General Information of the Protein
Protein ID
PT01812
Protein Name
Growth factor receptor-bound protein 2
Secondarily
Protein Name
Adapter protein GRB2
Protein Ash
SH2/SH3 adapter GRB2
Gene Name
GRB2
Secondarily
Gene Name
ASH
Sequence
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
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Organism
Homo sapiens, Human
Protein Classification
Other cytosolic protein
Function
Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.
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Uniprot ID
Primary ID:
P62993

Secondarily ID:
P29354
Q14450
Q63057
Q63059
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Ensembl ID
ENSG00000177885
HGNC ID
HGNC:4566
Subcellular Location
Nucleus
Cytoplasm
Endosome
Golgi apparatus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000284 , MDA-MB-453
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0463697
 Compound Info 
[4-[(2R)-2-acetamido-3-[[1-[[(2S)-4-amino-1-(3-naphthalen-1-ylpropylamino)-1,4-dioxobutan-2-yl]carbamoyl]cyclohexyl]amino]-3-oxopropyl]phenyl] dihydrogen phosphate
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C35H44N5O9P
  1
1
IC50 = 7 nM
 Bioactivity Info 
   TI
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   LO
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CP0534328
 Compound Info 
2-[[(2R)-1-[[1-[[(2S)-4-amino-1-(3-naphthalen-1-ylpropylamino)-1,4-dioxobutan-2-yl]carbamoyl]cyclohexyl]amino]-3-[4-(carboxymethyl)phenyl]-1-oxopropan-2-yl]amino]-2-oxoacetic acid
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C37H43N5O9
  1
1
IC50 = 600 nM
 Bioactivity Info 
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CP0449113
 Compound Info 
2-[4-[(2R)-3-[[1-[[(2S)-4-amino-1-(3-naphthalen-1-ylpropylamino)-1,4-dioxobutan-2-yl]carbamoyl]cyclohexyl]amino]-2-(oxaloamino)-3-oxopropyl]phenyl]-2,2-difluoroacetic acid
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C37H41F2N5O9
  1
1
IC50 = 2000 nM
 Bioactivity Info 
   TI
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CP0491649
 Compound Info 
2-Amino-3-(4-carboxymethoxy-phenyl)-propionic acid
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C11H13NO5
  1
1
IC50 = 2500 nM
 Bioactivity Info 
   TI
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   LO
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CP0511676
 Compound Info 
2-[4-[(2R)-2-acetamido-3-[[1-[[(2S)-4-amino-1-(3-naphthalen-1-ylpropylamino)-1,4-dioxobutan-2-yl]carbamoyl]cyclohexyl]amino]-3-oxopropyl]phenyl]acetic acid
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C37H45N5O7
  1
1
IC50 = 2500 nM
 Bioactivity Info 
   TI
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CP0527492
 Compound Info 
2-[[(2R)-1-[[1-[[(2S)-4-amino-1-(3-naphthalen-1-ylpropylamino)-1,4-dioxobutan-2-yl]carbamoyl]cyclohexyl]amino]-3-[4-(carboxymethoxy)phenyl]-1-oxopropan-2-yl]amino]-2-oxoacetic acid
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C37H43N5O10
  1
1
IC50 = 15000 nM
 Bioactivity Info 
   TI
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CP0463659
 Compound Info 
2-Amino-3-[4-(carboxy-difluoro-methyl)-phenyl]-propionic acid
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C11H11F2NO4
  1
1
IC50 = 28000 nM
 Bioactivity Info 
   TI
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CP0511439
 Compound Info 
2-[4-[(2R)-2-acetamido-3-[[1-[[(2S)-4-amino-1-(3-naphthalen-1-ylpropylamino)-1,4-dioxobutan-2-yl]carbamoyl]cyclohexyl]amino]-3-oxopropyl]phenyl]-2,2-difluoroacetic acid
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C37H43F2N5O7
  1
1
IC50 = 28000 nM
 Bioactivity Info 
   TI
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CP0529894
 Compound Info 
2-Amino-3-(4-carboxymethyl-phenyl)-propionic acid
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C11H13NO4
  1
1
IC50 = 65000 nM
 Bioactivity Info 
   TI
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CP0541014
 Compound Info 
2-[4-[(2R)-2-acetamido-3-[[1-[[(2S)-4-amino-1-(3-naphthalen-1-ylpropylamino)-1,4-dioxobutan-2-yl]carbamoyl]cyclohexyl]amino]-3-oxopropyl]phenoxy]acetic acid
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C37H45N5O8
  1
1
IC50 = 65000 nM
 Bioactivity Info 
   TI
   LI
   LO
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Biochemical Assays
Compound ID Compound Name Compound Formula
CP0119178
 Compound Info 
2-[(9S,10S,11E,14R,18S)-18-(2-amino-2-oxoethyl)-14-[(5-methylindol-1-yl)methyl]-8,17,20-trioxo-10-[4-(phosphonomethyl)phenyl]-7,16,19-triazaspiro[5.14]icos-11-en-9-yl]acetic acid
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C38H48N5O9P
  5
1 IC50 <= 10 nM
2 IC50 = 15 nM
3 Kd = 0.075 nM
4 Kd = 0.093 nM
5 Kd = 1.47 nM
Clinical Information about the Protein
Target 1 ( GRB2 messenger RNA (GRB2 mRNA) )
Target Type Clinical trial Target
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT06067 Growth factor receptor-bound protein 2 Mus musculus, Mouse
 Protein Info