Protein Information

General Information of the Protein

Protein ID	PT01194
Protein Name	Histamine H3 receptor
Secondarily Protein Name	G-protein coupled receptor 97
Gene Name	HRH3
Secondarily Gene Name	GPCR97
Sequence	MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Small molecule receptor (family A GPCR) > Monoamine receptor > Histamine receptor
Function	The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization. Show/Hide
Uniprot ID	Primary ID: Q9Y5N1 Secondarily ID: Q4QRI7 Q9GZX2 Q9H4K8 Show/Hide
HGNC ID	HGNC:5184
Subcellular Location	Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000901 , 661W

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0411059 Compound Info	(3S,4S)-4-ethyl-3-methyl-1-phenyl-2,4-dihydroquinolin-3-amine Show/Hide	C18H22N2	1
1	Ki = 3981.07 nM Bioactivity Info	TI LI LO TS
CP0391120 Compound Info	(1S,2R)-1-ethyl-7-methoxy-2-methyl-3,4-dihydro-1H-naphthalen-2-amine Show/Hide	C14H21NO	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0391121 Compound Info	(3S,4S)-4-ethyl-3,6-dimethyl-2,4-dihydrochromen-3-amine Show/Hide	C13H19NO	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000049 , C6

Cell Line Info

Cell Line ID: CL000011 , CHO

Cell Line Info

Cell Line ID: CL000026 , CHO-K1

Cell Line Info

Cell Line ID: CL000053 , COS-7

Cell Line Info

Cell Line ID: CL000088 , Flp-In-293

Cell Line Info

Cell Line ID: CL000025 , HEK-293T

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000065 , HEK293-EBNA

Cell Line Info

Cell Line ID: CL000913 , HEK293T-SP-FLAG-hH3R-CRE-CBR

Cell Line Info

Cell Line ID: CL000156 , HT-1080

Cell Line Info

Cell Line ID: CL000013 , Sf9

Cell Line Info

Cell Line ID: CL000074 , SK-N-MC

Cell Line Info

Cell Line ID: CL000043 , U2OS

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0098027 Compound Info	2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide Show/Hide	C6H10N4S	1
1	EC50 = 1.9 nM
CP0136874 Compound Info	(2R)-N,3-dimethyl-2-(methylamino)-N-[(1R,2S,5S,6S,9R,12S,13R,16S)-6,7,13-trimethyl-7-azapentacyclo[10.8.0.0^{2,9}.0^{5,9}.0^{13,18}]icos-18-en-16-yl]butanamide Show/Hide	C29H49N3O	1
1	EC50 = 3.3 nM
CP0047517 Compound Info	(1S,2S)-2-(1H-Imidazol-4-yl)-cyclopropylamine Show/Hide	C6H9N3	1
1	EC50 = 42 nM
CP0036920 Compound Info	2-(1H-imidazol-4-yl)ethan-1-amine Show/Hide	C5H9N3	4
1	EC50 = 77 nM
2	Ki = 12.8 nM
3	Ki = 16 nM
4	Ki = 33.88 nM
CP0114981 Compound Info	(1R,2R)-2-(1H-Imidazol-4-yl)-cyclopropylamine Show/Hide	C6H9N3	1
1	EC50 = 724 nM
CP0056575 Compound Info	1-(3-(4-(piperidin-1-ylmethyl)phenoxy)propyl)piperidine Show/Hide	C20H32N2O	8
1	IC50 = 0.53 nM
2	Kd = 0.1445 nM
3	Ki = 0.2754 nM
4	Ki = 0.5754 nM
5	Ki = 0.6 nM
6	Ki = 0.97 nM
7	Ki = 1 nM
8	Ki = 9.24 nM
CP0159421 Compound Info	5-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yloxy)-N-methylpyrazine-2-carboxamide Show/Hide	C20H24N4O2	2
1	IC50 = 0.631 nM
2	Ki = 0.1995 nM
CP0087367 Compound Info	5-fluoro-2-methyl-N-[2-methyl-4-[(3S)-3-[(2R)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]benzamide Show/Hide	C24H30FN3O	1
1	IC50 = 0.66 nM
CP0214957 Compound Info	5-fluoro-2-methyl-N-[2-methyl-4-[(3R)-3-[(2R)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]benzamide Show/Hide	C24H30FN3O	1
1	IC50 = 0.71 nM
CP0040569 Compound Info	1-[[4-(3-piperidin-1-ylpropoxy)phenyl]methyl]piperidin-4-ol Show/Hide	C20H32N2O2	2
1	IC50 = 0.72 nM
2	Ki = 0.7413 nM
CP0248952 Compound Info	1-(3,5-dichlorophenyl)-3-[4-[3-(2-methylpyrrolidin-1-yl)pyrrolidin-1-yl]phenyl]urea Show/Hide	C22H26Cl2N4O	1
1	IC50 = 0.95 nM
CP0082544 Compound Info	[1-[[4-(3-piperidin-1-ylpropoxy)phenyl]methyl]piperidin-4-yl]methanol Show/Hide	C21H34N2O2	1
1	IC50 = 1.3 nM
CP0284993 Compound Info	(4-propan-2-yl-1,4-diazepan-1-yl)-[1-[6-(trifluoromethyl)pyridin-3-yl]piperidin-4-yl]methanone Show/Hide	C20H29F3N4O	2
1	IC50 = 2.512 nM
2	Ki = 0.3162 nM
CP0314508 Compound Info	US8748435, 40 Show/Hide	C27H37N5	1
1	IC50 = 930 nM
CP0110803 Compound Info	4-(4-(1-isopropylpiperidin-4-yloxy)benzyl)morpholine Show/Hide	C19H30N2O2	3
