General Information of the Protein
Protein ID
PT01896
Protein Name
Bone morphogenetic protein 1
Secondarily
Protein Name
Mammalian tolloid protein
Procollagen C-proteinase
Gene Name
BMP1
Secondarily
Gene Name
PCOLC
Sequence
MPGVARLPLLLGLLLLPRPGRPLDLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDEEDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRGRSRSRRAATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVRENIQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFHLRYTSTKFQDTLHSRK
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Protease
>
Metallo protease
>
Metallo protease MAM clan
>
Metallo protease M12A subfamily
Function
Metalloprotease that plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins (PubMed:33206546). Thereby participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis, wound healing and tissue repair (PubMed:33169406, PubMed:32636307). Roles in ECM formation include cleavage of the C-terminal propeptides from procollagens such as procollagen I, II and III or the proteolytic activation of the enzyme lysyl oxidase LOX, necessary to formation of covalent cross-links in collagen and elastic fibers (PubMed:31152061, PubMed:33206546). Additional substrates include matricellular thrombospondin-1/THBS1 whose cleavage leads to cell adhesion disruption and TGF-beta activation (PubMed:32636307).
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Uniprot ID
Primary ID:
P13497

Secondarily ID:
A8K6F5
B2RN46
D3DSR0
Q13292
Q13872
Q14874
Q99421
Q99422
Q99423
Q9UL38
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Ensembl ID
ENSG00000168487
HGNC ID
HGNC:1067
Subcellular Location
Golgi apparatus
Trans-Golgi network
Secreted
Extracellular space
Extracellular matrix
Secreted
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0104223
 Compound Info 
[3-ethoxy-5-[5-[[[(2R)-2-[(1R)-1-[formyl(hydroxy)amino]propyl]heptanoyl]amino]methylcarbamoyl]furan-2-yl]phenyl]phosphonic acid
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C25H36N3O9P
  1
1
IC50 < 1 nM
 Bioactivity Info 
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CP0126696
 Compound Info 
(2S)-2-[[2-ethoxy-4-[5-[[[(2R)-2-[(1R)-1-[formyl(hydroxy)amino]propyl]heptanoyl]amino]methylcarbamoyl]furan-2-yl]benzoyl]amino]butanedioic acid
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C30H40N4O11
  1
1
IC50 < 1 nM
 Bioactivity Info 
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CP0392436
 Compound Info 
(2S)-2-[[3-ethoxy-5-[5-[[[(2R)-2-[(1R)-1-[formyl(hydroxy)amino]propyl]heptanoyl]amino]methylcarbamoyl]furan-2-yl]benzoyl]amino]butanedioic acid
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C30H40N4O11
  1
1
IC50 < 1 nM
 Bioactivity Info 
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CP0413964
 Compound Info 
2-ethoxy-4-[5-[[[(2R)-2-[(1R)-1-[formyl(hydroxy)amino]propyl]heptanoyl]amino]methylcarbamoyl]furan-2-yl]benzoic acid
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C26H35N3O8
  1
1
IC50 < 1 nM
 Bioactivity Info 
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CP0446430
 Compound Info 
5-(3-ethoxyphenyl)-N-[[[(2R)-2-[[formyl(hydroxy)amino]methyl]heptanoyl]amino]methyl]furan-2-carboxamide
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C23H31N3O6
  1
1
IC50 = 1 nM
 Bioactivity Info 
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CP0446432
 Compound Info 
4-[5-[[[(2R)-2-[[formyl(hydroxy)amino]methyl]heptanoyl]amino]methylcarbamoyl]furan-2-yl]benzoic acid
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C22H27N3O7
  1
1
IC50 = 1 nM
 Bioactivity Info 
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CP0468823
 Compound Info 
3-ethoxy-5-[5-[[[(2R)-2-[(1R)-1-[formyl(hydroxy)amino]propyl]heptanoyl]amino]methylcarbamoyl]furan-2-yl]benzoic acid
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C26H35N3O8
  1
1
IC50 < 1 nM
 Bioactivity Info 
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CP0472937
 Compound Info 
[2-ethoxy-4-[5-[[[(2R)-2-[(1R)-1-[formyl(hydroxy)amino]propyl]heptanoyl]amino]methylcarbamoyl]furan-2-yl]phenyl]phosphonic acid
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C25H36N3O9P
  1
1
