nM
8	IC50 = 251.19 nM
9	Kd = 0.76 nM
10	Kd = 0.86 nM
11	Kd = 1.1 nM
12	Kd = 1.2 nM
13	Kd = 1.5 nM
14	Kd = 1.7 nM
15	Kd = 3.7 nM
16	Kd = 4.1 nM
17	Kd = 4.5 nM
18	Kd = 7.1 nM
CP0071769 Compound Info	2-(difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)benzimidazol-4-ol Show/Hide	C19H21F2N7O3	3
1	IC50 = 0.12 nM
2	IC50 = 0.53 nM
3	IC50 = 0.83 nM
CP0108539 Compound Info	1-(4-{[4-(Dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea Show/Hide	C32H41N9O4	3
1	IC50 = 0.4 nM
2	IC50 = 6 nM
3	IC50 = 6.04 nM
CP0167775 Compound Info	6-(2-aminopyrimidin-5-yl)-8-morpholin-4-ylimidazo[1,2-a]pyrazine-2-carboxamide Show/Hide	C15H16N8O2	1
1	IC50 = 0.4 nM
CP0184421 Compound Info	2-[4-(2-chlorophenyl)-5-oxo-1H-1,2,4-triazol-3-yl]-4,5-dihydrothieno[3,2-d][1]benzoxepine-8-carboxamide Show/Hide	C21H15ClN4O3S	1
1	IC50 < 0.5 nM
CP0205588 Compound Info	2-[1-(2-chlorophenyl)tetrazol-5-yl]-4,5-dihydrothieno[3,2-d][1]benzoxepine-8-carboxamide Show/Hide	C20H14ClN5O2S	1
1	IC50 < 0.5 nM
CP0283411 Compound Info	2-[2-(2,4-difluorophenyl)-1,2,4-triazol-3-yl]-4,5-dihydrothieno[3,2-d][1]benzoxepine-8-carboxamide Show/Hide	C21H14F2N4O2S	1
1	IC50 < 0.5 nM
CP0333718 Compound Info	5-(2-chlorophenyl)-4-(4,5-dihydrothieno[3,2-d][1]benzoxepin-2-yl)-1,3-thiazol-2-amine Show/Hide	C21H15ClN2OS2	1
1	IC50 < 0.5 nM
CP0522710 Compound Info	2-[4-(2-chlorophenyl)-1,2,4-triazol-3-yl]-4,5-dihydrothieno[3,2-d][1]benzoxepine-8-carboxamide Show/Hide	C21H15ClN4O2S	1
1	IC50 < 0.5 nM
CP0558428 Compound Info	4-[5-(2,4-difluorophenyl)-2H-triazol-4-yl]-9-oxa-3-thia-14-azatricyclo[8.4.0.02,6]tetradeca-1(10),2(6),4,11,13-pentaene-12-carboxamide Show/Hide	C20H13F2N5O2S	1
1	IC50 < 0.5 nM
CP0085320 Compound Info	2-[4-[2-(2-propan-2-yl-1,2,4-triazol-3-yl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazol-8-yl]pyrazol-1-yl]ethanol Show/Hide	C21H22N6O2S	1
1	IC50 < 0.5 nM
CP0169553 Compound Info	6-(2-aminopyrimidin-5-yl)-N-[3-(dimethylamino)propyl]-8-morpholin-4-ylimidazo[1,2-a]pyrazine-2-carboxamide Show/Hide	C20H27N9O2	1
1	IC50 = 0.6 nM
CP0101176 Compound Info	2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide Show/Hide	C24H28N8O2	4
1	IC50 < 0.7 nM
2	Ki = 0.09 nM
3	Ki = 0.29 nM
4	Ki = 0.3 nM
CP0066248 Compound Info	N-[(E)-(5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylideneamino]-N,2-dimethyl-5-nitrobenzenesulfonamide Show/Hide	C17H14N6O4S	1
1	IC50 = 0.9 nM
CP0154471 Compound Info	6-(2-aminopyrimidin-5-yl)-N-(2-methoxyethyl)-3-methyl-8-morpholin-4-ylimidazo[1,2-a]pyrazine-2-carboxamide Show/Hide	C19H24N8O3	5
1	IC50 = 0.9 nM
2	Ki = 1.9 nM
3	Ki = 2.3 nM
4	Ki = 2.4 nM
5	Ki = 3.1 nM
CP0071675 Compound Info	2-(difluoromethyl)-3-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-7-methoxybenzimidazol-5-amine Show/Hide	C20H24F2N8O3	3
1	IC50 = 0.95 nM
2	IC50 = 1 nM
3	IC50 = 3.1 nM
CP0020505 Compound Info	(1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-6,11,16-trioxo-13,17-dioxapentacyclo[10.6.1.0^{2,10}.0^{5,9}.0^{15,19}]nonadeca-2(10),12(19),14-trien-3-yl acetate Show/Hide	C23H24O8	6
1	IC50 = 1 nM
2	IC50 = 12 nM
3	IC50 = 13 nM
4	IC50 = 17.6 nM
5	IC50 >= 1000 nM
6	Kd = 5.4 nM
CP0205610 Compound Info	2-[4-(2-chlorophenyl)-1H-pyrazol-5-yl]-4,5-dihydrothieno[3,2-d][1]benzoxepine-8-carboxamide Show/Hide	C22H16ClN3O2S	1
1	IC50 = 1 nM
CP0085563 Compound Info	4-(2-chlorophenyl)-3-(4,5-dihydrothieno[3,2-d][1]benzoxepin-2-yl)-1H-1,2,4-triazol-5-one Show/Hide	C20H14ClN3O2S	1
1	IC50 = 1.2 nM
CP0487811 Compound Info	1-(2,4-difluorophenyl)-5-(4,5-dihydrothieno[3,2-d][1]benzoxepin-2-yl)-1,2,4-triazole Show/Hide	C20H13F2N3OS	1
1	IC50 = 1.2 nM
CP0011997 Compound Info	N-[(E)-(5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylideneamino]-N-(2-hydroxyethyl)-2-methyl-5-nitrobenzenesulfonamide Show/Hide	C18H16N6O5S	1
1	IC50 = 1.3 nM
CP0095286 Compound Info	1-[4-(3-Ethyl-7-morpholin-4-yl-3H-[1,2,3]triazolo-[4,5-d]pyrimidin-5-yl)phenyl]-3-{4-[(4-methylpiperazin-1-yl)carbonyl]-phenyl}urea Show/Hide	C29H34N10O3	2
1	IC50 = 1.4 nM
2	IC50 = 2 nM
CP0278460 Compound Info	N-[4-(2-chlorophenyl)-5-(9-oxa-3-thia-14-azatricyclo[8.4.0.02,6]tetradeca-1(10),2(6),4,11,13-pentaen-4-yl)-1H-imidazol-2-yl]acetamide Show/Hide	C22H17ClN4O2S	1
1	IC50 < 1.4 nM
CP0184542 Compound Info	2-N-(2-chlorophenyl)-2-N-methyl-4,5-dihydrothieno[3,2-d][1]benzoxepine-2,8-dicarboxamide Show/Hide	C21H17ClN2O3S	2
1	IC50 = 1.5 nM
2	Ki = 1.2 nM
CP0013755 Compound Info	3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol Show/Hide	C19H16N4O3	30
1	IC50 = 1.76 nM
2	IC50 = 2 nM
3	IC50 = 3.22 nM
4	IC50 = 3.8 nM
5	IC50 = 3.9 nM
6	IC50 = 4 nM
7	IC50 = 4.4 nM
8	IC50 = 4.5 nM
9	IC50 = 5.8 nM
10	IC50 = 6 nM
11	IC50 = 6.1 nM
12	IC50 = 6.8 nM
13	IC50 = 7.5 nM
14	IC50 = 8 nM
15	IC50 = 8.7 nM
16	IC50 = 11 nM
17	IC50 = 12 nM
18	IC50 = 16.8 nM
19	IC50 = 17 nM
20	IC50 = 19.7 nM
21	IC50 = 75 nM
22	IC50 = 150 nM
23	IC50 = 5300 nM
24	Kd = 1.3 nM
25	Kd = 1.4 nM
26	Kd = 1.5 nM
27	Kd = 2.9 nM
28	Kd = 3 nM
29	Kd = 3.2 nM
30	Kd = 3.4 nM
CP0068590 Compound Info	(2R)-3-[6-[5-[(2-chloro-4-fluorophenyl)sulfonylamino]-6-methoxypyridin-3-yl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide Show/Hide	C25H23ClFN5O5S	1
1	IC50 = 1.8 nM
CP0057731 Compound Info	6-(2-aminopyrimidin-5-yl)-N-(6-methoxypyridin-3-yl)-2-morpholin-4-ylpyrimidin-4-amine Show/Hide	C18H20N8O2	1
1	IC50 < 2 nM
CP0067148 Compound Info	2-morpholino-N6-(6-phenoxypyridin-3-yl)-4,5'-bipyrimidine-2',6-diamine Show/Hide	C23H22N8O2	1
1	IC50 < 2 nM
CP0067162 Compound Info	2-morpholino-N6-(quinolin-3-yl)-4,5'-bipyrimidine-2',6-diamine Show/Hide	C21H20N8O	1
1	IC50 < 2 nM
CP0355792 Compound Info	6-(2-aminopyrimidin-5-yl)-N-[6-(1-methylpiperidin-4-yl)oxypyridin-3-yl]-2-morpholin-4-ylpyrimidin-4-amine Show/Hide	C23H29N9O2	1
1	IC50 < 2 nM
CP0066324 Compound Info	N-[6-[6-amino-5-(trifluoromethyl)pyridin-3-yl]imidazo[1,2-b]pyridazin-2-yl]acetamide Show/Hide	C14H11F3N6O	1
1	IC50 = 2 nM
CP0245774 Compound Info	3-(4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phenol Show/Hide	C16H15N3O2S	2
1	IC50 = 2 nM
2	IC50 = 41 nM
CP0403436 Compound Info	N-[6-(5-amino-6-propan-2-yloxypyrazin-2-yl)imidazo[1,2-a]pyridin-2-yl]acetamide Show/Hide	C16H18N6O2	1
1	IC50 = 2 nM
CP0169552 Compound Info	6-(2-aminopyrimidin-5-yl)-N-(2-methoxyethyl)-8-morpholin-4-ylimidazo[1,2-a]pyrazine-2-carboxamide Show/Hide	C18H22N8O3	1
1	IC50 = 2.7 nM
CP0075331 Compound Info	4-[4-[4-(difluoromethoxy)-2-(difluoromethyl)benzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]morpholine Show/Hide	C20H21F4N7O3	3
1	IC50 = 3 nM
2	IC50 = 4.7 nM
3	IC50 = 8.5 nM
CP0067896 Compound Info	N-[6-(5-amino-6-methoxypyrazin-2-yl)imidazo[1,2-a]pyridin-2-yl]acetamide Show/Hide	C14H14N6O2	1