1	Kd = 0.4786 nM
2	Ki = 2.1 nM
3	Ki = 2.138 nM
CP0134516 Compound Info	A-349,821 Show/Hide	C26H34N2O3	4
1	Kd = 2.138 nM
2	Ki = 0.4898 nM
3	Ki = 1.585 nM
4	Ki = 2 nM
CP0044460 Compound Info	N-cyclohexyl-4-(1H-imidazol-5-yl)piperidine-1-carbothioamide Show/Hide	C15H24N4S	6
1	Kd = 43.65 nM
2	Ki = 25 nM
3	Ki = 28.84 nM
4	Ki = 50.12 nM
5	Ki = 51.1 nM
6	Ki = 63.1 nM
CP0102038 Compound Info	2-(1-cyclobutylpiperidin-4-yl)-6-(1-cyclobutylpiperidin-4-yl)oxy-3,4-dihydroisoquinolin-1-one Show/Hide	C27H39N3O2	2
1	Ki = 0.03 nM
2	Ki = 0.8 nM
CP0102037 Compound Info	6-(1-propan-2-ylpiperidin-4-yl)oxy-2-(1-propan-2-ylpyrrolidin-3-yl)-3,4-dihydroisoquinolin-1-one Show/Hide	C24H37N3O2	2
1	Ki = 0.1 nM
2	Ki = 2.1 nM
CP0193419 Compound Info	6-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yloxy)-N-methylnicotinamide Show/Hide	C21H25N3O2	2
1	Ki = 0.12 nM
2	Ki = 0.1259 nM
CP0198937 Compound Info	(R)-2-(1-(6-ethoxypyridazin-3-yl)-5-methyl-1H-pyrazol-4-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline Show/Hide	C26H30N6O	2
1	Ki = 0.19 nM
2	Ki = 0.2 nM
CP0202877 Compound Info	2-Propyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone Show/Hide	C24H29N3O2	1
1	Ki = 0.2188 nM
CP0232075 Compound Info	2-Phenyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone Show/Hide	C27H27N3O2	1
1	Ki = 0.2188 nM
CP0091000 Compound Info	(R)-2-(2,7-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline Show/Hide	C24H27N5	1
1	Ki = 0.24 nM
CP0305864 Compound Info	2-Isopropyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone Show/Hide	C24H29N3O2	1
1	Ki = 0.25 nM
CP0056747 Compound Info	4-[(4-Chlorophenyl)methyl]-2-({(2R)-1-[4-(4-{[3-(hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)butyl]-2-pyrrolidinyl}methyl)-1(2H)-phthalazinone Show/Hide	C39H49ClN4O2	1
1	Ki = 0.2512 nM
CP0044094 Compound Info	(R)-2-(5-methyl-1-(pyridin-2-yl)-1H-pyrazol-4-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline Show/Hide	C25H27N5	1
1	Ki = 0.26 nM
CP0090976 Compound Info	(R)-2-(4-methyl-2-(pyrrolidin-1-yl)pyrimidin-5-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline Show/Hide	C25H31N5	2
1	Ki = 0.29 nM
2	Ki = 0.3 nM
CP0044006 Compound Info	(R)-2-methyl-3-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)-1,8-naphthyridine Show/Hide	C25H26N4	2
1	Ki = 0.3 nM
2	Ki = 0.34 nM
CP0203699 Compound Info	1-[[4-[4-(piperidin-1-ylmethyl)phenyl]phenyl]methyl]piperidine Show/Hide	C24H32N2	1
1	Ki = 0.3 nM
CP0119048 Compound Info	1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine Show/Hide	C17H26ClNO	2
1	Ki = 0.3 nM
2	Ki = 2.7 nM
CP0090649 Compound Info	2,7-Dimethyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone Show/Hide	C23H27N3O2	1
1	Ki = 0.3125 nM
CP0206059 Compound Info	6-Methoxy-2-methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone Show/Hide	C23H27N3O3	1
1	Ki = 0.3125 nM
CP0206060 Compound Info	2,5-Dimethyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone Show/Hide	C23H27N3O2	1
1	Ki = 0.3125 nM
CP0297753 Compound Info	2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-7-(trifluoromethyl)-4(3H)-quinazolinone Show/Hide	C23H24F3N3O2	1
1	Ki = 0.3125 nM
CP0194592 Compound Info	(R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofuran-5-yl)benzonitrile Show/Hide	C22H22N2O	4
1	Ki = 0.4 nM
2	Ki = 0.45 nM
3	Ki = 1.35 nM
4	Ki = 2.4 nM
CP0290003 Compound Info	5-Chloro-2-methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone Show/Hide	C22H24ClN3O2	1
1	Ki = 0.4062 nM
CP0305863 Compound Info	5-Methoxy-2-methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone Show/Hide	C23H27N3O3	1
1	Ki = 0.4062 nM
CP0126642 Compound Info	(R)-2-(1,3-dimethyl-1H-pyrazol-4-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline Show/Hide	C21H26N4	2
1	Ki = 0.45 nM
2	Ki = 0.5 nM
CP0305862 Compound Info	8-Fluoro-2-methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone Show/Hide	C22H24FN3O2	1
1	Ki = 0.4688 nM
CP0218857 Compound Info	6-Fluoro-2-methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone Show/Hide	C22H24FN3O2	1
