| Compound ID |
Compound Name |
Compound Formula |
|
CP0044960
|
(1S,2S,7S,10R,11S,14S,15S)-14-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-5-one
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|
C19H30O2
|
5
|
| 1 |
EC50 = 2 nM
|
|
|
| 2 |
IC50 = 1 nM
|
|
|
| 3 |
Ki = 0.2 nM
|
|
|
| 4 |
Ki = 0.3 nM
|
|
|
| 5 |
Ki = 0.9 nM
|
|
|
|
CP0357136
|
16-[(2-Methoxypyrimidin-5-yl)methylidene]-17beta-hydroxy-4-methyl-4-aza-5alpha-androst-1-en-3-one
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|
C25H33N3O3
|
2
|
| 1 |
EC50 = 2 nM
|
|
|
| 2 |
IC50 = 11 nM
|
|
|
|
CP0058724
|
16-{[(2-Methylamino)pyrimidin-5-yl]methylidene}-17beta-hydroxy-4-methyl-4-aza-5alpha-androst-1-en-3-one
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|
C25H34N4O2
|
2
|
| 1 |
EC50 = 5 nM
|
|
|
| 2 |
IC50 = 31 nM
|
|
|
|
CP0212295
|
(4aR,4bS,6aS,7S,9aS,9bR,11aR)-7-hydroxy-1,4a,6a-trimethyl-4b,5,6,6a,7,8,9,9a,9b,10,11,11a-dodecahydro-1H-indeno[5,4-f]quinolin-2(4aH)-one
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|
C19H29NO2
|
2
|
| 1 |
EC50 = 5 nM
|
|
|
| 2 |
IC50 = 7 nM
|
|
|
|
CP0058723
|
16-[(2-Methylpyrimidin-5-yl)methylidene]-17beta-hydroxy-4-methyl-4-aza-5alpha-androst-1-en-3-one
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|
C25H33N3O2
|
2
|
| 1 |
EC50 = 8 nM
|
|
|
| 2 |
IC50 = 43 nM
|
|
|
|
CP0289165
|
16-[(3,5-Difluorophenyl)methylidene]-17beta-hydroxy-4-methyl-4-aza-5alpha-androst-1-en-3-one
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|
C26H31F2NO2
|
2
|
| 1 |
EC50 = 8 nM
|
|
|
| 2 |
IC50 = 41 nM
|
|
|
|
CP0316554
|
16-[(3-Fluorophenyl)methylidene]-17beta-hydroxy-4-methyl-4-aza-5alpha-androst-1-en-3-one
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|
C26H32FNO2
|
2
|
| 1 |
EC50 = 12 nM
|
|
|
| 2 |
IC50 = 27 nM
|
|
|
|
CP0137917
|
16alpha-(3-Fluorobenzyl)-17beta-hydroxy-4-methyl-4-aza-5alpha-androst-1-en-3-one
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|
C26H34FNO2
|
2
|
| 1 |
EC50 = 14 nM
|
|
|
| 2 |
IC50 = 23 nM
|
|
|
|
CP0048863
|
16-(Pyrimidin-5-ylmethylidene)-17beta-hydroxy-4-methyl-4-aza-5alpha-androst-1-en-3-one
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|
C24H31N3O2
|
2
|
| 1 |
EC50 = 17 nM
|
|
|
| 2 |
IC50 = 59 nM
|
|
|
|
CP0289167
|
16-(Methylmethylidene)-17beta-hydroxy-4-methyl-4-aza-5alpha-androst-1-en-3-one
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|
C21H31NO2
|
2
|
| 1 |
EC50 = 17 nM
|
|
|
| 2 |
IC50 = 35 nM
|
|
|
|
CP0058722
|
16-[(2-cyclopropylpyrimidin-5-yl)methylidene]-17beta-hydroxy-4-methyl-4-aza-5alpha-androst-1-en-3-one
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|
C27H35N3O2
|
2
|
| 1 |
EC50 = 26 nM
|
|
|
| 2 |
IC50 = 51 nM
|
|
|
|
CP0316555
|
16-(Phenylmethylidene)-17beta-hydroxy-4-methyl-4-aza-5alpha-androst-1-en-3-one
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|
C26H33NO2
|
2
|
| 1 |
EC50 = 26 nM
|
|
|
| 2 |
IC50 = 116 nM
|
|
|
|
CP0322315
|
16-(Pyridin-3-ylmethylidene)-17beta-hydroxy-4-methyl-4-aza-5alpha-androst-1-en-3-one
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|
C25H32N2O2
|
2
|
| 1 |
EC50 = 62 nM
|
|
|
| 2 |
IC50 = 62 nM
|
|
|
|
CP0035018
|
16alpha-(Methyl)-17beta-hydroxy-4-methyl-4-aza-5alpha-androst-1-en-3-one
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|
C20H31NO2
|
2
|
| 1 |
EC50 = 119 nM
|
|
|
| 2 |
IC50 = 31 nM
|
|
|
|
CP0357135
|
16-(Pyridin-4-ylmethylidene)-17beta-hydroxy-4-methyl-4-aza-5alpha-androst-1-en-3-one
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|
C25H32N2O2
|
2
|
| 1 |
EC50 = 138 nM
|
|
|
| 2 |
IC50 = 129 nM
|
|
|
|
CP0137916
|
16alpha-(Methoxymethyl)-17beta-hydroxy-4-methyl-4-aza-5alpha-androst-1-en-3-one
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|
C21H33NO3
|
2
|
| 1 |
EC50 = 612 nM
|
|
|
| 2 |
IC50 = 24 nM
|
|
|
|
CP0145681
|
4-(2-hydroxyphenyl)-2-(trifluoromethyl)benzonitrile
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|
C14H8F3NO
|
1
|
| 1 |
IC50 = 0.02 nM
|
|
|
|
CP0487309
|
N-[(3aR,4R,5R,7S,7aS)-2-[4-cyano-3-(trifluoromethyl)phenyl]-4,7-dimethyl-1,3-dioxo-3a,5,6,7a-tetrahydro-4,7-epoxyisoindol-5-yl]benzenesulfonamide
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|
C24H20F3N3O5S
|
2
|
| 1 |
IC50 = 1 nM
|
|
|
| 2 |
Ki = 10 nM
|
|
|
|
CP0530362
|
(4-methylpiperazin-1-yl) N-[(3aR,4R,5R,7S,7aS)-2-[4-cyano-3-(trifluoromethyl)phenyl]-4,7-dimethyl-1,3-dioxo-3a,5,6,7a-tetrahydro-4,7-epoxyisoindol-5-yl]carbamate
Show/Hide
|
C24H26F3N5O5
|
2
|
| 1 |
IC50 = 6 nM
|
|
|
| 2 |
Ki = 7 nM
|
|
|
|
CP0854738
|
4-((2R,6S)-1,7-dimethyl-3,5-dioxo-10-oxa-4-aza-tricyclo[5.2.1.02,6]dec-4-yl)-2-iodo-benzonitrile
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|
C17H15IN2O3
|
2
|
| 1 |
IC50 = 7 nM
|
|
|
| 2 |
Ki = 1 nM
|
|
|
|
CP0922543
|
4-((2R,6S)-1,7-dimethyl-3,5-dioxo-10-oxa-4-aza-tricyclo[5.2.1.02,6]d-4-yl)-2-trifluoromethyl-benzonitrile
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|
C18H15F3N2O3
|
2
|
| 1 |
IC50 = 7 nM
|
|
|
| 2 |
Ki = 17 nM
|
|
|
|
CP0384988
|
N-[(3aR,4R,5R,7S,7aS)-2-[4-cyano-3-(trifluoromethyl)phenyl]-4,7-dimethyl-1,3-dioxo-3a,5,6,7a-tetrahydro-4,7-epoxyisoindol-5-yl]pyridine-3-sulfonamide
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|
C23H19F3N4O5S
|
2
|
| 1 |
IC50 = 7 nM
|
|
|
| 2 |
Ki = 2 nM
|
|
|
|
CP0874415
|
(1R,2R,6S,7S)-4-(4-Nitro-3-trifluoromethyl-phenyl)-4-aza-tricyclo[5.2.1.0*2,6*]decane-3,5-dione
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|
C16H13F3N2O4
|
2
|
| 1 |
IC50 = 10 nM
|
|
|
| 2 |
Ki = 5 nM
|
|
|
|
CP0876237
|
4-((2S,6R,8S)-8-hydroxy-1,7-dimethyl-3,5-dioxo-10-oxa-4-aza-tricyclo[5.2.1.02,6]dec-4-yl)-2-iodo-benzonitrile
Show/Hide
|
C17H15IN2O4
|
2
|
| 1 |
IC50 = 10 nM
|
|
|
| 2 |
Ki = 7.18 nM
|
|
|
|
CP0399140
|
4-(isopropylthio)-2-methoxybenzonitrile
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|
C11H13NOS
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0380188
|
N-[(3aR,4R,5R,7S,7aS)-2-[4-cyano-3-(trifluoromethyl)phenyl]-4,7-dimethyl-1,3-dioxo-3a,5,6,7a-tetrahydro-4,7-epoxyisoindol-5-yl]-2-fluorobenzenesulfonamide
Show/Hide
|
C24H19F4N3O5S
|
2
|
| 1 |
IC50 = 10 nM
|
|
|
| 2 |
Ki = 1 nM
|
|
|
|
CP0477239
|
4-[(3aR,4R,5S,7S,7aS)-5-hydroxy-4,7-dimethyl-1,3-dioxo-3a,5,6,7a-tetrahydro-4,7-epoxyisoindol-2-yl]-2-iodobenzonitrile
Show/Hide
|
C17H15IN2O4
|
2
|
| 1 |
IC50 = 10 nM
|
|
|
| 2 |
Ki = 8 nM
|
|
|
|
CP0854736
|
(2R,6S)-1,7-dimethyl-4-(4-nitro-3-trifluoromethyl-phenyl)-10-oxa-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione
Show/Hide
|
C17H15F3N2O5
|
2
|
| 1 |
IC50 = 11 nM
|
|
|
| 2 |
Ki = 17 nM
|
|
|
|
CP0412308
|
4-(propylthio)-2-(trifluoromethyl)benzonitrile
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|
C11H10F3NS
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0254841
|
(trifluoromethyl)benzonitrile, 14
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|
C15H13F3N2O
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0853960
|
(2S,6R)-4-(4-Nitro-3-trifluoromethyl-phenyl)-4-aza-tricyclo[5.2.1.0*2,6*]decane-3,5-dione
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|
C16H13F3N2O4
|
2
|
| 1 |
IC50 = 12 nM
|
|
|
| 2 |
Ki = 5 nM
|
|
|
|
CP0919903
|
7-((2R,6S)-1,7-dimethyl-3,5-dioxo-10-oxa-4-aza-tricyclo[5.2.1.02,6]dec-4-yl)-benzo[1,2,5]thiadiazole-4-carbonitrile
Show/Hide
|
C17H14N4O3S
|
2
|
| 1 |
IC50 = 16 nM
|
|
|
| 2 |
Ki = 3 nM
|
|
|
|
CP0922542
|
(2R,6S)-4-(3,5-dichloro-phenyl)-1,7-dimethyl-10-oxa-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione
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|
C16H15Cl2NO3
|
2
|
| 1 |
IC50 = 16 nM
|
|
|
| 2 |
Ki = 3 nM
|
|
|
|
CP0198555
|
N-[(3aR,4R,5R,7S,7aS)-2-[4-cyano-3-(trifluoromethyl)phenyl]-4,7-dimethyl-1,3-dioxo-3a,5,6,7a-tetrahydro-4,7-epoxyisoindol-5-yl]ethanesulfonamide
Show/Hide
|
C20H20F3N3O5S
|
2
|
| 1 |
IC50 = 16 nM
|
|
|
| 2 |
Ki = 1.7 nM
|
|
|
|
CP0919902
|
4-((2R,6S)-1,7-dimethyl-3,5-dioxo-10-oxa-4-aza-tricyclo[5.2.1.02,6]dec-4-yl)-2-methylsulfanyl-benzonitrile
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|
C18H18N2O3S
|
2
|
| 1 |
IC50 = 19 nM
|
|
|
| 2 |
Ki = 3 nM
|
|
|
|
CP0942368
|
4-((2R,6S,8R)-8-hydroxy-1,7-dimethyl-3,5-dioxo-10-oxa-4-aza-tricyclo[5.2.1.02,6]dec-4-yl)-2-iodo-benzonitrile
Show/Hide
|
C17H15IN2O4
|
2
|
| 1 |
IC50 = 19 nM
|
|
|
| 2 |
Ki = 2.41 nM
|
|
|
|
CP0918694
|
(2S,6R)-4-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]-1,7-dimethyl-10-oxa-4-azatricyclo[5.2.1.0^{2,6}]decane-3,5-dione
Show/Hide
|
C20H20N2O5
|
2
|
| 1 |
IC50 = 20 nM
|
|
|
| 2 |
Ki = 12 nM
|
|
|
|
CP0530909
|
N-[(3aR,4R,5R,7S,7aS)-2-[4-cyano-3-(trifluoromethyl)phenyl]-4,7-dimethyl-1,3-dioxo-3a,5,6,7a-tetrahydro-4,7-epoxyisoindol-5-yl]methanesulfonamide
Show/Hide
|
C19H18F3N3O5S
|
2
|
| 1 |
IC50 = 20 nM
|
|
|
| 2 |
Ki = 12 nM
|
|
|
|
CP0340598
|
4-(2-hydroxyphenyl)-2-methoxybenzonitrile
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|
C14H11NO2
|
1
|
| 1 |
IC50 = 20.1 nM
|
|
|
|
CP0380186
|
propan-2-yl (3aR,4R,5R,7S,7aS)-2-[4-cyano-3-(trifluoromethyl)phenyl]-4,7-dimethyl-1,3-dioxo-3a,5,6,7a-tetrahydro-4,7-epoxyisoindole-5-carboxylate
Show/Hide
|
C22H21F3N2O5
|
2
|
| 1 |
IC50 = 22 nM
|
|
|
| 2 |
Ki = 23 nM
|
|
|
|
CP0477240
|
N-[(3aR,4R,5R,7S,7aS)-2-[4-cyano-3-(trifluoromethyl)phenyl]-4,7-dimethyl-1,3-dioxo-3a,5,6,7a-tetrahydro-4,7-epoxyisoindol-5-yl]propanamide
Show/Hide
|
C21H20F3N3O4
|
2
|
| 1 |
IC50 = 23 nM
|
|
|
| 2 |
Ki = 3 nM
|
|
|
|
CP0040191
|
2-Hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide
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|
C11H11F3N2O4
|
2
|
| 1 |
IC50 = 26 nM
|
|
|
| 2 |
Ki = 43 nM
|
|
|
|
CP0191399
|
(R)-(+)-4-[4,4-Dimethyl-1-(4-methylsulfanyl-benzyl)-2-oxo-pyrrolidin-3-yloxy]-2-trifluoromethylbenzonitril
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|
C22H21F3N2O2S
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0434578
|
4-(2,6-dimethylphenylthio)-2-methoxybenzonitrile
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|
C16H15NOS
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0432787
|
4-[(1S,2R,6R,7R)-2-methyl-3,3-dioxo-3lambda6-thia-4-azatricyclo[5.2.1.02,6]dec-8-en-4-yl]-2-(trifluoromethyl)benzonitrile
Show/Hide
|
C17H15F3N2O2S
|
2
|
| 1 |
IC50 = 30 nM
|
|
|
| 2 |
Ki = 2 nM
|
|
|
|
CP0109247
|
4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile
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|
C17H18F3N3O3
|
2
|
| 1 |
IC50 = 31.1 nM
|
|
|
| 2 |
IC50 = 40 nM
|
|
|
|
CP0415605
|
4-[(3aR,4R,5R,7S,7aS)-4,7-dimethyl-5-(methylsulfamoylamino)-1,3-dioxo-3a,5,6,7a-tetrahydro-4,7-epoxyisoindol-2-yl]-2-(trifluoromethyl)benzonitrile
Show/Hide
|
C19H19F3N4O5S
|
2
|
| 1 |
IC50 = 34 nM
|
|
|
| 2 |
Ki = 50 nM
|
|
|
|
CP0545222
|
(3aR,4S,5R,7S,7aS)-2-[4-cyano-3-(trifluoromethyl)phenyl]-N,4,7-trimethyl-1,3-dioxo-N-phenyl-3a,5,6,7a-tetrahydro-4,7-epoxyisoindole-5-carboxamide
Show/Hide
|
C26H22F3N3O4
|
2
|
| 1 |
IC50 = 34 nM
|
|
|
| 2 |
Ki = 50 nM
|
|
|
|
CP0399141
|
2-methoxy-4-(2-methoxyphenylthio)benzonitrile
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|
C15H13NO2S
|
1
|
| 1 |
IC50 = 35 nM
|
|
|
|
CP0854742
|
(2R,6S)-1,7-dimethyl-4-(3-trifluoromethyl-phenyl)-10-oxa-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione
Show/Hide
|
C17H16F3NO3
|
2
|
| 1 |
IC50 = 36 nM
|
|
|
| 2 |
Ki = 41 nM
|
|
|
|
CP0399142
|
4-(2-methoxyphenylthio)-2-(trifluoromethyl)benzonitrile
Show/Hide
|
C15H10F3NOS
|
1
|
| 1 |
IC50 = 37 nM
|
|
|
|
CP0870021
|
3-chloro-5-((2R,6S)-1,7-dimethyl-3,5-dioxo-10-oxa-4-aza-tricyclo[5.2.1.02,6]dec-4-yl)-pyridine-2-carbonitrile
Show/Hide
|
C16H14ClN3O3
|
2
|
| 1 |
IC50 = 38 nM
|
|
|
| 2 |
Ki = 4 nM
|
|
|
|
CP0216059
|
(R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-yloxy)-2-(trifluoromethyl)-benzonitrile
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|
C21H19F3N2O2
|
1
|
| 1 |
IC50 = 38 nM
|
|
|
|
CP0854734
|
(2R,6S)-4-(5-bromo-4-nitro-naphthalen-1-yl)-1,7-dimethyl-10-oxa-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione
Show/Hide
|
C20H17BrN2O5
|
2
|
| 1 |
IC50 = 40 nM
|
|
|
| 2 |
Ki = 17 nM
|
|
|
|
CP0288829
|
4-[(1R,2R)-2-hydroxycyclohexyl]-2-(trifluoromethyl)benzonitrile
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|
C14H14F3NO
|
1
|
| 1 |
IC50 = 43 nM
|
|
|
|
CP0306708
|
(R)-(+)-4-(1-(2-Fluorobenzyl)-4,4-dimethyl-2-oxopyrrolidin-3yloxy)-2-(trifluoromethyl)-benzonitrile
Show/Hide
|
C21H18F4N2O2
|
1
|
| 1 |
IC50 = 44 nM
|
|
|
|
CP0385280
|
(1R,2R,6R,7S)-4-[4-cyano-3-(trifluoromethyl)phenyl]-N-methyl-3,3-dioxo-3lambda6-thia-4-azatricyclo[5.2.1.02,6]decane-2-carboxamide
Show/Hide
|
C18H18F3N3O3S
|
2
|
| 1 |
IC50 = 44 nM