IC50 < 1 nM
 Bioactivity Info 
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CP0467262
 Compound Info 
(3R)-6-cyclohexyl-3-[3-({[(3,4-dimethoxyphenyl)sulfonyl]-amino}carbonyl)-1,2,4-oxadiazol-5-yl]-N-hydroxyhexanamide
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C23H32N4O8S
  1
1
IC50 = 1.8 nM
 Bioactivity Info 
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CP0444379
 Compound Info 
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(4-pyridinyl)-1,2,4-oxadiazol-5-yl]hexanamide
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C19H26N4O3
  1
1
IC50 = 2 nM
 Bioactivity Info 
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CP0145177
 Compound Info 
(3R)-6-cyclohexyl-N-hydroxy-3-{3-[1-(methylsulfonyl)-4-piperidinyl]-1,2,4-oxadiazol-5-yl}hexanamide
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C21H37N5O5S
  1
1
IC50 = 3 nM
 Bioactivity Info 
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CP0427386
 Compound Info 
(3R)-3-(3-{[acetyl(methyl)amino]methyl}-1,2,4-oxadiazol-5-yl)-6-cyclohexyl-Nhydroxyhexanamide
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C18H30N4O4
  1
1
IC50 = 3 nM
 Bioactivity Info 
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CP0439783
 Compound Info 
(3R)-6-cyclohexyl-N-hydroxy-3-(3-{4-[(methylsulfonyl)amino]phenyl}-1,2,4-oxadiazol-5-yl)hexanamide
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C21H30N4O5S
  1
1
IC50 = 3 nM
 Bioactivity Info 
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CP0528617
 Compound Info 
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(4-morpholinylmethyl)-1,2,4-oxadiazol-5-yl]hexanamide
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C19H32N4O4
  1
1
IC50 = 5 nM
 Bioactivity Info 
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CP0052404
 Compound Info 
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(3-pyridinylmethyl)-1,2,4-oxadiazol-5-yl]hexanamide
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C20H28N4O3
  1
1
IC50 = 6 nM
 Bioactivity Info 
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CP0052406
 Compound Info 
2-(5-{(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl}-1,2,4-oxadiazol-3-yl)isonicotinic acid
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C20H26N4O5
  1
1
IC50 = 6 nM
 Bioactivity Info 
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CP0379094
 Compound Info 
(3R)-3-{3-[(cyclobutylamino)methyl]-1,2,4-oxadiazol-5-yl}-6-cyclohexyl-Nhydroxyhexanamide
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C19H32N4O3
  1
1
IC50 = 6 nM
 Bioactivity Info 
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CP0379100
 Compound Info 
3-(5-{(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl}-1,2,4-oxadiazol-3-yl)benzoic acid
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C21H27N3O5
  1
1
IC50 = 6 nM
 Bioactivity Info 
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CP0501053
 Compound Info 
(3R)-6-cyclohexyl-3-{3-[(cyclopropylamino)methyl]-1,2,4-oxadiazol-5-yl}-Nhydroxyhexanamide
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C18H30N4O3
  1
1
IC50 = 6 nM
 Bioactivity Info 
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CP0528618
 Compound Info 
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(2-pyridinylmethyl)-1,2,4-oxadiazol-5-yl]hexanamide
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C20H28N4O3
  1
1
IC50 = 6 nM
 Bioactivity Info 
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CP0052405
 Compound Info 
(3R)-6-cyclohexyl-N-hydroxy-3-(3-{[(phenylsulfonyl)amino]carbonyl}-1,2,4-oxadiazol-5-yl)hexanamide
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C21H28N4O6S
  1
1
IC50 = 7 nM
 Bioactivity Info 
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CP0052401
 Compound Info 
(3R)-6-cyclohexyl-N-hydroxy-3-(3-{[(2-hydroxy-1,1-dimethylethyl)amino]methyl}-1,2,4-oxadiazol-5-yl)hexanamide
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C19H34N4O4
  1
1
IC50 = 8 nM
 Bioactivity Info 
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CP0427387
 Compound Info 
(3R)-6-cyclohexyl-N-hydroxy-3-{3-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]-1,2,4-oxadiazol-5-yl}hexanamide