1	Ki = 0.5 nM
CP0291530 Compound Info	2-Ethyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone Show/Hide	C23H27N3O2	1
1	Ki = 0.5 nM
CP0164197 Compound Info	2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-5-(trifluoromethyl)-4(3H)-quinazolinone Show/Hide	C23H24F3N3O2	3
1	Ki = 0.5312 nM
2	Ki = 1.7 nM
3	Ki = 6.8 nM
CP0073728 Compound Info	7-Fluoro-2-methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone Show/Hide	C22H24FN3O2	1
1	Ki = 0.625 nM
CP0142753 Compound Info	2,8-Dimethyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone Show/Hide	C23H27N3O2	1
1	Ki = 0.625 nM
CP0206057 Compound Info	5-Fluoro-2-methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone Show/Hide	C22H24FN3O2	1
1	Ki = 0.6875 nM
CP0313614 Compound Info	2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-8-(trifluoromethyl)-4(3H)-quinazolinone Show/Hide	C23H24F3N3O2	1
1	Ki = 0.6875 nM
CP0047136 Compound Info	(2R)-1-(1H-imidazol-5-yl)propan-2-amine Show/Hide	C6H11N3	2
1	Ki = 0.7 nM
2	Ki = 0.88 nM
CP0767847 Compound Info	(R)-2-(2-(2-(3-methyl-4-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)-1H-pyrazol-1-yl)ethoxy)ethoxy)ethan-1-amine Show/Hide	C26H37N5O2	1
1	Ki = 0.7 nM
CP0310817 Compound Info	7-Methoxy-2-methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone Show/Hide	C23H27N3O3	1
1	Ki = 0.7188 nM
CP0045343 Compound Info	4-(1-propan-2-ylpiperidin-4-yl)oxy-N-(1-propan-2-ylpyrrolidin-3-yl)benzamide Show/Hide	C22H35N3O2	2
1	Ki = 0.9 nM
2	Ki = 5.7 nM
CP0282219 Compound Info	2-methyl-6-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]pyridazin-3-one Show/Hide	C19H25N3O2	1
1	Ki = 1 nM
CP0181076 Compound Info	4-(1-cyclopentylpiperidin-4-yl)oxy-N-(1-propan-2-ylpyrrolidin-3-yl)benzamide Show/Hide	C24H37N3O2	2
1	Ki = 1 nM
2	Ki = 8.6 nM
CP0305594 Compound Info	N-[1-(2-methylpropyl)pyrrolidin-3-yl]-4-(1-propan-2-ylpiperidin-4-yl)oxybenzamide Show/Hide	C23H37N3O2	2
1	Ki = 1 nM
2	Ki = 1.2 nM
CP0231381 Compound Info	3-(4-{[3-(1-Pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone Show/Hide	C21H23N3O2	1
1	Ki = 1.094 nM
CP0305865 Compound Info	2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone Show/Hide	C22H25N3O2	1
1	Ki = 1.094 nM
CP0296479 Compound Info	8-Methoxy-2-methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone trifluoroacetate Show/Hide	C23H27N3O3	1
1	Ki = 1.156 nM
CP0137854 Compound Info	1-(4-Chloro-phenyl)-4-(4-cyclopentyl-piperazin-1-yl)-butane-1,4-dione; hydrochloride Show/Hide	C19H25ClN2O2	1
1	Ki = 1.2 nM
CP0304085 Compound Info	1-[2-[4-[4-(2-piperidin-1-ylethyl)phenyl]phenyl]ethyl]piperidine Show/Hide	C26H36N2	1
1	Ki = 1.2 nM
CP0231995 Compound Info	2,6-Dimethyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone Show/Hide	C23H27N3O2	1
1	Ki = 1.25 nM
CP0095277 Compound Info	4-(3-(4-(piperidin-1-yl)but-1-ynyl)benzyl)morpholine Show/Hide	C20H28N2O	1
1	Ki = 1.3 nM
CP0262053 Compound Info	((2R,4S)-4-(4-chloro-3-methylphenoxy)pyrrolidin-2-yl)(4-cyclobutyl-1,4-diazepan-1-yl)methanone Show/Hide	C21H30ClN3O2	1
1	Ki = 1.3 nM
CP0106703 Compound Info	1-((2R,4S)-2-(4-cyclobutyl-1,4-diazepane-1-carbonyl)-4-(4-fluorophenoxy)pyrrolidin-1-yl)ethanone Show/Hide	C22H30FN3O3	1
1	Ki = 1.5 nM
CP0834373 Compound Info	tert-butyl (R)-(2-(2-(2-(3-methyl-4-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)-1H-pyrazol-1-yl)ethoxy)ethoxy)ethyl)carbamate Show/Hide	C31H45N5O4	1
1	Ki = 1.5 nM
CP0096441 Compound Info	(4-cyclobutyl-1,4-diazepan-1-yl)((2R,4S)-4-(4-fluorophenoxy)pyrrolidin-2-yl)methanone Show/Hide	C20H28FN3O2	1
1	Ki = 1.6 nM
CP0115802 Compound Info	1-((2R,4S)-2-(4-cyclobutyl-1,4-diazepane-1-carbonyl)-4-(3-fluorophenoxy)pyrrolidin-1-yl)ethanone Show/Hide	C22H30FN3O3	1
1	Ki = 1.6 nM
CP0085944 Compound Info	2-[[4-(3-piperidin-1-ylpropoxy)phenyl]methyl]-3,4-dihydro-1H-isoquinoline Show/Hide	C24H32N2O	1
1	Ki = 1.698 nM
CP0298758 Compound Info	(4-cyclobutyl-1,4-diazepan-1-yl)((2R,4S)-4-(4-fluorophenoxy)-1-methylpyrrolidin-2-yl)methanone Show/Hide	C21H30FN3O2	1