|
|
|
| 2 |
Ki = 3 nM
|
|
|
|
CP0061953
|
6-{methyl[(1R)-1-phenylethyl]amino}-4-(trifluoromethyl)pyridine-3-carbonitrile
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|
C16H14F3N3
|
1
|
| 1 |
IC50 = 45 nM
|
|
|
|
CP0412309
|
3-chloro-4-(o-tolyloxy)benzonitrile
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|
C14H10ClNO
|
1
|
| 1 |
IC50 = 46 nM
|
|
|
|
CP0399144
|
3-methoxy-4-(o-tolyloxy)benzonitrile
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|
C15H13NO2
|
1
|
| 1 |
IC50 = 48 nM
|
|
|
|
CP0881223
|
(2S,6R)-4-(4-Nitro-naphthalen-1-yl)-4-aza-tricyclo[5.3.2.0*2,6*]dodec-11-ene-3,5-dione
Show/Hide
|
C21H18N2O4
|
2
|
| 1 |
IC50 = 49 nM
|
|
|
| 2 |
Ki = 9 nM
|
|
|
|
CP0293483
|
4-(2-Fluorophenylthio)-2-(trifluoromethyl)benzonitrile
Show/Hide
|
C14H7F4NS
|
1
|
| 1 |
IC50 = 54 nM
|
|
|
|
CP0468022
|
4-(cyclopropylmethylthio)-2-methoxybenzonitrile
Show/Hide
|
C12H13NOS
|
1
|
| 1 |
IC50 = 55 nM
|
|
|
|
CP0558374
|
(1R,2R,6R,7S)-4-[4-cyano-3-(trifluoromethyl)phenyl]-3,3-dioxo-3lambda6-thia-4-azatricyclo[5.2.1.02,6]decane-2-carboxamide
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C17H16F3N3O3S
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2
|
| 1 |
IC50 = 55 nM
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| 2 |
Ki = 3 nM
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CP0385281
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(1S,2S,6R,7R,9S)-4-[4-cyano-3-(trifluoromethyl)phenyl]-9-fluoro-N-methyl-3,3-dioxo-3lambda6-thia-4-azatricyclo[5.2.1.02,6]decane-2-carboxamide
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C18H17F4N3O3S
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2
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| 1 |
IC50 = 57 nM
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| 2 |
Ki = 5 nM
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CP0891249
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(1S,6R,7S)-8-(4-Butyl-benzoyl)-4-(4-nitro-phenyl)-2,4,8-triaza-tricyclo[5.2.1.0*2,6*]decane-3,5-dione
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C24H24N4O5
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2
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| 1 |
IC50 = 60 nM
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| 2 |
Ki = 70 nM
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CP0238251
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4-(2,4-Difluorophenoxy)-2-(trifluoromethyl)benzonitrile
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C14H6F5NO
|
1
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| 1 |
IC50 = 60 nM
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CP0380187
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1-[(3aR,4R,5R,7S,7aS)-2-[4-cyano-3-(trifluoromethyl)phenyl]-4,7-dimethyl-1,3-dioxo-3a,5,6,7a-tetrahydro-4,7-epoxyisoindol-5-yl]-3-propan-2-ylurea
Show/Hide
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C22H23F3N4O4
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2
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| 1 |
IC50 = 60 nM
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| 2 |
Ki = 31 nM
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CP0452672
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4-[(3aR,4R,5R,7S,7aS)-5-amino-4,7-dimethyl-1,3-dioxo-3a,5,6,7a-tetrahydro-4,7-epoxyisoindol-2-yl]-2-(trifluoromethyl)benzonitrile
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C18H16F3N3O3
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2
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| 1 |
IC50 = 60 nM
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| 2 |
Ki = 31 nM
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CP0437490
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4-(butylthio)-2-methoxybenzonitrile
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C12H15NOS
|
1
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| 1 |
IC50 = 66 nM
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CP0411075
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4-[(1R,2S,6R,7R)-2-methyl-3,3,10-trioxo-3lambda6-thia-4-azatricyclo[5.2.1.02,6]decan-4-yl]-2-(trifluoromethyl)benzonitrile
Show/Hide
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C17H15F3N2O3S
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2
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| 1 |
IC50 = 67 nM
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| 2 |
Ki = 8 nM
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CP0881224
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(2R,6S)-4-(4-Bromo-3-methyl-phenyl)-4-aza-tricyclo[5.2.2.0*2,6*]undec-8-ene-3,5-dione
Show/Hide
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C17H16BrNO2
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2
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| 1 |
IC50 = 68 nM
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| 2 |
Ki = 171 nM
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CP0472126
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4-(mesitylthio)-2-methoxybenzonitrile
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C17H17NOS
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1
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| 1 |
IC50 = 69 nM
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CP0876238
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(2R,6S)-4-(6-mino-imidazo[1,2-a]pyridin-5-yl)-1,7-dimethyl-10-oxa-4-aza-tricyclo[5.2.1.*2,6]decane-3,5-dione
Show/Hide
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C17H18N4O3
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2
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| 1 |
IC50 = 70 nM
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| 2 |
Ki = 27 nM
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CP0475841
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4-[(1R,2R,6R,7S)-2-methyl-3,3-dioxo-3lambda6-thia-4-azatricyclo[5.2.1.02,6]decan-4-yl]-2-(trifluoromethyl)benzonitrile
Show/Hide
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C17H17F3N2O2S
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2
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| 1 |
IC50 = 73 nM
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| 2 |
Ki = 3 nM
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CP0399145
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3-chloro-4-(o-tolylthio)benzonitrile
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C14H10ClNS
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1
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| 1 |
IC50 = 78 nM
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CP0412310
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2-methoxy-4-(o-tolyloxy)benzonitrile
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C15H13NO2
|
1
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| 1 |
IC50 = 81 nM
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CP0892661
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4-((2R,6S)-1,7-dimethyl-3,5-dioxo-10-oxa-4-aza-tricyclo[5.2.1.02,6]dec-4-yl)-pyrazolo[1,5-a]pyridine-7-carbonitrile
Show/Hide
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C18H16N4O3
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2
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| 1 |
IC50 = 88 nM
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| 2 |
Ki = 18 nM
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CP0399138
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4-(isopropylthio)-2-(trifluoromethyl)benzonitrile
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C11H10F3NS
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1
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| 1 |
IC50 = 89 nM
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CP0071429
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4-(2-hydroxycyclohexyl)-2-(trifluoromethyl)benzonitrile
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C14H14F3NO
|
1
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| 1 |
IC50 = 90 nM
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CP0510688
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4-[(1S,2S,6R,7R,9S)-9-fluoro-2-methyl-3,3-dioxo-3lambda6-thia-4-azatricyclo[5.2.1.02,6]decan-4-yl]-2-(trifluoromethyl)benzonitrile
Show/Hide
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C17H16F4N2O2S
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2
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| 1 |
IC50 = 91 nM
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| 2 |
Ki = 8 nM
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CP0386264
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4-[(1S,2S,6R,7R,9S)-9-hydroxy-2-methyl-3,3-dioxo-3lambda6-thia-4-azatricyclo[5.2.1.02,6]decan-4-yl]-2-(trifluoromethyl)benzonitrile
Show/Hide
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C17H17F3N2O3S
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2
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| 1 |
IC50 = 106 nM
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| 2 |
Ki = 3 nM
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CP0883935
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(2S,6R)-4-(4-Nitro-3-trifluoromethyl-phenyl)-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-ene-3,5-dione
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C16H11F3N2O4
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2
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| 1 |
IC50 = 119 nM
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| 2 |
Ki = 55 nM
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CP0946670
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(2R,6S)-4-(6-amino-benzothiazol-7-yl)-1,7-dimethyl-10-oxa-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione
Show/Hide
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C17H17N3O3S
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2
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| 1 |
IC50 = 120 nM
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| 2 |
Ki = 17 nM
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CP0399148
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4-(o-tolylthio)-2-(trifluoromethyl)benzonitrile
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C15H10F3NS
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1
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| 1 |
IC50 = 123 nM
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CP0916358
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(R)-4-(3-trifluoromethyl-phenyl)-2,4-diaza-tricyclo[5.2.1.02,6]decane-3,5-dione
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C15H13F3N2O2
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2
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| 1 |
IC50 = 130 nM
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| 2 |
Ki = 21 nM
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CP0386263
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4-[(1R,2R,6R,7S)-3,3-dioxo-3lambda6-thia-4-azatricyclo[5.2.1.02,6]decan-4-yl]-2-(trifluoromethyl)benzonitrile
Show/Hide
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C16H15F3N2O2S
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2
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| 1 |
IC50 = 130 nM
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| 2 |
Ki = 3 nM
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CP0423168
|
4-(cyclopropylmethylthio)-2-(trifluoromethyl)benzonitrile
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C12H10F3NS
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1
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| 1 |
IC50 = 133 nM
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CP0526636
|
6-(4-methylpiperidin-1-yl)-4-(trifluoromethyl)nicotinonitrile
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C13H14F3N3
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1
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| 1 |
IC50 = 136 nM
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CP0874496
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(2S,6R)-4-(4-Bromo-3-trifluoromethyl-phenyl)-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-ene-3,5-dione
Show/Hide
|
C16H11BrF3NO2
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2
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| 1 |
