General Information of the Compound
Compound ID
CP0926480
Compound Name
(S)-N4-(3-cyclopropyl-1H-pyrazol-5-yl)-N2-(1-(4-fluorophenyl)ethyl)pyrimidine-2,4-diamine
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Structure
Formula
C18H19FN6
Molecular Weight
338.39
Canonical SMILES
C[C@H](Nc1nccc(Nc2cc(C3CC3)[nH]n2)n1)c1ccc(F)cc1
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InChI
InChI=1S/C18H19FN6/c1-11(12-4-6-14(19)7-5-12)21-18-20-9-8-16(23-18)22-17-10-15(24-25-17)13-2-3-13/h4-11,13H,2-3H2,1H3,(H3,20,21,22,23,24,25)/t11-/m0/s1
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InChIKey
HUUNMUHHQRBGBT-NSHDSACASA-N
Physicochemical Property
logP
4.1329
Rotatable Bonds
6
Heavy Atom Count
25
Polar Areas
78.52
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
5
Complexity
25

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 24949402
SID: 56247184
ChEMBL ID
CHEMBL456986
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00934, High affinity nerve growth factor receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000243 MCF-10A Homo sapiens (Human)  1
1
EC50 = 20 nM
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