1	Ki = 1.8 nM
CP0707832 Compound Info	3-(2-((1E,3E)-5-((E)-3,3-Dimethyl-5-sulfo-1-(3-sulfopropyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3-methyl-3-(6-((2-(2-(2-(3-methyl-4-(6-(2-((R)-2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)-1H-pyrazol-1-yl)ethoxy)ethoxy)ethyl)amino)-6-oxohexyl)-5-sulfo-3H-indol-1-ium-1-yl)propane-1-sulfonate Show/Hide	C62H81N7O15S4	1
1	Ki = 1.9 nM
CP0228017 Compound Info	((2R,4S)-4-(4-chlorophenoxy)pyrrolidin-2-yl)(4-cyclobutyl-1,4-diazepan-1-yl)methanone Show/Hide	C20H28ClN3O2	1
1	Ki = 2 nM
CP0246942 Compound Info	(4,4-Difluoropiperidin-1-yl)[1-isopropyl-5-(1-isopropylpiperidin-4-yloxy)-1H-indol-2-yl]methanone Show/Hide	C25H35F2N3O2	1
1	Ki = 2 nM
CP0304086 Compound Info	1-[[4-[4-(2-piperidin-1-ylethyl)phenyl]phenyl]methyl]piperidine Show/Hide	C25H34N2	1
1	Ki = 2 nM
CP0046463 Compound Info	3-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]-1H-pyridazin-6-one Show/Hide	C18H23N3O2	1
1	Ki = 2 nM
CP0078631 Compound Info	4-[(1R,2R)-2-(5,5-Dimethyl-hex-1-ynyl)-cyclopropyl]-1H-imidazole Show/Hide	C14H20N2	1
1	Ki = 2.138 nM
CP0095968 Compound Info	4-((3S,5R)-5-(4-cyclobutyl-1,4-diazepane-1-carbonyl)pyrrolidin-3-yloxy)benzonitrile Show/Hide	C21H28N4O2	1
1	Ki = 2.4 nM
CP0242533 Compound Info	2-(1,3-bis(3-(piperidin-1-yl)propyl)imidazolidin-2-ylidene)malononitrile Show/Hide	C22H36N6	1
1	Ki = 2.4 nM
CP0325312 Compound Info	((2R,4S)-4-(3-chlorophenoxy)pyrrolidin-2-yl)(4-cyclobutyl-1,4-diazepan-1-yl)methanone Show/Hide	C20H28ClN3O2	1
1	Ki = 2.5 nM
CP0115796 Compound Info	1-((2R,4S)-2-(4-cyclobutyl-1,4-diazepane-1-carbonyl)-4-(thiophen-3-yloxy)pyrrolidin-1-yl)ethanone Show/Hide	C20H29N3O3S	1
1	Ki = 2.7 nM
CP0306436 Compound Info	(4-cyclobutyl-1,4-diazepan-1-yl)((2R,4S)-4-(4-(methylthio)phenoxy)pyrrolidin-2-yl)methanone Show/Hide	C21H31N3O2S	1
1	Ki = 2.8 nM
CP0255637 Compound Info	1-[4-(4-Piperidin-1-ylmethyl-benzyloxy)-benzyl]-piperazine; compound with oxalic acid Show/Hide	C25H34N2O	1
1	Ki = 2.818 nM
CP0271597 Compound Info	6-[4-(1-cyclopentylpiperidin-4-yl)oxyphenyl]-2-methylpyridazin-3-one Show/Hide	C21H27N3O2	1
1	Ki = 3 nM
CP0292222 Compound Info	6-[4-(1-cyclobutylpiperidin-4-yl)oxyphenyl]-2-methylpyridazin-3-one Show/Hide	C20H25N3O2	1
1	Ki = 3 nM
CP0059288 Compound Info	(1R,6S)-5-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]-3,4-diazabicyclo[4.1.0]hept-4-en-2-one Show/Hide	C19H25N3O2	1
1	Ki = 3.1 nM
CP0158344 Compound Info	4-((3S,5R)-5-(4-cyclopentyl-1,4-diazepane-1-carbonyl)pyrrolidin-3-yloxy)benzonitrile Show/Hide	C22H30N4O2	1
1	Ki = 3.2 nM
CP0158336 Compound Info	(4-cyclobutyl-1,4-diazepan-1-yl)((2R,4S)-4-(3-fluorophenoxy)pyrrolidin-2-yl)methanone Show/Hide	C20H28FN3O2	1
1	Ki = 3.4 nM
CP0081592 Compound Info	(1S,2R)-trans-2-[2-(4-chlorobenzylamino)ethyl]-1-(1H-imidazol-4-yl)cyclopropane Show/Hide	C15H18ClN3	1
1	Ki = 3.6 nM
CP0310819 Compound Info	2-(1,4'-bipiperidin-1'-yl)-6-(2-methoxypyridin-4-yl)thiazolo[4,5-b]pyridine Show/Hide	C22H27N5OS	1
1	Ki = 4 nM
CP0158337 Compound Info	(4-cyclopentyl-1,4-diazepan-1-yl)((2R,4S)-4-(4-fluorophenoxy)pyrrolidin-2-yl)methanone Show/Hide	C21H30FN3O2	1
1	Ki = 4.1 nM
CP0325311 Compound Info	(4-cyclobutyl-1,4-diazepan-1-yl)((2R,4S)-4-(4-(trifluoromethyl)phenoxy)pyrrolidin-2-yl)methanone Show/Hide	C21H28F3N3O2	1
1	Ki = 4.1 nM
CP0088353 Compound Info	(1S,6R)-5-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]-3,4-diazabicyclo[4.1.0]hept-4-en-2-one Show/Hide	C19H25N3O2	1
1	Ki = 4.5 nM
CP0192538 Compound Info	(1S,2R)-trans-2-[2-(cyclohexylmethylamino)ethyl]-1-(1H-imidazol-4-yl)cyclopropane Show/Hide	C15H25N3	1
1	Ki = 5.3 nM
CP0123274 Compound Info	(4-cyclobutyl-1,4-diazepan-1-yl)((2R,4S)-4-phenoxypyrrolidin-2-yl)methanone Show/Hide	C20H29N3O2	1
1	Ki = 5.3 nM
CP0306438 Compound Info	(4-cyclobutyl-1,4-diazepan-1-yl)((2R,4S)-4-(thiophen-3-yloxy)pyrrolidin-2-yl)methanone Show/Hide	C18H27N3O2S	1
1	Ki = 5.3 nM
CP0066136 Compound Info	1-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]-2-morpholin-4-ylethanone Show/Hide	C20H30N2O3	1