IC50 = 146 nM
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| 2 |
Ki = 46 nM
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CP0871049
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(2R,6S)-4-(3,4-Dichloro-phenyl)-4-aza-tricyclo[5.2.2.0*2,6*]undec-8-ene-3,5-dione
Show/Hide
|
C16H13Cl2NO2
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2
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| 1 |
IC50 = 150 nM
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| 2 |
Ki = 83 nM
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CP0845025
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(2S,6R)-4-(3-Trifluoromethyl-phenyl)-4-aza-tricyclo[5.2.1.0*2,6*]decane-3,5-dione
Show/Hide
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C16H14F3NO2
|
2
|
| 1 |
IC50 = 152 nM
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| 2 |
Ki = 360 nM
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CP0399146
|
4-(cyclobutylthio)-3-(trifluoromethyl)benzonitrile
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C12H10F3NS
|
1
|
| 1 |
IC50 = 167 nM
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CP0146696
|
Bicalutamide
Show/Hide
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C18H14F4N2O4S
|
5
|
| 1 |
IC50 = 170 nM
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| 2 |
IC50 = 173 nM
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| 3 |
Ki = 64 nM
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| 4 |
Ki = 65 nM
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| 5 |
Ki = 151 nM
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CP0862669
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(2R,6S)-4-(3-Trifluoromethyl-phenyl)-4-aza-tricyclo[5.2.2.0*2,6*]undec-8-ene-3,5-dione
Show/Hide
|
C17H14F3NO2
|
2
|
| 1 |
IC50 = 196 nM
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| 2 |
Ki = 100 nM
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CP0412311
|
2-methoxy-4-(m-tolyloxy)benzonitrile
Show/Hide
|
C15H13NO2
|
1
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| 1 |
IC50 = 197 nM
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CP0886325
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4-fluorophenyl (5S,8S,8aR)-2-(4-cyano-3-(trifluoromethyl)phenyl)-1,3-dioxohexahydro-5,8-methanoimidazo[1,5-a]pyrazine-7(1H)-carboxylate
Show/Hide
|
C22H14F4N4O4
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2
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| 1 |
IC50 = 200 nM
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| 2 |
Ki = 10 nM
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CP0399147
|
2-methoxy-4-(p-tolyloxy)benzonitrile
Show/Hide
|
C15H13NO2
|
1
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| 1 |
IC50 = 209 nM
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CP0475840
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4-[(1S,2R,6R,7R)-3,3-dioxo-3lambda6-thia-4-azatricyclo[5.2.1.02,6]dec-8-en-4-yl]-2-(trifluoromethyl)benzonitrile
Show/Hide
|
C16H13F3N2O2S
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2
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| 1 |
IC50 = 219 nM
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| 2 |
Ki = 12 nM
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CP0874497
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(2S,6R)-4-(4-Bromo-3-methyl-phenyl)-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-ene-3,5-dione
Show/Hide
|
C16H14BrNO2
|
2
|
| 1 |
IC50 = 220 nM
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| 2 |
Ki = 125 nM
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CP0853961
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(2S,6R)-4-(4-Nitro-naphthalen-1-yl)-4-aza-tricyclo[5.2.2.0*2,6*]undec-8-ene-3,5-dione
Show/Hide
|
C20H16N2O4
|
2
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| 1 |
IC50 = 224 nM
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| 2 |
Ki = 19 nM
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CP0467152
|
6-(methyl(1-phenylethyl)amino)-4-(trifluoromethyl)nicotinonitrile
Show/Hide
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C16H14F3N3
|
1
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| 1 |
IC50 = 229 nM
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CP0897703
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(1R,6S,7R)-4-(4-Nitro-phenyl)-3,5-dioxo-2,4,8-triaza-tricyclo[5.2.1.0*2,6*]decane-8-carboxylic acid tert-butyl ester
Show/Hide
|
C18H20N4O6
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2
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| 1 |
IC50 = 250 nM
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| 2 |
Ki = 230 nM
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CP0455064
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6-(octahydroisoquinolin-2(1H)-yl)-4-(trifluoromethyl)nicotinonitrile
Show/Hide
|
C16H18F3N3
|
1
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| 1 |
IC50 = 260 nM
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CP0137918
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16-(Pyridin-2-ylmethylidene)-17beta-hydroxy-4-methyl-4-aza-5alpha-androst-1-en-3-one
Show/Hide
|
C25H32N2O2
|
1
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| 1 |
IC50 = 292 nM
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CP0860542
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4-((1S,6R,7S)-8-Benzoyl-3,5-dioxo-2,4,8-triaza-tricyclo[5.2.1.0*2,6*]dec-4-yl)-2-trifluoromethyl-benzonitrile
Show/Hide
|
C22H15F3N4O3
|
2
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| 1 |
IC50 = 300 nM
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| 2 |
Ki = 120 nM
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CP0917601
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(2R,6S)-4-(3,4-Dichloro-phenyl)-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-ene-3,5-dione
Show/Hide
|
C15H11Cl2NO2
|
2
|
| 1 |
IC50 = 307 nM
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| 2 |
Ki = 158 nM
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CP0855770
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(2S,6R)-4-(3,5-Dichloro-phenyl)-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-ene-3,5-dione
Show/Hide
|
C15H11Cl2NO2
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2
|
| 1 |
IC50 = 307 nM
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| 2 |
Ki = 158 nM
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CP0883970
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(1S,6R,7S)-4-(4-Nitro-naphthalen-1-yl)-3,5-dioxo-2,4,8-triaza-tricyclo[5.2.1.0*2,6*]decane-8-carboxylic acid 4-fluoro-phenyl ester
Show/Hide
|
C24H17FN4O6
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2
|
| 1 |
IC50 = 340 nM
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| 2 |
Ki = 10 nM
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CP0854744
|
(2R,6S)-1-methyl-4-(3-trifluoromethyl-phenyl)-10-oxa-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione
Show/Hide
|
C16H14F3NO3
|
2
|
| 1 |
IC50 = 343 nM
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| 2 |
Ki = 410 nM
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CP0938289
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(2R,6S)-4-(3-chloro-4-iodo-phenyl)-10-oxa-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione
Show/Hide
|
C14H11ClINO3
|
2
|
| 1 |
IC50 = 350 nM
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| 2 |
Ki = 221 nM
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CP0855813
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(2S,6R)-4-(8-Hydroxy-quinolin-5-yl)-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-ene-3,5-dione
Show/Hide
|
C18H14N2O3
|
2
|
| 1 |
IC50 = 418 nM
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| 2 |
Ki = 162 nM
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CP0455065
|
6-(piperidin-1-yl)-4-(trifluoromethyl)nicotinonitrile
Show/Hide
|
C12H12F3N3
|
1
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| 1 |
IC50 = 422 nM
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CP0386262
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4-[(1S,2R,6R,7S,8R)-8-hydroxy-2-methyl-3,3-dioxo-3lambda6-thia-4-azatricyclo[5.2.1.02,6]decan-4-yl]-2-(trifluoromethyl)benzonitrile
Show/Hide
|
C17H17F3N2O3S
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2
|
| 1 |
IC50 = 430 nM
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| 2 |
Ki = 28 nM
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CP0917995
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(2R,6S)-4-(3,4-dichloro-phenyl)-10-oxa-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione
Show/Hide
|
C14H11Cl2NO3
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2
|
| 1 |
IC50 = 480 nM
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| 2 |
Ki = 377 nM
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CP0854746
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(2R,6S)-4-(4-chloro-3-methyl-phenyl)-10-oxa-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione
Show/Hide
|
C15H14ClNO3
|
2
|
| 1 |
IC50 = 500 nM
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| 2 |
Ki = 77 nM
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CP0855754
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(2S,6R)-4-(3-Chloro-4-fluoro-phenyl)-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-ene-3,5-dione
Show/Hide
|
C15H11ClFNO2
|
2
|
| 1 |
IC50 = 517 nM
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| 2 |
Ki = 177 nM
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CP0860543
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4-[(1S,6R,7S)-8-(4-Butyl-benzoyl)-3,5-dioxo-2,4,8-triaza-tricyclo[5.2.1.0*2,6*]dec-4-yl]-benzonitrile
Show/Hide
|
C25H24N4O3
|
2
|
| 1 |
IC50 = 580 nM
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| 2 |
Ki = 100 nM
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CP0883546
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(1S,6R,7S)-4-(4-Cyano-naphthalen-1-yl)-3,5-dioxo-2,4,8-triaza-tricyclo[5.2.1.0*2,6*]decane-8-carboxylic acid 4-fluoro-phenyl ester
Show/Hide
|
C25H17FN4O4
|
2
|
| 1 |
IC50 = 580 nM
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| 2 |
Ki = 40 nM
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CP0910886
|
(1S,6S,7S)-4-(4-Cyano-3-trifluoromethyl-phenyl)-3,5-dioxo-2,4,8-triaza-tricyclo[5.2.1.0*2,6*]decane-8-carboxylic acid tert-butyl ester
Show/Hide
|
C20H19F3N4O4
|
2
|
| 1 |
IC50 = 640 nM
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| 2 |
Ki = 180 nM
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CP0880496
|
(2S,6R)-4-(3-Trifluoromethyl-phenyl)-4-aza-tricyclo[5.3.2.0*2,6*]dodecane-3,5-dione
Show/Hide
|
C18H18F3NO2
|
2
|
| 1 |
IC50 = 658 nM
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| 2 |
Ki = 2810 nM
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CP0883915
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(2R,6S)-4-(4-nitrophenyl)-4-azatricyclo[5.2.1.0~2,6~]dec-8-ene-3,5-dione
Show/Hide
|
C15H12N2O4
|
2
|
| 1 |
IC50 = 664 nM
|
|
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| 2 |
Ki = 192 nM
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CP0880754
|
(2R,6S)-4-(4-bromo-naphthalen-1-yl)-10-oxa-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione
Show/Hide
|
C18H14BrNO3
|
2
|
| 1 |
IC50 = 670 nM
|
|
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| 2 |
Ki = 53 nM
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CP0399150
|
4-(cyclobutylmethylthio)-2-(trifluoromethyl)benzonitrile
Show/Hide
|
C13H12F3NS
|
1
|
| 1 |
IC50 = 702 nM
|
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CP0293961
|
16-{[(Pyridin-2-yl)pyrimidin-5-yl]methylidene}-17beta-hydroxy-4-methyl-4-aza-5alpha-androst-1-en-3-one
Show/Hide
|
C29H34N4O2
|
1
|
| 1 |
IC50 = 715 nM
|
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CP0897803
|
(2S,6R)-4-(3-Trifluoromethyl-phenyl)-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-ene-3,5-dione
Show/Hide
|
C16H12F3NO2
|
2
|
| 1 |
IC50 = 744 nM
|
|
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| 2 |
Ki = 632 nM
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CP0891250
|
(1S,6R,7S)-4-(4-Cyano-3-trifluoromethyl-phenyl)-3,5-dioxo-2,4,8-triaza-tricyclo[5.2.1.0*2,6*]decane-8-carboxylic acid tert-butyl ester
Show/Hide
|
C20H19F3N4O4
|
2
|
| 1 |
IC50 = 770 nM
|
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| 2 |
Ki = 40 nM
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CP0945582
