General Information of the Compound
Compound ID
CP0037479
Compound Name
(4-cyclopropylpiperazin-1-yl)(4-(3,4-dichlorophenoxy)-3-((methylamino)methyl)phenyl)methanone
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Structure
Formula
C22H25Cl2N3O2
Molecular Weight
434.367
Canonical SMILES
CNCc1cc(ccc1Oc1ccc(Cl)c(Cl)c1)C(=O)N1CCN(CC1)C1CC1
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InChI
InChI=1S/C22H25Cl2N3O2/c1-25-14-16-12-15(22(28)27-10-8-26(9-11-27)17-3-4-17)2-7-21(16)29-18-5-6-19(23)20(24)13-18/h2,5-7,12-13,17,25H,3-4,8-11,14H2,1H3
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InChIKey
SBAQYPMYNRQKBF-UHFFFAOYSA-N
Physicochemical Property
logP
4.4253
Rotatable Bonds
6
Heavy Atom Count
29
Polar Areas
44.81
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 24890939
SID: 51083421
ChEMBL ID
CHEMBL402644
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01194, Histamine H3 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000074 SK-N-MC Homo sapiens (Human)  1
1
Ki = 23 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 23 nM