1	Ki = 5.4 nM
CP0773911 Compound Info	(R)-2-((2-(2-(2-(3-methyl-4-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)-1H-pyrazol-1-yl)ethoxy)ethoxy)ethyl)amino)-2-oxoethane-1-sulfonic acid Show/Hide	C28H39N5O6S	1
1	Ki = 5.6 nM
CP0424855 Compound Info	2-(1-(2-(piperidin-1-yl)ethyl)-3-(3-(piperidin-1-yl)propyl)imidazolidin-2-ylidene)malononitrile Show/Hide	C21H34N6	1
1	Ki = 6.6 nM
CP0144396 Compound Info	3-(8-(3,4-dichlorophenyl)-6-methyl-5,6,7,8-tetrahydro-2,6-naphthyridin-3-yloxy)-N,N-diethylpropan-1-amine Show/Hide	C22H29Cl2N3O	1
1	Ki = 7 nM
CP0202866 Compound Info	5-(2-(1,4'-bipiperidin-1'-yl)thiazolo[4,5-c]pyridin-6-yl)pyridin-2-ol Show/Hide	C21H25N5OS	1
1	Ki = 8 nM
CP0347010 Compound Info	(1R,2S)-trans-2-[2-(4-chlorobenzylamino)ethyl]-1-(1H-imidazol-4-yl)cyclopropane Show/Hide	C15H18ClN3	1
1	Ki = 8.4 nM
CP0165547 Compound Info	2-(1,4'-bipiperidin-1'-yl)-6-chlorothiazolo[4,5-c]pyridine Show/Hide	C16H21ClN4S	1
1	Ki = 10 nM
CP0282261 Compound Info	N-[5-[2-(4-piperidin-1-ylpiperidin-1-yl)-[1,3]thiazolo[4,5-b]pyridin-6-yl]pyridin-2-yl]acetamide Show/Hide	C23H28N6OS	1
1	Ki = 10 nM
CP0085130 Compound Info	1-[6-[(3-cyclobutyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)oxy]pyridin-3-yl]pyrrolidin-2-one Show/Hide	C23H27N3O2	1
1	Ki = 10 nM
CP0176249 Compound Info	1-[4-[3-(4-pyridin-4-ylpiperazin-1-yl)propoxy]phenyl]ethanone Show/Hide	C20H25N3O2	1
1	Ki = 10.2 nM
CP0176032 Compound Info	N-methyl-N-[[1-methyl-5-(3-piperidin-1-ylpropoxy)indol-2-yl]methyl]prop-2-yn-1-amine Show/Hide	C22H31N3O	1
1	Ki = 10.8 nM
CP0036621 Compound Info	4,5-diphenyl-2-(3-(piperidin-1-yl)propoxy)thiazole Show/Hide	C23H26N2OS	1
1	Ki = 11.2 nM
CP0215922 Compound Info	1-(7-(3-(piperidin-1-yl)propoxy)-1,2,4,5-tetrahydrobenzo[d]azepin-3-yl)ethanone Show/Hide	C20H30N2O2	1
1	Ki = 11.6 nM
CP0273794 Compound Info	2-[4-(3-Piperidin-1-yl-propoxy)-phenyl]-indolizine Show/Hide	C22H26N2O	1
1	Ki = 13 nM
CP0095048 Compound Info	2-(1,4'-bipiperidin-1'-yl)-6-(2-fluoropyridin-4-yl)thiazolo[4,5-b]pyridine Show/Hide	C21H24FN5S	1
1	Ki = 13 nM
CP0181646 Compound Info	5-(2-(1,4'-bipiperidin-1'-yl)thiazolo[4,5-b]pyridin-6-yl)nicotinonitrile Show/Hide	C22H24N6S	1
1	Ki = 16 nM
CP0341379 Compound Info	5-(2-(1,4'-bipiperidin-1'-yl)thiazolo[4,5-b]pyridin-6-yl)pyridin-2-amine Show/Hide	C21H26N6S	1
1	Ki = 16 nM
CP0261905 Compound Info	2-(1-(4-(piperidin-1-yl)butyl)-3-(2-(piperidin-1-yl)ethyl)imidazolidin-2-ylidene)malononitrile Show/Hide	C22H36N6	1
1	Ki = 16 nM
CP0296482 Compound Info	5-(2-(1,4'-bipiperidin-1'-yl)thiazolo[4,5-c]pyridin-6-yl)pyrazin-2-amine Show/Hide	C20H25N7S	1
1	Ki = 17 nM
CP0180649 Compound Info	5-(3-benzhydryloxypropyl)-1H-imidazole Show/Hide	C19H20N2O	2
1	Ki = 17 nM
2	Ki = 24 nM
CP0203201 Compound Info	2-(1,4'-bipiperidin-1'-yl)-6-(2-fluoropyridin-3-yl)thiazolo[4,5-c]pyridine Show/Hide	C21H24FN5S	1
1	Ki = 20 nM
CP0042242 Compound Info	5-(2-(1,4'-bipiperidin-1'-yl)thiazolo[4,5-c]pyridin-6-yl)nicotinonitrile Show/Hide	C22H24N6S	1
1	Ki = 22 nM
CP0037479 Compound Info	(4-cyclopropylpiperazin-1-yl)(4-(3,4-dichlorophenoxy)-3-((methylamino)methyl)phenyl)methanone Show/Hide	C22H25Cl2N3O2	1
1	Ki = 23 nM
CP0095046 Compound Info	5-(2-(1,4'-bipiperidin-1'-yl)thiazolo[4,5-b]pyridin-6-yl)-2-fluorobenzonitrile Show/Hide	C23H24FN5S	1
1	Ki = 23 nM
CP0157294 Compound Info	2-(1,3-bis(2-(piperidin-1-yl)ethyl)imidazolidin-2-ylidene)malononitrile Show/Hide	C20H32N6	1
1	Ki = 24 nM
CP0041914 Compound Info	4-(3-(piperidin-1-yl)propoxy)benzonitrile Show/Hide	C15H20N2O	2
1	Ki = 25 nM
2	Ki = 25.12 nM
CP0181647 Compound Info	2-(1,4'-bipiperidin-1'-yl)-6-(pyrimidin-5-yl)thiazolo[4,5-b]pyridine Show/Hide	C20H24N6S	1
1	Ki = 25 nM
CP0181648 Compound Info	2-(1,4'-bipiperidin-1'-yl)-6-(pyrimidin-5-yl)thiazolo[4,5-c]pyridine Show/Hide	C20H24N6S	1
1	Ki = 25 nM
CP0231999 Compound Info	5-(2-(1,4'-bipiperidin-1'-yl)thiazolo[4,5-c]pyridin-6-yl)pyridin-2-amine Show/Hide	C21H26N6S	1
1	Ki = 25 nM