|
(R)-4-(4-cyano-3-trifluoromethyl-phenyl)-3,5-dioxo-2,4,8-triaza-tricyclo[5.2.1.02,6]decane-8-carboxylic acid tert-butyl ester
Show/Hide
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C20H19F3N4O4
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2
|
| 1 |
IC50 = 774 nM
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| 2 |
Ki = 40 nM
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CP0464462
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(1S,6R,7S)-4-(4-Cyano-3-trifluoromethyl-phenyl)-6-methyl-3,5-dioxo-2,4,8-triaza-tricyclo[5.2.1.0*2,6*]decane-8-carboxylic acid tert-butyl ester
Show/Hide
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C21H21F3N4O4
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2
|
| 1 |
IC50 = 780 nM
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| 2 |
Ki = 1400 nM
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CP0880497
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(3a alpha,4beta,8beta,8a alpha)-4,5,6,7,8,8a-hexahydro-4,8-etheno-1H-cyclohepta[c]furan-1,3(3aH)-di-one
Show/Hide
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C21H16N2O4
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2
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| 1 |
IC50 = 786 nM
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| 2 |
Ki = 3 nM
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CP0525938
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4-(butylthio)-2-(trifluoromethyl)benzonitrile
Show/Hide
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C12H12F3NS
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1
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| 1 |
IC50 = 838 nM
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CP0855510
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(2S,6R)-4-Quinolin-7-yl-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-ene-3,5-dione
Show/Hide
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C18H14N2O2
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2
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| 1 |
IC50 = 1038 nM
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| 2 |
Ki = 530 nM
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CP0917994
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(2R,6S)-4-(4-chloro-3-nitro-phenyl)-10-oxa-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione
Show/Hide
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C14H11ClN2O5
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2
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| 1 |
IC50 = 1150 nM
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| 2 |
Ki = 692 nM
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CP0897800
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(2S,6R)-4-Naphthalen-2-yl-4-aza-tricyclo[5.2.1.0*2,6*]decane-3,5-dione
Show/Hide
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C19H17NO2
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2
|
| 1 |
IC50 = 1200 nM
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| 2 |
Ki = 284 nM
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CP0855812
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(2S,6R)-4-Naphthalen-2-yl-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-ene-3,5-dione
Show/Hide
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C19H15NO2
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2
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| 1 |
IC50 = 1210 nM
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| 2 |
Ki = 284 nM
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CP0901877
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(1R,6R,7S)-4-(4-Nitro-naphthalen-1-yl)-2,4-diaza-tricyclo[5.2.1.0*2,6*]decane-3,5-dione
Show/Hide
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C18H15N3O4
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2
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| 1 |
IC50 = 1300 nM
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| 2 |
Ki = 1 nM
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CP0874437
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(1S,6S,7S)-4-(4-Nitro-naphthalen-1-yl)-3,5-dioxo-2,4,8-triaza-tricyclo[5.2.1.0*2,6*]decane-8-carboxylic acid tert-butyl ester
Show/Hide
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C22H22N4O6
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2
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| 1 |
IC50 = 1330 nM
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| 2 |
Ki = 1030 nM
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CP0848003
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(2R,6S,8S,10R)-4-[3-(trifluoromethyl)phenyl]-4-azatetracyclo[5.3.2.0^{2,6}.0^{8,10}]dodec-11-ene-3,5-dione
Show/Hide
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C18H14F3NO2
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2
|
| 1 |
IC50 = 1700 nM
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| 2 |
Ki = 3200 nM
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CP0870105
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(2S,6R)-4-(3,5-Bis-trifluoromethyl-phenyl)-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-ene-3,5-dione
Show/Hide
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C17H11F6NO2
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2
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| 1 |
IC50 = 1746 nM
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| 2 |
Ki = 401 nM
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CP0037400
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2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
Show/Hide
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C11H11F3N2O3
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1
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| 1 |
IC50 = 2000 nM
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CP0860626
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(2S,6R)-4-(3,4-Dimethyl-phenyl)-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-ene-3,5-dione
Show/Hide
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C17H17NO2
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2
|
| 1 |
IC50 = 2014 nM
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| 2 |
Ki = 400 nM
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CP0854740
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(2R,6S)-4-(3-chloro-4-methyl-phenyl)-10-oxa-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione
Show/Hide
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C15H14ClNO3
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2
|
| 1 |
IC50 = 2290 nM
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| 2 |
Ki = 486 nM
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CP0871275
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(1S,6R,7S)-4-(4-Cyano-phenyl)-3,5-dioxo-2,4,8-triaza-tricyclo[5.2.1.0*2,6*]decane-8-carboxylic acid tert-butyl ester
Show/Hide
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C19H20N4O4
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2
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| 1 |
IC50 = 2540 nM
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| 2 |
Ki = 240 nM
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CP0918695
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4-((2R,6S)-3,5-dioxo-10-oxa-4-aza-tricyclo[5.2.1.02,6]dec-4-yl)-2-trifluoromethyl-benzonitrile
Show/Hide
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C16H11F3N2O3
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2
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| 1 |
IC50 = 2860 nM
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| 2 |
Ki = 1170 nM
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CP0876236
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(2R,6S)-4-(4-chloro-3-trifluoromethyl-phenyl)-10-oxa-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione
Show/Hide
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C15H11ClF3NO3
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2
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| 1 |
IC50 = 3310 nM
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| 2 |
Ki = 1110 nM
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CP0897702
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(1S,6R,7S)-4-(4-Nitro-naphthalen-1-yl)-3,5-dioxo-2,4,8-triaza-tricyclo[5.2.1.0*2,6*]decane-8-carboxylic acid tert-butyl ester
Show/Hide
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C22H22N4O6
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2
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| 1 |
IC50 = 3320 nM
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| 2 |
Ki = 60 nM
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CP0876327
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(2R,6R)-8-Methyl-4-(4-nitro-naphthalen-1-yl)-4,8-diaza-tricyclo[5.2.2.0*2,6*]undec-10-ene-3,5,9-trione
Show/Hide
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C20H15N3O5
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2
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| 1 |
IC50 = 4030 nM
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| 2 |
Ki > 5000 nM
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CP0848004
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(2R,6S,10R,11S)-4-(4-Bromo-3-methyl-phenyl)-10,11-dihydroxy-4-aza-tricyclo[5.2.2.0*2,6*]undec-8-ene-3,5-dione
Show/Hide
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C17H16BrNO4
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2
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| 1 |
IC50 = 5240 nM
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| 2 |
Ki = 432 nM
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CP0238111
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1-(5-{[(2S)-2-aminopropanamido]methyl}thiophen-3-yl)-N-[(2-methoxyphenyl)methyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide
Show/Hide
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C21H22F3N5O3S
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1
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| 1 |
IC50 > 10000 nM
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CP0417920
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1-(3-{[(2S)-2-aminopropanamido]methyl}phenyl)-N-[(2-methoxyphenyl)methyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide
Show/Hide
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C23H24F3N5O3
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1
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| 1 |
IC50 > 10000 nM
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CP0945574
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(2R,6S)-4-(3-trifluoromethyl-phenyl)-10-oxa-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione
Show/Hide
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C15H12F3NO3
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2
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| 1 |
IC50 = 11500 nM
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| 2 |
Ki = 4100 nM
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CP0914361
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4-[(1S,6R,7S)-8-(4-Butyl-benzoyl)-3,5-dioxo-2,4,8-triaza-tricyclo[5.2.1.0*2,6*]dec-4-yl]-2-trifluoromethyl-benzonitrile
Show/Hide
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C26H23F3N4O3
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2
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| 1 |
IC50 = 17900 nM
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| 2 |
Ki = 690 nM
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CP0860627
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(2S,6R)-4-(4-Nitro-naphthalen-1-yl)-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-ene-3,5-dione
Show/Hide
|
C19H14N2O4
|
2
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| 1 |
IC50 > 5 nM
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| 2 |
Ki = 1 nM
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CP0393048
|
6-(sec-butyl(methyl)amino)-4-(trifluoromethyl)nicotinonitrile
Show/Hide
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C12H14F3N3
|
1
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| 1 |
IC50 > 1000 nM
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CP0438917
|