1	IC50 = 3 nM
CP0074362 Compound Info	N-[6-(5-amino-6-ethoxypyrazin-2-yl)imidazo[1,2-a]pyridin-2-yl]acetamide Show/Hide	C15H16N6O2	1
1	IC50 = 3 nM
CP0099482 Compound Info	N-[6-[5-amino-6-(1,1,1-trifluoropropan-2-yloxy)pyrazin-2-yl]imidazo[1,2-a]pyridin-2-yl]acetamide Show/Hide	C16H15F3N6O2	1
1	IC50 = 3 nM
CP0133918 Compound Info	N-[6-[5-amino-6-(2,2,2-trifluoroethoxy)pyrazin-2-yl]imidazo[1,2-a]pyridin-2-yl]acetamide Show/Hide	C15H13F3N6O2	1
1	IC50 = 3 nM
CP0540714 Compound Info	2,4-difluoro-N-[2-methoxy-5-(4-oxopyrido[1,2-a]pyrimidin-7-yl)pyridin-3-yl]benzenesulfonamide Show/Hide	C20H14F2N4O4S	1
1	IC50 = 3.1 nM
CP0157210 Compound Info	6-(2-aminopyrimidin-5-yl)-N-(3-methoxypropyl)-8-morpholin-4-ylimidazo[1,2-a]pyrazine-2-carboxamide Show/Hide	C19H24N8O3	1
1	IC50 = 3.2 nM
CP0022562 Compound Info	N-[5-(3-chloro-4-oxopyrido[1,2-a]pyrimidin-7-yl)-2-methoxypyridin-3-yl]-2,4-difluorobenzenesulfonamide Show/Hide	C20H13ClF2N4O4S	1
1	IC50 = 3.4 nM
CP0044152 Compound Info	N-[6-[6-amino-5-(trifluoromethyl)pyridin-3-yl]imidazo[1,2-a]pyridin-2-yl]acetamide Show/Hide	C15H12F3N5O	4
1	IC50 = 3.6 nM
2	IC50 = 4 nM
3	IC50 = 5.9 nM
4	IC50 = 12 nM
CP0279244 Compound Info	2-[2-(2-methylpropyl)-1,2,4-triazol-3-yl]-4,5-dihydrothieno[3,2-d][1]benzoxepine-8-carboxamide Show/Hide	C19H20N4O2S	1
1	IC50 = 4 nM
CP0333717 Compound Info	2-(2-propan-2-yl-1,2,4-triazol-3-yl)-4,5-dihydrothieno[3,2-d][1]benzoxepine-8-carboxamide Show/Hide	C18H18N4O2S	1
1	IC50 = 4 nM
CP0465619 Compound Info	2-[2-(2-hydroxy-2-methylpropyl)-1,2,4-triazol-3-yl]-4,5-dihydrothieno[3,2-d][1]benzoxepine-8-carboxamide Show/Hide	C19H20N4O3S	1
1	IC50 = 4 nM
CP0055472 Compound Info	(2S)-1-N-(8-tert-butyl-4,5-dihydro-[1,3]thiazolo[4,5-h]quinazolin-2-yl)pyrrolidine-1,2-dicarboxamide Show/Hide	C19H24N6O2S	1
1	IC50 = 4 nM
CP0055473 Compound Info	(2S,4R)-1-N-(8-tert-butyl-4,5-dihydro-[1,3]thiazolo[4,5-h]quinazolin-2-yl)-4-(dimethylamino)pyrrolidine-1,2-dicarboxamide Show/Hide	C21H29N7O2S	1
1	IC50 = 4 nM
CP0154469 Compound Info	6-(2-aminopyrimidin-5-yl)-N-[2-(dimethylamino)ethyl]-8-morpholin-4-ylimidazo[1,2-a]pyrazine-2-carboxamide Show/Hide	C19H25N9O2	1
1	IC50 = 4.6 nM
CP0008405 Compound Info	(2S)-1-N-[4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide Show/Hide	C19H22F3N5O2S	4
1	IC50 = 4.6 nM
2	IC50 = 5 nM
3	IC50 = 9.5 nM
4	IC50 = 17.8 nM
CP0066777 Compound Info	(2S,3R)-3-methyl-1-N-[12-(1,1,1-trifluoro-2-methylpropan-2-yl)-8-oxa-3-thia-5,11-diazatricyclo[7.4.0.02,6]trideca-1(13),2(6),4,9,11-pentaen-4-yl]pyrrolidine-1,2-dicarboxamide Show/Hide	C20H22F3N5O3S	1
1	IC50 = 5 nM
CP0124222 Compound Info	(2S,3R)-3-methyl-1-N-[8-(1,1,1-trifluoro-2-methylpropan-2-yl)-4,5-dihydro-[1,3]thiazolo[4,5-h]quinazolin-2-yl]pyrrolidine-1,2-dicarboxamide Show/Hide	C20H23F3N6O2S	1
1	IC50 = 5 nM
CP0176371 Compound Info	(2S)-1-N-(8-tert-butyl-4,5-dihydro-[1,3]thiazolo[4,5-h]quinazolin-2-yl)-2-methylpyrrolidine-1,2-dicarboxamide Show/Hide	C20H26N6O2S	1
1	IC50 = 5 nM
CP0215337 Compound Info	(2S,3S)-1-N-(8-tert-butyl-4,5-dihydro-[1,3]thiazolo[4,5-h]quinazolin-2-yl)-3-[(dimethylamino)methyl]pyrrolidine-1,2-dicarboxamide Show/Hide	C22H31N7O2S	1
1	IC50 = 5 nM
CP0350954 Compound Info	N-[6-(6-amino-5-methoxypyridin-3-yl)imidazo[1,2-b]pyridazin-2-yl]acetamide Show/Hide	C14H14N6O2	1
1	IC50 = 5 nM
CP0125424 Compound Info	1-[4-[5-[5-amino-6-(benzotriazol-1-yl)pyrazin-2-yl]-1-methylpyrazol-3-yl]piperidin-1-yl]-2-(dimethylamino)ethanone Show/Hide	C23H28N10O	1
1	IC50 = 6 nM
CP0099116 Compound Info	(1S,5R)-2-N-(8-tert-butyl-4,5-dihydro-[1,3]thiazolo[4,5-h]quinazolin-2-yl)-2-azabicyclo[3.1.0]hexane-1,2-dicarboxamide Show/Hide	C20H24N6O2S	1
1	IC50 = 6 nM
CP0144577 Compound Info	(2S,3R)-1-N-(8-tert-butyl-4,5-dihydro-[1,3]thiazolo[4,5-h]quinazolin-2-yl)-3-methylpyrrolidine-1,2-dicarboxamide Show/Hide	C20H26N6O2S	1
1	IC50 = 6 nM
CP0350953 Compound Info	N-[6-[6-amino-5-(2-methoxyethoxy)pyridin-3-yl]imidazo[1,2-b]pyridazin-2-yl]acetamide Show/Hide	C16H18N6O3	1
1	IC50 = 6 nM
CP0090916 Compound Info	6-(1H-indazol-4-yl)-1-methyl-4-(4-(methylsulfonyl)phenoxy)-1H-pyrazolo[3,4-b]pyridine Show/Hide	C21H17N5O3S	2
1	IC50 = 6.8 nM
2	IC50 = 7 nM
CP0065610 Compound Info	1-[4-[[2-(1H-indazol-4-yl)-4-morpholin-4-ylthieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-6-methylhept-5-ene-1,4-dione Show/Hide	C30H35N7O3S	1
1	IC50 = 6.8 nM
CP0267762 Compound Info	N-[6-[2-(methylamino)pyrimidin-5-yl]-2-morpholin-4-ylpyrimidin-4-yl]quinolin-3-amine Show/Hide	C22H22N8O	1
1	IC50 = 7 nM
CP0214220 Compound Info	2-[2-(2,2,2-trifluoroethyl)-1,2,4-triazol-3-yl]-4,5-dihydrothieno[3,2-d][1]benzoxepine-8-carboxamide Show/Hide	C17H13F3N4O2S	1
1	IC50 = 7 nM
CP0232134 Compound Info	N-(2-chlorophenyl)-N-methyl-9-oxa-3-thia-14-azatricyclo[8.4.0.02,6]tetradeca-1(10),2(6),4,11,13-pentaene-4-carboxamide Show/Hide	C19H15ClN2O2S	1
1	IC50 = 7 nM
CP0109038 Compound Info	(2S)-1-N-[5-(2-tert-butylpyrimidin-4-yl)-4-methyl-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide Show/Hide	C18H24N6O2S	3
1	IC50 = 7 nM
2	IC50 = 7.5 nM
3	IC50 = 20 nM
CP0145100 Compound Info	4-(2-chlorophenyl)-3-(4,5-dihydrothieno[3,2-d][1]benzoxepin-2-yl)-1,2,4-triazole Show/Hide	C20H14ClN3OS	1
1	IC50 = 7.3 nM
CP0492328 Compound Info	N-(2-morpholin-4-yl-6-pyrimidin-5-ylpyrimidin-4-yl)quinolin-3-amine Show/Hide	C21H19N7O	1
1	IC50 = 8 nM
CP0205608 Compound Info	2-(2-cyclobutyl-1,2,4-triazol-3-yl)-4,5-dihydrothieno[3,2-d][1]benzoxepine-8-carboxamide Show/Hide	C19H18N4O2S	1
1	IC50 = 8 nM
CP0059183 Compound Info	(2S)-1-N-(7-tert-butyl-4,5-dihydro-[1,3]thiazolo[5,4-e][1,3]benzothiazol-2-yl)-2-methylpyrrolidine-1,2-dicarboxamide Show/Hide	C19H25N5O2S2	1
1	IC50 = 8 nM
CP0429707 Compound Info	N-[6-[5-amino-6-(2-methoxyethoxy)pyrazin-2-yl]imidazo[1,2-a]pyridin-2-yl]acetamide Show/Hide	C16H18N6O3	1
1	IC50 = 8 nM
CP0120405 Compound Info	(2S,3R)-3-methyl-1-N-[7-(1,1,1-trifluoro-2-methylpropan-2-yl)-4,5-dihydro-[1,3]thiazolo[5,4-e][1,3]benzothiazol-2-yl]pyrrolidine-1,2-dicarboxamide Show/Hide	C19H22F3N5O2S2	1
1	IC50 = 9 nM
CP0176375 Compound Info	(1S,5R)-2-N-(7-tert-butyl-4,5-dihydro-[1,3]thiazolo[5,4-e][1,3]benzothiazol-2-yl)-2-azabicyclo[3.1.0]hexane-1,2-dicarboxamide Show/Hide	C19H23N5O2S2	1
1	IC50 = 9 nM
CP0157490 Compound Info	(2S)-1-N-[5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide Show/Hide	C18H20F3N5O2S	1
1	IC50 = 9.5 nM
CP0238435 Compound Info	CHEMBL2058168 Show/Hide	C21H26N8O3	1
1	IC50 = 10 nM
CP0055471 Compound Info	(2S,3S)-1-N-(7-tert-butyl-4,5-dihydro-[1,3]thiazolo[5,4-e][1,3]benzothiazol-2-yl)-3-[(dimethylamino)methyl]pyrrolidine-1,2-dicarboxamide Show/Hide	C21H30N6O2S2	1