CP0746436 Compound Info	4-((2-(2-(2-(3-methyl-4-(6-(2-((R)-2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)-1H-pyrazol-1-yl)ethoxy)ethoxy)ethyl)carbamoyl)cyclobutane-1,2,3-tricarboxylic acid Show/Hide	C34H43N5O9	1
1	Ki = 25.4 nM
CP0232079 Compound Info	N-[5-[2-(4-piperidin-1-ylpiperidin-1-yl)-[1,3]thiazolo[4,5-c]pyridin-6-yl]pyridin-2-yl]acetamide Show/Hide	C23H28N6OS	1
1	Ki = 27 nM
CP0095045 Compound Info	4-(2-(1,4'-bipiperidin-1'-yl)thiazolo[4,5-b]pyridin-6-yl)benzonitrile Show/Hide	C23H25N5S	1
1	Ki = 28 nM
CP0432836 Compound Info	Aplysamine-1 Show/Hide	C15H24Br2N2O	1
1	Ki = 30 nM
CP0095053 Compound Info	2-(1,4'-bipiperidin-1'-yl)-6-(6-fluoropyridin-3-yl)thiazolo[4,5-c]pyridine Show/Hide	C21H24FN5S	1
1	Ki = 35 nM
CP0165548 Compound Info	2-(1,4'-bipiperidin-1'-yl)-6-(6-methoxypyridin-3-yl)thiazolo[4,5-b]pyridine Show/Hide	C22H27N5OS	1
1	Ki = 35 nM
CP0552696 Compound Info	1-[4-(4-tert-butylphenoxy)butyl]-4-pyridin-4-ylpiperazine Show/Hide	C23H33N3O	1
1	Ki = 37.8 nM
CP0095052 Compound Info	5-(2-(1,4'-bipiperidin-1'-yl)thiazolo[4,5-b]pyridin-6-yl)pyridin-2-ol Show/Hide	C21H25N5OS	1
1	Ki = 42 nM
CP0282258 Compound Info	2-(1,4'-bipiperidin-1'-yl)-6-(2-fluoropyridin-3-yl)thiazolo[4,5-b]pyridine Show/Hide	C21H24FN5S	1
1	Ki = 42 nM
CP0073734 Compound Info	2-(1,4'-bipiperidin-1'-yl)-6-(2-fluoropyridin-4-yl)thiazolo[4,5-c]pyridine Show/Hide	C21H24FN5S	1
1	Ki = 44 nM
CP0062562 Compound Info	4-((3R,5S)-5-(4-cyclobutyl-1,4-diazepane-1-carbonyl)pyrrolidin-3-yloxy)benzonitrile Show/Hide	C21H28N4O2	1
1	Ki = 45 nM
CP0099745 Compound Info	4-[3-(4-cyclopropanecarbonylphenoxy)propyl]-1H-imidazole Show/Hide	C16H18N2O2	2
1	Ki = 46 nM
2	Ki = 63 nM
CP0167796 Compound Info	1-(5-(1,4'-bipiperidin-1'-yl)-1,3,4-thiadiazol-2-yl)-3-cyclopentylurea Show/Hide	C18H30N6OS	1
1	Ki = 49 nM
CP0115794 Compound Info	1-((2S,4S)-2-(4-cyclobutyl-1,4-diazepane-1-carbonyl)-4-(4-(methylthio)phenoxy)pyrrolidin-1-yl)ethanone Show/Hide	C23H33N3O3S	1
1	Ki = 50 nM
CP0230695 Compound Info	2-(1,4'-bipiperidin-1'-yl)-6-(6-fluoropyridin-3-yl)thiazolo[4,5-b]pyridine Show/Hide	C21H24FN5S	1
1	Ki = 63 nM
CP0253732 Compound Info	2-(1,4'-bipiperidin-1'-yl)-6-(2-methoxypyridin-4-yl)thiazolo[4,5-c]pyridine Show/Hide	C22H27N5OS	1
1	Ki = 64 nM
CP0042243 Compound Info	5-(2-(1,4'-bipiperidin-1'-yl)thiazolo[4,5-b]pyridin-6-yl)pyrazin-2-amine Show/Hide	C20H25N7S	1
1	Ki = 66 nM
CP0137827 Compound Info	7-(3-piperidin-1-ylpropoxy)-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazoline Show/Hide	C19H27N3O	1
1	Ki = 76.2 nM
CP0673695 Compound Info	N-{[5-(3-(1-Benzylpiperidin-4-yl)propoxy)-1-methyl-1Hindol-2-yl]methyl}-N-methylprop-2-yn-1-amine Show/Hide	C29H37N3O	1
1	Ki = 84.2 nM
CP0021188 Compound Info	N-methyl-2-(4-phenylmethoxypiperidin-1-yl)ethanamine Show/Hide	C15H24N2O	1
1	Ki = 87 nM
CP0042241 Compound Info	2-(1,4'-bipiperidin-1'-yl)-6-(6-methoxypyridin-3-yl)thiazolo[4,5-c]pyridine Show/Hide	C22H27N5OS	1
1	Ki = 93 nM
CP0290723 Compound Info	2-(1,4'-bipiperidin-1'-yl)-6-(6-methylpyridin-3-yl)thiazolo[4,5-c]pyridine Show/Hide	C22H27N5S	1
1	Ki = 104 nM
CP0345088 Compound Info	1-[7-(4-chlorophenoxy)heptyl]piperidine Show/Hide	C18H28ClNO	1
1	Ki = 128 nM
CP0044000 Compound Info	2-(1,4'-bipiperidin-1'-yl)-6-(6-methylpyridin-3-yl)thiazolo[4,5-b]pyridine Show/Hide	C22H27N5S	1
1	Ki = 133 nM
CP0154610 Compound Info	[(2S,5S)-5-(1H-imidazol-5-yl)oxolan-2-yl]methanamine Show/Hide	C8H13N3O	1
1	Ki = 218.78 nM
CP0130853 Compound Info	Imifuramine Show/Hide	C8H13N3O	1
1	Ki = 229.09 nM
CP0348117 Compound Info	5-[(2R,5R)-5-(phenylmethoxymethyl)oxolan-2-yl]-1H-imidazole Show/Hide	C15H18N2O2	1
1	Ki = 245.47 nM
CP0528102 Compound Info	1-[4-[3-(4-pyridin-2-ylpiperazin-1-yl)propoxy]phenyl]ethanone Show/Hide	C20H25N3O2	1
1	Ki = 315 nM
CP0172969 Compound Info	5-[(2R,5S)-5-(phenylmethoxymethyl)oxolan-2-yl]-1H-imidazole Show/Hide	C15H18N2O2	1
1	Ki = 331.13 nM
CP0795071 Compound Info	2-(4-(4-(4-(tert-pentyl)phenoxy)butyl)piperazin-1-yl)pyrazine Show/Hide	C23H34N4O	1
1	Ki = 683 nM