6-(butyl(methyl)amino)-4-(trifluoromethyl)nicotinonitrile
Show/Hide
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C12H14F3N3
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1
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| 1 |
IC50 > 1000 nM
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CP0455066
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6-(dipropylamino)-4-(trifluoromethyl)nicotinonitrile
Show/Hide
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C13H16F3N3
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1
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| 1 |
IC50 > 1000 nM
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CP0467153
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6-((cyclopropylmethyl)(propyl)amino)-4-(trifluoromethyl)nicotinonitrile
Show/Hide
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C14H16F3N3
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1
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| 1 |
IC50 > 1000 nM
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CP0399143
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2-methoxy-4-(propylthio)benzonitrile
Show/Hide
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C11H13NOS
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1
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| 1 |
IC50 > 1000 nM
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CP0883977
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(1R,6S,7R)-4-(4-Cyano-3-trifluoromethyl-phenyl)-3,5-dioxo-2,4,8-triaza-tricyclo[5.2.1.0*2,6*]decane-8-carboxylic acid tert-butyl ester
Show/Hide
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C20H19F3N4O4
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2
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| 1 |
IC50 > 5000 nM
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| 2 |
Ki > 5000 nM
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CP0883980
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(1S,6R,7S)-8-Benzoyl-4-(4-nitro-phenyl)-2,4,8-triaza-tricyclo[5.2.1.0*2,6*]decane-3,5-dione
Show/Hide
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C20H16N4O5
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2
|
| 1 |
IC50 > 5000 nM
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| 2 |
Ki = 10 nM
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CP0897704
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(1S,6S,7S)-4-(4-Cyano-phenyl)-3,5-dioxo-2,4,8-triaza-tricyclo[5.2.1.0*2,6*]decane-8-carboxylic acid tert-butyl ester
Show/Hide
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C19H20N4O4
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2
|
| 1 |
IC50 > 5000 nM
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| 2 |
Ki = 190 nM
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CP0922544
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(2R,6S)-4-(4-nitro-naphthalen-1-yl)-10-oxa-4-aza-tricyclo[5.2.1.2,6]decane-3,5-dione
Show/Hide
|
C18H14N2O5
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2
|
| 1 |
IC50 > 5000 nM
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| 2 |
Ki = 3 nM
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CP0509199
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(3aR,4R,5R,7S,7aS)-2-[4-cyano-3-(trifluoromethyl)phenyl]-4,7-dimethyl-1,3-dioxo-3a,5,6,7a-tetrahydro-4,7-epoxyisoindole-5-carboxylic acid
Show/Hide
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C19H15F3N2O5
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2
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| 1 |
IC50 > 5000 nM
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| 2 |
Ki = 1600 nM
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CP0381822
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oxazolidin-2-imine, 6d
Show/Hide
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C15H13ClF3N3O2
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1
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| 1 |
Ki = 0.2 nM
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CP0087810
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[(8R,9S,10R,13S,14S,17S)-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl] propanoate
Show/Hide
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C22H32O3
|
1
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| 1 |
Ki = 0.25 nM
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CP0434850
|
BMS-665139
Show/Hide
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C15H13ClF3N3O2
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1
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| 1 |
Ki = 0.3 nM
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CP0434910
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oxazolidin-2-imine, 6b
Show/Hide
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C14H14ClN3O2
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1
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| 1 |
Ki = 0.3 nM
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CP0498559
|
oxazolidin-2-imine, 6f
Show/Hide
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C15H13ClF3N3O2
|
1
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| 1 |
Ki = 0.3 nM
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CP0462960
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2-Chloro-4-((3aS,4R)-4-hydroxy-1,1,3-trioxo-tetrahydro-1lambda*6*-thia-2,6a-diaza-pentalen-2-yl)-3-methyl-benzonitrile
Show/Hide
|
C13H12ClN3O4S
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1
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| 1 |
Ki = 0.45 nM
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CP0475167
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4-[(1S,7aR)-1-hydroxy-7-methyl-5-oxo-2,3,5,7a-tetrahydro-1H-pyrrolizin-6-yl]-2-chloro-3-methylbenzonitrile
Show/Hide
|
C16H15ClN2O2
|
1
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| 1 |
Ki = 0.5 nM
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CP0877320
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Z-4-[(1R,7R,7aS)-7-hydroxy-1-isopropyltetrahydropyrrolo[1,2-c]oxazol-3-ylideneamino]-2-chloro-3-methylbenzonitrile
Show/Hide
|
C17H20ClN3O2
|
1
|
| 1 |
Ki = 0.7 nM
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CP0419986
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4-[(1S,7R,7aR)-1-ethyl-7-hydroxy-3-oxo-hexahydro-1H-pyrrolo[1,2-a]imidazolidin-2-yl]-2-chloro-3-methylbenzonitrile
Show/Hide
|
C16H18ClN3O2
|
1
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| 1 |
Ki = 0.7 nM
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CP0498560
|
oxazolidin-2-imine, 6a
Show/Hide
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C14H14ClN3O2
|
1
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| 1 |
Ki = 0.8 nM
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CP0036395
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4-[(1S,7S,7aR)-1-ethyl-7-hydroxy-3-oxo-hexahydro-1H-pyrrolo[1,2-a]imidazolidin-2-yl]-2-chloro-3-methylbenzonitrile
Show/Hide
|
C16H18ClN3O2
|
1
|
| 1 |
Ki = 0.9 nM
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CP0405803
|
4-[(1R,7S,7aR)-7-hydroxy-3-oxo-1-(trifluoromethyl)-hexahydro-1H-pyrrolo[1,2-a]imidazolidin-2-yl]-2-chloro-3-methylbenzonitrile
Show/Hide
|
C15H13ClF3N3O2
|
1
|
| 1 |
Ki = 0.9 nM
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CP0417188
|
(2R)-2-methyl-1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-1H,2H,3H,6H,7H-quinolino[7,6-b][1,4]oxazin-7-one
Show/Hide
|
C15H12F6N2O2
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2
|
| 1 |
Ki = 0.9 nM
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| 2 |
Ki = 7.1 nM
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CP0847835
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(1S,6R,7R)-4-(4-nitro-1-naphthyl)-2,4-diazatricyclo[5.2.1.0~2,6~]decane-3,5-dione
Show/Hide
|
C18H15N3O4
|
1
|
| 1 |
Ki = 1 nM
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|
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CP0475168
|
4-[(1R,7R,7aR)-7-hydroxy-3-oxo-1-(trifluoromethyl)-hexahydro-1H-pyrrolo[1,2-a]imidazolidin-2-yl]-2-chloro-3-methylbenzonitrile
Show/Hide
|
C15H13ClF3N3O2
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1
|
| 1 |
Ki = 1 nM
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CP0432004
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(2R)-2-(3-methylphenyl)-1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-3,6-dihydro-2H-pyrido[3,2-g][1,4]benzoxazin-7-one
Show/Hide
|
C21H16F6N2O2
|
1
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| 1 |
Ki = 1.1 nM
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CP0155404
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1-ethyl-9-(trifluoromethyl)-1H,2H,3H,6H,7H-quinolino[7,6-b][1,4]oxazin-7-one
Show/Hide
|
C14H13F3N2O2
|
1
|
| 1 |
Ki = 1.2 nM
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CP0441553
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(2R)-2-phenyl-1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-3,6-dihydro-2H-pyrido[3,2-g][1,4]benzoxazin-7-one
Show/Hide
|
C20H14F6N2O2
|
1
|
| 1 |
Ki = 1.3 nM
|
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|
|
CP0255862
|
BMS-564929
Show/Hide
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C14H12ClN3O3
|
3
|
| 1 |
Ki = 1.4 nM
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|
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| 2 |
Ki = 2.11 nM
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|
| 3 |
Ki = 14 nM
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CP0170782
|
6-[bis(2,2,2-trifluoroethyl)amino]-4-(trifluoromethyl)-1,2-dihydroquinolin-2-one
Show/Hide
|
C14H9F9N2O
|
1
|
| 1 |
Ki = 1.5 nM
|
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CP0849428
|
(6R)-tetrahydro-6-hydroxy-2-(4-nitro-1-naphthalenyl)-1H-pyrrolo[1,2-c]imidazole-1,3(2H)-dione
Show/Hide
|
C16H13N3O5
|
1
|
| 1 |
Ki = 1.5 nM
|
|
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CP0474737
|
4-[(1S,7S,7aR)-7-hydroxy-1-methyl-3-oxo-hexahydro-1H-pyrrolo[1,2-a]imidazolidin-2-yl]-2-chloro-3-methylbenzonitrile
Show/Hide
|
C15H16ClN3O2
|
2
|
| 1 |
Ki = 1.5 nM
|
|
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| 2 |
Ki = 1.6 nM
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CP0159674
|
1-(cyclopropylmethyl)-9-(trifluoromethyl)-1H,2H,3H,6H,7H-quinolino[7,6-b][1,4]oxazin-7-one
Show/Hide
|
C16H15F3N2O2
|
1
|
| 1 |
Ki = 1.6 nM
|
|
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CP0419987
|
4-[(1R,7S,7aR)-1-ethyl-7-hydroxy-3-oxo-hexahydro-1H-pyrrolo[1,2-a]imidazolidin-2-yl]-2-chloro-3-methylbenzonitrile
Show/Hide
|
C16H18ClN3O2
|
1
|
| 1 |
Ki = 1.6 nM
|
|
|
|
CP0873296
|
tetrahydro-2-(4-nitro-1-naphthalenyl)-1H-pyrrolo[1,2-c]imidazole-1,3(2H)-dione
Show/Hide
|
C16H13N3O4
|
1
|
| 1 |
Ki = 1.7 nM
|
|
|
|
CP0443500
|
guanidine derivative, 12
Show/Hide
|
C15H17ClN4O
|
1
|
| 1 |
Ki = 1.9 nM
|
|
|
|
CP0419990
|
4-[(1S,7S,7aR)-7-hydroxy-3-oxo-1-(trifluoromethyl)-hexahydro-1H-pyrrolo[1,2-a]imidazolidin-2-yl]-2-chloro-3-methylbenzonitrile
Show/Hide
|
C15H13ClF3N3O2
|
1
|
| 1 |
Ki = 1.9 nM
|
|
|
|
CP0474544
|
4-[(7R,7aR)-7-hydroxy-3-oxo-hexahydro-1H-pyrrolo[1,2-a]imidazolidin-2-yl]-2-chloro-3-methylbenzonitrile
Show/Hide
|
C14H14ClN3O2
|
2
|
| 1 |
Ki = 2 nM
|
|
|
| 2 |
Ki = 6 nM
|
|
|
|
CP0465115
|
4-[(3aR,4R,6aS)-4-hydroxy-1-oxo-octahydrocyclopenta[c]pyrrol-2-yl]-2-chloro-3-methylbenzonitrile
Show/Hide
|
C15H15ClN2O2
|
1
|
| 1 |
Ki = 2.2 nM
|
|
|
|
CP0522579
|
4-[(1S,7R,7aR)-7-hydroxy-3-oxo-1-(trifluoromethyl)-hexahydro-1H-pyrrolo[1,2-a]imidazolidin-2-yl]-2-chloro-3-methylbenzonitrile
Show/Hide
|
C15H13ClF3N3O2
|
1
|
| 1 |
Ki = 2.2 nM
|
|
|
|
CP0443499
|
oxazolidin-2-imine, 6e
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C15H13ClF3N3O2
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1
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| 1 |
Ki = 2.3 nM
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CP0419984
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4-[(1R,7R,7aR)-1-ethyl-7-hydroxy-3-oxo-hexahydro-1H-pyrrolo[1,2-a]imidazolidin-2-yl]-2-chloro-3-methylbenzonitrile
Show/Hide
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C16H18ClN3O2
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1
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| 1 |
Ki = 2.3 nM
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CP0412809