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C19H33N5O3
  1
1
IC50 = 8 nM
 Bioactivity Info 
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CP0446431
 Compound Info 
3-[5-[[[(2R)-2-[[formyl(hydroxy)amino]methyl]heptanoyl]amino]methylcarbamoyl]furan-2-yl]benzoic acid
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C22H27N3O7
  1
1
IC50 = 8 nM
 Bioactivity Info 
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CP0128115
 Compound Info 
(R)-5-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-N,N-dimethyl-1,2,4-oxadiazole-3-carboxamide
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C17H28N4O4
  1
1
IC50 = 10 nM
 Bioactivity Info 
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CP0052400
 Compound Info 
(3R)-6-cyclohexyl-3-[3-(2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)-1,2,4-oxadiazol-5-yl]-N-hydroxyhexanamide
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C18H25N5O5
  1
1
IC50 = 10 nM
 Bioactivity Info 
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CP0427191
 Compound Info 
(3R)-3-{3-[(tert-butylamino)methyl]-1,2,4-oxadiazol-5-yl}-6-cyclohexyl-Nhydroxyhexanamide
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C19H34N4O3
  1
1
IC50 = 10 nM
 Bioactivity Info 
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CP0052399
 Compound Info 
(3R)-6-cyclohexyl-N-hydroxy-3-(3-{[(methylsulfonyl)amino]-methyl}-1,2,4-oxadiazol-5-yl)hexanamide
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C16H28N4O5S
  1
1
IC50 = 11 nM
 Bioactivity Info 
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CP0439782
 Compound Info 
(3R)-6-cyclohexyl-N-hydroxy-3-{3-[6-(methylamino)-3-pyridinyl]-1,2,4-oxadiazol-5-yl}hexanamide
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C20H29N5O3
  1
1
IC50 = 13 nM
 Bioactivity Info 
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CP0444377
 Compound Info 
(3R)-6-cyclohexyl-N-hydroxy-3-{3-[(4-hydroxy-1-piperidinyl)methyl]-1,2,4-oxadiazol-5-yl}hexanamide
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C20H34N4O4
  1
1
IC50 = 13 nM
 Bioactivity Info 
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CP0379099
 Compound Info 
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(5-pyrimidinyl)-1,2,4-oxadiazol-5-yl]hexanamide
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C18H25N5O3
  1
1
IC50 = 14 nM
 Bioactivity Info 
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CP0428682
 Compound Info 
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(2-pyrazinyl)-1,2,4-oxadiazol-5-yl]hexanamide
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C18H25N5O3
  1
1
IC50 = 14 nM
 Bioactivity Info 
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CP0554272
 Compound Info 
(3R)-6-cyclohexyl-N-hydroxy-3-[3-({[(4-methylphenyl)sulfonyl]amino}-carbonyl)-1,2,4-oxadiazol-5-yl]hexanamide
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C22H30N4O6S
  1
1
IC50 = 14 nM
 Bioactivity Info 
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CP0532158
 Compound Info 
(3R)-6-cyclohexyl-3-[3-(1,1-dioxido-2-isothiazolidinyl)-1,2,4-oxadiazol-5-yl]-Nhydroxyhexanamide
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C18H30N4O5S
  1
1
IC50 = 15 nM
 Bioactivity Info 
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CP0508884
 Compound Info 
(R)-2-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-5-methyloxazole-4-carboxamide
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C17H27N3O4
  1
1
IC50 = 17 nM
 Bioactivity Info 
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CP0521462
 Compound Info 
(R)-2-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-N,N,5-trimethyloxazole-4-carboxamide
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C19H31N3O4
  1
1
IC50 = 17 nM
 Bioactivity Info 
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CP0460078
 Compound Info 
5-(5-{(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl}-1,2,4-oxadiazol-3-yl)nicotinic acid
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C20H26N4O5
  1
1
IC50 = 17 nM
 Bioactivity Info 
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CP0462758