1	IC50 = 10 nM
CP0074912 Compound Info	8-[(3,5-difluoro-N-methylanilino)methyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide Show/Hide	C24H25F2N3O4	2
1	IC50 = 10 nM
2	IC50 = 25 nM
CP0167773 Compound Info	6-(2-aminopyrimidin-5-yl)-8-morpholin-4-yl-N-(2-morpholin-4-ylethyl)imidazo[1,2-a]pyrazine-2-carboxamide Show/Hide	C21H27N9O3	1
1	IC50 = 10.4 nM
CP0095462 Compound Info	(2S,3R)-1-N-(7-tert-butyl-4,5-dihydro-[1,3]thiazolo[5,4-e][1,3]benzothiazol-2-yl)-3-methylpyrrolidine-1,2-dicarboxamide Show/Hide	C19H25N5O2S2	1
1	IC50 = 11 nM
CP0074363 Compound Info	N-[6-(6-amino-5-ethoxypyridin-3-yl)imidazo[1,2-b]pyridazin-2-yl]acetamide Show/Hide	C15H16N6O2	1
1	IC50 = 11 nM
CP0238436 Compound Info	6-(2-aminopyrimidin-5-yl)-5-chloro-N-(2-methoxyethyl)-8-morpholin-4-ylimidazo[1,2-a]pyrazine-2-carboxamide Show/Hide	C18H21ClN8O3	1
1	IC50 = 11.2 nM
CP0145099 Compound Info	4-[5-(2-chlorophenyl)-1,3-oxazol-4-yl]-9-oxa-3-thia-14-azatricyclo[8.4.0.02,6]tetradeca-1(10),2(6),4,11,13-pentaene Show/Hide	C20H13ClN2O2S	1
1	IC50 = 12 nM
CP0102055 Compound Info	(2S)-1-N-[4-methyl-5-[2-(1-methylcyclopropyl)pyrimidin-4-yl]-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide Show/Hide	C18H22N6O2S	1
1	IC50 = 12 nM
CP0283808 Compound Info	8-[(1R)-1-(3,5-difluoroanilino)ethyl]-N,N-dimethyl-2-[(2S)-2-methylmorpholin-4-yl]-4-oxochromene-6-carboxamide Show/Hide	C25H27F2N3O4	1
1	IC50 = 12 nM
CP0353573 Compound Info	2-morpholino-N6-(tetrahydro-2H-pyran-4-yl)-4,5'-bipyrimidine-2',6-diamine Show/Hide	C17H23N7O2	1
1	IC50 = 13 nM
CP0055470 Compound Info	(2S)-1-N-(7-tert-butyl-4,5-dihydro-[1,3]thiazolo[5,4-e][1,3]benzothiazol-2-yl)pyrrolidine-1,2-dicarboxamide Show/Hide	C18H23N5O2S2	1
1	IC50 = 13 nM
CP0099118 Compound Info	(2S,3S)-1-N-(7-tert-butyl-4,5-dihydro-[1,3]thiazolo[5,4-e][1,3]benzothiazol-2-yl)-3-methylpyrrolidine-1,2-dicarboxamide Show/Hide	C19H25N5O2S2	1
1	IC50 = 13 nM
CP0455105 Compound Info	N-[6-(6-amino-5-methoxypyridin-3-yl)imidazo[1,2-a]pyridin-2-yl]acetamide Show/Hide	C15H15N5O2	1
1	IC50 = 13 nM
CP0001930 Compound Info	5-(2,6-dimorpholin-4-ylpyrimidin-4-yl)-4-(trifluoromethyl)pyridin-2-amine Show/Hide	C18H21F3N6O2	9
1	IC50 = 13 nM
2	IC50 = 20 nM
3	IC50 = 25 nM
4	IC50 = 30 nM
5	IC50 = 44 nM
6	IC50 = 45 nM
7	IC50 = 52 nM
8	IC50 = 52.48 nM
9	Ki = 20 nM
CP0167778 Compound Info	6-(2-aminopyrimidin-5-yl)-8-morpholin-4-yl-N-(oxan-4-yl)imidazo[1,2-a]pyrazine-2-carboxamide Show/Hide	C20H24N8O3	1
1	IC50 = 13.1 nM
CP0014549 Compound Info	2-morpholino-4,5'-bipyrimidin-2'-amine Show/Hide	C12H14N6O	1
1	IC50 = 14 nM
CP0107865 Compound Info	(2S)-1-N-[5-(2-tert-butylpyridin-4-yl)-4-methyl-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide Show/Hide	C19H25N5O2S	1
1	IC50 = 14 nM
CP0099117 Compound Info	(2R)-1-N-(8-tert-butyl-4,5-dihydro-[1,3]thiazolo[4,5-h]quinazolin-2-yl)-2-[(dimethylamino)methyl]pyrrolidine-1,2-dicarboxamide Show/Hide	C22H31N7O2S	1
1	IC50 = 14 nM
CP0184540 Compound Info	2-[2-(2-hydroxyethyl)-1,2,4-triazol-3-yl]-4,5-dihydrothieno[3,2-d][1]benzoxepine-8-carboxamide Show/Hide	C17H16N4O3S	1
1	IC50 = 15 nM
CP0054682 Compound Info	(2S)-1-N-[5-(2-tert-butyl-1,3-thiazol-4-yl)-4-methyl-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide Show/Hide	C17H23N5O2S2	2
1	IC50 = 15 nM
2	IC50 = 32 nM
CP0038259 Compound Info	(3-(9-(1-(4-(3-(dimethylamino)propoxy)benzyl)piperidin-4-yl)-6-morpholino-9H-purin-2-yl)phenyl)methanol Show/Hide	C33H43N7O3	1
1	IC50 = 16 nM
CP0184539 Compound Info	N-(2-chlorophenyl)-N-methyl-4,5-dihydrothieno[3,2-d][1]benzoxepine-2-carboxamide Show/Hide	C20H16ClNO2S	4
1	IC50 = 16 nM
2	IC50 = 24 nM
3	Ki = 16 nM
4	Ki = 16.3 nM
CP0102057 Compound Info	(2S)-1-N-[4-methyl-5-(2-propan-2-ylpyrimidin-4-yl)-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide Show/Hide	C17H22N6O2S	1
1	IC50 = 16 nM
CP0107860 Compound Info	(2S)-1-N-[5-[2-(diethylamino)pyrimidin-4-yl]-4-methyl-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide Show/Hide	C18H25N7O2S	1
1	IC50 = 16 nM
CP0072499 Compound Info	1-[4-[4-[5-amino-6-(benzotriazol-1-yl)pyrazin-2-yl]pyrazol-1-yl]piperidin-1-yl]-2-(dimethylamino)ethanone Show/Hide	C22H26N10O	1
1	IC50 = 16 nM
CP0447635 Compound Info	N-[6-(6-amino-5-ethoxypyridin-3-yl)imidazo[1,2-a]pyridin-2-yl]acetamide Show/Hide	C16H17N5O2	1
1	IC50 = 16 nM
CP0006058 Compound Info	2-amino-N-[(1S)-1-[8-[2-(1-methylpyrazol-4-yl)ethynyl]-1-oxo-2-phenylisoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide Show/Hide	C30H24N8O2	1
1	IC50 = 17 nM
CP0177294 Compound Info	8-[(1R)-1-(3,5-difluoroanilino)ethyl]-N-methyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide Show/Hide	C23H23F2N3O4	1
1	IC50 = 18 nM
CP0107861 Compound Info	(2S)-1-N-[5-[2-(1-cyanocyclopropyl)pyridin-4-yl]-4-methyl-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide Show/Hide	C19H20N6O2S	1
1	IC50 = 19 nM
CP0116057 Compound Info	(2S)-1-N-[5-(2-tert-butylpyrimidin-4-yl)-4-methyl-1,3-thiazol-2-yl]azetidine-1,2-dicarboxamide Show/Hide	C17H22N6O2S	1
1	IC50 = 19 nM
CP0078092 Compound Info	(2S,3R)-3-methyl-1-N-[4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide Show/Hide	C20H24F3N5O2S	1
1	IC50 = 19 nM
CP0057012 Compound Info	(2S)-1-N-[5-(2-cyclobutylpyrimidin-4-yl)-4-methyl-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide Show/Hide	C18H22N6O2S	1
1	IC50 = 20 nM
CP0674357 Compound Info	1-(4-(4-(5-amino-6-(1H-benzo[d][1,2,3]triazol-1-yl)pyrazin-2-yl)-2H-1,2,3-triazol-2-yl)piperidin-1-yl)-2-(dimethylamino)ethanone Show/Hide	C21H25N11O	1
1	IC50 = 21 nM
CP0674930 Compound Info	(2S)-N1-[4-methyl-5-[2-[2,2,2-trideuterio-1,1-bis(trideuteriomethyl)ethyl]pyrimidin-4-yl]thiazol-2-yl]pyrrolidine-1,2-dicarboxamide Show/Hide	C18H24N6O2S	1
1	IC50 = 22 nM
CP0177288 Compound Info	8-[(1R)-1-(3-chloro-5-fluoroanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide Show/Hide	C24H25ClFN3O4	1
1	IC50 = 25 nM
CP0689001 Compound Info	1-(4-(3-(5-amino-6-(1H-benzo[d][1,2,3]triazol-1-yl)pyrazin-2-yl)-1H-pyrazol-1-yl)piperidin-1-yl)-2-(dimethylamino)ethanone Show/Hide	C22H26N10O	1
1	IC50 = 27 nM
CP0258576 Compound Info	8-[(1R)-1-(3-chloro-2-fluoroanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide Show/Hide	C24H25ClFN3O4	1
1	IC50 = 28 nM
CP0354016 Compound Info	(2S)-1-[[4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl]carbamoyl]pyrrolidine-2-carboxylic acid Show/Hide	C19H21F3N4O3S	1
1	IC50 = 28.6 nM
CP0089056 Compound Info	6-(azetidine-1-carbonyl)-8-[(1R)-1-(3,5-difluoroanilino)ethyl]-2-morpholin-4-ylchromen-4-one Show/Hide	C25H25F2N3O4	1
1	IC50 = 29 nM
