General Information of the Protein
Protein ID
PT06067
Protein Name
Growth factor receptor-bound protein 2
Secondarily
Protein Name
Adapter protein GRB2
SH2/SH3 adapter GRB2
Gene Name
GRB2
Sequence
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQMPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
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Organism
Mus musculus, Mouse
Protein Classification
Other cytosolic protein
Function
Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.
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Uniprot ID
Primary ID:
Q60631

Secondarily ID:
Q61240
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Ensembl ID
ENSG00000177885
Subcellular Location
Nucleus
Cytoplasm
Endosome
Golgi apparatus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000279 , B104-1-1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0502346
 Compound Info 
Actinomycin D analogue
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C68H82N12O16
  1
1
IC50 = 900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0467439
 Compound Info 
Actinomycin D analogue
   Show/Hide
C60H82N12O16
  1
1
IC50 = 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0374659
 Compound Info 
Actinomycin D analogue
   Show/Hide
C68H82N12O16
  1
1
IC50 = 1200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0505383
 Compound Info 
Actinomycin D analogue
   Show/Hide
C70H86N12O18
  1
1
IC50 = 1500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0398479
 Compound Info 
Actinomycin D analogue
   Show/Hide
C68H82N12O16
  1
1
IC50 = 1800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0453541
 Compound Info 
Actinomycin D analogue
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C70H86N12O18
  1
1
IC50 = 2000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0467394
 Compound Info 
Actinomycin D analogue
   Show/Hide
C70H86N12O18
  1
1
IC50 = 2000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0016340
 Compound Info 
2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[(3R,6S,7R,10S,16S)-7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide
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C62H86N12O16
  1
1
IC50 = 5000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0373341
 Compound Info 
2-amino-1-N,9-N-bis[(3R,6S,7R,10S,16S)-3-[(2R)-butan-2-yl]-7,14-dimethyl-2,5,9,12,15-pentaoxo-10-propan-2-yl-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]-4,6-dimethyl-3-oxophenoxazine-1,9-dicarboxamide
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C62H86N12O16
  1
1
IC50 = 5900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0516282
 Compound Info 
2-amino-1-N,9-N-bis[(3R,6S,7R,10R,16S)-3,10-bis[(2R)-butan-2-yl]-7,14-dimethyl-2,5,9,12,15-pentaoxo-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]-4,6-dimethyl-3-oxophenoxazine-1,9-dicarboxamide
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C64H90N12O16
  1
1
IC50 = 7600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT01812 Growth factor receptor-bound protein 2 Homo sapiens, Human
 Protein Info