 Compound Info 
2-(5-{(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl}-1,2,4-oxadiazol-3-yl)isonicotinamide
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C20H27N5O4
  1
1
IC50 = 17 nM
 Bioactivity Info 
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CP0528619
 Compound Info 
2-(5-{(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl}-1,2,4-oxadiazol-3-yl)-N,N-dimethylisonicotinamide
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C22H31N5O4
  1
1
IC50 = 17 nM
 Bioactivity Info 
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CP0554270
 Compound Info 
(3R)-6-cyclohexyl-N-hydroxy-3-[3-({[(4-methoxyphenyl)sulfonyl]amino}carbonyl)-1,2,4-oxadiazol-5-yl]hexanamide
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C22H30N4O7S
  1
1
IC50 = 17 nM
 Bioactivity Info 
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CP0379098
 Compound Info 
(3R)-3-[3-(6-amino-3-pyridinyl)-1,2,4-oxadiazol-5-yl]-6-cyclohexyl-Nhydroxyhexanamide
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C19H27N5O3
  1
1
IC50 = 18 nM
 Bioactivity Info 
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CP0379093
 Compound Info 
(3R)-3-{3-[(acetylamino)methyl]-1,2,4-oxadiazol-5-yl}-6-cyclohexyl-Nhydroxyhexanamide
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C17H28N4O4
  1
1
IC50 = 19 nM
 Bioactivity Info 
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CP0554275
 Compound Info 
(3R)-6-cyclohexyl-N-hydroxy-3-(3-{2-[(methylsulfonyl)amino]ethyl}-1,2,4-oxadiazol-5-yl)hexanamide
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C18H33N5O5S
  1
1
IC50 = 20 nM
 Bioactivity Info 
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CP0417140
 Compound Info 
N-[[[(2R)-2-[[formyl(hydroxy)amino]methyl]heptanoyl]amino]methyl]-5-(3-methoxyphenyl)furan-2-carboxamide
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C22H29N3O6
  1
1
IC50 = 20 nM
 Bioactivity Info 
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CP0235360
 Compound Info 
(R)-5-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-N-isopropyl-1,2,4-oxadiazole-3-carboxamide
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C18H30N4O4
  1
1
IC50 = 21 nM
 Bioactivity Info 
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CP0502181
 Compound Info 
(R)-2-(5-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-1,2,4-oxadiazole-3-carboxamido)acetic acid
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C17H26N4O6
  1
1
IC50 = 21 nM
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CP0427192
 Compound Info 
(3R)-6-cyclohexyl-3-{3-[(ethylamino)methyl]-1,2,4-oxadiazol-5-yl}-Nhydroxyhexanamide
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C17H30N4O3
  1
1
IC50 = 21 nM
 Bioactivity Info 
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CP0509507
 Compound Info 
(3R)-6-cyclohexyl-N-hydroxy-3-(3-{[(isopropylsulfonyl)amino]methyl}-1,2,4-oxadiazol-5-yl)hexanamide
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C18H32N4O5S
  1
1
IC50 = 21 nM
 Bioactivity Info 
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CP0379095
 Compound Info 
(3R)-6-cyclohexyl-N-hydroxy-3-{3-[(methylamino)methyl]-1,2,4-oxadiazol-5-yl}hexanamide
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C16H28N4O3
  1
1
IC50 = 23 nM
 Bioactivity Info 
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CP0427388
 Compound Info 
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(2-pyrimidinyl)-1,2,4-oxadiazol-5-yl]hexanamide
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C18H25N5O3
  1
1
IC50 = 23 nM
 Bioactivity Info 
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CP0444380
 Compound Info 
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(3-pyridinyl)-1,2,4-oxadiazol-5-yl]hexanamide
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C19H26N4O3
  1
1
IC50 = 23 nM
 Bioactivity Info 
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CP0460077
 Compound Info 
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(1-pyrrolidinylmethyl)-1,2,4-oxadiazol-5-yl]hexanamide
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C19H32N4O3
  1
1
IC50 = 24 nM
 Bioactivity Info 
