General Information of the Compound
Compound ID
CP0326564
Compound Name
5-[[(1S)-1-(6-chloro-7-methoxy-2-oxo-1H-quinolin-3-yl)ethyl]amino]-1-methyl-6-oxopyridine-2-carbonitrile
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Structure
Formula
C19H17ClN4O3
Molecular Weight
384.823
Canonical SMILES
COc1cc2[nH]c(=O)c(cc2cc1Cl)[C@H](C)Nc1ccc(C#N)n(C)c1=O
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InChI
InChI=1S/C19H17ClN4O3/c1-10(22-15-5-4-12(9-21)24(2)19(15)26)13-6-11-7-14(20)17(27-3)8-16(11)23-18(13)25/h4-8,10,22H,1-3H3,(H,23,25)/t10-/m0/s1
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InChIKey
NSSCFMGYDFCYNL-JTQLQIEISA-N
Physicochemical Property
logP
2.93358
Rotatable Bonds
4
Heavy Atom Count
27
Polar Areas
99.91
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118955424
ChEMBL ID
CHEMBL4437754
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02997, Isocitrate dehydrogenase [NADP] cytoplasmic
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000067 HCT 116 Homo sapiens (Human)  2
1
IC50 = 4 nM
   TI
   LI
   LO
   TS
2
IC50 = 14 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 11 nM
2 IC50 = 40 nM