General Information of the Compound
Compound ID
CP0451334
Compound Name
2-[Benzo[1,3]dioxol-5-ylmethyl-((R)-4-methoxy-benzenesulfonyl)-amino]-N-hydroxy-3-(3-nitro-phenylmethanesulfonylamino)-propionamide
    Show/Hide
Structure
Formula
C25H26N4O11S2
Molecular Weight
622.634
Canonical SMILES
COc1ccc(cc1)S(=O)(=O)N(Cc1ccc2OCOc2c1)[C@H](CNS(=O)(=O)Cc1cccc(c1)[N+]([O-])=O)C(=O)NO
    Show/Hide
InChI
InChI=1S/C25H26N4O11S2/c1-38-20-6-8-21(9-7-20)42(36,37)28(14-17-5-10-23-24(12-17)40-16-39-23)22(25(30)27-31)13-26-41(34,35)15-18-3-2-4-19(11-18)29(32)33/h2-12,22,26,31H,13-16H2,1H3,(H,27,30)/t22-/m1/s1
    Show/Hide
InChIKey
QBLWHVMKEVMUMG-JOCHJYFZSA-N
Physicochemical Property
logP
1.5166
Rotatable Bonds
13
Heavy Atom Count
42
Polar Areas
203.71
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
11
Complexity
42

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 44306387
ChEMBL ID
CHEMBL265069
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01896, Bone morphogenetic protein 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000156 HT-1080 Homo sapiens (Human)  1
1
Ki = 28 nM
   TI
   LI
   LO
   TS