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CP0130693
 Compound Info 
(R)-6-cyclohexyl-N-hydroxy-3-(3-(morpholine-4-carbonyl)-1,2,4-oxadiazol-5-yl)hexanamide
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C19H30N4O5
  1
1
IC50 = 25 nM
 Bioactivity Info 
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CP0511168
 Compound Info 
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(2-pyridinyl)-1,2,4-oxadiazol-5-yl]hexanamide
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C19H26N4O3
  1
1
IC50 = 25 nM
 Bioactivity Info 
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CP0487911
 Compound Info 
N-[[[(2R)-2-[[formyl(hydroxy)amino]methyl]heptanoyl]amino]methyl]-5-phenylfuran-2-carboxamide
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C21H27N3O5
  1
1
IC50 = 25 nM
 Bioactivity Info 
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CP0203299
 Compound Info 
(R)-6-cyclohexyl-N-hydroxy-3-(3-(piperidine-1-carbonyl)-1,2,4-oxadiazol-5-yl)hexanamide
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C20H32N4O4
  1
1
IC50 = 26 nM
 Bioactivity Info 
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CP0427189
 Compound Info 
(3R)-6-cyclohexyl-N-hydroxy-3-(3-{[(phenylsulfonyl)amino]methyl}-1,2,4-oxadiazol-5-yl)hexanamide
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C21H30N4O5S
  1
1
IC50 = 26 nM
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CP0467263
 Compound Info 
(3R)-6-cyclohexyl-3-(3-{[(ethylsulfonyl)amino]methyl}-1,2,4-oxadiazol-5-yl)-Nhydroxyhexanamide
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C17H30N4O5S
  1
1
IC50 = 26 nM
 Bioactivity Info 
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CP0532159
 Compound Info 
(3R)-6-cyclohexyl-N-hydroxy-3-(3-{[(3-pyridinylsulfonyl)amino]methyl}-1,2,4-oxadiazol-5-yl)hexanamide
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C20H29N5O5S
  1
1
IC50 = 26 nM
 Bioactivity Info 
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CP0444378
 Compound Info 
(3R)-6-cyclohexyl-N-hydroxy-3-(3-{6-[(methylsulfonyl)amino]-3-pyridinyl}-1,2,4-oxadiazol-5-yl)hexanamide
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C15H26N4O5S
  1
1
IC50 = 27 nM
 Bioactivity Info 
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CP0091027
 Compound Info 
(R)-5-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-N-methyl-1,2,4-oxadiazole-3-carboxamide
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C16H26N4O4
  1
1
IC50 = 28 nM
 Bioactivity Info 
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CP0379096
 Compound Info 
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(4-pyridinylmethyl)-1,2,4-oxadiazol-5-yl]hexanamide
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C20H28N4O3
  1
1
IC50 = 28 nM
 Bioactivity Info 
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CP0501061
 Compound Info 
(3R)-6-cyclohexyl-3-{3-[6-(dimethylamino)-3-pyridinyl]-1,2,4-oxadiazol-5-yl}-Nhydroxyhexanamide
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C21H31N5O3
  1
1
IC50 = 28 nM
 Bioactivity Info 
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CP0532161
 Compound Info 
(3R)-6-cyclohexyl-N-hydroxy-3-{3-[(isopropylamino)methyl]-1,2,4-oxadiazol-5-yl}hexanamide
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C18H32N4O3
  1
1
IC50 = 29 nM
 Bioactivity Info 
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CP0427530
 Compound Info 
2-(5-{(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl}-1,2,4-oxadiazol-3-yl)-N-methylisonicotinamide
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C21H29N5O4
  1
1
IC50 = 30 nM
 Bioactivity Info 
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CP0528620
 Compound Info 
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(6-methyl-3-pyridazinyl)-1,2,4-oxadiazol-5-yl]hexanamide
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C19H27N5O3
  1
1
IC50 = 30 nM
 Bioactivity Info 
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CP0509494
 Compound Info 
(3R)-6-cyclohexyl-3-{3-[(dimethylamino)methyl]-1,2,4-oxadiazol-5-yl}-Nhydroxyhexanamide
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C17H30N4O3
  1
1
