General Information of the Compound
Compound ID
CP0115794
Compound Name
1-((2S,4S)-2-(4-cyclobutyl-1,4-diazepane-1-carbonyl)-4-(4-(methylthio)phenoxy)pyrrolidin-1-yl)ethanone
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Structure
Formula
C23H33N3O3S
Molecular Weight
431.602
Canonical SMILES
CSc1ccc(O[C@H]2C[C@H](N(C2)C(C)=O)C(=O)N2CCCN(CC2)C2CCC2)cc1
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InChI
InChI=1S/C23H33N3O3S/c1-17(27)26-16-20(29-19-7-9-21(30-2)10-8-19)15-22(26)23(28)25-12-4-11-24(13-14-25)18-5-3-6-18/h7-10,18,20,22H,3-6,11-16H2,1-2H3/t20-,22-/m0/s1
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InChIKey
GNICZGVXXCYLIS-UNMCSNQZSA-N
Physicochemical Property
logP
2.8635
Rotatable Bonds
5
Heavy Atom Count
30
Polar Areas
53.09
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
5
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46888207
ChEMBL ID
CHEMBL1095533
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01194, Histamine H3 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000074 SK-N-MC Homo sapiens (Human)  1
1
Kd = 20.89 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 50 nM