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(2R)-2-(2-methylsulfanylethyl)-1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-3,6-dihydro-2H-pyrido[3,2-g][1,4]benzoxazin-7-one
Show/Hide
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C17H16F6N2O2S
|
1
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| 1 |
Ki = 2.4 nM
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CP0412810
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(2R)-2-(fluoromethyl)-1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-3,6-dihydro-2H-pyrido[3,2-g][1,4]benzoxazin-7-one
Show/Hide
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C15H11F7N2O2
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1
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| 1 |
Ki = 2.6 nM
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CP0432982
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(2R)-2-ethyl-1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-1H,2H,3H,6H,7H-quinolino[7,6-b][1,4]oxazin-7-one
Show/Hide
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C16H14F6N2O2
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1
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| 1 |
Ki = 2.8 nM
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CP0419991
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4-[(1S,7R,7aR)-7-hydroxy-1-methyl-3-oxo-hexahydro-1H-pyrrolo[1,2-a]imidazolidin-2-yl]-2-chloro-3-methylbenzonitrile
Show/Hide
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C15H16ClN3O2
|
1
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| 1 |
Ki = 2.9 nM
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CP0645750
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(7R,7aS)-4-(tetrahydro-7-hydroxy-1,3-dioxo-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl)-1-naphthalenecarbonitrile
Show/Hide
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C17H13N3O3
|
1
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| 1 |
Ki = 3.2 nM
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CP0847834
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tetrahydro-7-hydroxy-2-(4-nitro-1-naphthalenyl)-1H-pyrrolo[1,2-c]imidazole-1,3(2H)-dione
Show/Hide
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C16H13N3O5
|
1
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| 1 |
Ki = 3.5 nM
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CP0844858
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4-[(1S,2S,6R,7R)-9-(6-Chloro-pyrimidin-4-yl)-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl]-2-trifluoromethyl-benzonitrile
Show/Hide
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C22H17ClF3N5O3
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1
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| 1 |
Ki = 3.5 nM
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CP0867205
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4-((1S,2S,6R,7R)-9-Methoxy-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-2-trifluoromethyl-benzonitrile
Show/Hide
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C19H18F3N3O4
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1
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| 1 |
Ki = 3.7 nM
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CP0320793
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1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-1H,2H,3H,6H,7H-quinolino[7,6-b][1,4]oxazin-7-one
Show/Hide
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C14H10F6N2O2
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1
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| 1 |
Ki = 4 nM
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CP0432984
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1-(cyclopropylmethyl)-2-methyl-9-(trifluoromethyl)-1H,2H,3H,6H,7H-quinolino[7,6-b][1,4]oxazin-7-one
Show/Hide
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C17H17F3N2O2
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1
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| 1 |
Ki = 4 nM
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CP0419992
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4-[(1R,7S,7aR)-7-hydroxy-1-methyl-3-oxo-hexahydro-1H-pyrrolo[1,2-a]imidazolidin-2-yl]-2-chloro-3-methylbenzonitrile
Show/Hide
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C15H16ClN3O2
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1
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| 1 |
Ki = 4 nM
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CP0432985
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1-ethyl-2-methyl-9-(trifluoromethyl)-1H,2H,3H,6H,7H-quinolino[7,6-b][1,4]oxazin-7-one
Show/Hide
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C15H15F3N2O2
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1
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| 1 |
Ki = 4.2 nM
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CP0918726
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(6S)-tetrahydro-6-hydroxy-2-(4-nitro-1-naphthalenyl)-1H-pyrrolo[1,2-c]imidazole-1,3(2H)-dione
Show/Hide
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C16H13N3O5
|
1
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| 1 |
Ki = 4.3 nM
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CP0203868
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6-(diethylamino)-4-(trifluoromethyl)-1,2-dihydroquinolin-2-one
Show/Hide
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C14H15F3N2O
|
1
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| 1 |
Ki = 4.4 nM
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CP0878549
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4-(tetrahydro-7-hydroxy-1,3-dioxo-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl)-1-naphthalenecarbonitrile
Show/Hide
|
C17H13N3O3
|
1
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| 1 |
Ki = 5.5 nM
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CP0483870
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1,2-diethyl-9-(trifluoromethyl)-1H,2H,3H,6H,7H-quinolino[7,6-b][1,4]oxazin-7-one
Show/Hide
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C16H17F3N2O2
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1
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| 1 |
Ki = 5.6 nM
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CP0394102
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(1R,2S,10S,11S,14S,15S,17S)-1-fluoro-14,17-dihydroxy-2,14,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one
Show/Hide
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C20H29FO3
|
1
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| 1 |
Ki = 5.7 nM
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CP0434484
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(2S)-2-methyl-1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-1H,2H,3H,6H,7H-quinolino[7,6-b][1,4]oxazin-7-one
Show/Hide
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C15H12F6N2O2
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1
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| 1 |
Ki = 5.7 nM
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CP0844848
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(1S,2S,6R,7R)-4-(4-Cyano-3-trifluoromethyl-phenyl)-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undecane-9-carboxylic acid ethyl ester
Show/Hide
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C21H20F3N3O5
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1
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| 1 |
Ki = 5.7 nM
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CP0394257
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(2R)-1-(2,2,2-trifluoroethyl)-2,9-bis(trifluoromethyl)-3,6-dihydro-2H-pyrido[3,2-g][1,4]benzoxazin-7-one
Show/Hide
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C15H9F9N2O2
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1
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| 1 |
Ki = 5.9 nM
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CP0859770
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4-((1S,2S,6R,7R)-1,7-Dimethyl-3,5-dioxo-9-pyrimidin-2-yl-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-2-trifluoromethyl-benzonitrile
Show/Hide
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C22H18F3N5O3
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1
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| 1 |
Ki = 6.1 nM
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CP0390933
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6-[bis(cyclopropylmethyl)amino]-4-(trifluoromethyl)-1,2-dihydroquinolin-2-one
Show/Hide
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C18H19F3N2O
|
1
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| 1 |
Ki = 6.3 nM
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CP0441554
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2-(difluoromethyl)-1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-3,6-dihydro-2H-pyrido[3,2-g][1,4]benzoxazin-7-one
Show/Hide
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C15H10F8N2O2
|
1
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| 1 |
Ki = 6.6 nM
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CP0844856
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(1S,2S,6R,7R)-4-(4-Cyano-3-trifluoromethyl-phenyl)-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undecane-9-carboxylic acid propyl ester
Show/Hide
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C22H22F3N3O5
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1
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| 1 |
Ki = 6.6 nM
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CP0203867
|
6-[ethyl(2,2,2-trifluoroethyl)amino]-4-(trifluoromethyl)-1,2-dihydroquinolin-2-one
Show/Hide
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C14H12F6N2O
|
1
|
| 1 |
Ki = 7.1 nM
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CP0390988
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6-[(cyclopropylmethyl)(2,2,2-trifluoroethyl)amino]-4-(trifluoromethyl)-1,2-dihydroquinolin-2-one
Show/Hide
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C16H14F6N2O
|
1
|
| 1 |
Ki = 7.1 nM
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CP0390934
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6-[ethyl(propan-2-yl)amino]-4-(trifluoromethyl)-1,2-dihydroquinolin-2-one
Show/Hide
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C15H17F3N2O
|
1
|
| 1 |
Ki = 7.4 nM
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CP0253730
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2-methyl-1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-1H,2H,3H,6H,7H-quinolino[7,6-b][1,4]oxazin-7-one
Show/Hide
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C15H12F6N2O2
|
1
|
| 1 |
Ki = 7.8 nM
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CP0501696
|
2-chloro-4-((3aS,4R)-4-hydroxy-3a-methyl-1,1,3-trioxo-tetrahydro-1lambda6-thia-2,6a-diaza-pentalen-2-yl)-3-methyl-benzonitrile
Show/Hide
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C14H14ClN3O4S
|
1
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| 1 |
Ki = 8.2 nM
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CP0865304
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(+/-)-1-(2,2,2-trifluoroethyl)-2,9-bis(trifluoromethyl)-2,3-dihydro-1H-[1,4]oxazino[3,2-g]quinolin-7(6H)-one
Show/Hide
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C15H9F9N2O2
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1
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| 1 |
Ki = 8.3 nM
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CP0906735
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3-[(1S,2S,6R,7R)-4-(4-Cyano-3-trifluoromethyl-phenyl)-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-9-yl]-benzamide
Show/Hide
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C25H21F3N4O4
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1
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| 1 |
Ki = 9 nM
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CP0082236
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2-ethyl-1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-1H,2H,3H,6H,7H-quinolino[7,6-b][1,4]oxazin-7-one
Show/Hide
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C16H14F6N2O2
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1