CP0072498 Compound Info	1-[4-[5-[5-amino-6-(benzotriazol-1-yl)pyrazin-2-yl]-1-methyl-1,2,4-triazol-3-yl]piperidin-1-yl]-2-(dimethylamino)ethanone Show/Hide	C22H27N11O	1
1	IC50 = 29 nM
CP0142914 Compound Info	2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol-1-yl)-6-methyl-1,3,5-triazin-2-ylamino)acetonitrile Show/Hide	C19H16N8O	1
1	IC50 = 32 nM
CP0009496 Compound Info	N-[3-(dimethylamino)propyl]-6-(1H-indazol-4-yl)-8-morpholin-4-ylimidazo[1,2-a]pyrazine-2-carboxamide Show/Hide	C23H28N8O2	1
1	IC50 = 35 nM
CP0014178 Compound Info	8-[(1R)-1-(3,5-difluoroanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide Show/Hide	C24H25F2N3O4	1
1	IC50 = 35 nM
CP0300568 Compound Info	4-[2-(1H-indazol-4-yl)thieno[3,2-d]pyrimidin-4-yl]morpholine Show/Hide	C17H15N5OS	1
1	IC50 = 36 nM
CP0051959 Compound Info	(2S)-1-N-[4-chloro-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide Show/Hide	C18H19ClF3N5O2S	1
1	IC50 = 39 nM
CP0330198 Compound Info	US8653092, 68 Show/Hide	C24H29F3N6O3	2
1	IC50 = 43 nM
2	IC50 = 44 nM
CP0322007 Compound Info	N-[6-(5-aminopyrazin-2-yl)-2-morpholin-4-ylpyrimidin-4-yl]quinolin-3-amine Show/Hide	C21H20N8O	1
1	IC50 = 44 nM
CP0071674 Compound Info	2-(difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-5-methoxybenzimidazol-4-ol Show/Hide	C20H23F2N7O4	3
1	IC50 = 49 nM
2	IC50 = 70 nM
3	IC50 = 158 nM
CP0094320 Compound Info	(S)-2-(3-((1H-indol-3-yl)methyl)morpholino)-5,5-dimethyl-5,6-dihydrobenzo[d]thiazol-7(4H)-one Show/Hide	C22H25N3O2S	1
1	IC50 = 51 nM
CP0145096 Compound Info	N-(2,4-difluorophenyl)-N-methyl-4,5-dihydrothieno[3,2-d][1]benzoxepine-2-carboxamide Show/Hide	C20H15F2NO2S	1
1	IC50 = 52 nM
CP0355469 Compound Info	N-[6-(6-aminopyridin-3-yl)-2-morpholin-4-ylpyrimidin-4-yl]quinolin-3-amine Show/Hide	C22H21N7O	2
1	IC50 = 55 nM
2	IC50 = 110 nM
CP0177291 Compound Info	US8673906, 4.15 Show/Hide	C25H27F2N3O5	1
1	IC50 = 57 nM
CP0094325 Compound Info	(S)-2-(3-((1H-indol-3-yl)methyl)morpholino)-7,7-dimethyl-5,6,7,8-tetrahydrothiazolo[5,4-c]azepin-4-one Show/Hide	C22H26N4O2S	1
1	IC50 = 59 nM
CP0089057 Compound Info	US8673906, 4.17 Show/Hide	C24H25F2N3O4	1
1	IC50 = 59 nM
CP0264752 Compound Info	3-(2-morpholino-6-(quinolin-3-ylamino)pyrimidin-4-yl)phenol Show/Hide	C23H21N5O2	1
1	IC50 = 61 nM
CP0249149 Compound Info	1-[4-[2-[5-amino-6-(benzotriazol-1-yl)pyrazin-2-yl]-1-methylimidazol-4-yl]piperidin-1-yl]-2-(dimethylamino)ethanone Show/Hide	C23H28N10O	1
1	IC50 = 64 nM
CP0124221 Compound Info	(2S)-1-N-[7-(cyclopropylmethyl)-4,5-dihydro-[1,3]thiazolo[5,4-e][1,3]benzothiazol-2-yl]pyrrolidine-1,2-dicarboxamide Show/Hide	C18H21N5O2S2	1
1	IC50 = 70 nM
CP0053978 Compound Info	9-[(1R)-1-(3,5-difluoroanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidine-7-carboxamide Show/Hide	C23H25F2N5O3	1
1	IC50 = 75 nM
CP0068001 Compound Info	US8653092, 67 Show/Hide	C21H25F3N6O2	3
1	IC50 = 75.5 nM
2	IC50 = 244 nM
3	IC50 = 262 nM
CP0258575 Compound Info	US8673906, 3.09 Show/Hide	C24H26ClN3O4	1
1	IC50 = 85 nM
CP0086020 Compound Info	US8673906, 4.07 Show/Hide	C25H27F2N3O5	1
1	IC50 = 90 nM
CP0114229 Compound Info	9-[1-(3-chloro-2-fluoroanilino)ethyl]-N-[2-(dimethylamino)ethyl]-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidine-7-carboxamide Show/Hide	C25H30ClFN6O3	1
1	IC50 = 92 nM
CP0258574 Compound Info	8-[(3,5-difluoroanilino)methyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide Show/Hide	C23H23F2N3O4	1
1	IC50 = 93 nM
CP0091859 Compound Info	US8673906, 4.02 Show/Hide	C26H27F2N3O4	1
1	IC50 = 98 nM
CP0265356 Compound Info	(4aS,7R,12cS)-10,11-Dihydroxy-4,4,7,12c-tetramethyl-2,3,4,4a,5,6,7,12c-octahydro-1H-8-oxa-dibenzo[a,h]azulene-9-carbaldehyde Show/Hide	C22H28O4	1
1	IC50 = 100 nM
CP0086018 Compound Info	N,N-dimethyl-2-morpholin-4-yl-4-oxo-8-[(1R)-1-(3,4,5-trifluoroanilino)ethyl]chromene-6-carboxamide Show/Hide	C24H24F3N3O4	1
1	IC50 = 110 nM
CP0086019 Compound Info	US8673906, 3.33 Show/Hide	C24H25Cl2N3O4	1
1	IC50 = 110 nM
CP0302579 Compound Info	US8673906, 4.11 Show/Hide	C25H27F2N3O4	1
1	IC50 = 110 nM
CP0419316 Compound Info	1-[(3S)-3-[6-(3,4-dimethoxyphenyl)quinazolin-4-yl]oxypyrrolidin-1-yl]ethanone Show/Hide	C22H23N3O4	1
1	IC50 = 126 nM
CP0345063 Compound Info	1-[4-[3-[6-(3,4-dimethoxyphenyl)quinazolin-4-yl]benzoyl]piperazin-1-yl]ethanone Show/Hide	C29H28N4O4	1
1	IC50 = 127 nM
CP0089058 Compound Info	8-[(1S)-1-(3,5-difluoroanilino)ethyl]-N,N-dimethyl-2-[(2S)-2-methylmorpholin-4-yl]-4-oxochromene-6-carboxamide Show/Hide	C25H27F2N3O4	1
1	IC50 = 130 nM
CP0258577 Compound Info	US8673906, 3.16 Show/Hide	C25H28FN3O4	1
1	IC50 = 130 nM
CP0492327 Compound Info	N-(2-morpholin-4-yl-6-pyridin-3-ylpyrimidin-4-yl)quinolin-3-amine Show/Hide	C22H20N6O	1
1	IC50 = 135 nM
CP0283805 Compound Info	N,N-dimethyl-2-morpholin-4-yl-4-oxo-8-[(1R)-1-(2,3,5-trifluoroanilino)ethyl]chromene-6-carboxamide Show/Hide	C24H24F3N3O4	1
1	IC50 = 140 nM
CP0085980 Compound Info	tert-butyl (3S)-3-[6-(3,4-dimethoxyphenyl)quinazolin-4-yl]oxypyrrolidine-1-carboxylate Show/Hide	C25H29N3O5	1
1	IC50 = 148 nM
CP0086022 Compound Info	US8673906, 4.01 Show/Hide	C26H29F2N3O4	1
1	IC50 = 150 nM
CP0177287 Compound Info	US8673906, 3.3 Show/Hide	C25H28FN3O5	1
1	IC50 = 160 nM
CP0086017 Compound Info	8-[(1R)-1-(3,4-difluoroanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide Show/Hide	C24H25F2N3O4	1
1	IC50 = 170 nM
CP0227062 Compound Info	US8673906, 3.05 Show/Hide	C24H25ClFN3O4	1
1	IC50 = 170 nM
CP0010760 Compound Info	5-fluoro-3-phenyl-2-[(1S)-1-(7H-purin-6-ylamino)propyl]quinazolin-4-one Show/Hide	C22H18FN7O	13
1	IC50 = 177.2 nM
2	IC50 = 306.4 nM
3	IC50 = 391.3 nM
4	IC50 = 467 nM
5	IC50 = 583 nM
6	IC50 = 737 nM
7	IC50 = 800 nM
8	IC50 = 820 nM
9	IC50 = 822 nM
10	IC50 = 1650 nM
11	IC50 = 9700 nM
12	IC50 = 10000 nM
13	IC50 > 500 nM
CP0302544 Compound Info	8-[(1R)-1-(3,5-difluoro-N-methylanilino)ethyl]-N-(2-hydroxyethyl)-N-methyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide Show/Hide	C26H29F2N3O5	1
1	IC50 = 180 nM
CP0002420 Compound Info	2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one Show/Hide	C19H17NO3	15
1	IC50 = 200 nM
2	IC50 = 300 nM
3	IC50 = 356 nM
4	IC50 = 480 nM
5	IC50 = 481 nM
6	IC50 = 500 nM
7	IC50 = 550 nM
8	IC50 = 600 nM
9	IC50 = 630 nM
10	IC50 = 720 nM
11	IC50 = 730 nM
12	IC50 = 2300 nM
13	IC50 = 4000 nM
14	IC50 = 6180 nM
15	IC50 = 62800 nM
CP0088830 Compound Info	US8673906, 4.1 Show/Hide	C27H29F2N3O4	1
1	IC50 = 200 nM
CP0237222 Compound Info	1-[(3S)-3-[6-(6-methoxypyridin-3-yl)quinazolin-4-yl]oxypyrrolidin-1-yl]propan-1-one Show/Hide	C21H22N4O3	1
1	IC50 = 218 nM
CP0182845 Compound Info	US8673906, 3.12 Show/Hide	C24H26FN3O4	1
1	IC50 = 220 nM
CP0214687 Compound Info	1-[(3S)-3-[6-(6-methoxypyridin-3-yl)quinolin-4-yl]oxypyrrolidin-1-yl]propan-1-one Show/Hide	C22H23N3O3	1
