Brief Information of the Cell Line and Protein
Cell Line ID: CL000481 , HCC1954
Synonyms
HCC-1954
Hamon Cancer Center 1954
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_1259
Protein ID: PT01045 , Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Gene Name PIK3CA
Organism Homo sapiens, Human
Protein Classification Enzyme
Uniprot ID P42336
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000481  Protein ID: PT01045
 
Compound ID Compound Name Compound Formula
CP0543864
(S)-2-((2-((S)-4-(difluoromethyl)- 2-oxooxazolidin-3-yl)-5,6- dihydrobenzo[f]imidazo[1,2- d][1,4]oxazepin-9- yl)amino)propanamide
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C18H19F2N5O4
 1
1
EC50 = 19 nM
   TI
   LI
   LO
   TS
CP0101176
2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide
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C24H28N8O2
 1
1
EC50 = 24 nM
   TI
   LI
   LO
   TS
CP0579285
(S)-2-cyclopropyl-2-((2-((S)-4- (fluoromethyl)-2-oxooxazolidin-3- yl)-5,6- dihydrobenzo[f]imidazo[1,2- d][1,4]oxazepin-9- yl)amino)acetamide
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C20H22FN5O4
 1
1
EC50 = 27 nM
   TI
   LI
   LO
   TS
CP0567669
(S)-2-cyclopropyl-2-((2-((S)-4- (difluoromethyl)-2-oxooxazolidin- 3-yl)-5,6- dihydrobenzo[f]imidazo[1,2- d][1,4]oxazepin-9- yl)amino)acetamide
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C20H21F2N5O4
 1
1
EC50 = 28 nM
   TI
   LI
   LO
   TS
CP0576041
(2S)-2-[[2-[5-(hydroxymethyl)-2-(2,2,2-trifluoroethyl)-1,2,4-triazol-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]oxy]propanamide
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C19H19F3N6O4
 1
1
EC50 = 39 nM
   TI
   LI
   LO
   TS
CP0550609
(2S)-1-[2-[(4S)-2-oxo-4-(trifluoromethyl)-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]pyrrolidine-2-carboxamide
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C20H20F3N5O4
 1
1
EC50 = 40 nM
   TI
   LI
   LO
   TS
CP0579284
(2S)-2-[[2-[(4S)-2-oxo-4-(trifluoromethyl)-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]propanamide
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C18H18F3N5O4
 1
1
EC50 = 49 nM
   TI
   LI
   LO
   TS
CP0569719
(2S)-2-cyclopropyl-2-[[2-[(4S)-2-oxo-4-(trifluoromethyl)-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]acetamide
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C20H20F3N5O4
 1
1
EC50 = 52 nM
   TI
   LI
   LO
   TS
CP0580037
(2S)-2-[[2-[(4S)-2-oxo-4-(trifluoromethyl)-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]butanamide
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C19H20F3N5O4
 1
1
EC50 = 56 nM
   TI
   LI
   LO
   TS
CP0576522
(2S)-1-[2-[(3S)-3-hydroxy-2-oxopyrrolidin-1-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]pyrrolidine-2-carboxamide
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C20H23N5O4
 1
1
EC50 = 63 nM
   TI
   LI
   LO
   TS
CP0579283
(2S)-2-[[2-(5-amino-2-propan-2-yl-1,2,4-triazol-3-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]oxy]propanamide
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C19H23N7O3
 1
1
EC50 = 65 nM
   TI
   LI
   LO
   TS
CP0212773
(2S)-2-[[2-(2-propan-2-yl-1,2,4-triazol-3-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]oxy]propanamide
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C19H22N6O3
 1
1
EC50 = 89 nM
   TI
   LI
   LO
   TS
CP0578777
(2S)-3-methyl-2-[[2-[(4S)-2-oxo-4-(trifluoromethyl)-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]butanamide
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C20H22F3N5O4
 1
1
EC50 = 157 nM
   TI
   LI
   LO
   TS