CP0862785 Compound Info	2-(4-(4-(4-(tert-butyl)phenoxy)butyl)piperazin-1-yl)pyrimidine Show/Hide	C22H32N4O	1
1	Ki = 883 nM
CP0352542 Compound Info	1-[4-[4-(4-pyridin-3-ylpiperazin-1-yl)butoxy]phenyl]ethanone Show/Hide	C21H27N3O2	1
1	Ki = 908 nM
CP0154225 Compound Info	[(2R,5R)-5-(1H-imidazol-5-yl)-2,5-dihydrofuran-2-yl]methanamine Show/Hide	C8H11N3O	1
1	Ki = 1023.29 nM
CP0304548 Compound Info	1-[[4-(piperidin-1-ylmethyl)phenyl]methyl]piperidine Show/Hide	C18H28N2	1
1	Ki = 1230 nM
CP0352541 Compound Info	1-[4-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butoxy]phenyl]ethanone Show/Hide	C20H26N4O2	1
1	Ki = 1230 nM
CP0097151 Compound Info	[(2R,5S)-5-(1H-imidazol-5-yl)oxolan-2-yl]methanamine Show/Hide	C8H13N3O	1
1	Ki = 1698.24 nM
CP0002071 Compound Info	N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-N-prop-2-enylprop-2-en-1-amine Show/Hide	C17H22N2O	1
1	Ki = 1698.24 nM
CP0516955 Compound Info	1-[4-[3-(4-pyrazin-2-ylpiperazin-1-yl)propoxy]phenyl]propan-1-one Show/Hide	C20H26N4O2	1
1	Ki = 1720 nM
CP0182141 Compound Info	[(2S,5R)-5-(1H-imidazol-5-yl)oxolan-2-yl]methanamine Show/Hide	C8H13N3O	1
1	Ki = 2041.74 nM
CP0307262 Compound Info	N-butyl-N-[3-[4-(5-methylimidazo[1,2-a]pyridin-2-yl)phenoxy]propyl]butan-1-amine Show/Hide	C25H35N3O	1
1	Ki = 2100 nM
CP0100890 Compound Info	1-cyano-3-[[(2R,5R)-5-(1H-imidazol-5-yl)oxolan-2-yl]methyl]-2-methylguanidine Show/Hide	C11H16N6O	1
1	Ki = 2187.76 nM
CP0041262 Compound Info	5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-indole Show/Hide	C14H16ClN3O	2
1	Ki = 2238.72 nM
2	Ki = 5125 nM
CP0718475 Compound Info	2-(4-(4-(4-(tert-pentyl)phenoxy)butyl)piperazin-1-yl)pyrimidine Show/Hide	C23H34N4O	1
1	Ki = 2264 nM
CP0532197 Compound Info	1-[4-[3-(4-pyrimidin-2-ylpiperazin-1-yl)propoxy]phenyl]ethanone Show/Hide	C19H24N4O2	1
1	Ki = 2316 nM
CP0100889 Compound Info	[(2S,5S)-5-(1H-imidazol-5-yl)-2,5-dihydrofuran-2-yl]methanamine Show/Hide	C8H11N3O	1
1	Ki = 2511.89 nM
CP0842770 Compound Info	1-(4-(4-(tert-butyl)phenoxy)butyl)-4-(pyridin-2-yl)piperazine Show/Hide	C23H33N3O	1
1	Ki = 2957 nM
CP0470593 Compound Info	1-[4-[3-(4-pyrimidin-2-ylpiperazin-1-yl)propoxy]phenyl]propan-1-one Show/Hide	C20H26N4O2	1
1	Ki = 3390 nM
CP0842769 Compound Info	1-(4-(4-(tert-butyl)phenoxy)butyl)-4-(pyridin-3-yl)piperazine Show/Hide	C23H33N3O	1
1	Ki = 3420 nM
CP0396770 Compound Info	1-[4-[4-(4-pyridin-2-ylpiperazin-1-yl)butoxy]phenyl]ethanone Show/Hide	C21H27N3O2	1
1	Ki = 3697 nM
CP0718476 Compound Info	2-(4-(3-(4-(tert-butyl)phenoxy)propyl)piperazin-1-yl)pyrimidine Show/Hide	C21H30N4O	1
1	Ki = 3827 nM
CP0833058 Compound Info	2-(4-(4-(4-(tert-butyl)phenoxy)butyl)piperazin-1-yl)pyrazine Show/Hide	C22H32N4O	1
1	Ki = 5477 nM
CP0122622 Compound Info	5-[(2S,5R)-5-(phenylmethoxymethyl)oxolan-2-yl]-1H-imidazole Show/Hide	C15H18N2O2	1
1	Ki = 6918.31 nM
CP0279022 Compound Info	1-cyano-3-[[(2S,5R)-5-(1H-imidazol-5-yl)oxolan-2-yl]methyl]-2-methylguanidine Show/Hide	C11H16N6O	1
1	Ki = 7079.46 nM
CP0035258 Compound Info	N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine Show/Hide	C17H18F3NO	1
1	Ki = 7300 nM
CP0099909 Compound Info	1-cyano-3-[[(2R,5S)-5-(1H-imidazol-5-yl)oxolan-2-yl]methyl]-2-methylguanidine Show/Hide	C11H16N6O	1
1	Ki = 8128.31 nM
CP0309840 Compound Info	5-[(2S,5S)-5-(phenylmethoxymethyl)oxolan-2-yl]-1H-imidazole Show/Hide	C15H18N2O2	1
1	Ki = 10471.29 nM
CP0055652 Compound Info	[(2S,5R)-5-(1H-imidazol-5-yl)-2,5-dihydrofuran-2-yl]methanamine Show/Hide	C8H11N3O	1
1	Ki = 11481.54 nM
CP0066043 Compound Info	(5-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperazin-1-yl)-methanone Show/Hide	C13H15ClN4O	2
1	Ki = 14053 nM
2	Ki = 20000 nM
CP0195654 Compound Info	1-cyano-3-[[(2S,5S)-5-(1H-imidazol-5-yl)oxolan-2-yl]methyl]-2-methylguanidine Show/Hide	C11H16N6O	1
1	Ki = 18620.87 nM
CP0038430 Compound Info	[(2R,5S)-5-(1H-imidazol-5-yl)-2,5-dihydrofuran-2-yl]methanamine Show/Hide	C8H11N3O	1
1	Ki = 19952.62 nM
CP0949327 Compound Info	1-(4-(4-(tert-pentyl)phenoxy)butyl)-4-(pyridin-3-yl)piperazine Show/Hide	C24H35N3O	1
1	Ki > 10000 nM