1	IC50 = 220 nM
CP0213155 Compound Info	US8673906, 4.09 Show/Hide	C27H29F2N3O5	1
1	IC50 = 230 nM
CP0287208 Compound Info	N-(2-morpholin-4-yl-6-pyrazin-2-ylpyrimidin-4-yl)quinolin-3-amine Show/Hide	C21H19N7O	1
1	IC50 = 231 nM
CP0140244 Compound Info	5-[4-[3-(4-acetylpiperazine-1-carbonyl)phenyl]quinazolin-6-yl]-2-methoxypyridine-3-carbonitrile Show/Hide	C28H24N6O3	1
1	IC50 = 262 nM
CP0066459 Compound Info	US8653092, 63 Show/Hide	C21H24F3N5O3	3
1	IC50 = 262 nM
2	IC50 = 791 nM
3	IC50 = 792 nM
CP0086021 Compound Info	8-[(1R)-1-(3,5-difluoro-N-methylanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide Show/Hide	C25H27F2N3O4	1
1	IC50 = 280 nM
CP0116954 Compound Info	1-[4-[5-[5-amino-6-(benzotriazol-1-yl)pyrazin-2-yl]-2-methyl-1,2,4-triazol-3-yl]piperidin-1-yl]-2-(dimethylamino)ethanone Show/Hide	C22H27N11O	1
1	IC50 = 280 nM
CP0300738 Compound Info	US8673906, 4.24 Show/Hide	C26H29F2N3O5	1
1	IC50 = 290 nM
CP0091860 Compound Info	US8673906, 2.07 Show/Hide	C26H27F2N3O5	1
1	IC50 = 300 nM
CP0050326 Compound Info	2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazin-2-ylamino)acetonitrile Show/Hide	C18H14N8O	1
1	IC50 = 320 nM
CP0102054 Compound Info	(2S)-1-N-[4-methyl-5-(6-propan-2-ylpyrimidin-4-yl)-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide Show/Hide	C17H22N6O2S	1
1	IC50 = 320 nM
CP0258835 Compound Info	9-[1-(3,4-difluoroanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidine-7-carboxamide Show/Hide	C23H25F2N5O3	1
1	IC50 = 340 nM
CP0132804 Compound Info	9-(1-anilinoethyl)-N-[2-(dimethylamino)ethyl]-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidine-7-carboxamide Show/Hide	C25H32N6O3	2
1	IC50 = 370 nM
2	IC50 = 2300 nM
CP0177292 Compound Info	8-[(1R)-1-(3,5-difluoro-N-methylanilino)ethyl]-6-(4-hydroxypiperidine-1-carbonyl)-2-morpholin-4-ylchromen-4-one Show/Hide	C28H31F2N3O5	1
1	IC50 = 370 nM
CP0274584 Compound Info	US8673906, 3.1 Show/Hide	C24H25F2N3O4	1
1	IC50 = 370 nM
CP0303600 Compound Info	US8653092, 83 Show/Hide	C24H32N6O3	2
1	IC50 = 373 nM
2	IC50 = 432 nM
CP0140106 Compound Info	2-methoxy-5-[4-[(3S)-1-propanoylpyrrolidin-3-yl]oxyquinazolin-6-yl]pyridine-3-carbonitrile Show/Hide	C22H21N5O3	1
1	IC50 = 386 nM
CP0131435 Compound Info	1-[4-[3-[6-(6-methoxypyridin-3-yl)quinazolin-4-yl]benzoyl]piperazin-1-yl]ethanone Show/Hide	C27H25N5O3	1
1	IC50 = 418 nM
CP0140243 Compound Info	1-[(3S)-3-[[6-(6-methoxypyridin-3-yl)-1,5-naphthyridin-4-yl]oxy]pyrrolidin-1-yl]propan-1-one Show/Hide	C21H22N4O3	1
1	IC50 = 424 nM
CP0180777 Compound Info	7-fluoro-6-[6-(methoxymethyl)pyridin-3-yl]-4-[[(1S)-1-(1-methylpyrazol-3-yl)ethyl]amino]quinoline-3-carboxamide Show/Hide	C23H23FN6O2	1
1	IC50 = 445 nM
CP0213052 Compound Info	US8673906, 3.15 Show/Hide	C24H25F2N3O4	1
1	IC50 = 450 nM
CP0140107 Compound Info	1-[(3R)-3-[7-(3,4-dimethoxyphenyl)quinoxalin-2-yl]oxypyrrolidin-1-yl]propan-1-one Show/Hide	C23H25N3O4	1
1	IC50 = 491 nM
CP0205068 Compound Info	US8673906, 6 Show/Hide	C27H29F2N3O4	1
1	IC50 = 510 nM
CP0086623 Compound Info	9-(1-anilinoethyl)-N,N-dimethyl-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidine-7-carboxamide Show/Hide	C23H27N5O3	2
1	IC50 = 560 nM
2	IC50 = 2500 nM
CP0068002 Compound Info	US8653092, 61 Show/Hide	C24H28F3N5O4	2
1	IC50 = 589 nM
2	IC50 = 590 nM
CP0107863 Compound Info	N-[5-(2-tert-butylpyridin-4-yl)-4-methyl-1,3-thiazol-2-yl]pyrrolidine-1-carboxamide Show/Hide	C18H24N4OS	1
1	IC50 = 620 nM
CP0067930 Compound Info	US8653092, 81 Show/Hide	C21H28N6O2	1
1	IC50 = 651 nM
CP0177296 Compound Info	US8673906, 2.01 Show/Hide	C24H26FN3O4	1
1	IC50 = 810 nM
CP0177298 Compound Info	8-[(1R)-1-(3,5-difluorophenoxy)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide Show/Hide	C24H24F2N2O5	1
1	IC50 = 970 nM
CP0094318 Compound Info	2-morpholin-4-yl-5,6-dihydro-4H-benzothiazol-7-one Show/Hide	C13H18N2O2S	2
1	IC50 = 975 nM
2	IC50 = 1333 nM
CP0688695 Compound Info	7-methyl-9-(2-methylbenzylamino)-2-morpholino-4H-pyrido[1,2-a]pyrimidin-4-one Show/Hide	C21H24N4O2	1
1	IC50 = 1100 nM
CP0371471 Compound Info	9-[1-(4-fluoroanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidine-7-carboxamide Show/Hide	C23H26FN5O3	1
1	IC50 = 1300 nM
CP0043078 Compound Info	US8653092, 1 Show/Hide	C24H31N5O4	3
1	IC50 = 1940 nM
2	IC50 = 2037.8 nM
3	IC50 = 2038 nM
CP0249954 Compound Info	1-[4-[3-[6-(6-methoxypyridin-3-yl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]phenoxy]piperidin-1-yl]ethanone Show/Hide	C26H29N5O3	1
1	IC50 = 2020 nM
CP0180776 Compound Info	6-[6-(methoxymethyl)pyridin-3-yl]-4-[[(1S)-1-(oxan-4-yl)ethyl]amino]quinoline-3-carboxamide Show/Hide	C24H28N4O3	1
1	IC50 = 2110 nM
CP0186648 Compound Info	2-(4-morpholin-4-yl-6-oxo-1H-pyrimidin-2-yl)-N-phenylacetamide Show/Hide	C16H18N4O3	1
1	IC50 = 2138 nM
CP0123998 Compound Info	6-[6-[3-(dimethylamino)propoxy]pyridin-3-yl]-4-[[(1S)-1-(oxan-4-yl)ethyl]amino]cinnoline-3-carboxamide Show/Hide	C26H34N6O3	1
1	IC50 = 2200 nM
CP0084873 Compound Info	8-(1-anilinoethyl)-6-methyl-2-morpholin-4-ylchromen-4-one Show/Hide	C22H24N2O3	1
1	IC50 = 2600 nM
CP0051973 Compound Info	(2S)-1-N-[5-(2-tert-butylpyridin-4-yl)-4-methyl-1,3-thiazol-2-yl]-2-N-methylpyrrolidine-1,2-dicarboxamide Show/Hide	C20H27N5O2S	1
1	IC50 = 2700 nM
CP0128743 Compound Info	(2S)-2-amino-1-[4-[4-[2-(difluoromethyl)benzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]piperazin-1-yl]propan-1-one Show/Hide	C22H27F2N9O2	2
1	IC50 = 3500 nM
2	IC50 = 8200 nM
CP0189386 Compound Info	6-[6-[3-(dimethylamino)propoxy]pyridin-3-yl]-N-methyl-4-[[(1S)-1-(oxan-4-yl)ethyl]amino]cinnoline-3-carboxamide Show/Hide	C27H36N6O3	1
1	IC50 = 3800 nM
CP0569111 Compound Info	5-chloro-3-(3-fluorophenyl)-2-[(2S,5S)-5-methyl-1-(7H-purin-6-yl)pyrrolidin-2-yl]quinazolin-4-one Show/Hide	C24H19ClFN7O	1
1	IC50 = 4425 nM
CP0105849 Compound Info	(2S)-2-amino-1-[4-[4-[2-(difluoromethyl)benzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]piperazin-1-yl]-3-phenylpropan-1-one Show/Hide	C28H31F2N9O2	2
1	IC50 = 4700 nM
2	IC50 = 12000 nM
CP0231955 Compound Info	1-[(3S)-3-[6-(6-methoxypyridin-3-yl)cinnolin-4-yl]oxypyrrolidin-1-yl]propan-1-one Show/Hide	C21H22N4O3	1
1	IC50 = 5080 nM
CP0003061 Compound Info	9-(1-anilinoethyl)-7-methyl-2-morpholin-4-ylpyrido[1,2-a]pyrimidin-4-one Show/Hide	C21H24N4O2	2
1	IC50 = 5800 nM
2	IC50 > 1000 nM
CP0157447 Compound Info	(2S,3S)-2-amino-1-[4-[4-[2-(difluoromethyl)benzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]piperazin-1-yl]-3-methylpentan-1-one Show/Hide	C25H33F2N9O2	2
1	IC50 = 6300 nM
2	IC50 = 9200 nM
