Brief Information of the Cell Line and Protein
Cell Line ID: CL000243 , MCF-10A
Synonyms
MCF 10A
MCF.10A
MCF10A
MCF10-A
MCF10a
MCF-10 Attached
Michigan Cancer Foundation-10A
Category Spontaneously immortalized cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0598
Protein ID: PT00934 , High affinity nerve growth factor receptor
Gene Name NTRK1
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID P04629
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000243  Protein ID: PT00934
 
Compound ID Compound Name Compound Formula
CP0106653
5-chloro-2-N-[(1S)-1-(5-fluoropyridin-2-yl)ethyl]-4-N-(3-propan-2-yloxy-1H-pyrazol-5-yl)pyrimidine-2,4-diamine
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C17H19ClFN7O
 1
1
EC50 = 1 nM
   TI
   LI
   LO
   TS
CP0922794
(R)-3-(5-Chloro-2-((S)-1-(5-fluoropyridin-2-yl)ethylamino)-6-(5-isopropoxy-1H-pyrazol-3-ylamino)pyrimidin-4-ylamino)propane-1,2-diol
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C20H26ClFN8O3
 1
1
EC50 = 1 nM
   TI
   LI
   LO
   TS
CP0922795
5-chloro-4-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-N-[(1S)-1-(5-fluoropyridin-2-yl)ethyl]pyrimidine-2,4-diamine
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C17H17ClFN7
 1
1
EC50 = 1 nM
   TI
   LI
   LO
   TS
CP0922793
5-chloro-2-N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-4-N-(3-propan-2-yloxy-1H-pyrazol-5-yl)pyrimidine-2,4-diamine
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C16H18ClFN8O
 1
1
EC50 = 2 nM
   TI
   LI
   LO
   TS
CP0926220
2-[5-chloro-2-[[(1S)-1-(5-fluoropyridin-2-yl)ethyl]amino]-6-[(3-propan-2-yloxy-1H-pyrazol-5-yl)amino]pyrimidin-4-yl]oxypropane-1,3-diol
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C20H25ClFN7O4
 1
1
EC50 = 2 nM
   TI
   LI
   LO
   TS
CP0845503
2-[[5-Chloro-6-[(5-cyclopropyl-2H-pyrazol-3-yl)amino]-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]pyrimidin-4-yl]amino]ethanol
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C20H23ClFN7O
 1
1
EC50 = 3 nM
   TI
   LI
   LO
   TS
CP0955240
2-[[5-Chloro-6-[(5-cyclopropyl-2H-pyrazol-3-yl)amino]-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]pyrimidin-4-yl]amino]propane-1,3-diol
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C21H25ClFN7O2
 1
1
EC50 = 3 nM
   TI
   LI
   LO
   TS
CP0372588
(2R)-2-({5-chloro-4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)-2-(4-fluorophenyl)ethan-1-ol
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C18H18ClFN6O
 1
1
EC50 = 4 nM
   TI
   LI
   LO
   TS
CP0916689
2-[[5-chloro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(3-propan-2-yloxy-1H-pyrazol-5-yl)amino]pyrimidin-4-yl]amino]propane-1,3-diol
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C21H27ClFN7O3
 1
1
EC50 = 4 nM
   TI
   LI
   LO
   TS
CP0423298
4-aminopyrazolylpyrimidine analogue, 10k
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C18H18BrFN6
 1
1
EC50 = 6 nM
   TI
   LI
   LO
   TS
CP0926222
5-Chloro-N-[(1S)-1-(4-fluorophenyl)ethyl]-N'-(5-propan-2-yloxy-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
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C18H20ClFN6O
 1
1
EC50 = 6 nM
   TI
   LI
   LO
   TS
CP0913323
4-N-(5-cyclopropyl-1H-pyrazol-3-yl)-5-fluoro-2-N-[(1S)-1-(5-fluoropyridin-2-yl)ethyl]pyrimidine-2,4-diamine
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C17H17F2N7
 1
1
EC50 = 7 nM
   TI
   LI
   LO
   TS
CP0913329
(2R)-3-[[5-chloro-6-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]pyrimidin-4-yl]amino]propane-1,2-diol
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C21H25ClFN7O2
 1
1
EC50 = 9 nM
   TI
   LI
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   TS
CP0917230
N'-(5-Cyclopropyl-2H-pyrazol-3-yl)-N-[(1S)-1-(4-fluorophenyl-)ethyl]-5-methylpyrimidine-2,4-diamine
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C19H21FN6
 1
1
EC50 = 10 nM
   TI
   LI
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CP0922791
(2R)-2-({5-Chloro-4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]-6-[(2-morpholin-4-ylethyl)amino] pyrimidin-2-yl}amino)-2-(4-fluorophenyl)ethanol
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C24H30ClFN8O2
 1
1
EC50 = 12 nM
   TI
   LI
   LO
   TS
CP0955241
N'-(5-Cyclopropyl-2H-pyrazol-3-yl)-5-fluoro-N-[(1S)-1-(4-fluorophenyl)ethyl]pyrimidine-2,4-diamine
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C18H18F2N6
 1
1
EC50 = 17 nM
   TI
   LI
   LO
   TS
CP0926480
(S)-N4-(3-cyclopropyl-1H-pyrazol-5-yl)-N2-(1-(4-fluorophenyl)ethyl)pyrimidine-2,4-diamine
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C18H19FN6
 1
1
EC50 = 20 nM
   TI
   LI
   LO
   TS
CP0932614
(2R)-3-[[6-[(5-Cyclopropyl-1H-pyrazol-3-yl)amino]-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]pyrimidin-4-yl]amino]propane-1,2-diol
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C21H26FN7O2
 1
1
EC50 = 24 nM
   TI
   LI
   LO
   TS
CP0922792
(2R)-2-[[5-Chloro-4-[(5-methylsulfanyl-2H-pyrazol-3-yl)amino]pyrimidin-2-yl]amino]-2-(4-fluorophenyl)ethanol
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C16H16ClFN6OS
 1
1
EC50 = 36 nM
   TI
   LI
   LO
   TS
CP0926481
(2R)-3-[[2-[[(1S)-1-(4-Fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-4-yl]amino]propane-1,2-diol
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C19H24FN7O2
 1
1
EC50 = 60 nM
   TI
   LI
   LO
   TS
CP0904493
5-chloro-2-N-[(1S)-1-(4-fluorophenyl)ethyl]-4-N-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
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C16H16ClFN6
 1
1
EC50 = 81 nM
   TI
   LI
   LO
   TS
CP0932613
(2R)-2-[[5-Chloro-4-[(5-propoxy-2H-pyrazol-3-yl)amino]pyrimidin-2-yl]amino]-2-(4-fluorophenyl)ethanol
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C18H20ClFN6O2
 1
1
EC50 = 280 nM
   TI
   LI
   LO
   TS
CP0913328
(2R)-2-[[5-Chloro-4-(2H-pyrazol-3-ylamino)pyrimidin-2-yl]amino]-2-(4-fluorophenyl)ethanol
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C15H14ClFN6O
 1
1
EC50 = 1500 nM
   TI
   LI
   LO
   TS
CP0916690
N'-(5-tert-Butyl-1H-pyrazol-3-yl)-5-chloro-N-[(1S)-1-(4-fluorophenyl)ethyl]pyrimidine-2,4-diamine
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C19H22ClFN6
 1
1
EC50 = 3000 nM
   TI
   LI
   LO
   TS