General Information of the Compound
Compound ID
CP0016340
Compound Name
2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[(3R,6S,7R,10S,16S)-7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide
    Show/Hide
Synonyms
1H-Pyrrolo(2,1-1)-(1,4,7,10,13)oxatetraazacyclohexadecine
4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide
ACT D
ACTINOMYCIN D AMP
AD (VAN)
Actactinomycin A IV
Actinomycin 11 cosmegen
Actinomycin 7
Actinomycin A IV
Actinomycin Aiv
Actinomycin C (sub1)
Actinomycin C(sub1)
Actinomycin C1
Actinomycin D (JP15)
Actinomycin D deriv. of 3H-phenoxaocardazine
Actinomycin D, sodium deoxyribonucleic acid complex
Actinomycin I
Actinomycin I (sub1)
Actinomycin I(sub 1)
Actinomycin I(sub1)
Actinomycin I1
Actinomycin IV
Actinomycin X 1
Actinomycin X1
Actinomycin cl
Actinomycin x i
Actinomycin-(threo-val-pro-sar-meval)
Actinomycin-IV
Actinomycin-[threo-val-pro-sar-meval]
Actinomycindioic D acid, dilactone
Actinomyein-theo-val-pro-sar-meval
Acto-D
Antibiotic from Streptomyces parvullus
COSMEGEN (TN)
Chounghwamycin B
Cosmegen
D Actinomycin
DVA-DPR-SAR-MVA-(c1)DTH-PXZ-(c11)DTH-DVA-DPR-SAR-MVA
Dactinomicina
Dactinomicina [INN-Spanish]
Dactinomycin
Dactinomycin (USP)
Dactinomycin D
Dactinomycin [USAN:BAN]
Dactinomycine
Dactinomycine [INN-French]
Dactinomycinum
Dactinomycinum [INN-Latin]
Dactinomyein d
Dilactone actin omycindioic D acid
Dilactone actinomycin D acid
Dilactone actinomycindioic D acid
GNF-PF-1977
HBF 386
HBF 386 meractinomycin
Lyovac cosmegen
Meractinomycin
NP-005932
O)-(1-oxo-1,2-ethanediyl)]bis(N-methyl)L-valine
Oncostatin K
PXZ-THR-DVA-PRO-SAR-MVA-THR-DVA-PRO-SAR-MVA
X 97
    Show/Hide
Structure
Formula
C62H86N12O16
Molecular Weight
1255.438
Canonical SMILES
CC(C)[C@H]1NC(=O)[C@@H](NC(=O)c2ccc(C)c3oc4c(C)c(=O)c(N)c(C(=O)N[C@H]5[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]6CCCN6C(=O)[C@H](NC5=O)C(C)C)c4nc23)[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C1=O
    Show/Hide
InChI
InChI=1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)/t33-,34-,36+,37+,42-,43-,44+,45+,48+,49+/m1/s1
    Show/Hide
InChIKey
RJURFGZVJUQBHK-IIXSONLDSA-N
CAS
50-76-0
Physicochemical Property
logP
0.72564
Rotatable Bonds
8
Heavy Atom Count
90
Polar Areas
359.98
Hydrogen Bond Donor Count
5
Hydrogen Bond Acceptor Count
18
Complexity
90

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 457193
SID: 15015952
ChEMBL ID
CHEMBL1554
DrugBank ID
DB00970
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT06067, Growth factor receptor-bound protein 2
 Protein Info 
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000279 B104-1-1
 Cell Line Info 
Mus musculus (Mouse)  1
1
IC50 = 5000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( Dactinomycin )
Drug Name Dactinomycin
Indication
Solid tumour/cancer
Approved