CP0241717 Compound Info	1-[(3S)-3-[[6-(6-methoxypyridin-3-yl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]oxy]pyrrolidin-1-yl]propan-1-one Show/Hide	C20H25N5O3	1
1	IC50 = 6660 nM
CP0067931 Compound Info	1-[4-[3-[6-(6-methoxypyridin-3-yl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]benzoyl]piperazin-1-yl]ethanone Show/Hide	C26H28N6O3	1
1	IC50 = 6940 nM
CP0053343 Compound Info	4-amino-6-[[(1S)-1-(6-fluoro-3,4-dipyridin-2-ylquinolin-2-yl)ethyl]amino]pyrimidine-5-carbonitrile Show/Hide	C26H19FN8	1
1	IC50 = 7900 nM
CP0068243 Compound Info	(3R)-4-[2-(1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]-3-methylmorpholine Show/Hide	C21H24N4O3S	1
1	IC50 = 13000 nM
CP0003452 Compound Info	1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one Show/Hide	C35H28F3N5O2	1
1	Kd = 23 nM
CP0543864 Compound Info	(S)-2-((2-((S)-4-(difluoromethyl)- 2-oxooxazolidin-3-yl)-5,6- dihydrobenzo[f]imidazo[1,2- d][1,4]oxazepin-9- yl)amino)propanamide Show/Hide	C18H19F2N5O4	1
1	Ki = 0.034 nM
CP0579285 Compound Info	(S)-2-cyclopropyl-2-((2-((S)-4- (fluoromethyl)-2-oxooxazolidin-3- yl)-5,6- dihydrobenzo[f]imidazo[1,2- d][1,4]oxazepin-9- yl)amino)acetamide Show/Hide	C20H22FN5O4	1
1	Ki = 0.051 nM
CP0567669 Compound Info	(S)-2-cyclopropyl-2-((2-((S)-4- (difluoromethyl)-2-oxooxazolidin- 3-yl)-5,6- dihydrobenzo[f]imidazo[1,2- d][1,4]oxazepin-9- yl)amino)acetamide Show/Hide	C20H21F2N5O4	1
1	Ki = 0.06 nM
CP0576041 Compound Info	(2S)-2-[[2-[5-(hydroxymethyl)-2-(2,2,2-trifluoroethyl)-1,2,4-triazol-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]oxy]propanamide Show/Hide	C19H19F3N6O4	1
1	Ki = 0.062 nM
CP0579284 Compound Info	(2S)-2-[[2-[(4S)-2-oxo-4-(trifluoromethyl)-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]propanamide Show/Hide	C18H18F3N5O4	1
1	Ki = 0.095 nM
CP0569719 Compound Info	(2S)-2-cyclopropyl-2-[[2-[(4S)-2-oxo-4-(trifluoromethyl)-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]acetamide Show/Hide	C20H20F3N5O4	1
1	Ki = 0.1 nM
CP0579283 Compound Info	(2S)-2-[[2-(5-amino-2-propan-2-yl-1,2,4-triazol-3-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]oxy]propanamide Show/Hide	C19H23N7O3	1
1	Ki = 0.107 nM
CP0209641 Compound Info	2-[3-[4-[2-(5-methyl-2-propan-2-yl-1,2,4-triazol-3-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]pyrazol-1-yl]azetidin-1-yl]ethanol Show/Hide	C25H30N8O2	1
1	Ki = 0.11 nM
CP0199042 Compound Info	2-methyl-1-[4-[2-(2-propan-2-yl-1,2,4-triazol-3-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]pyrazol-1-yl]propan-2-ol Show/Hide	C23H27N7O2	1
1	Ki = 0.14 nM
CP0550609 Compound Info	(2S)-1-[2-[(4S)-2-oxo-4-(trifluoromethyl)-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]pyrrolidine-2-carboxamide Show/Hide	C20H20F3N5O4	1
1	Ki = 0.15 nM
CP0580037 Compound Info	(2S)-2-[[2-[(4S)-2-oxo-4-(trifluoromethyl)-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]butanamide Show/Hide	C19H20F3N5O4	1
1	Ki = 0.157 nM
CP0057541 Compound Info	2-[4-[2-(2-propan-2-yl-1,2,4-triazol-3-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]pyrazol-1-yl]ethanol Show/Hide	C21H23N7O2	1
1	Ki = 0.17 nM
CP0212773 Compound Info	(2S)-2-[[2-(2-propan-2-yl-1,2,4-triazol-3-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]oxy]propanamide Show/Hide	C19H22N6O3	2
1	Ki = 0.2 nM
2	Ki = 0.346 nM
CP0199043 Compound Info	2-(5-methyl-2-propan-2-yl-1,2,4-triazol-3-yl)-9-(1-methylpyrazol-4-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine Show/Hide	C21H23N7O	1
1	Ki = 0.29 nM
CP0195833 Compound Info	4-amino-2,6-dimethyl-N-(1H-pyrrolo[2,3-b]pyridin-5-yl)quinazoline-8-carboxamide Show/Hide	C18H16N6O	1
1	Ki = 0.3 nM
CP0363073 Compound Info	2-(5-methyl-2-propan-2-yl-1,2,4-triazol-3-yl)-9-[1-(2-morpholin-4-ylethyl)pyrazol-4-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine Show/Hide	C26H32N8O2	1
1	Ki = 0.3 nM
CP0339746 Compound Info	(2S)-2-hydroxy-1-[3-[4-[2-(5-methyl-2-propan-2-yl-1,2,4-triazol-3-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]pyrazol-1-yl]azetidin-1-yl]propan-1-one Show/Hide	C26H30N8O3	1
1	Ki = 0.34 nM
CP0576522 Compound Info	(2S)-1-[2-[(3S)-3-hydroxy-2-oxopyrrolidin-1-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]pyrrolidine-2-carboxamide Show/Hide	C20H23N5O4	1
1	Ki = 0.355 nM
CP0085319 Compound Info	2-[4-[2-(5-methyl-2-propan-2-yl-1,2,4-triazol-3-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]pyrazol-1-yl]ethanol Show/Hide	C22H25N7O2	1
1	Ki = 0.4 nM
CP0054466 Compound Info	4-amino-2-methyl-N-(6-methylpyridin-3-yl)quinazoline-8-carboxamide Show/Hide	C16H15N5O	1
1	Ki = 0.5 nM
CP0282725 Compound Info	4-amino-2,6-dimethyl-N-(6-methylpyridin-3-yl)quinazoline-8-carboxamide Show/Hide	C17H17N5O	1
1	Ki = 0.5 nM
CP0578777 Compound Info	(2S)-3-methyl-2-[[2-[(4S)-2-oxo-4-(trifluoromethyl)-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]butanamide Show/Hide	C20H22F3N5O4	1
1	Ki = 0.692 nM
CP0057540 Compound Info	2-[4-[2-[2-(2,2,2-trifluoroethyl)-1,2,4-triazol-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]pyrazol-1-yl]ethanol Show/Hide	C20H18F3N7O2	1
1	Ki < 1 nM
CP0198652 Compound Info	5-[6-(2-methoxypropan-2-yl)-4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl]pyrimidin-2-amine Show/Hide	C18H22N6O2S	1
1	Ki = 1 nM
CP0199338 Compound Info	N-[6-[6-chloro-5-[(4-fluorophenyl)sulfonylamino]pyridin-3-yl]-1,3-benzothiazol-2-yl]acetamide Show/Hide	C20H14ClFN4O3S2	1
1	Ki = 1.2 nM
CP0015891 Compound Info	5-[5-chloro-2-[(4-methylsulfonylpiperazin-1-yl)methyl]-8-morpholin-4-ylimidazo[1,2-a]pyrazin-6-yl]pyrimidin-2-amine Show/Hide	C20H26ClN9O3S	3
1	Ki = 1.73 nM
2	Ki = 2.77 nM
3	Ki = 3.07 nM
CP0002073 Compound Info	5-[2-[(4-methylsulfonylpiperazin-1-yl)methyl]-8-morpholin-4-ylimidazo[1,2-a]pyrazin-6-yl]pyrimidin-2-amine Show/Hide	C20H27N9O3S	3
1	Ki = 1.77 nM
2	Ki = 1.89 nM
3	Ki = 2.33 nM
CP0057249 Compound Info	2-amino-4-[5-chloro-2-[[6-chloro-5-(dimethylsulfamoylamino)pyridin-3-yl]amino]pyridin-3-yl]-6-methyl-1,3,5-triazine Show/Hide	C16H17Cl2N9O2S	1
1	Ki = 2 nM
CP0330594 Compound Info	4-[2-[(6-methoxypyridin-3-yl)amino]-5-[(4-methylsulfonylphenyl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine Show/Hide	C23H23N7O3S	1
1	Ki = 2 nM
CP0371423 Compound Info	N-[5-[[3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-5-(oxan-4-yl)pyridin-2-yl]amino]-2-chloropyridin-3-yl]methanesulfonamide Show/Hide	C20H23ClN8O3S	1
1	Ki = 2 nM
CP0204864 Compound Info	5-[6-(3-methoxyoxetan-3-yl)-7-methyl-4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl]pyrimidin-2-amine Show/Hide	C19H22N6O3S	1
1	Ki = 2 nM
CP0292752 Compound Info	N-[5-[[3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-5-(morpholin-4-ylmethyl)pyridin-2-yl]amino]-2-chloropyridin-3-yl]methanesulfonamide Show/Hide	C20H24ClN9O3S	1