Clinical Information about the Protein

Target 1 ( Histamine H3 receptor (H3R) )

Target Type	Successful Target
Disease	15 Target-related Diseases				15
1	Excessive daytime sleepiness [ICD-11: MG42]
2	Cognitive impairment [ICD-11: 6D71]
3	Alzheimer disease [ICD-11: 8A20]
4	Attention deficit hyperactivity disorder [ICD-11: 6A05.Z]
5	Dementia [ICD-11: 6D80-6D86]
6	Alcohol dependence [ICD-11: 6C40.2]
7	Insulin-resistant disorder [ICD-11: 5A44]
8	Schizophrenia [ICD-11: 6A20]
9	Allergic rhinitis [ICD-11: CA08.0]
10	Anxiety disorder [ICD-11: 6B00-6B0Z]
11	Pain [ICD-11: MG30-MG3Z]
12	Obesity [ICD-11: 5B81]
13	Neurological disorder [ICD-11: 6B60]
14	Narcolepsy [ICD-11: 7A20]
15	Central nervous system disease [ICD-11: 8A04-8D87]
Approved Drug(s)	1 Approved Drug				1
1	Pitolisant	Drug Info	Approved	Excessive daytime sleepiness
Clinical Trial Drug(s)	9 Clinical Trial Drugs				9
1	SUVN-G3031	Drug Info	Phase 3	Cognitive impairment
2	ABT-288	Drug Info	Phase 2	Alzheimer disease
3	Bavisant	Drug Info	Phase 2	Attention deficit hyperactivity disorder
4	GSK239512	Drug Info	Phase 2	Dementia
5	JNJ-39220675	Drug Info	Phase 2	Alcohol dependence
6	ABT-239	Drug Info	Phase 1	Cognitive impairment
7	Irdabisant	Drug Info	Phase 1	Cognitive impairment
8	MK-3134	Drug Info	Phase 1	Dementia
9	MK-0249	Drug Info	Clinical trial	Insulin-resistant disorder
Discontinued Drug(s)	6 Discontinued Drugs				6
1	Cipralisant	Drug Info	Discontinued in Phase 2	Attention deficit hyperactivity disorder
2	GSK1004723	Drug Info	Discontinued in Phase 1	Allergic rhinitis
3	GT-2016	Drug Info	Terminated	Alzheimer disease
4	GT-2203	Drug Info	Terminated	Anxiety disorder
5	Thioperamide	Drug Info	Terminated	Cognitive impairment
6	UCL-1390	Drug Info	Terminated	Pain
Investigative Drug(s)	8 Investigative Drugs				8
1	A-317920	Drug Info	Investigative	Attention deficit hyperactivity disorder
2	A-331440	Drug Info	Investigative	Obesity
3	Ciproxifan	Drug Info	Investigative	Obesity
4	FUB-130	Drug Info	Investigative	Neurological disorder
5	GSK-334429	Drug Info	Investigative	Cognitive impairment
6	GSK189254A	Drug Info	Investigative	Cognitive impairment
7	JNJ-5207852	Drug Info	Investigative	Narcolepsy
8	SCH79687	Drug Info	Investigative	Central nervous system disease
Patented Agent(s)	1 Patented Agent				1
1	PMID29334795-Compound-23	Drug Info	Patented	Schizophrenia

Similar Protein(s) and Bioactivity Statistics

50% Identity

Protein ID	Protein Name	Protein Organism
PT00577	Histamine receptor H3	Macaca mulatta, Rhesus macaque	Protein Info
PT03573	Histamine H3 receptor	Cavia porcellus, Guinea pig	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han