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| 1 |
Ki = 9.4 nM
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CP0412815
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(2R)-2-(methoxymethyl)-1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-3,6-dihydro-2H-pyrido[3,2-g][1,4]benzoxazin-7-one
Show/Hide
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C16H14F6N2O3
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1
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| 1 |
Ki = 9.4 nM
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CP0902637
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4-[(1S,2S,6R,7R)-9-(3-Methanesulfonyl-phenyl)-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl]-2-trifluoromethyl-benzonitrile
Show/Hide
|
C25H22F3N3O5S
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1
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| 1 |
Ki = 9.4 nM
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CP0433610
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1-propyl-9-(trifluoromethyl)-1H,2H,3H,6H,7H-quinolino[7,6-b][1,4]oxazin-7-one
Show/Hide
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C15H15F3N2O2
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1
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| 1 |
Ki = 9.6 nM
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CP0474545
|
guanidine derivative, 11
Show/Hide
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C14H15ClN4O
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1
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| 1 |
Ki = 10 nM
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CP0049184
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6-ethyl-4-(trifluoromethyl)-1H,2H,6H,7H,8H,9H-pyrido[3,2-g]quinolin-2-one
Show/Hide
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C15H15F3N2O
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1
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| 1 |
Ki = 11 nM
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CP0844851
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(1S,2S,6R,7R)-4-(4-Cyano-3-trifluoromethyl-phenyl)-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undecane-9-carboxylic acid isopropyl ester
Show/Hide
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C22H22F3N3O5
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1
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| 1 |
Ki = 11 nM
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CP0916497
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4-[(1R,2R,6S,7S)-3,5-dioxo-9-(phenylsulfonyl)-11-oxa-4,9-diazatricyclo[5.3.1.0 2,6]undec-4-yl]-2-(trifluoromethyl)benzonitrile
Show/Hide
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C24H20F3N3O5S
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1
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| 1 |
Ki = 12 nM
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CP0536440
|
2-chloro-4-((3aR,4R)-4-hydroxy-1,1-dioxo-tetrahydro-1lambda6-thia-2,6a-diaza-pentalen-2-yl)-3-methyl-benzonitrile
Show/Hide
|
C13H14ClN3O3S
|
1
|
| 1 |
Ki = 14 nM
|
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CP0871744
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4-((1S,2S,6R,7R)-1,7-Dimethyl-3,5-dioxo-9-propyl-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-2-trifluoromethyl-benzonitrile
Show/Hide
|
C21H22F3N3O3
|
1
|
| 1 |
Ki = 14 nM
|
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CP0904024
|
4-((1S,2S,6R,7R)-9-Isopropyl-1,7-dimethyl-3,5,8,10-tetraoxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-2-trifluoromethyl-benzonitrile
Show/Hide
|
C21H18F3N3O5
|
1
|
| 1 |
Ki = 14 nM
|
|
|
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CP0444567
|
1-methyl-9-(trifluoromethyl)-1H,2H,3H,6H,7H-quinolino[7,6-b][1,4]oxazin-7-one
Show/Hide
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C13H11F3N2O2
|
1
|
| 1 |
Ki = 15 nM
|
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|
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CP0386694
|
(2R)-2-(hydroxymethyl)-1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-3,6-dihydro-2H-pyrido[3,2-g][1,4]benzoxazin-7-one
Show/Hide
|
C15H12F6N2O3
|
1
|
| 1 |
Ki = 15 nM
|
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CP0358612
|
4-(trifluoromethyl)-1,2,7,8,9,10,10a,11-octahydro-12-oxa-1,6000100-diazatetraphen-2-one
Show/Hide
|
C16H15F3N2O2
|
1
|
| 1 |
Ki = 16 nM
|
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CP0913170
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4-((1S,2S,6R,7R)-9-Ethanesulfonyl-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-2-trifluoromethyl-benzonitrile
Show/Hide
|
C20H20F3N3O5S
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1
|
| 1 |
Ki = 16 nM
|
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CP0877321
|
(1S,7S,7aR)-2-(3-chloro-4-cyano-2-methylphenyl)-7-hydroxy-1-methyl-hexahydropyrrolo[1,2-c]imidazol-3-ylidenecyanamide
Show/Hide
|
C16H18ClN5O
|
1
|
| 1 |
Ki = 17 nM
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|
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CP0431961
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1-(2-methylpropyl)-9-(trifluoromethyl)-1H,2H,3H,6H,7H-quinolino[7,6-b][1,4]oxazin-7-one
Show/Hide
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C16H17F3N2O2
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1
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| 1 |
Ki = 17 nM
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CP0394253
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2-[7-oxo-1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-3,6-dihydro-2H-pyrido[3,2-g][1,4]benzoxazin-2-yl]acetonitrile
Show/Hide
|
C16H11F6N3O2
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1
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| 1 |
Ki = 18 nM
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CP0458065
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(2R)-1,2-bis(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-3,6-dihydro-2H-pyrido[3,2-g][1,4]benzoxazin-7-one
Show/Hide
|
C16H11F9N2O2
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1
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| 1 |
Ki = 18 nM
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CP0882940
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Z-(7R,7aR)-3-(3-chloro-4-cyano-2-methyl-phenylimino)-7-hydroxytetrahydropyrrolo[1,2-c]imidazole-2-carboxylic acid amide
Show/Hide
|
C15H16ClN5O2
|
1
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| 1 |
Ki = 19 nM
|
|
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CP0394105
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(2S)-2-ethyl-1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-1H,2H,3H,6H,7H-quinolino[7,6-b][1,4]oxazin-7-one
Show/Hide
|
C16H14F6N2O2
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1
|
| 1 |
Ki = 19 nM
|
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|
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CP0530871
|
2-chloro-4-((3aR,4S)-4-hydroxy-3-methyl-1,1-dioxo-tetrahydro-1lambda6-thia-2,6a-diaza-pentalen-2-yl)-3-methyl-benzonitrile
Show/Hide
|
C14H16ClN3O3S
|
1
|
| 1 |
Ki = 20 nM
|
|
|
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CP0844850
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2-Trifluoromethyl-4-((1S,2S,6R,7R)-1,7,9-trimethyl-3,5,8,10-tetraoxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-benzonitrile
Show/Hide
|
C19H14F3N3O5
|
1
|
| 1 |
Ki = 20 nM
|
|
|
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CP0859766
|
4-((1S,2S,6R,7R)-1,7-Dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-2-trifluoromethyl-benzonitrile
Show/Hide
|
C18H16F3N3O3
|
1
|
| 1 |
Ki = 21 nM
|
|
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CP0412808
|
(2S)-2-(hydroxymethyl)-1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-3,6-dihydro-2H-pyrido[3,2-g][1,4]benzoxazin-7-one
Show/Hide
|
C15H12F6N2O3
|
1
|
| 1 |
Ki = 22 nM
|
|
|
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CP0860897
|
3-[(1S,2S,6R,7R)-4-(4-Cyano-3-trifluoromethyl-phenyl)-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-9-yl]-benzenesulfonamide
Show/Hide
|
C24H21F3N4O5S
|
1
|
| 1 |
Ki = 22 nM
|
|
|
|
CP0202560
|
1-(cyclopropylmethyl)-2-ethyl-9-(trifluoromethyl)-1H,2H,3H,6H,7H-quinolino[7,6-b][1,4]oxazin-7-one
Show/Hide
|
C18H19F3N2O2
|
1
|
| 1 |
Ki = 23 nM
|
|
|
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CP0405804
|
4-[(1R,7R,7aR)-7-hydroxy-3-oxo-1-(propan-2-yl)-hexahydro-1H-pyrrolo[1,2-a]imidazolidin-2-yl]-2-chloro-3-methylbenzonitrile
Show/Hide
|
C17H20ClN3O2
|
1
|
| 1 |
Ki = 23 nM
|
|
|
|
CP0914809
|
4-((1S,2S,6R,7R)-9-Benzoyl-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-2-trifluoromethyl-benzonitrile
Show/Hide
|
C25H20F3N3O4
|
1
|
| 1 |
Ki = 23 nM
|
|
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CP0847884
|
(5alpha,8alpha,8aalpha)-4-(octahydro-1,3-dioxo-5,8-methanoimidazo[1,5-a]pyridine-2yl)-1-naphthalenecarbonitrile
Show/Hide
|
C19H15N3O2
|
1
|
| 1 |
Ki = 24 nM
|
|
|
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CP0483839
|
(15R)-7-(trifluoromethyl)-17-oxa-4,11-diazatetracyclo[8.7.0.0^{3,8}.0^{11,15}]heptadeca-1,3(8),6,9-tetraen-5-one
Show/Hide
|
C15H13F3N2O2
|
1
|
| 1 |
Ki = 27 nM
|
|
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CP0505479
|
2-chloro-4-((3aS,4S)-4-hydroxy-1,1,3-trioxo-tetrahydro-1lambda6-thia-2,6a-diaza-pentalen-2-yl)-3-methyl-benzonitrile
Show/Hide
|
C13H12ClN3O4S
|
1
|
| 1 |
Ki = 29 nM
|
|
|
|
CP0859768
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(1S,2S,6R,7R)-4-(4-Cyano-3-trifluoromethyl-phenyl)-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undecane-9-carboxylic acid(4-fluoro-phenyl)-amide
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C25H20F4N4O4
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1
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| 1 |
Ki = 29 nM
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CP0434033
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3-ethyl-1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-1H,2H,3H,6H,7H-quinolino[7,6-b][1,4]oxazin-7-one
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C16H14F6N2O2
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1
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| 1 |
Ki = 30 nM
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CP0412813
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(2S)-2-(fluoromethyl)-1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-3,6-dihydro-2H-pyrido[3,2-g][1,4]benzoxazin-7-one
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C15H11F7N2O2
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1
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| 1 |
Ki = 32 nM
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CP0845618
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4-[(1S,2S,6R,7R)-9-(4-Fluoro-benzenesulfonyl)-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl]-2-trifluoromethyl-benzonitrile
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C24H19F4N3O5S
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1
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| 1 |
Ki = 32 nM
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CP0433974
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1,3-dimethyl-9-(trifluoromethyl)-1H,2H,3H,6H,7H-quinolino[7,6-b][1,4]oxazin-7-one
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C14H13F3N2O2
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1
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| 1 |
Ki = 33 nM
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CP0378461
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1,3-diethyl-9-(trifluoromethyl)-1H,2H,3H,6H,7H-quinolino[7,6-b][1,4]oxazin-7-one
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C16H17F3N2O2
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1
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| 1 |
Ki = 34 nM
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CP0539652
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(2S,3R)-methyl 1-(3-chloro-4-cyano-2-methylphenylsulfonyl)-3-hydroxypyrrolidine-2-carboxylate
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C14H15ClN2O5S
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1
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| 1 |
Ki = 36 nM
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CP0859765