IC50 = 31 nM
 Bioactivity Info 
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CP0274383
 Compound Info 
(R)-5-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-N-propyl-1,2,4-oxadiazole-3-carboxamide
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C18H30N4O4
  1
1
IC50 = 32 nM
 Bioactivity Info 
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CP0379102
 Compound Info 
4-(5-{(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl}-1,2,4-oxadiazol-3-yl)benzoic acid
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C21H27N3O5
  1
1
IC50 = 32 nM
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CP0417141
 Compound Info 
N-[[[(2R)-2-[(1R)-1-[formyl(hydroxy)amino]propyl]heptanoyl]amino]methyl]-5-phenylfuran-2-carboxamide
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C23H31N3O5
  1
1
IC50 = 32 nM
 Bioactivity Info 
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CP0329408
 Compound Info 
(R)-5-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-N-(cyclopropylmethyl)-1,2,4-oxadiazole-3-carboxamide
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C19H30N4O4
  1
1
IC50 = 33 nM
 Bioactivity Info 
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CP0464611
 Compound Info 
(3R)-6-cyclohexyl-3-[3-({[(4-fluorophenyl)sulfonyl]amino}carbonyl)-1,2,4-oxadiazol-5-yl]-N-hydroxyhexanamide
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C21H27FN4O6S
  1
1
IC50 = 33 nM
 Bioactivity Info 
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CP0052407
 Compound Info 
(R)-ethyl 5-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-1,2,4-oxadiazole-3-carboxylate
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C17H27N3O5
  1
1
IC50 = 36 nM
 Bioactivity Info 
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CP0329409
 Compound Info 
(R)-5-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-N-(pyridin-2-ylmethyl)-1,2,4-oxadiazole-3-carboxamide
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C21H29N5O4
  1
1
IC50 = 37 nM
 Bioactivity Info 
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CP0379092
 Compound Info 
(3R)-6-cyclohexyl-N-hydroxy-3-(3-{[methyl(methylsulfonyl)amino]methyl}-1,2,4-oxadiazol-5-yl)hexanamide
   Show/Hide
C17H30N4O5S
  1
1
IC50 = 38 nM
 Bioactivity Info 
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CP0427193
 Compound Info 
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(1H-pyrazol-4-yl)-1,2,4-oxadiazol-5-yl]hexanamide
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C17H25N5O3
  1
1
IC50 = 39 nM
 Bioactivity Info 
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CP0332992
 Compound Info 
(R)-5-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-N-methyl-N-(pyridin-2-ylmethyl)-1,2,4-oxadiazole-3-carboxamide
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C22H31N5O4
  1
1
IC50 = 40 nM
 Bioactivity Info 
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CP0324865
 Compound Info 
(R)-6-cyclohexyl-N-hydroxy-3-(3-(pyrrolidine-1-carbonyl)-1,2,4-oxadiazol-5-yl)hexanamide
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C19H30N4O4
  1
1
IC50 = 43 nM
 Bioactivity Info 
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CP0052398
 Compound Info 
(3R)-6-cyclohexyl-N-hydroxy-3-(1,2,4-oxadiazol-5-yl)hexanamide
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C15H24N4O4
  1
1
IC50 = 44 nM
 Bioactivity Info 
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CP0524369
 Compound Info 
(R)-2-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-N,N-dimethyloxazole-4-carboxamide
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C18H29N3O4
  1
1
IC50 = 45 nM
 Bioactivity Info 
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CP0462759
 Compound Info 
(3R)-6-cyclohexyl-3-[3-(2-furyl)-1,2,4-oxadiazol-5-yl]-N-hydroxyhexanamide
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C18H25N3O4
  1
1
IC50 = 46 nM
 Bioactivity Info 
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CP0296747
 Compound Info 
(R)-5-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-N-methyl-N-((4-methylpiperazin-1-yl)methyl)-1,2,4-oxadiazole-3-carboxamide
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C22H38N6O4
