General Information of the Compound
Compound ID
CP0913328
Compound Name
(2R)-2-[[5-Chloro-4-(2H-pyrazol-3-ylamino)pyrimidin-2-yl]amino]-2-(4-fluorophenyl)ethanol
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Structure
Formula
C15H14ClFN6O
Molecular Weight
348.769
Canonical SMILES
OC[C@H](Nc1ncc(Cl)c(Nc2cc[nH]n2)n1)c1ccc(F)cc1
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InChI
InChI=1S/C15H14ClFN6O/c16-11-7-18-15(22-14(11)21-13-5-6-19-23-13)20-12(8-24)9-1-3-10(17)4-2-9/h1-7,12,24H,8H2,(H3,18,19,20,21,22,23)/t12-/m0/s1
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InChIKey
HNQOAQHKRHXPNW-LBPRGKRZSA-N
Physicochemical Property
logP
2.8813
Rotatable Bonds
6
Heavy Atom Count
24
Polar Areas
98.75
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
6
Complexity
24

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 24949551
SID: 56247333
ChEMBL ID
CHEMBL456153
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00934, High affinity nerve growth factor receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000243 MCF-10A Homo sapiens (Human)  1
1
EC50 = 1500 nM
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