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4-((1S,2S,6R,7R)-9-Cyclopropanecarbonyl-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-2-trifluoromethyl-benzonitrile
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C22H20F3N3O4
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1
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| 1 |
Ki = 36 nM
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CP0906734
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4-((1S,2S,6R,7R)-9-Hydroxy-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-2-trifluoromethyl-benzonitrile
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C18H16F3N3O4
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1
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| 1 |
Ki = 37 nM
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CP0844854
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4-((1S,2S,6R,7R)-9-Isobutyryl-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-2-trifluoromethyl-benzonitrile
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C22H22F3N3O4
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1
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| 1 |
Ki = 39 nM
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CP0902636
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(1S,2S,6R,7R)-4-(4-Cyano-3-trifluoromethyl-phenyl)-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undecane-9-carboxylic acid phenylamide
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C25H21F3N4O4
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1
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| 1 |
Ki = 40 nM
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CP0434434
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2-chloro-4-((3aS,5S)-5-hydroxy-1,1,3-trioxo-tetrahydro-1lambda6-thia-2,6a-diaza-pentalen-2-yl)-3-methyl-benzonitrile
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C13H12ClN3O4S
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1
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| 1 |
Ki = 44 nM
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CP0394101
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1-tert-butyl-9-(trifluoromethyl)-1H,2H,3H,6H,7H-quinolino[7,6-b][1,4]oxazin-7-one
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C16H17F3N2O2
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1
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| 1 |
Ki = 48 nM
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CP0859767
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4-((1S,2S,6R,7R)-9-Cyclopropylmethyl-1,7-dimethyl-3,5,8,10-tetraoxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-2-trifluoromethyl-benzonitrile
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C22H18F3N3O5
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1
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| 1 |
Ki = 50 nM
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CP0437277
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(2R)-2-(propan-2-yl)-1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-1H,2H,3H,6H,7H-quinolino[7,6-b][1,4]oxazin-7-one
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C17H16F6N2O2
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1
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| 1 |
Ki = 51 nM
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CP0390987
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6-(propylamino)-4-(trifluoromethyl)-1,2-dihydroquinolin-2-one
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C13H13F3N2O
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1
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| 1 |
Ki = 54 nM
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CP0860898
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4-((1S,2S,6R,7R)-9-Methanesulfonyl-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-2-trifluoromethyl-benzonitrile
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C19H18F3N3O5S
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1
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| 1 |
Ki = 56 nM
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CP0374883
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6-(propan-2-ylamino)-4-(trifluoromethyl)-1,2-dihydroquinolin-2-one
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C13H13F3N2O
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1
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| 1 |
Ki = 58 nM
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CP0378430
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3-ethyl-1-methyl-9-(trifluoromethyl)-1H,2H,3H,6H,7H-quinolino[7,6-b][1,4]oxazin-7-one
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C15H15F3N2O2
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1
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| 1 |
Ki = 58 nM
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CP0359750
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6-(dipropylamino)-4-(trifluoromethyl)-1,2-dihydroquinolin-2-one
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C16H19F3N2O
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1
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| 1 |
Ki = 64 nM
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CP0902635
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4-[(1R,2R,6S,7S)-3,5-dioxo-9-propionyl-11-oxa-4,9-diazatricyclo[5.3.1.02,6]undec-4-yl]-2-(trifluoromethyl)benzonitrile
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C21H20F3N3O4
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1
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| 1 |
Ki = 84 nM
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CP0844849
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4-[(1S,2S,6R,7R)-1,7-Dimethyl-3,5-dioxo-9-(pyridine-2-sulfonyl)-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl]-2-trifluoromethyl-benzonitrile
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C23H19F3N4O5S
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1
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| 1 |
Ki = 93 nM
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CP0858358
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(1S,2S,6R,7R)-4-(4-Cyano-3-trifluoromethyl-phenyl)-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undecane-9-carboxylic acid isopropylamide
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C22H23F3N4O4
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1
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| 1 |
Ki = 98 nM
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CP0437275
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(2R)-2-(2-methylpropyl)-1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-1H,2H,3H,6H,7H-quinolino[7,6-b][1,4]oxazin-7-one
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C18H18F6N2O2
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1
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| 1 |
Ki = 109 nM
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CP0412814
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(2S)-2-(methoxymethyl)-1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-3,6-dihydro-2H-pyrido[3,2-g][1,4]benzoxazin-7-one
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C16H14F6N2O3
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1
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| 1 |
Ki = 109 nM
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CP0458132
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2-methyl-9-(trifluoromethyl)-1H,2H,3H,6H,7H-quinolino[7,6-b][1,4]oxazin-7-one
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C13H11F3N2O2
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1
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| 1 |
Ki = 113 nM
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CP0471355
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(2S)-2-phenyl-1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-3,6-dihydro-2H-pyrido[3,2-g][1,4]benzoxazin-7-one
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C20H14F6N2O2
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1
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| 1 |
Ki = 150 nM
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CP0390990
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6-(dimethylamino)-4-(trifluoromethyl)-1,2-dihydroquinolin-2-one
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C12H11F3N2O
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1
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| 1 |
Ki = 153 nM
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CP0860896
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(1S,2S,6R,7R)-4-(4-Cyano-3-trifluoromethyl-phenyl)-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undecane-9-carboxylic acid ethylamide
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C21H21F3N4O4
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1
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| 1 |
Ki = 176 nM
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CP0412812
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(2S)-2-(3-methylphenyl)-1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-3,6-dihydro-2H-pyrido[3,2-g][1,4]benzoxazin-7-one
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C21H16F6N2O2
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1
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| 1 |
Ki = 180 nM
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CP0462962
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2-chloro-4-((3aR,4S)-4-hydroxy-1,1-dioxo-tetrahydro-1lambda6-thia-2,6a-diaza-pentalen-2-yl)-3-methyl-benzonitrile
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C13H14ClN3O3S
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1
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| 1 |
Ki = 189 nM
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CP0431962
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1-benzyl-9-(trifluoromethyl)-1H,2H,3H,6H,7H-quinolino[7,6-b][1,4]oxazin-7-one
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C19H15F3N2O2
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1
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| 1 |
Ki = 206 nM
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CP0390992
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6-(dibutylamino)-4-(trifluoromethyl)-1,2-dihydroquinolin-2-one
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C18H23F3N2O
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1
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| 1 |
Ki = 222 nM
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CP0394222
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(2S)-1-(2,2,2-trifluoroethyl)-2,9-bis(trifluoromethyl)-3,6-dihydro-2H-pyrido[3,2-g][1,4]benzoxazin-7-one
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C15H9F9N2O2
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1
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| 1 |
Ki = 281 nM
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CP0859764
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4-((1S,2S,6R,7R)-9-Isopropyl-1,7-dimethyl-3,5,8,10-tetraoxo-9-oxy-11-oxa-4,9-diaza-tricyclo[5.3.1.0*2,6*]undec-4-yl)-2-trifluoromethyl-benzonitrile
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C21H18F3N3O6
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1
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| 1 |
Ki = 3600 nM
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CP0428662
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6-amino-4-(trifluoromethyl)-1,2-dihydroquinolin-2-one
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C10H7F3N2O
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1
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| 1 |
Ki > 10000 nM
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CP0394087
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7H-[1,4]Oxazino[3,2-g]quinolin-7-one based compound, 11a
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C12H9F3N2O2
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1
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| 1 |
Ki > 1000 nM
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