  1
1
IC50 = 54 nM
 Bioactivity Info 
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CP0311583
 Compound Info 
(R)-N-benzyl-5-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-1,2,4-oxadiazole-3-carboxamide
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C22H30N4O4
  1
1
IC50 = 57 nM
 Bioactivity Info 
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CP0467265
 Compound Info 
5-(5-{(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl}-1,2,4-oxadiazol-3-yl)-2-pyridinecarboxylic acid
   Show/Hide
C20H26N4O5
  1
1
IC50 = 59 nM
 Bioactivity Info 
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CP0274379
 Compound Info 
(R)-N-benzyl-5-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-N-methyl-1,2,4-oxadiazole-3-carboxamide
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C23H32N4O4
  1
1
IC50 = 65 nM
 Bioactivity Info 
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CP0514561
 Compound Info 
(R)-2-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)oxazole-4-carboxamide
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C16H25N3O4
  1
1
IC50 = 73 nM
 Bioactivity Info 
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CP0532163
 Compound Info 
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(1H-pyrazol-3-yl)-1,2,4-oxadiazol-5-yl]hexanamide
   Show/Hide
C17H25N5O3
  1
1
IC50 = 74 nM
 Bioactivity Info 
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CP0379101
 Compound Info 
(3R)-6-cyclohexyl-3-(3-{4-[(dimethylamino)sulfonyl]phenyl}-1,2,4-oxadiazol-5-yl)-Nhydroxyhexanamidehydroxyhexanamide
   Show/Hide
C21H30N4O5S
  1
1
IC50 = 75 nM
 Bioactivity Info 
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CP0428681
 Compound Info 
(3R)-6-cyclohexyl-N-hydroxy-3-(3-{[(1H-pyrazol-4-ylsulfonyl)amino]methyl}-1,2,4-oxadiazol-5-yl)hexanamide
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C18H28N6O5S
  1
1
IC50 = 88 nM
 Bioactivity Info 
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CP0532162
 Compound Info 
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(1-methyl-1H-imidazol-2-yl)-1,2,4-oxadiazol-5-yl]hexanamide
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C18H27N5O3
  1
1
IC50 = 92 nM
 Bioactivity Info 
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CP0505532
 Compound Info 
(3R)-3-(3-{[(aminosulfonyl)amino]methyl}-1,2,4-oxadiazol-5-yl)-6-cyclohexyl-Nhydroxyhexanamide
   Show/Hide
C15H27N5O5S
  1
1
IC50 = 98 nM
 Bioactivity Info 
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CP0532160
 Compound Info 
(3R)-6-cyclohexyl-N-hydroxy-3-(3-{[(2-pyridinylsulfonyl)amino]methyl}-1,2,4-oxadiazol-5-yl)hexanamide
   Show/Hide
C20H29N5O5S
  1
1
IC50 = 107 nM
 Bioactivity Info 
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CP0428680
 Compound Info 
(3R)-6-cyclohexyl-N-hydroxy-3-(3-phenyl-1,2,4-oxadiazol-5-yl)hexanamide
   Show/Hide
C20H27N3O3
  1
1
IC50 = 116 nM
 Bioactivity Info 
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CP0462757
 Compound Info 
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(aminomethyl)-1,2,4-oxadiazol-5-yl]hexanamide
   Show/Hide
C15H26N4O3
  1
1
IC50 = 122 nM
 Bioactivity Info 
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CP0335169
 Compound Info 
N-[[[(2R)-2-[(1R)-1-[formyl(hydroxy)amino]propyl]heptanoyl]amino]methyl]-7-methoxy-1-benzofuran-2-carboxamide
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C22H31N3O6
  1
1
IC50 = 126 nM
 Bioactivity Info 
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CP0439784
 Compound Info 
ethyl 4-[5-[(3R)-6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl]-1,2,4-oxadiazol-3-yl]benzoate
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C23H31N3O5
  1
1
IC50 = 154 nM
 Bioactivity Info 
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CP0238669
 Compound Info 
N-[[[(2R)-2-[[formyl(hydroxy)amino]methyl]heptanoyl]amino]methyl]-7-methoxy-1-benzofuran-2-carboxamide
   Show/Hide
C20H27N3O6
  1
1
IC50 = 160 nM
 Bioactivity Info 
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CP0238670
 Compound Info 
N-[[[(2R)-2-benzyl-3-[formyl(hydroxy)amino]propanoyl]amino]methyl]-7-methoxy-1-benzofuran-2-carboxamide