1	Ki = 4 nM
CP0054465 Compound Info	4-amino-2,6-dimethyl-N-(1H-pyrazol-4-yl)quinazoline-8-carboxamide Show/Hide	C14H14N6O	1
1	Ki = 5 nM
CP0047685 Compound Info	(2S)-1-N-[4-methyl-5-(4-pyrazol-1-ylphenyl)-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide Show/Hide	C19H20N6O2S	1
1	Ki = 5 nM
CP0172054 Compound Info	4-[5-(3,6-dihydro-2H-pyran-4-yl)-2-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine Show/Hide	C20H21N7O2	1
1	Ki = 5 nM
CP0279598 Compound Info	N-[5-[[3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-5-(2-methoxyethoxy)pyridin-2-yl]amino]-2-chloropyridin-3-yl]methanesulfonamide Show/Hide	C18H21ClN8O4S	1
1	Ki = 5 nM
CP0395569 Compound Info	N-[5-[[3-(4-amino-6-methyl-1,3,5-triazin-2-yl)pyridin-2-yl]amino]-2-chloropyridin-3-yl]-4-fluorobenzenesulfonamide Show/Hide	C20H16ClFN8O2S	1
1	Ki = 5 nM
CP0295372 Compound Info	N-[5-(2-amino-1,3-benzothiazol-6-yl)-2-chloropyridin-3-yl]-4-fluorobenzenesulfonamide Show/Hide	C18H12ClFN4O2S2	1
1	Ki = 5.6 nM
CP0252600 Compound Info	3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(1H-indazol-4-yl)imidazo[1,2-a]pyridin-2-amine Show/Hide	C18H15N9	1
1	Ki = 5.6 nM
CP0750882 Compound Info	3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(5-fluoro-6-methoxypyridin-3-yl)-6-(piperazin-1-yl)imidazo[1,2-a]pyridin-2-amine Show/Hide	C21H23FN10O	1
1	Ki = 5.7 nM
CP0174697 Compound Info	N-[5-[[3-(4-amino-6-methyl-1,3,5-triazin-2-yl)pyridin-2-yl]amino]-2-chloropyridin-3-yl]cyclopropanesulfonamide Show/Hide	C17H17ClN8O2S	1
1	Ki = 6 nM
CP0688569 Compound Info	4-(3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-2-(5-fluoro-6-methoxypyridin-3-ylamino)imidazo[1,2-a]pyridin-6-yl)-N,N-dimethylpiperazine-1-carboxamide Show/Hide	C24H28FN11O2	1
1	Ki = 6.1 nM
CP0750883 Compound Info	3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(5-fluoro-6-methoxypyridin-3-yl)-6-(4-(2-methoxyethyl)piperazin-1-yl)imidazo[1,2-a]pyridin-2-amine Show/Hide	C24H29FN10O2	1
1	Ki = 6.3 nM
CP0765233 Compound Info	3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(5-fluoro-6-methoxypyridin-3-yl)-6-(4-isopropylpiperazin-1-yl)imidazo[1,2-a]pyridin-2-amine Show/Hide	C24H29FN10O	1
1	Ki = 6.5 nM
CP0195835 Compound Info	4-amino-2,6-dimethyl-N-(1H-pyrazol-5-yl)quinazoline-8-carboxamide Show/Hide	C14H14N6O	1
1	Ki = 7 nM
CP0131208 Compound Info	N-[5-[[3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-5-methoxypyridin-2-yl]amino]-2-chloropyridin-3-yl]methanesulfonamide Show/Hide	C16H17ClN8O3S	1
1	Ki = 7 nM
CP0191321 Compound Info	4-[2-[(6-methoxypyridin-3-yl)amino]-5-(6-methylpyridin-3-yl)pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine Show/Hide	C21H20N8O	1
1	Ki = 8 nM
CP0192152 Compound Info	4-[2-[(6-methoxypyridin-3-yl)amino]-5-(1-methylpyrazol-4-yl)pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine Show/Hide	C19H19N9O	1
1	Ki = 8 nM
CP0717560 Compound Info	4-(3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-2-(6-methoxypyridin-3-ylamino)imidazo[1,2-a]pyridin-6-yl)-N,N-dimethylpiperazine-1-carboxamide Show/Hide	C24H29N11O2	1
1	Ki = 8.3 nM
CP0009370 Compound Info	4-[2-[(6-methoxypyridin-3-yl)amino]-5-[(4-methylsulfonylpiperazin-1-yl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine Show/Hide	C21H27N9O3S	1
1	Ki = 9 nM
CP0087634 Compound Info	4-[2-[(6-methoxypyridin-3-yl)amino]-5-[(1-methylsulfonylpiperidin-4-yl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine Show/Hide	C22H28N8O3S	1
1	Ki = 9 nM
CP0093388 Compound Info	N-[5-[[3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-5-chloropyridin-2-yl]amino]-2-methoxypyridin-3-yl]methanesulfonamide Show/Hide	C16H17ClN8O3S	1
1	Ki = 10 nM
CP0072230 Compound Info	2-[3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-2-[(5-fluoro-6-methoxypyridin-3-yl)amino]imidazo[1,2-a]pyridin-6-yl]propan-2-ol Show/Hide	C20H21FN8O2	1
1	Ki = 11 nM
CP0330470 Compound Info	N-[5-[[3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-5-methoxypyridin-2-yl]amino]-2-chloropyridin-3-yl]morpholine-4-sulfonamide Show/Hide	C19H22ClN9O4S	1
1	Ki = 11 nM
CP0191632 Compound Info	N-[5-(1,3-benzothiazol-6-yl)-2-chloropyridin-3-yl]-4-fluorobenzenesulfonamide Show/Hide	C18H11ClFN3O2S2	1
1	Ki = 13 nM
CP0284307 Compound Info	3-[[3-(4-amino-6-methyl-1,3,5-triazin-2-yl)pyridin-2-yl]amino]phenol Show/Hide	C15H14N6O	1
1	Ki = 13 nM
CP0252602 Compound Info	3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(5-fluoro-6-methoxypyridin-3-yl)imidazo[1,2-a]pyridin-2-amine Show/Hide	C17H15FN8O	1
1	Ki = 14 nM
CP0093391 Compound Info	N-[5-[[3-(4-amino-6-methyl-1,3,5-triazin-2-yl)pyridin-2-yl]amino]-2-chloropyridin-3-yl]morpholine-4-sulfonamide Show/Hide	C18H20ClN9O3S	1
1	Ki = 14 nM
CP0218104 Compound Info	2-amino-4-[2-[[6-chloro-5-(dimethylsulfamoylamino)pyridin-3-yl]amino]-5-methoxypyridin-3-yl]-6-methyl-1,3,5-triazine Show/Hide	C17H20ClN9O3S	1
1	Ki = 14 nM
CP0087633 Compound Info	4-[2-[(6-methoxypyridin-3-yl)amino]-5-[(3-methylsulfonylpyrrolidin-1-yl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine Show/Hide	C21H26N8O3S	1
1	Ki = 16 nM
CP0174686 Compound Info	4-[[5-(4-amino-6-methyl-1,3,5-triazin-2-yl)-6-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]methyl]-N,N-dimethylpiperazine-1-sulfonamide Show/Hide	C22H30N10O3S	1
1	Ki = 17 nM
CP0076062 Compound Info	4-[4-[(6-methoxypyridin-3-yl)amino]pyrimidin-5-yl]-6-methyl-1,3,5-triazin-2-amine Show/Hide	C14H14N8O	1
1	Ki = 18 nM
CP0338291 Compound Info	4-[2-[(6-methoxypyridin-3-yl)amino]-5-[(4-methylsulfonylpiperidin-1-yl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine Show/Hide	C22H28N8O3S	1
1	Ki = 22 nM
CP0087590 Compound Info	3-[[3-(6-amino-2-methylpyrimidin-4-yl)pyridin-2-yl]amino]phenol Show/Hide	C16H15N5O	1
1	Ki = 24 nM
CP0711390 Compound Info	2-(3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-2-(6-methoxypyridin-3-ylamino)imidazo[1,2-a]pyridin-6-yl)propan-2-ol Show/Hide	C20H22N8O2	1
1	Ki = 26 nM
CP0177940 Compound Info	3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(6-methoxypyridin-3-yl)imidazo[1,2-a]pyridin-2-amine Show/Hide	C17H16N8O	1
1	Ki = 29 nM
CP0143583 Compound Info	N-[3-(4-amino-6-methyl-1,3,5-triazin-2-yl)pyridin-2-yl]-1H-indazol-4-amine Show/Hide	C16H14N8	1
1	Ki = 33 nM
CP0282689 Compound Info	N-[3-(2-methyl-7H-purin-6-yl)pyridin-2-yl]-1H-indazol-4-amine Show/Hide	C18H14N8	1
1	Ki = 36 nM
CP0649593 Compound Info	N-(3-(4-amino-6-methyl-1,3,5-triazin-2-yl)imidazo[1,2-a]pyridin-2-yl)quinolin-7-amine Show/Hide	C20H16N8	1
1	Ki = 43 nM
