General Information of the Compound
Compound ID
CP0916690
Compound Name
N'-(5-tert-Butyl-1H-pyrazol-3-yl)-5-chloro-N-[(1S)-1-(4-fluorophenyl)ethyl]pyrimidine-2,4-diamine
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Structure
Formula
C19H22ClFN6
Molecular Weight
388.878
Canonical SMILES
C[C@H](Nc1ncc(Cl)c(Nc2cc(C(C)(C)C)[nH]n2)n1)c1ccc(F)cc1
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InChI
InChI=1S/C19H22ClFN6/c1-11(12-5-7-13(21)8-6-12)23-18-22-10-14(20)17(25-18)24-16-9-15(26-27-16)19(2,3)4/h5-11H,1-4H3,(H3,22,23,24,25,26,27)/t11-/m0/s1
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InChIKey
NLHJVAVGCUYPTA-NSHDSACASA-N
Physicochemical Property
logP
5.2064
Rotatable Bonds
5
Heavy Atom Count
27
Polar Areas
78.52
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
5
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 24949243
SID: 56247017
ChEMBL ID
CHEMBL456996
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00934, High affinity nerve growth factor receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000243 MCF-10A Homo sapiens (Human)  1
1
EC50 = 3000 nM
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