   Show/Hide
C22H23N3O6
  1
1
IC50 = 160 nM
 Bioactivity Info 
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CP0428683
 Compound Info 
ethyl 3-[5-[(3R)-6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl]-1,2,4-oxadiazol-3-yl]benzoate
   Show/Hide
C23H31N3O5
  1
1
IC50 = 184 nM
 Bioactivity Info 
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CP0467264
 Compound Info 
(3R)-3-(3-{[(aminocarbonyl)amino]methyl}-1,2,4-oxadiazol-5-yl)-6-cyclohexyl-Nhydroxyhexanamide
   Show/Hide
C16H27N5O4
  1
1
IC50 = 324 nM
 Bioactivity Info 
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CP0118590
 Compound Info 
(R)-2-(3-Cyclohexyl-propyl)-N*1*-[(S)-2,2-dimethyl-1-((R)-1-phenyl-ethylcarbamoyl)-propyl]-N*4*-hydroxy-succinamide
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C27H43N3O4
  1
1
IC50 = 820 nM
 Bioactivity Info 
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CP0126695
 Compound Info 
N-[[[(2R)-2-[[formyl(hydroxy)amino]methyl]pentanoyl]amino]methyl]-7-methoxy-1-benzofuran-2-carboxamide
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C18H23N3O6
  1
1
IC50 = 1250 nM
 Bioactivity Info 
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CP0540631
 Compound Info 
N-[[[(2S)-2-[[formyl(hydroxy)amino]methyl]heptanoyl]amino]methyl]-7-methoxy-1-benzofuran-2-carboxamide
   Show/Hide
C20H27N3O6
  1
1
IC50 = 4000 nM
 Bioactivity Info 
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CP0540630
 Compound Info 
N-[[3-[formyl(hydroxy)amino]propanoylamino]methyl]-7-methoxy-1-benzofuran-2-carboxamide
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C15H17N3O6
  1
1
IC50 = 6300 nM
 Bioactivity Info 
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CP0163469
 Compound Info 
(R)-ethyl 5-(1-(hydroxyamino)-1-oxo-6-phenylhexan-3-yl)-1,2,4-oxadiazole-3-carboxylate
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C17H21N3O5
  1
1
IC50 = 6600 nM
 Bioactivity Info 
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CP0056331
 Compound Info 
(R)-N'-((S)-3,3-dimethyl-1-oxo-1-((R)-1-phenylethylamino)butan-2-yl)-N4-hydroxy-2-(3-phenylpropyl)succinamide
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C27H37N3O4
  1
1
IC50 = 8765 nM
 Bioactivity Info 
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CP0335168
 Compound Info 
N-[[[(2R)-2-[(1S)-1-[formyl(hydroxy)amino]propyl]heptanoyl]amino]methyl]-7-methoxy-1-benzofuran-2-carboxamide
   Show/Hide
C22H31N3O6
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0091028
 Compound Info 
(S)-5-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-1,2,4-oxadiazole-3-carboxamide
   Show/Hide
C15H24N4O4
  1
1
IC50 > 2000 nM
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Cell Line ID: CL000856 , CHO E1a
 Cell Line Info 
Cell Line ID: CL000156 , HT-1080
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0128115
 Compound Info 
(R)-5-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-N,N-dimethyl-1,2,4-oxadiazole-3-carboxamide
   Show/Hide
C17H28N4O4
  1
1 IC50 = 9.3 nM
CP0175273
 Compound Info 
3-[[4-(benzylcarbamoylamino)phenyl]sulfonyl-[2-(4-methoxyphenyl)ethyl]amino]-N-hydroxypropanamide
   Show/Hide
C26H30N4O6S
  1
1 IC50 = 10 nM
CP0052398
 Compound Info 
(3R)-6-cyclohexyl-N-hydroxy-3-(1,2,4-oxadiazol-5-yl)hexanamide
   Show/Hide
C15H24N4O4
  1
1 IC50 = 26 nM
CP0164742
 Compound Info 
N-[(4R)-4-[1,3-benzodioxol-5-ylmethyl-(4-methoxyphenyl)sulfonylamino]-5-(hydroxyamino)-5-oxopentyl]benzamide
   Show/Hide
C27H29N3O8S
  1
1 IC50 = 98 nM
CP0104223
 Compound Info 
[3-ethoxy-5-[5-[[[(2R)-2-[(1R)-1-[formyl(hydroxy)amino]propyl]heptanoyl]amino]methylcarbamoyl]furan-2-yl]phenyl]phosphonic acid
   Show/Hide
C25H36N3O9P
  1
1 Ki = 0.04 nM
CP0052399
 Compound Info 
(3R)-6-cyclohexyl-N-hydroxy-3-(3-{[(methylsulfonyl)amino]-methyl}-1,2,4-oxadiazol-5-yl)hexanamide
   Show/Hide
C16H28N4O5S
  1
1 Ki = 11 nM
Clinical Information about the Protein
Target 1 ( Bone morphogenetic protein 1 (BMP1) )
Target Type Literature-reported Target
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT06770 Tolloid-like protein 2 Homo sapiens, Human
 Protein Info