CP0731810 Compound Info	3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(6-methoxypyridin-3-yl)-6-(piperazin-1-yl)imidazo[1,2-a]pyridin-2-amine Show/Hide	C21H24N10O	1
1	Ki = 43 nM
CP0499598 Compound Info	2-amino-4-[2-[[6-chloro-5-[[methyl(propan-2-yl)sulfamoyl]amino]pyridin-3-yl]amino]pyridin-3-yl]-6-methyl-1,3,5-triazine Show/Hide	C18H22ClN9O2S	1
1	Ki = 44 nM
CP0218935 Compound Info	N-[6-(2-methylsulfanylpyrimidin-4-yl)-1,3-benzothiazol-2-yl]acetamide Show/Hide	C14H12N4OS2	1
1	Ki = 53 nM
CP0192153 Compound Info	4-[5-methoxy-2-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine Show/Hide	C16H17N7O2	1
1	Ki = 55 nM
CP0139562 Compound Info	6-[3-[(6-methoxypyridin-3-yl)amino]pyrazin-2-yl]-2-methylpyrimidin-4-amine Show/Hide	C15H15N7O	1
1	Ki = 59 nM
CP0192150 Compound Info	4-[2-[(6-methoxypyridin-3-yl)amino]-5-(piperazin-1-ylmethyl)pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine Show/Hide	C20H25N9O	1
1	Ki = 61 nM
CP0188464 Compound Info	N-(6-methoxypyridin-3-yl)-3-(2-methyl-7H-purin-6-yl)pyridin-2-amine Show/Hide	C17H15N7O	1
1	Ki = 62 nM
CP0172047 Compound Info	[5-(4-amino-6-methyl-1,3,5-triazin-2-yl)-6-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]methanol Show/Hide	C16H17N7O2	1
1	Ki = 63 nM
CP0282688 Compound Info	4-[5-benzyl-2-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine Show/Hide	C22H21N7O	1
1	Ki = 65 nM
CP0369237 Compound Info	4-[5-chloro-2-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine Show/Hide	C15H14ClN7O	1
1	Ki = 70 nM
CP0284209 Compound Info	N-[5-[[3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-5-chloropyridin-2-yl]amino]-2-methylpyridin-3-yl]methanesulfonamide Show/Hide	C16H17ClN8O2S	1
1	Ki = 85 nM
CP0192151 Compound Info	4-[2-[(6-methoxypyridin-3-yl)amino]-5-(morpholin-4-ylmethyl)pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine Show/Hide	C20H24N8O2	1
1	Ki = 104 nM
CP0349679 Compound Info	4-[2-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine Show/Hide	C15H15N7O	1
1	Ki = 107 nM
CP0143584 Compound Info	N-[3-(6-amino-2-methylpyrimidin-4-yl)pyridin-2-yl]-1H-indazol-4-amine Show/Hide	C17H15N7	1
1	Ki = 130 nM
CP0173323 Compound Info	3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(6-ethoxypyridin-3-yl)imidazo[1,2-a]pyridin-2-amine Show/Hide	C18H18N8O	1
1	Ki = 148 nM
CP0339164 Compound Info	4-[2-[(6-methoxypyridin-3-yl)amino]-5-(piperidin-1-ylmethyl)pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine Show/Hide	C21H26N8O	1
1	Ki = 153 nM
CP0343352 Compound Info	4-[5-(azetidin-1-ylmethyl)-2-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine Show/Hide	C19H22N8O	1
1	Ki = 160 nM
CP0302072 Compound Info	N-[3-(2-methyl-7H-purin-6-yl)pyridin-2-yl]-1H-indol-4-amine Show/Hide	C19H15N7	1
1	Ki = 181 nM
CP0142948 Compound Info	N-[3-(4-amino-6-methyl-1,3,5-triazin-2-yl)pyridin-2-yl]-1H-indol-4-amine Show/Hide	C17H15N7	1
1	Ki = 187 nM
CP0087588 Compound Info	1-[[5-(4-amino-6-methyl-1,3,5-triazin-2-yl)-6-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]methyl]piperidin-4-ol Show/Hide	C21H26N8O2	1
1	Ki = 199 nM
CP0131195 Compound Info	4-[2-[(6-methoxypyridin-3-yl)amino]-5-methylpyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine Show/Hide	C16H17N7O	1
1	Ki = 242 nM
CP0292692 Compound Info	4-[5-bromo-2-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine Show/Hide	C15H14BrN7O	1
1	Ki = 247 nM
CP0172042 Compound Info	4-[2-[(6-methoxypyridin-3-yl)amino]-5-[(4-methylpiperazin-1-yl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine Show/Hide	C21H27N9O	1
1	Ki = 258 nM
CP0313976 Compound Info	4-[2-[(6-methoxypyridin-3-yl)amino]-5-(pyrrolidin-1-ylmethyl)pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine Show/Hide	C20H24N8O	1
1	Ki = 266 nM
CP0087587 Compound Info	[(3R)-1-[[5-(4-amino-6-methyl-1,3,5-triazin-2-yl)-6-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]methyl]pyrrolidin-3-yl]methanol Show/Hide	C21H26N8O2	1
1	Ki = 278 nM
CP0191322 Compound Info	4-[5-[(2-methoxyethylamino)methyl]-2-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine Show/Hide	C19H24N8O2	1
1	Ki = 283 nM
CP0346732 Compound Info	5-N-[3-(4-amino-6-methyl-1,3,5-triazin-2-yl)pyridin-2-yl]-2-chloropyridine-3,5-diamine Show/Hide	C14H13ClN8	1
1	Ki = 324 nM
CP0064828 Compound Info	4-[3-[(6-methoxypyridin-3-yl)amino]pyrazin-2-yl]-6-methyl-1,3,5-triazin-2-amine Show/Hide	C14H14N8O	1
1	Ki = 327 nM
CP0330553 Compound Info	4-[2-[(6-methoxypyridin-3-yl)amino]phenyl]-6-methyl-1,3,5-triazin-2-amine Show/Hide	C16H16N6O	1
1	Ki = 396 nM
CP0041963 Compound Info	N-[3-(4-amino-6-methyl-1,3,5-triazin-2-yl)imidazo[1,2-a]pyridin-2-yl]quinolin-6-amine Show/Hide	C20H16N8	1
1	Ki = 529 nM
CP0346280 Compound Info	N-[3-(6-amino-5-fluoro-2-methylpyrimidin-4-yl)pyridin-2-yl]-1H-indazol-4-amine Show/Hide	C17H14FN7	1
1	Ki = 802 nM
CP0328888 Compound Info	4-[3-[(6-methoxypyridin-3-yl)amino]pyridin-4-yl]-6-methyl-1,3,5-triazin-2-amine Show/Hide	C15H15N7O	1
1	Ki = 868 nM
CP0191327 Compound Info	N-[3-(6-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)pyridin-2-yl]-1H-indazol-4-amine Show/Hide	C18H14N8	1
1	Ki = 1411 nM
CP0174742 Compound Info	N-[3-[6-amino-2-(trifluoromethyl)pyrimidin-4-yl]pyridin-2-yl]-1H-indazol-4-amine Show/Hide	C17H12F3N7	1
1	Ki = 3139 nM
CP0229154 Compound Info	N-(6-methoxypyridin-3-yl)-3-(7H-purin-6-yl)pyridin-2-amine Show/Hide	C16H13N7O	1
1	Ki = 7277 nM
CP0087589 Compound Info	N-[3-(7H-purin-6-yl)pyridin-2-yl]-1H-indazol-4-amine Show/Hide	C17H12N8	1
1	Ki = 22621 nM

Clinical Information about the Protein

Target 1 ( PI3-kinase alpha (PIK3CA) )

Target Type	Successful Target
Disease	4 Target-related Diseases				4
1	Breast cancer [ICD-11: 2C60-2C65]
2	Solid tumour/cancer [ICD-11: 2A00-2F9Z]
3	Colorectal cancer [ICD-11: 2B91.Z]
4	Rheumatoid arthritis [ICD-11: FA20]
Approved Drug(s)	1 Approved Drug				1
1	Alpelisib	Drug Info	Approved	Breast cancer
Clinical Trial Drug(s)	5 Clinical Trial Drugs				5
1	Buparlisib	Drug Info	Phase 3	Breast cancer
2	GDC-0032	Drug Info	Phase 3	Breast cancer
3	HHCYH33	Drug Info	Phase 1	Breast cancer
4	MLN1117	Drug Info	Phase 1/2	Solid tumour/cancer
5	PA-799	Drug Info	Phase 1/2	Colorectal cancer
Investigative Drug(s)	1 Investigative Drug				1
1	ETP-46321	Drug Info	Investigative	Rheumatoid arthritis

Similar Protein(s) and Bioactivity Statistics

90% Identity

Protein ID	Protein Name	Protein Organism
PT01368	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Bos taurus, Bovine	Protein Info
PT03525	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Mus musculus, Mouse	Protein Info
PT07498	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Rattus norvegicus, Rat	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han